{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:13:11Z","timestamp":1791846791146,"version":"4.3.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002373"],"award-info":[{"award-number":["UL1TR002373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR002374"],"award-info":[{"award-number":["KL2TR002374"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK109508"],"award-info":[{"award-number":["R01DK109508"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01AR073340"],"award-info":[{"award-number":["K01AR073340"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s00109-022-02205-3","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T20:02:26Z","timestamp":1652212946000},"page":"1253-1265","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["X-linked genes exhibit miR6891-5p-regulated skewing in Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1007","volume":"100","author":[{"given":"Teressa M.","family":"Shaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara S.","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Pagenkopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana M.","family":"Carp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell H.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueer","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Scofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Galipeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3043-5139","authenticated-orcid":false,"given":"Yun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"2205_CR1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nrrheum.2018.39","volume":"14","author":"J Collison","year":"2018","unstructured":"Collison J (2018) Autoimmunity: the ABCs of autoimmune disease. Nat Rev Rheumatol 14:248. https:\/\/doi.org\/10.1038\/nrrheum.2018.39","journal-title":"Nat Rev Rheumatol"},{"key":"2205_CR2","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/ni0901-777","volume":"2","author":"CC Whitacre","year":"2001","unstructured":"Whitacre CC (2001) Sex differences in autoimmune disease. Nat Immunol 2:777\u2013780. https:\/\/doi.org\/10.1038\/ni0901-777","journal-title":"Nat Immunol"},{"key":"2205_CR3","doi-asserted-by":"publisher","unstructured":"Manuel RSJ, Liang Y (2021) Sexual dimorphism in immunometabolism and autoimmunity: impact on personalized medicine. Autoimmun Rev: 102775. https:\/\/doi.org\/10.1016\/j.autrev.2021.102775","DOI":"10.1016\/j.autrev.2021.102775"},{"key":"2205_CR4","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/nri2394","volume":"8","author":"EN Fish","year":"2008","unstructured":"Fish EN (2008) The X-files in immunity: sex-based differences predispose immune responses. Nat Rev Immunol 8:737\u2013744. https:\/\/doi.org\/10.1038\/nri2394","journal-title":"Nat Rev Immunol"},{"key":"2205_CR5","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1002\/art.39560","volume":"68","author":"K Liu","year":"2016","unstructured":"Liu K, Kurien BT, Zimmerman SL, Kaufman KM, Taft DH, Kottyan LC, Lazaro S, Weaver CA, Ice JA, Adler AJ et al (2016) X chromosome dose and sex bias in autoimmune diseases: increased prevalence of 47, XXX in systemic lupus erythematosus and Sjogren\u2019s syndrome. Arthritis Rheumatol 68:1290\u20131300. https:\/\/doi.org\/10.1002\/art.39560","journal-title":"Arthritis Rheumatol"},{"key":"2205_CR6","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1002\/art.40207","volume":"69","author":"R Sharma","year":"2017","unstructured":"Sharma R, Harris VM, Cavett J, Kurien BT, Liu K, Koelsch KA, Fayaaz A, Chaudhari KS, Radfar L, Lewis D et al (2017) Rare X chromosome abnormalities in systemic lupus erythematosus and Sjogren\u2019s syndrome. Arthritis Rheumatol 69:2187\u20132192. https:\/\/doi.org\/10.1002\/art.40207","journal-title":"Arthritis Rheumatol"},{"key":"2205_CR7","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1002\/art.23701","volume":"58","author":"RH Scofield","year":"2008","unstructured":"Scofield RH, Bruner GR, Namjou B, Kimberly RP, Ramsey-Goldman R, Petri M, Reveille JD, Alarcon GS, Vila LM, Reid J et al (2008) Klinefelter\u2019s syndrome (47, XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum 58:2511\u20132517. https:\/\/doi.org\/10.1002\/art.23701","journal-title":"Arthritis Rheum"},{"key":"2205_CR8","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nrg2987","volume":"12","author":"S Augui","year":"2011","unstructured":"Augui S, Nora EP, Heard E (2011) Regulation of X-chromosome inactivation by the X-inactivation centre. Nat Rev Genet 12:429\u2013442. https:\/\/doi.org\/10.1038\/nrg2987","journal-title":"Nat Rev Genet"},{"key":"2205_CR9","doi-asserted-by":"publisher","unstructured":"Fang H, Disteche CM, Berletch JB (2019) X inactivation and escape: epigenetic and structural features. Front Cell Dev Biol 7.\u00a0https:\/\/doi.org\/10.3389\/fcell.2019.00219","DOI":"10.3389\/fcell.2019.00219"},{"key":"2205_CR10","doi-asserted-by":"publisher","first-page":"6248","DOI":"10.1073\/pnas.97.12.6248","volume":"97","author":"MF Lyon","year":"2000","unstructured":"Lyon MF (2000) LINE-1 elements and X chromosome inactivation: a function for \u201cjunk\u201d DNA? Proc Natl Acad Sci U S A 97:6248\u20136249. https:\/\/doi.org\/10.1073\/pnas.97.12.6248","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2205_CR11","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00439-011-1011-z","volume":"130","author":"JB Berletch","year":"2011","unstructured":"Berletch JB, Yang F, Xu J, Carrel L, Disteche CM (2011) Genes that escape from X inactivation. Hum Genet 130:237\u2013245. https:\/\/doi.org\/10.1007\/s00439-011-1011-z","journal-title":"Hum Genet"},{"key":"2205_CR12","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1002\/art.21026","volume":"52","author":"Z Ozbalkan","year":"2005","unstructured":"Ozbalkan Z, Bagislar S, Kiraz S, Akyerli CB, Ozer HT, Yavuz S, Birlik AM, Calguneri M, Ozcelik T (2005) Skewed X chromosome inactivation in blood cells of women with scleroderma. Arthritis Rheum 52:1564\u20131570. https:\/\/doi.org\/10.1002\/art.21026","journal-title":"Arthritis Rheum"},{"key":"2205_CR13","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/sj.ejhg.5201614","volume":"14","author":"T Ozcelik","year":"2006","unstructured":"Ozcelik T, Uz E, Akyerli CB, Bagislar S, Mustafa CA, Gursoy A, Akarsu N, Toruner G, Kamel N, Gullu S (2006) Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity. Eur J Hum Genet 14:791\u2013797. https:\/\/doi.org\/10.1038\/sj.ejhg.5201614","journal-title":"Eur J Hum Genet"},{"key":"2205_CR14","doi-asserted-by":"publisher","first-page":"5949","DOI":"10.1210\/jc.2005-1366","volume":"90","author":"TH Brix","year":"2005","unstructured":"Brix TH, Knudsen GP, Kristiansen M, Kyvik KO, Orstavik KH, Hegedus L (2005) High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity. J Clin Endocrinol Metab 90:5949\u20135953. https:\/\/doi.org\/10.1210\/jc.2005-1366","journal-title":"J Clin Endocrinol Metab"},{"key":"2205_CR15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13293-015-0037-7","volume":"6","author":"JE Brandt","year":"2015","unstructured":"Brandt JE, Priori R, Valesini G, Fairweather D (2015) Sex differences in Sj\u00f6gren\u2019s syndrome: a comprehensive review of immune mechanisms. Biol Sex Differ 6:19\u201319","journal-title":"Biol Sex Differ"},{"key":"2205_CR16","doi-asserted-by":"publisher","unstructured":"Mougeot J-L, Noll B, Bahrani Mougeot F (2019) Sj\u00f6gren\u2019s syndrome X-chromosome dose effect: An epigenetic perspective. Oral Dis 25: 372-384. https:\/\/doi.org\/10.1111\/odi.12825","DOI":"10.1111\/odi.12825"},{"key":"2205_CR17","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jcyt.2020.09.008","volume":"23","author":"SS McCoy","year":"2021","unstructured":"McCoy SS, Giri J, Das R, Paul PK, Pennati A, Parker M, Liang Y, Galipeau J (2021) Minor salivary gland mesenchymal stromal cells derived from patients with Sjgren\u2019s syndrome deploy intact immune plasticity. Cytotherapy 23:301\u2013310. https:\/\/doi.org\/10.1016\/j.jcyt.2020.09.008","journal-title":"Cytotherapy"},{"key":"2205_CR18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/2055-7124-18-9","volume":"18","author":"C Yoo","year":"2014","unstructured":"Yoo C, Vines JB, Alexander G, Murdock K, Hwang P, Jun HW (2014) Adult stem cells and tissue engineering strategies for salivary gland regeneration: a review. Biomater Res 18:9. https:\/\/doi.org\/10.1186\/2055-7124-18-9","journal-title":"Biomater Res"},{"key":"2205_CR19","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1517\/14712598.8.5.569","volume":"8","author":"SS Iyer","year":"2008","unstructured":"Iyer SS, Rojas M (2008) Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies. Expert Opin Biol Ther 8:569\u2013581. https:\/\/doi.org\/10.1517\/14712598.8.5.569","journal-title":"Expert Opin Biol Ther"},{"key":"2205_CR20","doi-asserted-by":"publisher","first-page":"122","DOI":"10.15283\/ijsc.2009.2.2.122","volume":"2","author":"EW Choi","year":"2009","unstructured":"Choi EW (2009) Adult stem cell therapy for autoimmune disease. Int J Stem Cells 2:122\u2013128. https:\/\/doi.org\/10.15283\/ijsc.2009.2.2.122","journal-title":"Int J Stem Cells"},{"key":"2205_CR21","doi-asserted-by":"publisher","first-page":"W395","DOI":"10.1093\/nar\/gkaa434","volume":"48","author":"V Jalili","year":"2020","unstructured":"Jalili V, Afgan E, Gu Q, Clements D, Blankenberg D, Goecks J, Taylor J, Nekrutenko A (2020) The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2020 update. Nucleic Acids Res 48:W395\u2013W402. https:\/\/doi.org\/10.1093\/nar\/gkaa434","journal-title":"Nucleic Acids Res"},{"key":"2205_CR22","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1002\/art.30381","volume":"63","author":"TE Daniels","year":"2011","unstructured":"Daniels TE, Cox D, Shiboski CH, Schiodt M, Wu A, Lanfranchi H, Umehara H, Zhao Y, Challacombe S, Lam MY et al (2011) Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjogren\u2019s syndrome among 1,726 registry participants. Arthritis Rheum 63:2021\u20132030. https:\/\/doi.org\/10.1002\/art.30381","journal-title":"Arthritis Rheum"},{"key":"2205_CR23","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s13059-015-0762-6","volume":"16","author":"SE Castel","year":"2015","unstructured":"Castel SE, Levy-Moonshine A, Mohammadi P, Banks E, Lappalainen T (2015) Tools and best practices for data processing in allelic expression analysis. Genome Biol 16:195. https:\/\/doi.org\/10.1186\/s13059-015-0762-6","journal-title":"Genome Biol"},{"key":"2205_CR24","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1172\/JCI78082","volume":"125","author":"K Rubtsova","year":"2015","unstructured":"Rubtsova K, Marrack P, Rubtsov AV (2015) Sexual dimorphism in autoimmunity. J Clin Invest 125:2187\u20132193. https:\/\/doi.org\/10.1172\/JCI78082","journal-title":"J Clin Invest"},{"key":"2205_CR25","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nri2815","volume":"10","author":"C Libert","year":"2010","unstructured":"Libert C, Dejager L, Pinheiro I (2010) The X chromosome in immune functions: when a chromosome makes the difference. Nat Rev Immunol 10:594\u2013604. https:\/\/doi.org\/10.1038\/nri2815","journal-title":"Nat Rev Immunol"},{"key":"2205_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0961203318815768","volume":"28","author":"EAA Christou","year":"2019","unstructured":"Christou EAA, Banos A, Kosmara D, Bertsias GK, Boumpas DT (2019) Sexual dimorphism in SLE: above and beyond sex hormones. Lupus 28:3\u201310. https:\/\/doi.org\/10.1177\/0961203318815768","journal-title":"Lupus"},{"key":"2205_CR27","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/odi.12825","volume":"25","author":"JL Mougeot","year":"2019","unstructured":"Mougeot JL, Noll BD, Bahrani Mougeot FK (2019) Sjogren\u2019s syndrome X-chromosome dose effect: An epigenetic perspective. Oral Dis 25:372\u2013384. https:\/\/doi.org\/10.1111\/odi.12825","journal-title":"Oral Dis"},{"key":"2205_CR28","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/35057149","volume":"409","author":"R Sachidanandam","year":"2001","unstructured":"Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL et al (2001) A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409:928\u2013933. https:\/\/doi.org\/10.1038\/35057149","journal-title":"Nature"},{"key":"2205_CR29","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/cdd.2013.158","volume":"21","author":"S Ma","year":"2014","unstructured":"Ma S, Xie N, Li W, Yuan B, Shi Y, Wang Y (2014) Immunobiology of mesenchymal stem cells. Cell Death Differ 21:216\u2013225. https:\/\/doi.org\/10.1038\/cdd.2013.158","journal-title":"Cell Death Differ"},{"key":"2205_CR30","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13293-015-0053-7","volume":"6","author":"BP Balaton","year":"2015","unstructured":"Balaton BP, Cotton AM, Brown CJ (2015) Derivation of consensus inactivation status for X-linked genes from genome-wide studies. Biol Sex Differ 6:35. https:\/\/doi.org\/10.1186\/s13293-015-0053-7","journal-title":"Biol Sex Differ"},{"key":"2205_CR31","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/nature24265","volume":"550","author":"T Tukiainen","year":"2017","unstructured":"Tukiainen T, Villani AC, Yen A, Rivas MA, Marshall JL, Satija R, Aguirre M, Gauthier L, Fleharty M, Kirby A et al (2017) Landscape of X chromosome inactivation across human tissues. Nature 550:244\u2013248. https:\/\/doi.org\/10.1038\/nature24265","journal-title":"Nature"},{"key":"2205_CR32","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/sj.cr.7310149","volume":"17","author":"P Gallinari","year":"2007","unstructured":"Gallinari P, Di Marco S, Jones P, Pallaoro M, Steinkuhler C (2007) HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics. Cell Res 17:195\u2013211. https:\/\/doi.org\/10.1038\/sj.cr.7310149","journal-title":"Cell Res"},{"key":"2205_CR33","doi-asserted-by":"publisher","unstructured":"Thul PJ, Akesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Bjork L, Breckels LM et al (2017) A subcellular map of the human proteome. Science 356. https:\/\/doi.org\/10.1126\/science.aal3321","DOI":"10.1126\/science.aal3321"},{"key":"2205_CR34","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.cell.2016.07.013","volume":"166","author":"JC Chow","year":"2016","unstructured":"Chow JC, Ciaudo C, Fazzari MJ, Mise N, Servant N, Glass JL, Attreed M, Avner P, Wutz A, Barillot E et al (2016) LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation. Cell 166:782. https:\/\/doi.org\/10.1016\/j.cell.2016.07.013","journal-title":"Cell"},{"key":"2205_CR35","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/754825","volume":"2015","author":"A Nezos","year":"2015","unstructured":"Nezos A, Mavragani CP (2015) Contribution of genetic factors to Sjogren\u2019s syndrome and Sjogren\u2019s syndrome related lymphomagenesis. J Immunol Res 2015:754825. https:\/\/doi.org\/10.1155\/2015\/754825","journal-title":"J Immunol Res"},{"key":"2205_CR36","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.clim.2017.04.018","volume":"182","author":"LY Teos","year":"2017","unstructured":"Teos LY, Alevizos I (2017) Genetics of Sjogren\u2019s syndrome. Clin Immunol 182:41\u201347. https:\/\/doi.org\/10.1016\/j.clim.2017.04.018","journal-title":"Clin Immunol"},{"key":"2205_CR37","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/j.1399-0039.1975.tb00653.x","volume":"6","author":"ME Gershwin","year":"1975","unstructured":"Gershwin ME, Terasaki I, Graw R, Chused TM (1975) Increased frequency of HL-A8 in Sjogren\u2019s syndrome. Tissue Antigens 6:342\u2013346. https:\/\/doi.org\/10.1111\/j.1399-0039.1975.tb00653.x","journal-title":"Tissue Antigens"},{"key":"2205_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.33","volume":"47","author":"S Kim","year":"2015","unstructured":"Kim S, Yu NK, Kaang BK (2015) CTCF as a multifunctional protein in genome regulation and gene expression. Exp Mol Med 47:e166. https:\/\/doi.org\/10.1038\/emm.2015.33","journal-title":"Exp Mol Med"},{"key":"2205_CR39","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.scr.2011.08.003","volume":"8","author":"RA Pelekanos","year":"2012","unstructured":"Pelekanos RA, Li J, Gongora M, Chandrakanthan V, Scown J, Suhaimi N, Brooke G, Christensen ME, Doan T, Rice AM et al (2012) Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities. Stem Cell Res 8:58\u201373. https:\/\/doi.org\/10.1016\/j.scr.2011.08.003","journal-title":"Stem Cell Res"},{"key":"2205_CR40","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/jcb.21994","volume":"106","author":"KR Shockley","year":"2009","unstructured":"Shockley KR, Lazarenko OP, Czernik PJ, Rosen CJ, Churchill GA, Lecka-Czernik B (2009) PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem 106:232\u2013246. https:\/\/doi.org\/10.1002\/jcb.21994","journal-title":"J Cell Biochem"},{"key":"2205_CR41","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10392","volume":"4","author":"A Chougule","year":"2020","unstructured":"Chougule A, Kolli V, Baroi S, Ebraheim N, Czernik PJ, Loh YP, Lecka-Czernik B (2020) Nonenzymatic and trophic activities of carboxypeptidase e regulate bone mass and bioenergetics of skeletal stem cells in mice. JBMR Plus 4:e10392. https:\/\/doi.org\/10.1002\/jbm4.10392","journal-title":"JBMR Plus"},{"key":"2205_CR42","doi-asserted-by":"publisher","first-page":"34626","DOI":"10.1074\/jbc.M112.390401","volume":"287","author":"Y Wang","year":"2012","unstructured":"Wang Y, Tong X, Omoregie ES, Liu W, Meng S, Ye X (2012) Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner. J Biol Chem 287:34626\u201334634. https:\/\/doi.org\/10.1074\/jbc.M112.390401","journal-title":"J Biol Chem"},{"key":"2205_CR43","doi-asserted-by":"publisher","first-page":"19179","DOI":"10.1074\/jbc.M110.200790","volume":"286","author":"B Ruffell","year":"2011","unstructured":"Ruffell B, Poon GF, Lee SS, Brown KL, Tjew SL, Cooper J, Johnson P (2011) Differential use of chondroitin sulfate to regulate hyaluronan binding by receptor CD44 in inflammatory and interleukin 4-activated macrophages. J Biol Chem 286:19179\u201319190. https:\/\/doi.org\/10.1074\/jbc.M110.200790","journal-title":"J Biol Chem"},{"key":"2205_CR44","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/annurev-genet-120116-024611","volume":"52","author":"R Galupa","year":"2018","unstructured":"Galupa R, Heard E (2018) X-chromosome inactivation: a crossroads between chromosome architecture and gene regulation. Annu Rev Genet 52:535\u2013566. https:\/\/doi.org\/10.1146\/annurev-genet-120116-024611","journal-title":"Annu Rev Genet"},{"key":"2205_CR45","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fgene.2015.00022","volume":"6","author":"WH Brooks","year":"2015","unstructured":"Brooks WH, Renaudineau Y (2015) Epigenetics and autoimmune diseases: the X chromosome-nucleolus nexus. Front Genet 6:22. https:\/\/doi.org\/10.3389\/fgene.2015.00022","journal-title":"Front Genet"},{"key":"2205_CR46","doi-asserted-by":"publisher","first-page":"453","DOI":"10.2174\/138920207783591690","volume":"8","author":"SC Gough","year":"2007","unstructured":"Gough SC, Simmonds MJ (2007) The HLA region and autoimmune disease: associations and mechanisms of action. Curr Genomics 8:453\u2013465. https:\/\/doi.org\/10.2174\/138920207783591690","journal-title":"Curr Genomics"},{"key":"2205_CR47","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3389\/fimmu.2017.00583","volume":"8","author":"N Chitnis","year":"2017","unstructured":"Chitnis N, Clark PM, Kamoun M, Stolle C, Brad Johnson F, Monos DS (2017) An Expanded Role for HLA Genes: HLA-B encodes a microRNA that regulates IgA and other immune response transcripts. Front Immunol 8:583. https:\/\/doi.org\/10.3389\/fimmu.2017.00583","journal-title":"Front Immunol"},{"key":"2205_CR48","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3389\/fgene.2020.00998","volume":"11","author":"J Zhang","year":"2020","unstructured":"Zhang J, Zhang YZ, Jiang J, Duan CG (2020) The crosstalk between epigenetic mechanisms and alternative RNA processing regulation. Front Genet 11:998. https:\/\/doi.org\/10.3389\/fgene.2020.00998","journal-title":"Front Genet"},{"key":"2205_CR49","doi-asserted-by":"publisher","first-page":"5339","DOI":"10.1038\/s41467-019-13340-w","volume":"10","author":"A Zito","year":"2019","unstructured":"Zito A, Davies MN, Tsai PC, Roberts S, Andres-Ejarque R, Nardone S, Bell JT, Wong CCY, Small KS (2019) Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age. Nat Commun 10:5339. https:\/\/doi.org\/10.1038\/s41467-019-13340-w","journal-title":"Nat Commun"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-022-02205-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00109-022-02205-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-022-02205-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:04:47Z","timestamp":1661328287000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00109-022-02205-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["2205"],"URL":"https:\/\/doi.org\/10.1007\/s00109-022-02205-3","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]},"assertion":[{"value":"14 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval of human studies was granted by the UW-Madison Institutional Review Board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}