{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:09:33Z","timestamp":1783706973144,"version":"3.55.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070912 and 91543131"],"award-info":[{"award-number":["82070912 and 91543131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773326"],"award-info":[{"award-number":["81773326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2017BN04"],"award-info":[{"award-number":["2017BN04"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20171347, BE2019676"],"award-info":[{"award-number":["BK20171347, BE2019676"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK2071117"],"award-info":[{"award-number":["BK2071117"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00109-021-02073-3","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T08:06:55Z","timestamp":1617955615000},"page":"1009-1020","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Soluble IL-6R-mediated IL-6 trans-signaling activation contributes to the pathological development of psoriasis"],"prefix":"10.1007","volume":"99","author":[{"given":"Hui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2868-5112","authenticated-orcid":false,"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"issue":"9","key":"2073_CR1","first-page":"1365","volume":"63","author":"S Ahmed","year":"2017","unstructured":"Ahmed S, Hussain S, Ammar A, Jahan S, Khaliq S, Kaul H (2017) Interleukin 6 receptor (IL6-R) gene polymorphisms underlie susceptibility to rheumatoid arthritis. Clin Lab 63(9):1365\u20131369","journal-title":"Clin Lab"},{"issue":"5","key":"2073_CR2","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1530\/EJE-07-0389","volume":"157","author":"M Bustamante","year":"2007","unstructured":"Bustamante M, Nogues X, Mellibovsky L, Agueda L, Jurado S, Caceres E, Blanch J, Carreras R, Diez-Perez A, Grinberg D et al (2007) Polymorphisms in the interleukin-6 receptor gene are associated with bone mineral density and body mass index in Spanish postmenopausal women. Eur J Endocrinol 157(5):677\u2013684","journal-title":"Eur J Endocrinol"},{"issue":"6-7","key":"2073_CR3","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.ejcb.2010.10.007","volume":"90","author":"A Chalaris","year":"2011","unstructured":"Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J (2011) The soluble Interleukin 6 receptor: generation and role in inflammation and cancer. Eur J Cell Biol 90(6-7):484\u2013494","journal-title":"Eur J Cell Biol"},{"issue":"7429","key":"2073_CR4","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1038\/492S50a","volume":"492","author":"JM Crow","year":"2012","unstructured":"Crow JM (2012) Psoriasis uncovered. NATURE 492(7429):S50\u2013S51","journal-title":"NATURE"},{"key":"2073_CR5","doi-asserted-by":"publisher","unstructured":"Davies R, Williams J, Sime K, Jin HS, Thompson C, Jordan L, Lang D, Halcox JP, Ellins E, Jones GW et al (2020) The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis. Rheumatology (Oxford). https:\/\/doi.org\/10.1093\/rheumatology\/keaa725","DOI":"10.1093\/rheumatology\/keaa725"},{"issue":"2","key":"2073_CR6","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jaci.2013.01.057","volume":"132","author":"J Esparza-Gordillo","year":"2013","unstructured":"Esparza-Gordillo J, Schaarschmidt H, Liang L, Cookson W, Bauerfeind A, Lee-Kirsch MA, Nemat K, Henderson J, Paternoster L, Harper JI et al (2013) A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis. J Allergy Clin Immunol 132(2):371\u2013377","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"2073_CR7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1365-2265.2006.02553.x","volume":"65","author":"E Esteve","year":"2006","unstructured":"Esteve E, Villuendas G, Mallolas J, Vendrell J, Lopez-Bermejo A, Rodriguez M, Recasens M, Ricart W, San MJ, Escobar-Morreale H et al (2006) Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome. Clin Endocrinol 65(1):88\u201391","journal-title":"Clin Endocrinol"},{"issue":"6","key":"2073_CR8","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/sj.gene.6364120","volume":"5","author":"JC Galicia","year":"2004","unstructured":"Galicia JC, Tai H, Komatsu Y, Shimada Y, Akazawa K, Yoshie H (2004) Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced. Genes Immun 5(6):513\u2013516","journal-title":"Genes Immun"},{"issue":"17","key":"2073_CR9","doi-asserted-by":"publisher","first-page":"14804","DOI":"10.1074\/jbc.M111.229393","volume":"286","author":"C Garbers","year":"2011","unstructured":"Garbers C, Janner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J (2011) Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding. J Biol Chem 286(17):14804\u201314811","journal-title":"J Biol Chem"},{"issue":"2","key":"2073_CR10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1600-0625.2010.01210.x","volume":"20","author":"S Gerdes","year":"2011","unstructured":"Gerdes S, Rostami-Yazdi M, Mrowietz U (2011) Adipokines and psoriasis. Exp Dermatol 20(2):81\u201387","journal-title":"Exp Dermatol"},{"issue":"5","key":"2073_CR11","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.4049\/jimmunol.0803721","volume":"183","author":"WA Goodman","year":"2009","unstructured":"Goodman WA, Levine AD, Massari JV, Sugiyama H, McCormick TS, Cooper KD (2009) IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells. J Immunol 183(5):3170\u20133176","journal-title":"J Immunol"},{"issue":"5","key":"2073_CR12","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/CMR.0b013e32830658b2","volume":"18","author":"F Gu","year":"2008","unstructured":"Gu F, Qureshi AA, Niu T, Kraft P, Guo Q, Hunter DJ, Han J (2008) Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma. Melanoma Res 18(5):330\u2013335","journal-title":"Melanoma Res"},{"issue":"2","key":"2073_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cyto.2015.06.018","volume":"76","author":"M Jasiewicz","year":"2015","unstructured":"Jasiewicz M, Knapp M, Waszkiewicz E, Ptaszynska-Kopczynska K, Szpakowicz A, Sobkowicz B, Musial WJ, Kaminski KA (2015) Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage. Cytokine 76(2):187\u2013192","journal-title":"Cytokine"},{"issue":"3","key":"2073_CR14","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0167-4889(02)00319-1","volume":"1592","author":"SA Jones","year":"2002","unstructured":"Jones SA, Rose-John S (2002) The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R\/IL-6 complex. Biochim Biophys Acta 1592(3):251\u2013263","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"2073_CR15","first-page":"542","volume":"90","author":"PM Kluck","year":"1993","unstructured":"Kluck PM, Wiegant J, Jansen RP, Bolk MW, Raap AK, Willemze R, Landegent JE (1993) The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21.HUM. GENET 90(5):542\u2013544","journal-title":"GENET"},{"issue":"1","key":"2073_CR16","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/sj.icb.7100113","volume":"86","author":"H Knupfer","year":"2008","unstructured":"Knupfer H, Preiss R (2008) sIL-6R: more than an agonist? Immunol Cell Biol 86(1):87\u201391","journal-title":"Immunol Cell Biol"},{"issue":"6","key":"2073_CR17","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1080\/1354750X.2018.1458151","volume":"23","author":"AA Korotaeva","year":"2018","unstructured":"Korotaeva AA, Samoilova EV, Chepurnova DA, Zhitareva IV, Shuvalova YA, Prokazova NV (2018) Soluble glycoprotein 130 is inversely related to severity of coronary atherosclerosis. Biomarkers 23(6):527\u2013532","journal-title":"Biomarkers"},{"issue":"3","key":"2073_CR18","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.cyto.2012.12.025","volume":"61","author":"JR Lamas","year":"2013","unstructured":"Lamas JR, Rodriguez-Rodriguez L, Tornero-Esteban P, Villafuertes E, Hoyas J, Abasolo L, Varade J, Alvarez-Lafuente R, Urcelay E, Fernandez-Gutierrez B (2013) Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis. Cytokine 61(3):720\u2013723","journal-title":"Cytokine"},{"issue":"8","key":"2073_CR19","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.3899\/jrheum.091455","volume":"37","author":"JR Lamas","year":"2010","unstructured":"Lamas JR, Rodriguez-Rodriguez L, Varade J, Lopez-Romero P, Tornero-Esteban P, Abasolo L, Urcelay E, Fernandez-Gutierrez B (2010) Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis. J Rheumatol 37(8):1579\u20131581","journal-title":"J Rheumatol"},{"issue":"3","key":"2073_CR20","doi-asserted-by":"publisher","first-page":"767766978","DOI":"10.1177\/2045894018780734","volume":"8","author":"LD Maston","year":"2018","unstructured":"Maston LD, Jones DT, Giermakowska W, Resta TC, Ramiro-Diaz J, Howard TA, Jernigan NL, Herbert L, Maurice AA, Gonzalez BL (2018) Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension. Pulm Circ 8(3):767766978","journal-title":"Pulm Circ"},{"issue":"4","key":"2073_CR21","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1042\/CS20110340","volume":"122","author":"M Mihara","year":"2012","unstructured":"Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M (2012) IL-6\/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci (Lond) 122(4):143\u2013159","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"2073_CR22","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.atherosclerosis.2015.04.014","volume":"240","author":"VI Moreno","year":"2015","unstructured":"Moreno VI, Golabkesh Z, Kallberg H, Leander K, de Faire U, Gigante B (2015) Circulating levels of interleukin 6 soluble receptor and its natural antagonist, sgp130, and the risk of myocardial infarction. Atherosclerosis 240(2):477\u2013481","journal-title":"Atherosclerosis"},{"issue":"2","key":"2073_CR23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cytogfr.2011.02.003","volume":"22","author":"MF Neurath","year":"2011","unstructured":"Neurath MF, Finotto S (2011) IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 22(2):83\u201389","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"2073_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00296-010-1606-z","volume":"32","author":"P Oelzner","year":"2012","unstructured":"Oelzner P, Franke S, Lehmann G, Eidner T, Hein G, Wolf G (2012) The balance between soluble receptors regulating IL-6 trans-signaling is predictive for the RANKL\/osteoprotegerin ratio in postmenopausal women with rheumatoid arthritis. Rheumatol Int 32(1):199\u2013206","journal-title":"Rheumatol Int"},{"issue":"4","key":"2073_CR25","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3325\/cmj.2012.53.350","volume":"53","author":"SP Oranskiy","year":"2012","unstructured":"Oranskiy SP, Yeliseyeva LN, Tsanaeva AV, Zaytseva NV (2012) Body composition and serum levels of adiponectin, vascular endothelial growth factor, and interleukin-6 in patients with rheumatoid arthritis. Croat Med J 53(4):350\u2013356","journal-title":"Croat Med J"},{"key":"2073_CR26","first-page":"56","volume":"16","author":"P Robson-Ansley","year":"2010","unstructured":"Robson-Ansley P, Cockburn E, Walshe I, Stevenson E, Nimmo M (2010) The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response. Exerc Immunol Rev 16:56\u201376","journal-title":"Exerc Immunol Rev"},{"issue":"2","key":"2073_CR27","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1189\/jlb.1105674","volume":"80","author":"S Rose-John","year":"2006","unstructured":"Rose-John S, Scheller J, Elson G, Jones SA (2006) Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol 80(2):227\u2013236","journal-title":"J Leukoc Biol"},{"issue":"1","key":"2073_CR28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nm1162","volume":"11","author":"S Sano","year":"2005","unstructured":"Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, Itami S, Nickoloff BJ, DiGiovanni J (2005) Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 11(1):43\u201349","journal-title":"Nat Med"},{"issue":"5","key":"2073_CR29","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","volume":"1813","author":"J Scheller","year":"2011","unstructured":"Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S (2011) The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 1813(5):878\u2013888","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"2073_CR30","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B et al (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9(7):676\u2013682","journal-title":"Nat Methods"},{"issue":"3","key":"2073_CR31","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1159\/000083509","volume":"210","author":"J Schmitt","year":"2005","unstructured":"Schmitt J, Wozel G (2005) The psoriasis area and severity index is the adequate criterion to define severity in chronic plaque-type psoriasis. Dermatology 210(3):194\u2013199","journal-title":"Dermatology"},{"issue":"1","key":"2073_CR32","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s13075-017-1346-5","volume":"19","author":"M Schoels","year":"2017","unstructured":"Schoels M, Alasti F, Smolen JS, Aletaha D (2017) Evaluation of newly proposed remission cut-points for disease activity score in 28 joints (DAS28) in rheumatoid arthritis patients upon IL-6 pathway inhibition. Arthritis Res Ther 19(1):155","journal-title":"Arthritis Res Ther"},{"issue":"17","key":"2073_CR33","doi-asserted-by":"publisher","first-page":"5426","DOI":"10.1158\/1078-0432.CCR-09-0287","volume":"15","author":"S Shinriki","year":"2009","unstructured":"Shinriki S, Jono H, Ota K, Ueda M, Kudo M, Ota T, Oike Y, Endo M, Ibusuki M, Hiraki A et al (2009) Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma. Clin Cancer Res 15(17):5426\u20135434","journal-title":"Clin Cancer Res"},{"issue":"2","key":"2073_CR34","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1182\/blood-2011-07-367052","volume":"119","author":"OW Stephens","year":"2012","unstructured":"Stephens OW, Zhang Q, Qu P, Zhou Y, Chavan S, Tian E, Williams DR, Epstein J, Barlogie B, Shaughnessy JJ (2012) An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification. Blood 119(2):503\u2013512","journal-title":"Blood"},{"issue":"6","key":"2073_CR35","doi-asserted-by":"publisher","first-page":"e67078","DOI":"10.1371\/journal.pone.0067078","volume":"8","author":"J Sun","year":"2013","unstructured":"Sun J, Zhao Y, Hu J (2013) Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice. Plos One 8(6):e67078","journal-title":"Plos One"},{"issue":"1","key":"2073_CR36","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/cei.13124","volume":"193","author":"T Tvedt","year":"2018","unstructured":"Tvedt T, Hovland R, Tsykunova G, Ahmed AB, Gedde-Dahl T, Bruserud O (2018) A pilot study of single nucleotide polymorphisms in the interleukin-6 receptor and their effects on pre- and post-transplant serum mediator level and outcome after allogeneic stem cell transplantation. Clin Exp Immunol 193(1):130\u2013141","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"2073_CR37","first-page":"443","volume":"11","author":"H Urbanska-Rys","year":"2000","unstructured":"Urbanska-Rys H, Wiersbowska A, Stepien H, Robak T (2000) Relationship between circulating interleukin-10 (IL-10) with interleukin-6 (IL-6) type cytokines (IL-6, interleukin-11 (IL-11), oncostatin M (OSM)) and soluble interleukin-6 (IL-6) receptor (sIL-6R) in patients with multiple myeloma. Eur Cytokine Netw 11(3):443\u2013451","journal-title":"Eur Cytokine Netw"},{"issue":"1","key":"2073_CR38","doi-asserted-by":"publisher","first-page":"462","DOI":"10.4049\/jimmunol.1102224","volume":"188","author":"AB Van Belle","year":"2012","unstructured":"Van Belle AB, de Heusch M, Lemaire MM, Hendrickx E, Warnier G, Dunussi-Joannopoulos K, Fouser LA, Renauld JC, Dumoutier L (2012) IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice. J Immunol 188(1):462\u2013469","journal-title":"J Immunol"},{"issue":"9","key":"2073_CR39","doi-asserted-by":"publisher","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","volume":"182","author":"L van der Fits","year":"2009","unstructured":"van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens EP et al (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis. J Immunol 182(9):5836\u20135845","journal-title":"J Immunol"},{"issue":"1","key":"2073_CR40","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/j.0022-202X.2004.22736.x","volume":"123","author":"XP Wang","year":"2004","unstructured":"Wang XP, Schunck M, Kallen KJ, Neumann C, Trautwein C, Rose-John S, Proksch E (2004) The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. J Invest Dermatol 123(1):124\u2013131","journal-title":"J Invest Dermatol"},{"key":"2073_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2010.02.067","volume":"1327","author":"M Wang","year":"2010","unstructured":"Wang M, Song H, Jia J (2010) Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer\u2019s disease in Chinese Han. Brain Res 1327:1\u20135","journal-title":"Brain Res"},{"issue":"9","key":"2073_CR42","doi-asserted-by":"publisher","first-page":"4141","DOI":"10.4049\/jimmunol.1102137","volume":"188","author":"CM Wunderlich","year":"2012","unstructured":"Wunderlich CM, Delic D, Behnke K, Meryk A, Strohle P, Chaurasia B, Al-Quraishy S, Wunderlich F, Bruning JC, Wunderlich FT (2012) Cutting edge: inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. J Immunol 188(9):4141\u20134144","journal-title":"J Immunol"},{"issue":"7","key":"2073_CR43","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1038\/jid.2015.82","volume":"135","author":"S Xie","year":"2015","unstructured":"Xie S, Su Z, Zhang B, Ge J, Song S, Sun G, Sun X, Yi L, Wang Y, Sun W, Wang H, Gao Q (2015) SIRT1 activation ameliorates Aldara-induced psoriasiform phenotype and histology in mice. J Invest Dermatol 135(7):1915\u20131918","journal-title":"J Invest Dermatol"},{"issue":"2","key":"2073_CR44","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1365-2249.1995.tb03672.x","volume":"100","author":"A Yokoyama","year":"1995","unstructured":"Yokoyama A, Kohno N, Hirasawa Y, Kondo K, Abe M, Inoue Y, Fujioka S, Fujino S, Ishida S, Hiwada K (1995) Evaluation of soluble IL-6 receptor concentration in serum and epithelial lining fluid from patients with interstitial lung diseases. Clin Exp Immunol 100(2):325\u2013329","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"2073_CR45","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/1043-4666(90)90069-6","volume":"2","author":"K Yoshizaki","year":"1990","unstructured":"Yoshizaki K, Nishimoto N, Matsumoto K, Tagoh H, Taga T, Deguchi Y, Kuritani T, Hirano T, Hashimoto K, Okada N et al (1990) Interleukin 6 and expression of its receptor on epidermal keratinocytes. Cytokine 2(5):381\u2013387","journal-title":"Cytokine"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-021-02073-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00109-021-02073-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-021-02073-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T05:03:30Z","timestamp":1650258210000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00109-021-02073-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,9]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["2073"],"URL":"https:\/\/doi.org\/10.1007\/s00109-021-02073-3","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,9]]},"assertion":[{"value":"8 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Medical Ethical Commission of the First Affiliated Hospital of Nanjing Medical University (reference number: 2017-SRFA-106), and participants were required to sign an informed consent form before participation. All animal experiments were conducted in compliance with the Guide for the Care and Use of Laboratory Animals published by the NIH (National Institutes of Health, Bethesda, MD, USA) and were approved by the Institutional Animal Care and Use Committee at the Nanjing University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All listed authors consent to the submission, and all data are used with the consent of the person generating the data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}