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Its most prominent effects are the regulation of renal phosphate reabsorption and calcitriol (active vitamin D, 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>) formation, effects dependent on its co-receptor \u03b1Klotho. Besides these actions, further paracrine and endocrine effects exist. The production of FGF23 is regulated\u00a0by 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>, parathyroid hormone, dietary phosphate intake, iron status, as well as inflammation. Glucocorticoids are hormones with anti-inflammatory properties and are, therefore, widely used for acute and chronic inflammatory diseases, autoimmune disorders, and malignancies. The present study explored whether glucocorticoids influence the production of FGF23 in vitro as well as in mice<jats:italic>. Fgf23<\/jats:italic> transcription was analyzed by semi-quantitative real-time PCR. Serum concentrations of FGF23 and 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> were measured by ELISA. Urinary phosphate and Ca<jats:sup>2+<\/jats:sup> excretion were determined in metabolic cages. As a result, in UMR106 rat osteoblast-like cells and in MC3T3-E1 cells, both, dexamethasone and prednisolone, downregulated <jats:italic>Fgf23<\/jats:italic> transcription and FGF23 protein synthesis. Dexamethasone increased <jats:italic>Dmp1<\/jats:italic> and <jats:italic>Phex<\/jats:italic> (encoding FGF23-regulating genes) as well as <jats:italic>Nfkbia<\/jats:italic> (encoding NF\u03baB inhibitor I\u03baB\u03b1) transcription in UMR106 cells. In mice, a single injection of dexamethasone or prednisolone was followed by a significant decrease of serum C-terminal and intact FGF23 concentration and bone <jats:italic>Fgf23<\/jats:italic> mRNA expression within 12\u00a0h. These effects were paralleled by increased renal phosphate excretion and enhanced 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> formation. We conclude that a single glucocorticoid treatment strongly downregulates the FGF23 plasma concentration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key messages<\/jats:title>\n                <jats:p><jats:list list-type=\"bullet\">\n                  <jats:list-item>\n                    <jats:p>Glucocorticoids dexamethasone and prednisolone suppress the formation of bone-derived hormone fibroblast growth factor 23 (FGF23) in vitro.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>The effect is accompanied by an upregulation of Dmp1, Phex, and I\u03baB\u03b1, negative regulators of FGF23, in UMR106 osteoblast-like cells.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>Glucocorticoid receptor antagonist RU-486 attenuates the effect of dexamethasone on FGF23, Dmp1, and Phex.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>In mice, a single glucocorticoid dose suppresses FGF23 and enhances 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> (active vitamin D).<\/jats:p>\n                  <\/jats:list-item>\n                <\/jats:list><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00109-021-02036-8","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T22:02:25Z","timestamp":1612044145000},"page":"699-711","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Glucocorticoids dexamethasone and prednisolone suppress fibroblast growth factor 23 (FGF23)"],"prefix":"10.1007","volume":"99","author":[{"given":"Martina","family":"Feger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Ewendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Strotmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Sch\u00e4ffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Kempe-Teufel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Glosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele I.","family":"Stangl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-4827","authenticated-orcid":false,"given":"Michael","family":"F\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,30]]},"reference":[{"issue":"1","key":"2036_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00424-018-2238-5","volume":"471","author":"MC Hu","year":"2019","unstructured":"Hu MC, Shi M, Moe OW (2019) Role of \u03b1Klotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters. 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