{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:38:27Z","timestamp":1780965507482,"version":"3.54.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100016808","name":"Natural Science Foundation of Xiamen City","doi-asserted-by":"publisher","award":["3502720224ZD1222"],"award-info":[{"award-number":["3502720224ZD1222"]}],"id":[{"id":"10.13039\/100016808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s00109-023-02403-7","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T15:01:36Z","timestamp":1701702096000},"page":"213-229","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis"],"prefix":"10.1007","volume":"102","author":[{"given":"Fengyue","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roumei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daowei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9025-9168","authenticated-orcid":false,"given":"Jinling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"2403_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1158\/1055-9965.Epi-15-0578","volume":"25","author":"LA Torre","year":"2016","unstructured":"Torre LA, Siegel RL, Ward EM, Jemal A (2016) Global Cancer Incidence and Mortality Rates and Trends\u2014An Update. Cancer Epidemiol Biomark Prev 25:16\u201327. https:\/\/doi.org\/10.1158\/1055-9965.Epi-15-0578","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"2403_CR2","doi-asserted-by":"publisher","unstructured":"Crosby D, Bhatia S, Brindle KM, Coussens LM, Dive C, Emberton M, Esener S, Fitzgerald RC, Gambhir SS, Kuhn P et al (2022) Early detection of cancer. Science 375:eaay9040.\u00a0https:\/\/doi.org\/10.1126\/science.aay9040. Published online EpubMar 18","DOI":"10.1126\/science.aay9040"},{"key":"2403_CR3","doi-asserted-by":"publisher","unstructured":"Ugai T, Sasamoto N, Lee HY, Ando M, Song M, Tamimi RM, Kawachi I, Campbell PT, Giovannucci EL, Weiderpass E et al (2022) Is early-onset cancer an emerging global epidemic? Current evidence and future implications. Nat Rev Clin Oncol 19:656\u2013673. https:\/\/doi.org\/10.1038\/s41571-022-00672-8.\u00a0Published online EpubOct","DOI":"10.1038\/s41571-022-00672-8"},{"key":"2403_CR4","doi-asserted-by":"publisher","unstructured":"Reddy SM, Reuben A, Barua S, Jiang H, Zhang S, Wang L, Gopalakrishnan V, Hudgens CW, Tetzlaff MT, Reuben JM et al (2019) Poor response to neoadjuvant chemotherapy correlates with mast cell infiltration in inflammatory breast cancer. Cancer Immunol Res 7:1025\u20131035. https:\/\/doi.org\/10.1158\/2326-6066.CIR-18-0619.\u00a0Published online EpubJun","DOI":"10.1158\/2326-6066.CIR-18-0619"},{"key":"2403_CR5","doi-asserted-by":"publisher","unstructured":"Yan Y, Feng X, Li C, Lerut T, Li H (2022) Treatments for resectable esophageal cancer: from traditional systemic therapy to immunotherapy. Chin Med J (Engl) 135:2143\u20132156. https:\/\/doi.org\/10.1097\/cm9.0000000000002371.\u00a0Published online EpubSep 20","DOI":"10.1097\/cm9.0000000000002371"},{"key":"2403_CR6","doi-asserted-by":"publisher","unstructured":"Qamar Z, Qizilbash FF, Iqubal MK, Ali A, Narang JK, Ali J, Baboota S (2019) Nano-based drug delivery system: recent strategies for the treatment of ocular disease and future perspective. Recent Pat Drug Deliv Formul 13:246\u2013254. https:\/\/doi.org\/10.2174\/1872211314666191224115211","DOI":"10.2174\/1872211314666191224115211"},{"key":"2403_CR7","doi-asserted-by":"publisher","unstructured":"Ren WW, Xu SH, Sun LP, Zhang K (2022) Ultrasound-Based Drug Delivery System. Curr Med Chem 29:1342\u20131351. https:\/\/doi.org\/10.2174\/0929867328666210617103905.\u00a0Published online EpubMar 4","DOI":"10.2174\/0929867328666210617103905"},{"key":"2403_CR8","doi-asserted-by":"publisher","unstructured":"Zhang S, Sun J (2022) Nano-drug delivery system for the treatment of acute myelogenous leukemia. Zhejiang Da Xue Xue Bao Yi Xue Ban 51:233\u2013240. https:\/\/doi.org\/10.3724\/zdxbyxb-2022-0084.\u00a0Published online EpubApr 25","DOI":"10.3724\/zdxbyxb-2022-0084"},{"key":"2403_CR9","doi-asserted-by":"publisher","unstructured":"Shueng PW, Yu LY, Hou HH, Chiu HC, Lo CL (2022) Charge conversion polymer-liposome complexes to overcome the limitations of cationic liposomes in mitochondrial-targeting drug delivery. Int J Mol Sci 23. https:\/\/doi.org\/10.3390\/ijms23063080.\u00a0Published online EpubMar ARTN 3080","DOI":"10.3390\/ijms23063080"},{"key":"2403_CR10","doi-asserted-by":"publisher","unstructured":"Sriwidodo A, Umar AK, Wathoni N, Zothantluanga JH, Das S, Luckanagul JA (2022) Liposome-polymer complex for drug delivery system and vaccine stabilization. Heliyon 8:e08934. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e08934.\u00a0Published online EpubFeb","DOI":"10.1016\/j.heliyon.2022.e08934"},{"key":"2403_CR11","doi-asserted-by":"publisher","unstructured":"Hanafy NAN, Sheashaa RF, Moussa EA, Mahfouz ME (2023) Potential of curcumin and niacin-loaded targeted chitosan coated liposomes to activate autophagy in hepatocellular carcinoma cells: An in vitro evaluation in HePG2 cell line. International journal of biological macromolecules 245:125572. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.125572.\u00a0Published online EpubAug 1","DOI":"10.1016\/j.ijbiomac.2023.125572"},{"key":"2403_CR12","doi-asserted-by":"publisher","unstructured":"Mohamed M, Abu Lila AS, Shimizu T, Alaaeldin E, Hussein A, Sarhan HA, Szebeni J, Ishida T (2019) PEGylated liposomes: immunological responses. Science and Technology of Advanced Materials 20:710\u2013724. https:\/\/doi.org\/10.1080\/14686996.2019.1627174","DOI":"10.1080\/14686996.2019.1627174"},{"key":"2403_CR13","doi-asserted-by":"publisher","unstructured":"Allen TM, Cullis PR (2013) Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev 65:36\u201348. https:\/\/doi.org\/10.1016\/j.addr.2012.09.037.\u00a0Published online EpubJan","DOI":"10.1016\/j.addr.2012.09.037"},{"key":"2403_CR14","doi-asserted-by":"publisher","unstructured":"Krivi\u0107 H, Himbert S, Rheinst\u00e4dter MC (2022) Perspective on the Application of Erythrocyte Liposome-Based Drug Delivery for Infectious Diseases. Membranes (Basel) 12. https:\/\/doi.org\/10.3390\/membranes12121226.\u00a0Published online EpubDec 3","DOI":"10.3390\/membranes12121226"},{"key":"2403_CR15","doi-asserted-by":"publisher","unstructured":"O\u011fuzhan Kaya H, Karpuz M, Nur Topkaya S (2022) Electrochemical Analysis of Liposome\u2010encapsulated Colistimethate Sodium. Electroanalysis 34:1114\u20131120. https:\/\/doi.org\/10.1002\/elan.202100570","DOI":"10.1002\/elan.202100570"},{"key":"2403_CR16","doi-asserted-by":"publisher","unstructured":"Nsairat H, Khater D, Sayed U, Odeh F, Al Bawab A, Alshaer W (2022) Liposomes: structure, composition, types, and clinical applications. Heliyon 8:e09394. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e09394.\u00a0Published online EpubMay","DOI":"10.1016\/j.heliyon.2022.e09394"},{"key":"2403_CR17","doi-asserted-by":"publisher","first-page":"815","DOI":"10.2174\/1567201818666211213102308","volume":"19","author":"TK Shaw","year":"2022","unstructured":"Shaw TK, Paul P (2022) Recent Approaches and Success of Liposome-Based Nano Drug Carriers for the Treatment of Brain Tumor. Curr Drug Deliv 19:815\u2013829. https:\/\/doi.org\/10.2174\/1567201818666211213102308","journal-title":"Curr Drug Deliv"},{"key":"2403_CR18","doi-asserted-by":"publisher","first-page":"678","DOI":"10.2174\/1389200223666220609141459","volume":"23","author":"P Kesharwani","year":"2022","unstructured":"Kesharwani P, Kumari K, Gururani R, Jain S, Sharma S (2022) Approaches to Address PK-PD Challenges of Conventional Liposome Formulation with Special Reference to Cancer, Alzheimer\u2019s, Diabetes, and Glaucoma: An Update on Modified Liposomal Drug Delivery System. Curr Drug Metab 23:678\u2013692. https:\/\/doi.org\/10.2174\/1389200223666220609141459","journal-title":"Curr Drug Metab"},{"key":"2403_CR19","doi-asserted-by":"publisher","unstructured":"Zhang S, Contini C, Hindley JW, Bolognesi G, Elani Y, Ces O (2021) Engineering motile aqueous phase-separated droplets via liposome stabilisation. Nat Commun 12:1673. https:\/\/doi.org\/10.1038\/s41467-021-21832-x.\u00a0Published online EpubMar 15","DOI":"10.1038\/s41467-021-21832-x"},{"key":"2403_CR20","first-page":"193","volume":"6","author":"H Maeda","year":"1989","unstructured":"Maeda H, Matsumura Y (1989) Tumoritropic and Lymphotropic Principles of Macromolecular Drugs. Crit Rev Ther Drug 6:193\u2013210","journal-title":"Crit Rev Ther Drug"},{"key":"2403_CR21","doi-asserted-by":"publisher","unstructured":"Lerman-Sagie T, Lerman P (1999) Phenobarbital still has a role in epilepsy treatment. J Child Neurol 14:820\u2013821. https:\/\/doi.org\/10.1177\/088307389901401210.\u00a0Published online EpubDec","DOI":"10.1177\/088307389901401210"},{"key":"2403_CR22","doi-asserted-by":"publisher","unstructured":"Li J, Yang D, Zhao D, Li N, Lin W (2019) Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China. Seizure 71:207\u2013213. https:\/\/doi.org\/10.1016\/j.seizure.2019.06.012.\u00a0Published online EpubOct","DOI":"10.1016\/j.seizure.2019.06.012"},{"key":"2403_CR23","doi-asserted-by":"publisher","unstructured":"Yasiry Z, Shorvon SD (2012) How phenobarbital revolutionized epilepsy therapy: The story of phenobarbital therapy in epilepsy in the last 100 years. Epilepsia 53:26\u201339. https:\/\/doi.org\/10.1111\/epi.12026.\u00a0\u00a0Published online EpubDec","DOI":"10.1111\/epi.12026"},{"key":"2403_CR24","unstructured":"Peraino C, Staffeldt EF, Haugen DA, Lombard LS, Stevens FJ, Fry RM (1980) Effects of Varying the Dietary Concentration of Phenobarbital on Its Enhan- cement of 2- Acetylaminofluorene-induced Hepatic Tumorigenesis1. Cancer Res 40:3268\u20133273"},{"key":"2403_CR25","doi-asserted-by":"crossref","unstructured":"Hino O, Kitagawa T, Nomura K, Sugano H (1984) Dose-response studies on promoting and anticarcino-genic effects of phenobarb-ital and DDT in the rat hepatocarcinogene-sis. Carcinogenesis 5:1653\u20131656","DOI":"10.1093\/carcin\/5.12.1653"},{"key":"2403_CR26","unstructured":"Olsen JH, Wallin H, Boice JD Jr, Rask K, Schulgen G, Fraumeni JF Jr (1993) Phenobarbital, drug metabolism, and human cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2:449\u2013452. Published online EpubSep-Oct"},{"key":"2403_CR27","unstructured":"Pereira MA, Klaunig JE, Freund SLH, Ruch RJ (1986) Effect of Phenobarbital on the Development of Liver Tumors in Juvenile and Adult Mice JNCI 77"},{"key":"2403_CR28","doi-asserted-by":"publisher","unstructured":"Lu Y, Low PS (2002) Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv Drug Deliv Rev 54:675\u2013693. https:\/\/doi.org\/10.1016\/s0169-409x(02)00042-x.\u00a0Published online EpubSep 13","DOI":"10.1016\/s0169-409x(02)00042-x"},{"key":"2403_CR29","doi-asserted-by":"publisher","unstructured":"Cavallaro G, Licciardi M, Salmaso S, Caliceti P, Gaetano G (2006) Folate-mediated targeting of polymeric conjugates of gemcitabine. Int J Pharm 307:258\u2013269. https:\/\/doi.org\/10.1016\/j.ijpharm.2005.10.015.\u00a0Published online EpubJan 13","DOI":"10.1016\/j.ijpharm.2005.10.015"},{"key":"2403_CR30","doi-asserted-by":"publisher","unstructured":"Wang S, Low PS (1998) Folate-mediated targeting of antineoplastic drugs, imaging agents, and nucleic acids to cancer cells. J Control Release 53:39\u201348. https:\/\/doi.org\/10.1016\/s0168-3659(97)00236-8.\u00a0Published online EpubApr 30","DOI":"10.1016\/s0168-3659(97)00236-8"},{"key":"2403_CR31","doi-asserted-by":"publisher","unstructured":"Moharil P, Wan Z, Pardeshi A, Li J, Huang H, Luo Z, Rathod S, Zhang Z, Chen Y, Zhang B et al (2022) Engineering a folic acid-decorated ultrasmall gemcitabine nanocarrier for breast cancer therapy: Dual targeting of tumor cells and tumor-associated macrophages. Acta Pharm Sin B 12:1148\u20131162. https:\/\/doi.org\/10.1016\/j.apsb.2021.09.024.\u00a0Published online EpubMar","DOI":"10.1016\/j.apsb.2021.09.024"},{"key":"2403_CR32","doi-asserted-by":"publisher","unstructured":"Suriamoorthy P, Zhang X, Hao G, Joly AG, Singh S, Hossu M, Sun X, Chen W (2010) Folic acid-CdTe quantum dot conjugates and their applications for cancer cell targeting. Cancer Nanotechnol 1:19\u201328. https:\/\/doi.org\/10.1007\/s12645-010-0003-3","DOI":"10.1007\/s12645-010-0003-3"},{"key":"2403_CR33","doi-asserted-by":"publisher","unstructured":"Akhtar A, Ghali L, Wang SX, Bell C, Li D, Wen X (2019) Optimisation of Folate-Mediated Liposomal Encapsulated Arsenic Trioxide for Treating HPV-Positive Cervical Cancer Cells In Vitro. Int J Mol Sci 20. https:\/\/doi.org\/10.3390\/ijms20092156.\u00a0Published online EpubApr 30","DOI":"10.3390\/ijms20092156"},{"key":"2403_CR34","doi-asserted-by":"publisher","unstructured":"Chatterji DC, Gallelli JF (1978) Thermal and photolytic decomposition of methotrexate in aqueous solutions. J Pharm Sci 67:526\u2013531. https:\/\/doi.org\/10.1002\/jps.2600670422.\u00a0Published online EpubApr","DOI":"10.1002\/jps.2600670422"},{"key":"2403_CR35","doi-asserted-by":"publisher","unstructured":"Grim J, Chl\u00e1dek J, Mart\u00ednkov\u00e1 J (2003) Pharmacokinetics and pharmacodynamics of methotrexate in non-neoplastic diseases. Clin Pharmacokinet 42:139\u2013151. https:\/\/doi.org\/10.2165\/00003088-200342020-00003","DOI":"10.2165\/00003088-200342020-00003"},{"key":"2403_CR36","doi-asserted-by":"publisher","unstructured":"Bleyer WA (1978) The clinical pharmacology of methotrexate: new applications of an old drug. Cancer 41:36\u201351. https:\/\/doi.org\/10.1002\/1097-0142(197801)41:1<36::aid-cncr2820410108>3.0.co;2-i.\u00a0Published online EpubJan","DOI":"10.1002\/1097-0142(197801)41:1<36::aid-cncr2820410108>3.0.co;2-i"},{"key":"2403_CR37","doi-asserted-by":"publisher","unstructured":"Pfister C, Gravis G, Fl\u00e9chon A, Chevreau C, Mahammedi H, Laguerre B, Guillot A, Joly F, Souli\u00e9 M, Allory Y et al (2022) Dose-Dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin or Gemcitabine and Cisplatin as Perioperative Chemotherapy for Patients With Nonmetastatic Muscle-Invasive Bladder Cancer: Results of the GETUG-AFU V05 VESPER Trial. J Clin Oncol 40:2013\u20132022. https:\/\/doi.org\/10.1200\/jco.21.02051.\u00a0Published online EpubJun 20","DOI":"10.1200\/jco.21.02051"},{"key":"2403_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.683389","volume":"8","author":"C Corley","year":"2021","unstructured":"Corley C, Allen AR (2021) A Bibliometric Analysis of Cyclophosphamide, Methotrexate, and Fluorouracil Breast Cancer Treatments: Implication for the Role of Inflammation in Cognitive Dysfunction. Front Mol Biosci 8:683389. https:\/\/doi.org\/10.3389\/fmolb.2021.683389","journal-title":"Front Mol Biosci"},{"key":"2403_CR39","doi-asserted-by":"publisher","unstructured":"Misra R, Upadhyay M, Perumal V, Mohanty S (2015) In vitro control release, cytotoxicity assessment and cellular uptake of methotrexate loaded liquid-crystalline folate nanocarrier. Biomed Pharmacother 69:102\u2013110. https:\/\/doi.org\/10.1016\/j.biopha.2014.11.012.\u00a0Published online EpubFeb","DOI":"10.1016\/j.biopha.2014.11.012"},{"key":"2403_CR40","doi-asserted-by":"publisher","unstructured":"Scaranti M, Cojocaru E, Banerjee S, Banerji U (2020) Exploiting the folate receptor \u03b1 in oncology. Nat Rev Clin Oncol 17:349\u2013359. https:\/\/doi.org\/10.1038\/s41571-020-0339-5.\u00a0Published online EpubJun","DOI":"10.1038\/s41571-020-0339-5"},{"key":"2403_CR41","doi-asserted-by":"publisher","unstructured":"Wei X, Xie F, Zhou X, Wu Y, Yan H, Liu T, Huang J, Wang F, Zhou F, Zhang L (2022) Role of pyroptosis in inflammation and cancer. Cellular & molecular immunology 19:971\u2013992. https:\/\/doi.org\/10.1038\/s41423-022-00905-x.\u00a0Published online EpubSep","DOI":"10.1038\/s41423-022-00905-x"},{"key":"2403_CR42","doi-asserted-by":"publisher","unstructured":"Latz E, Xiao TS, Stutz A (2013) Activation and regulation of the inflammasomes. Nature reviews. Immunology 13:397\u2013411. https:\/\/doi.org\/10.1038\/nri3452.\u00a0Published online EpubJun","DOI":"10.1038\/nri3452"},{"key":"2403_CR43","doi-asserted-by":"publisher","unstructured":"Akbal A, Dernst A, Lovotti M, Mangan MSJ, McManus RM, Latz E (2022) How location and cellular signaling combine to activate the NLRP3 inflammasome. Cellular & molecular immunology 19:1201\u20131214. https:\/\/doi.org\/10.1038\/s41423-022-00922-w.\u00a0Published online EpubNov","DOI":"10.1038\/s41423-022-00922-w"},{"key":"2403_CR44","doi-asserted-by":"publisher","unstructured":"Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok TMY, Ansara J et al (2020) Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature 579:415\u2013420. https:\/\/doi.org\/10.1038\/s41586-020-2071-9.\u00a0Published online EpubMar","DOI":"10.1038\/s41586-020-2071-9"},{"key":"2403_CR45","doi-asserted-by":"publisher","unstructured":"Wang Y, Gao W, Shi X, Ding J, Liu W, He H, Wang K, Shao F (2017) Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547:99\u2013103. https:\/\/doi.org\/10.1038\/nature22393.\u00a0Published online EpubJul 6","DOI":"10.1038\/nature22393"},{"key":"2403_CR46","doi-asserted-by":"publisher","unstructured":"Wang QY, Wang YP, Ding JJ, Wang CH, Zhou XH, Gao WQ, Huang HW, Shao F, Liu ZB (2020) A bioorthogonal system reveals antitumour immune function of pyroptosis. Nature 579:421. https:\/\/doi.org\/10.1038\/s41586-020-2079-1. Published online EpubMar","DOI":"10.1038\/s41586-020-2079-1"},{"key":"2403_CR47","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1177\/088506660101600203","volume":"16","author":"K Mikawa","year":"2001","unstructured":"Mikawa K, Akamatsu H, Nishina K, Shiga M, Obara H, Niwa Y (2001) Inhibitory Effects of Pentobarbital and Phenobarbital on Human Neutrophil Functions. J Intensive Care Med 16:79\u201387. https:\/\/doi.org\/10.1177\/088506660101600203","journal-title":"J Intensive Care Med"},{"key":"2403_CR48","doi-asserted-by":"publisher","unstructured":"Siwowska K, Schmid RM, Cohrs S, Schibli R, Muller C (2017) Folate Receptor-Positive Gynecological Cancer Cells: In Vitro and In Vivo Characterization. Pharmaceuticals 10. https:\/\/doi.org\/10.3390\/ph10030072.\u00a0Published online EpubAug 15","DOI":"10.3390\/ph10030072"},{"key":"2403_CR49","doi-asserted-by":"publisher","unstructured":"Xia L, Gu W, Zhang M, Chang YN, Chen K, Bai X, Yu L, Li J, Li S, Xing G (2016) Endocytosed nanoparticles hold endosomes and stimulate binucleated cells formation. Particle and Fibre Toxicology 13:63. https:\/\/doi.org\/10.1186\/s12989-016-0173-1.\u00a0Published online EpubNov 29","DOI":"10.1186\/s12989-016-0173-1"},{"key":"2403_CR50","doi-asserted-by":"publisher","unstructured":"Kubota C, Torii S, Hou N, Saito N, Yoshimoto Y, Imai H, Takeuchi T (2010) Constitutive reactive oxygen species generation from autophagosome\/lysosome in neuronal oxidative toxicity. J Biol Chem\u00a0285:667\u2013674. https:\/\/doi.org\/10.1074\/jbc.M109.053058.\u00a0Published online EpubJan 1","DOI":"10.1074\/jbc.M109.053058"},{"key":"2403_CR51","doi-asserted-by":"publisher","unstructured":"Nehra M, Uthappa UT, Kumar V, Kumar R, Dixit C, Dilbaghi N, Mishra YK, Kumar S, Kaushik A (2021) Nanobiotechnology-assisted therapies to manage brain cancer in personalized manner. J Control Release 338:224\u2013243. https:\/\/doi.org\/10.1016\/j.jconrel.2021.08.027.\u00a0Published online EpubOct 10","DOI":"10.1016\/j.jconrel.2021.08.027"},{"key":"2403_CR52","doi-asserted-by":"publisher","first-page":"717","DOI":"10.7150\/ijbs.64350","volume":"18","author":"Z Liu","year":"2022","unstructured":"Liu Z, Li Y, Zhu Y, Li N, Li W, Shang C, Song G, Li S, Cong J, Li T et al (2022) Apoptin induces pyroptosis of colorectal cancer cells via the GSDME-dependent pathway. Int J Biol Sci 18:717\u2013730. https:\/\/doi.org\/10.7150\/ijbs.64350","journal-title":"Int J Biol Sci"},{"key":"2403_CR53","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41420-020-00349-0","volume":"6","author":"M Jiang","year":"2020","unstructured":"Jiang M, Qi L, Li L, Li Y (2020) The caspase-3\/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer. Cell Death Discov 6:112. https:\/\/doi.org\/10.1038\/s41420-020-00349-0","journal-title":"Cell Death Discov"},{"key":"2403_CR54","doi-asserted-by":"crossref","unstructured":"Tian W, Wang Z, Tang NN, Li JT, Liu Y, Chu Wf, Yang BF (2020) Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis. Front Pharmacol 11.\u00a0Published online EpubFeb 21","DOI":"10.3389\/fphar.2020.00123"},{"key":"2403_CR55","doi-asserted-by":"publisher","unstructured":"Wang JL, Zhan LH, Cai Z, Liu XM, Wang JS, Zhong HR, Huang XW, Lai QX, Tan QZ, Xiu YB et al (2020) Arsenic trioxide induces gasdermin E mediated pyroptosis in astroglioma cells. Transl Cancer Res 9:1926\u20131930. https:\/\/doi.org\/10.21037\/tcr.2020.02.17.\u00a0Published online EpubMar","DOI":"10.21037\/tcr.2020.02.17"},{"key":"2403_CR56","doi-asserted-by":"publisher","unstructured":"Yang D, Liang Y, Zhao S, Ding Y, Zhuang Q, Shi Q, Ai T, Wu SQ, Han J (2020) ZBP1 mediates interferon-induced necroptosis. Cellular & molecular immunology 17:356\u2013368. https:\/\/doi.org\/10.1038\/s41423-019-0237-x.\u00a0Published online EpubApr","DOI":"10.1038\/s41423-019-0237-x"},{"key":"2403_CR57","doi-asserted-by":"publisher","unstructured":"Wang J, Yang D, Shen X, Wang J, Liu X, Lin J, Zhong J, Zhao Y, Qi Z (2020) BPTES inhibits anthrax lethal toxin-induced inflammatory response. Int Immunopharmacol\u00a085:106664. https:\/\/doi.org\/10.1016\/j.intimp.2020.106664.\u00a0Published online EpubAug","DOI":"10.1016\/j.intimp.2020.106664"},{"key":"2403_CR58","doi-asserted-by":"publisher","unstructured":"Deng B, Yang D, Wu H, Wang L, Wu R, Zhu H, Huang A, Song J, Cai T, Liu S et al (2022) Ketamine inhibits TNF-alpha-induced cecal damage by enhancing RIP1 ubiquitination to attenuate lethal SIRS. Cell Death Discovery 8:72. https:\/\/doi.org\/10.1038\/s41420-022-00869-x.\u00a0Published online EpubFeb 19","DOI":"10.1038\/s41420-022-00869-x"},{"key":"2403_CR59","doi-asserted-by":"publisher","unstructured":"Wang J, Peng X, Yang D, Guo M, Xu X, Yin F, Wang Y, Huang J, Zhan L, Qi Z (2022) Bcl-2 hijacks the arsenic trioxide resistance in SH-SaY5Y cells. J Cell Mol Med 26:563\u2013569. https:\/\/doi.org\/10.1111\/jcmm.17128.\u00a0Published online EpubJan","DOI":"10.1111\/jcmm.17128"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-023-02403-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00109-023-02403-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-023-02403-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T03:02:29Z","timestamp":1707534149000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00109-023-02403-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,4]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["2403"],"URL":"https:\/\/doi.org\/10.1007\/s00109-023-02403-7","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,4]]},"assertion":[{"value":"27 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"Animal experiments were conducted with the permission of the Xiamen University animal committee. Ethics approval and consent to participate involving human material are not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}