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The ESM file was now corrected.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Human studies were approved by these institutional review boards (IRB): Bahauddin Zakariya University, Colorado Multiple IRB, Helsinki University Hospital, University of Maryland Baltimore, University of Minnesota, University of Texas Medical Branch, University of Virginia, and University of Washington. Informed consent was obtained from all study participants. Mouse studies were approved by the Institutional Animal Care and Use Committees of the Veterans Affairs Medical Center, San Diego.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Dr. Allen Ryan is a co-founder of, shareholder in, and uncompensated consultant to Otonomy, Inc., a relationship that was approved by the University of California, San Diego. The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"ANNOVAR, annovar.openbioinformatics.orgBurrows-Wheeler Aligner, bio-bwa.sourceforge.netCombined Annotation Dependent Depletion, cadd.gs.washington.edudbNSFP, sites.google.com\/site\/jpopgen\/dbNSFPExplicet, Genetic Power Calculator, Genetic Variant Interpretation Tool, Genome Aggregation Database, gnomad.broadinstitute.orgGenome Analysis Toolkit, gatk.broadinstitute.orgGenotype-Tissue Expression (GTEx) Portal, gtexportal.orgInterPro, Likelihood Ratio Test, MutationAssessor, mutationassessor.org\/r3\/MutationTaster, Online Mendelian Inheritance in Man, PolyPhen-2, genetics.bwh.harvard.edu\/pph2\/PROVEAN, provean.jcvi.orgsilva, Seurat, satijalab.org\/seurat\/UCSC Genome Browser, genome.ucsc.edu","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Web resources"}}]}}