{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:15:31Z","timestamp":1784823331745,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00109-022-02192-5","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T04:05:57Z","timestamp":1651032357000},"page":"1027-1038","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Receptor-interacting protein kinase-1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms"],"prefix":"10.1007","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8771-3219","authenticated-orcid":false,"given":"Muhammad","family":"Farooq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-4839","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Simoes Eug\u00e9nio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3198-1975","authenticated-orcid":false,"given":"Claire","family":"Piquet-Pellorce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-7462","authenticated-orcid":false,"given":"Sarah","family":"Dion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8428-9558","authenticated-orcid":false,"given":"C\u00e9line","family":"Raguenes-Nicol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-0136","authenticated-orcid":false,"given":"Kathleen","family":"Santamaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-7551","authenticated-orcid":false,"given":"Ghania Hounana","family":"Kara-Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Larcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-7780","authenticated-orcid":false,"given":"Marie-Th\u00e9r\u00e8se","family":"Dimanche-Boitrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-2284","authenticated-orcid":false,"given":"Michel","family":"Samson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-3311","authenticated-orcid":false,"given":"Jacques","family":"Le Seyec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"2192_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","volume":"15","author":"Z Younossi","year":"2018","unstructured":"Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E (2018) Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 15:11\u201320. https:\/\/doi.org\/10.1038\/nrgastro.2017.109","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2192_CR2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","volume":"64","author":"ZM Younossi","year":"2016","unstructured":"Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M (2016) Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology (Baltimore, MD) 64:73\u201384. https:\/\/doi.org\/10.1002\/hep.28431","journal-title":"Hepatology (Baltimore, MD)"},{"key":"2192_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17050774","author":"L Calzadilla Bertot","year":"2016","unstructured":"Calzadilla Bertot L, Adams LA (2016) The natural course of non-alcoholic fatty liver disease. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms17050774","journal-title":"Int J Mol Sci"},{"key":"2192_CR4","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1053\/j.gastro.2014.11.039","volume":"148","author":"RJ Wong","year":"2015","unstructured":"Wong RJ, Aguilar M, Cheung R, Perumpail RB, Harrison SA, Younossi ZM, Ahmed A (2015) Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology 148:547\u2013555. https:\/\/doi.org\/10.1053\/j.gastro.2014.11.039","journal-title":"Gastroenterology"},{"key":"2192_CR5","doi-asserted-by":"publisher","unstructured":"Buzzetti E, Pinzani M, Tsochatzis EA (2016) The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism: clinical and experimental 65:1038\u20131048.\u00a0https:\/\/doi.org\/10.1016\/j.metabol.2015.12.012","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"2192_CR6","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1002\/hep.24001","volume":"52","author":"H Tilg","year":"2010","unstructured":"Tilg H, Moschen AR (2010) Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology (Baltimore, MD) 52:1836\u20131846. https:\/\/doi.org\/10.1002\/hep.24001","journal-title":"Hepatology (Baltimore, MD)"},{"key":"2192_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jcmgh.2014.11.005","volume":"1","author":"P Hirsova","year":"2015","unstructured":"Hirsova P, Gores GJ (2015) Death receptor-mediated cell death and proinflammatory signaling in nonalcoholic steatohepatitis. Cell Mol Gastroenterol Hepatol 1:17\u201327. https:\/\/doi.org\/10.1016\/j.jcmgh.2014.11.005","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2192_CR8","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.jhep.2007.02.003","volume":"46","author":"S Hemmann","year":"2007","unstructured":"Hemmann S, Graf J, Roderfeld M, Roeb E (2007) Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol 46:955\u2013975. https:\/\/doi.org\/10.1016\/j.jhep.2007.02.003","journal-title":"J Hepatol"},{"key":"2192_CR9","doi-asserted-by":"publisher","first-page":"G245","DOI":"10.1152\/ajpgi.2000.279.2.G245","volume":"279","author":"MJ Arthur","year":"2000","unstructured":"Arthur MJ (2000) Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis. Am J Physiol Gastrointest Liver Physiol 279:G245-249. https:\/\/doi.org\/10.1152\/ajpgi.2000.279.2.G245","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2192_CR10","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/1479-7364-4-3-194","volume":"4","author":"BC Jackson","year":"2010","unstructured":"Jackson BC, Nebert DW, Vasiliou V (2010) Update of human and mouse matrix metalloproteinase families. Hum Genomics 4:194\u2013201. https:\/\/doi.org\/10.1186\/1479-7364-4-3-194","journal-title":"Hum Genomics"},{"key":"2192_CR11","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","volume":"147","author":"T Luedde","year":"2014","unstructured":"Luedde T, Kaplowitz N, Schwabe RF (2014) Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology 147:765-783.e764. https:\/\/doi.org\/10.1053\/j.gastro.2014.07.018","journal-title":"Gastroenterology"},{"key":"2192_CR12","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/s41575-018-0065-y","volume":"15","author":"RF Schwabe","year":"2018","unstructured":"Schwabe RF, Luedde T (2018) Apoptosis and necroptosis in the liver: a matter of life and death. Nat Rev Gastroenterol Hepatol 15:738\u2013752. https:\/\/doi.org\/10.1038\/s41575-018-0065-y","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2192_CR13","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/0092-8674(95)90072-1","volume":"81","author":"BZ Stanger","year":"1995","unstructured":"Stanger BZ, Leder P, Lee TH, Kim E, Seed B (1995) RIP: a novel protein containing a death domain that interacts with Fas\/APO-1 (CD95) in yeast and causes cell death. Cell 81:513\u2013523. https:\/\/doi.org\/10.1016\/0092-8674(95)90072-1","journal-title":"Cell"},{"key":"2192_CR14","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/s1074-7613(00)80252-6","volume":"4","author":"H Hsu","year":"1996","unstructured":"Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (1996) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4:387\u2013396. https:\/\/doi.org\/10.1016\/s1074-7613(00)80252-6","journal-title":"Immunity"},{"key":"2192_CR15","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/s1074-7613(00)80400-8","volume":"7","author":"PM Chaudhary","year":"1997","unstructured":"Chaudhary PM, Eby M, Jasmin A, Bookwalter A, Murray J, Hood L (1997) Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity 7:821\u2013830. https:\/\/doi.org\/10.1016\/s1074-7613(00)80400-8","journal-title":"Immunity"},{"key":"2192_CR16","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41419-018-1277-3","volume":"10","author":"M Farooq","year":"2019","unstructured":"Farooq M, Filliol A, Simoes Eug\u00e9nio M, Piquet-Pellorce C, Dion S, Raguenes-Nicol C, Jan A, Dimanche-Boitrel MT, Le Seyec J, Samson M (2019) Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis. Cell Death Dis 10:12. https:\/\/doi.org\/10.1038\/s41419-018-1277-3","journal-title":"Cell Death Dis"},{"key":"2192_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.362","volume":"7","author":"A Filliol","year":"2016","unstructured":"Filliol A, Piquet-Pellorce C, Le Seyec J, Farooq M, Genet V, Lucas-Clerc C, Bertin J, Gough PJ, Dimanche-Boitrel MT, Vandenabeele P et al (2016) RIPK1 protects from TNF-\u03b1-mediated liver damage during hepatitis. Cell Death Dis 7:e2462. https:\/\/doi.org\/10.1038\/cddis.2016.362","journal-title":"Cell Death Dis"},{"key":"2192_CR18","doi-asserted-by":"publisher","first-page":"G518","DOI":"10.1152\/ajpgi.00024.2006","volume":"292","author":"P Brun","year":"2007","unstructured":"Brun P, Castagliuolo I, Di Leo V, Buda A, Pinzani M, Pal\u00f9 G, Martines D (2007) Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 292:G518-525. https:\/\/doi.org\/10.1152\/ajpgi.00024.2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2192_CR19","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.3748\/wjg.v18.i21.2609","volume":"18","author":"Y Ilan","year":"2012","unstructured":"Ilan Y (2012) Leaky gut and the liver: a role for bacterial translocation in nonalcoholic steatohepatitis. World J Gastroenterol 18:2609\u20132618. https:\/\/doi.org\/10.3748\/wjg.v18.i21.2609","journal-title":"World J Gastroenterol"},{"key":"2192_CR20","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.jcmgh.2015.01.001","volume":"1","author":"J Luther","year":"2015","unstructured":"Luther J, Garber JJ, Khalili H, Dave M, Bale SS, Jindal R, Motola DL, Luther S, Bohr S, Jeoung SW et al (2015) Hepatic injury in nonalcoholic steatohepatitis contributes to altered intestinal permeability. Cell Mol Gastroenterol Hepatol 1:222\u2013232. https:\/\/doi.org\/10.1016\/j.jcmgh.2015.01.001","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2192_CR21","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1002\/hep.22848","volume":"49","author":"L Miele","year":"2009","unstructured":"Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, Ricci R, Mascian\u00e0 R, Forgione A, Gabrieli ML, Perotti G et al (2009) Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology (Baltimore, MD) 49:1877\u20131887. https:\/\/doi.org\/10.1002\/hep.22848","journal-title":"Hepatology (Baltimore, MD)"},{"key":"2192_CR22","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.jhep.2017.01.005","volume":"66","author":"A Filliol","year":"2017","unstructured":"Filliol A, Piquet-Pellorce C, Ragu\u00e9n\u00e8s-Nicol C, Dion S, Farooq M, Lucas-Clerc C, Vandenabeele P, Bertrand MJM, Le Seyec J, Samson M (2017) RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis. J Hepatol 66:1205\u20131213. https:\/\/doi.org\/10.1016\/j.jhep.2017.01.005","journal-title":"J Hepatol"},{"key":"2192_CR23","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ccell.2016.11.009","volume":"31","author":"AT Schneider","year":"2017","unstructured":"Schneider AT, Gautheron J, Feoktistova M, Roderburg C, Loosen SH, Roy S, Benz F, Schemmer P, B\u00fcchler MW, Nachbur U et al (2017) RIPK1 Suppresses a TRAF2-dependent pathway to liver cancer. Cancer Cell 31:94\u2013109. https:\/\/doi.org\/10.1016\/j.ccell.2016.11.009","journal-title":"Cancer Cell"},{"key":"2192_CR24","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1172\/jci92508","volume":"127","author":"TM Van","year":"2017","unstructured":"Van TM, Polykratis A, Straub BK, Kondylis V, Papadopoulou N, Pasparakis M (2017) Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis. J Clin Investig 127:2662\u20132677. https:\/\/doi.org\/10.1172\/jci92508","journal-title":"J Clin Investig"},{"key":"2192_CR25","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.jhep.2019.11.008","volume":"72","author":"A Majdi","year":"2020","unstructured":"Majdi A, Aoudjehane L, Ratziu V, Islam T, Afonso MB, Conti F, Mestiri T, Lagouge M, Foufelle F, Ballenghien F et al (2020) Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease. J Hepatol 72:627\u2013635. https:\/\/doi.org\/10.1016\/j.jhep.2019.11.008","journal-title":"J Hepatol"},{"key":"2192_CR26","doi-asserted-by":"publisher","unstructured":"Tao L, Yi Y, Chen Y, Zhang H, Orning P, Lien E, Jie J, Zhang W, Xu Q, Li Y et al (2020) RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages. Cell death and differentiation.\u00a0https:\/\/doi.org\/10.1038\/s41418-020-00668-w","DOI":"10.1038\/s41418-020-00668-w"},{"key":"2192_CR27","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/hep.21874","volume":"46","author":"N Matsuzawa","year":"2007","unstructured":"Matsuzawa N, Takamura T, Kurita S, Misu H, Ota T, Ando H, Yokoyama M, Honda M, Zen Y, Nakanuma Y et al (2007) Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology (Baltimore, MD) 46:1392\u20131403. https:\/\/doi.org\/10.1002\/hep.21874","journal-title":"Hepatology (Baltimore, MD)"},{"key":"2192_CR28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev-pathol-121808-102132","volume":"5","author":"DG Tiniakos","year":"2010","unstructured":"Tiniakos DG, Vos MB, Brunt EM (2010) Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol 5:145\u2013171. https:\/\/doi.org\/10.1146\/annurev-pathol-121808-102132","journal-title":"Annu Rev Pathol"},{"key":"2192_CR29","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","volume":"94","author":"EM Brunt","year":"1999","unstructured":"Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR (1999) Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 94:2467\u20132474. https:\/\/doi.org\/10.1111\/j.1572-0241.1999.01377.x","journal-title":"Am J Gastroenterol"},{"key":"2192_CR30","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/978-1-60761-869-0_14","volume":"677","author":"J Diana","year":"2011","unstructured":"Diana J, Beaudoin L, Gautron AS, Lehuen A (2011) NKT and tolerance. Methods in molecular biology (Clifton, NJ) 677:193\u2013206. https:\/\/doi.org\/10.1007\/978-1-60761-869-0_14","journal-title":"Methods in molecular biology (Clifton, NJ)"},{"key":"2192_CR31","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1002\/eji.201041006","volume":"41","author":"M Lisbonne","year":"2011","unstructured":"Lisbonne M, L\u2019Helgoualc\u2019h A, Nauwelaers G, Turlin B, Lucas C, Herbelin A, Piquet-Pellorce C, Samson M (2011) Invariant natural killer T-cell-deficient mice display increased CCl4-induced hepatitis associated with CXCL1 over-expression and neutrophil infiltration. Eur J Immunol 41:1720\u20131732. https:\/\/doi.org\/10.1002\/eji.201041006","journal-title":"Eur J Immunol"},{"key":"2192_CR32","doi-asserted-by":"publisher","first-page":"48563","DOI":"10.18632\/oncotarget.18335","volume":"8","author":"P Vasseur","year":"2017","unstructured":"Vasseur P, Dion S, Filliol A, Genet V, Lucas-Clerc C, Jean-Philippe G, Silvain C, Lecron JC, Piquet-Pellorce C, Samson M (2017) Endogenous IL-33 has no effect on the progression of fibrosis during experimental steatohepatitis. Oncotarget 8:48563\u201348574. https:\/\/doi.org\/10.18632\/oncotarget.18335","journal-title":"Oncotarget"},{"key":"2192_CR33","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3389\/fphys.2016.00017","volume":"7","author":"S Liang","year":"2016","unstructured":"Liang S, Kisseleva T, Brenner DA (2016) The role of NADPH oxidases (NOXs) in liver fibrosis and the activation of myofibroblasts. Front Physiol 7:17. https:\/\/doi.org\/10.3389\/fphys.2016.00017","journal-title":"Front Physiol"},{"key":"2192_CR34","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/s0016-5085(03)00907-7","volume":"125","author":"AE Feldstein","year":"2003","unstructured":"Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ (2003) Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125:437\u2013443. https:\/\/doi.org\/10.1016\/s0016-5085(03)00907-7","journal-title":"Gastroenterology"},{"key":"2192_CR35","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/hep.20283","volume":"40","author":"AE Feldstein","year":"2004","unstructured":"Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, Burgart LJ, Gores GJ (2004) Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology (Baltimore, MD) 40:185\u2013194. https:\/\/doi.org\/10.1002\/hep.20283","journal-title":"Hepatology (Baltimore, MD)"},{"key":"2192_CR36","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/j.jhep.2014.11.033","volume":"62","author":"L Idrissova","year":"2015","unstructured":"Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB et al (2015) TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. J Hepatol 62:1156\u20131163. https:\/\/doi.org\/10.1016\/j.jhep.2014.11.033","journal-title":"J Hepatol"},{"key":"2192_CR37","doi-asserted-by":"publisher","first-page":"9205","DOI":"10.1038\/s41598-017-09789-8","volume":"7","author":"A Filliol","year":"2017","unstructured":"Filliol A, Farooq M, Piquet-Pellorce C, Genet V, Dimanche-Boitrel MT, Vandenabeele P, Bertrand MJM, Samson M, Le Seyec J (2017) RIPK1 protects hepatocytes from death in Fas-induced hepatitis. Sci Rep 7:9205. https:\/\/doi.org\/10.1038\/s41598-017-09789-8","journal-title":"Sci Rep"},{"key":"2192_CR38","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nature14191","volume":"517","author":"M Pasparakis","year":"2015","unstructured":"Pasparakis M, Vandenabeele P (2015) Necroptosis and its role in inflammation. Nature 517:311\u2013320. https:\/\/doi.org\/10.1038\/nature14191","journal-title":"Nature"},{"key":"2192_CR39","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nchembio.83","volume":"4","author":"A Degterev","year":"2008","unstructured":"Degterev A, Hitomi J, Germscheid M, Ch\u2019en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G et al (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4:313\u2013321. https:\/\/doi.org\/10.1038\/nchembio.83","journal-title":"Nat Chem Biol"},{"key":"2192_CR40","doi-asserted-by":"publisher","unstructured":"Afonso MB, Rodrigues PM, Carvalho T, Caridade M, Borralho P, Cortez-Pinto H, Castro RE, Rodrigues CM (2015) Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis. Clinical science (London, England : 1979) 129:721-739.\u00a0https:\/\/doi.org\/10.1042\/cs20140732","DOI":"10.1042\/cs20140732"},{"key":"2192_CR41","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.jhep.2012.05.024","volume":"57","author":"C von Montfort","year":"2012","unstructured":"von Montfort C, Matias N, Fernandez A, Fucho R, Conde de la Rosa L, Martinez-Chantar ML, Mato JM, Machida K, Tsukamoto H, Murphy MP et al (2012) Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol 57:852\u2013859. https:\/\/doi.org\/10.1016\/j.jhep.2012.05.024","journal-title":"J Hepatol"},{"key":"2192_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.176","volume":"3","author":"N Takahashi","year":"2012","unstructured":"Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C et al (2012) Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis 3:e437. https:\/\/doi.org\/10.1038\/cddis.2012.176","journal-title":"Cell Death Dis"},{"key":"2192_CR43","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","volume":"15","author":"S Schuster","year":"2018","unstructured":"Schuster S, Cabrera D, Arrese M, Feldstein AE (2018) Triggering and resolution of inflammation in NASH. Nat Rev Gastroenterol Hepatol 15:349\u2013364. https:\/\/doi.org\/10.1038\/s41575-018-0009-6","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2192_CR44","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1194\/jlr.M003004","volume":"51","author":"J Hua","year":"2010","unstructured":"Hua J, Ma X, Webb T, Potter JJ, Oelke M, Li Z (2010) Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease. J Lipid Res 51:1696\u20131703. https:\/\/doi.org\/10.1194\/jlr.M003004","journal-title":"J Lipid Res"},{"key":"2192_CR45","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/hep.20826","volume":"42","author":"Z Li","year":"2005","unstructured":"Li Z, Soloski MJ, Diehl AM (2005) Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology (Baltimore, MD) 42:880\u2013885. https:\/\/doi.org\/10.1002\/hep.20826","journal-title":"Hepatology (Baltimore, MD)"},{"key":"2192_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081949","volume":"8","author":"T Tang","year":"2013","unstructured":"Tang T, Sui Y, Lian M, Li Z, Hua J (2013) Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death. PLoS ONE 8:e81949. https:\/\/doi.org\/10.1371\/journal.pone.0081949","journal-title":"PLoS ONE"},{"key":"2192_CR47","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/j.1365-2036.2007.03586.x","volume":"27","author":"MH Jarrar","year":"2008","unstructured":"Jarrar MH, Baranova A, Collantes R, Ranard B, Stepanova M, Bennett C, Fang Y, Elariny H, Goodman Z, Chandhoke V et al (2008) Adipokines and cytokines in non-alcoholic fatty liver disease. Aliment Pharmacol Ther 27:412\u2013421. https:\/\/doi.org\/10.1111\/j.1365-2036.2007.03586.x","journal-title":"Aliment Pharmacol Ther"},{"key":"2192_CR48","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1126\/science.aar2641","volume":"361","author":"D Cuchet-Louren\u00e7o","year":"2018","unstructured":"Cuchet-Louren\u00e7o D, Eletto D, Wu C, Plagnol V, Papapietro O, Curtis J, Ceron-Gutierrez L, Bacon CM, Hackett S, Alsaleem B et al (2018) Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science (New York, NY) 361:810\u2013813. https:\/\/doi.org\/10.1126\/science.aar2641","journal-title":"Science (New York, NY)"},{"key":"2192_CR49","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/jci24282","volume":"115","author":"R Bataller","year":"2005","unstructured":"Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Investig 115:209\u2013218. https:\/\/doi.org\/10.1172\/jci24282","journal-title":"J Clin Investig"},{"key":"2192_CR50","doi-asserted-by":"publisher","first-page":"d69","DOI":"10.2741\/887","volume":"8","author":"E G\u00e4bele","year":"2003","unstructured":"G\u00e4bele E, Brenner DA, Rippe RA (2003) Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Front Biosci 8:d69-77. https:\/\/doi.org\/10.2741\/887","journal-title":"Front Biosci"},{"key":"2192_CR51","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.matbio.2015.01.004","volume":"44\u201346","author":"S Duarte","year":"2015","unstructured":"Duarte S, Baber J, Fujii T, Coito AJ (2015) Matrix metalloproteinases in liver injury, repair and fibrosis. Matrix biology\u202f: journal of the International Society for Matrix Biology 44\u201346:147\u2013156. https:\/\/doi.org\/10.1016\/j.matbio.2015.01.004","journal-title":"Matrix biology : journal of the International Society for Matrix Biology"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-022-02192-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00109-022-02192-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-022-02192-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T08:04:48Z","timestamp":1655798688000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00109-022-02192-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["2192"],"URL":"https:\/\/doi.org\/10.1007\/s00109-022-02192-5","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]},"assertion":[{"value":"8 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal studies were reviewed and approved by the \u201cComit\u00e9 d\u2019Ethique en Exp\u00e9rimentation Animale\u201d (C2EA\u201307) under the supervision of the French Ministry of Higher Education and Research (permission #: 5656\u20132016061401105051). Investigations were carried out in strict compliance with the recommendations in the Guide for the Care and Use of Laboratory Animals, EEC Council Directive 2010\/63\/EU.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}