{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:25:16Z","timestamp":1790036716497,"version":"4.0.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172509"],"award-info":[{"award-number":["82172509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102634"],"award-info":[{"award-number":["82102634"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s00109-025-02548-7","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T02:35:10Z","timestamp":1746239710000},"page":"713-724","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Role of aberrant activated fibro\/adipogenic progenitors and suppressed ferroptosis in disused skeletal muscle atrophy and fatty infiltration"],"prefix":"10.1007","volume":"103","author":[{"given":"Jiale","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beijie","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5457-6046","authenticated-orcid":false,"given":"Yaying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"issue":"2","key":"2548_CR1","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/jcsm.12901","volume":"13","author":"CW Li","year":"2022","unstructured":"Li CW, Yu K, Shyh-Chang N, Jiang Z, Liu T, Ma S et al (2022) Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review. J Cachexia Sarcopenia Muscle 13(2):781\u2013794","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"2548_CR2","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/BOR.0b013e328358d59b","volume":"24","author":"JD Walston","year":"2012","unstructured":"Walston JD (2012) Sarcopenia in older adults. Curr Opin Rheumatol 24(6):623\u2013627","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"2548_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1172\/JCI88880","volume":"127","author":"H Wu","year":"2017","unstructured":"Wu H, Ballantyne CM (2017) Skeletal muscle inflammation and insulin resistance in obesity. J Clin Investig 127(1):43\u201354","journal-title":"J Clin Investig"},{"issue":"1","key":"2548_CR4","doi-asserted-by":"publisher","first-page":"100197","DOI":"10.1016\/j.jhepr.2020.100197","volume":"3","author":"J Linge","year":"2021","unstructured":"Linge J, Ekstedt M, Dahlqvist LO (2021) Adverse muscle composition is linked to poor functional performance and metabolic comorbidities in NAFLD. JHEP Rep: Innov Hepatol 3(1):100197","journal-title":"JHEP Rep: Innov Hepatol"},{"issue":"4","key":"2548_CR5","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1007\/s00330-019-06573-2","volume":"30","author":"D Albano","year":"2020","unstructured":"Albano D, Messina C, Vitale J, Sconfienza LM (2020) Imaging of sarcopenia: old evidence and new insights. Eur Radiol 30(4):2199\u20132208","journal-title":"Eur Radiol"},{"key":"2548_CR6","doi-asserted-by":"publisher","first-page":"1406046","DOI":"10.3389\/fendo.2024.1406046","volume":"15","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Hu Y, Pan Y, Li M, Niu Y, Zhang T et al (2024) Fatty infiltration in the musculoskeletal system: pathological mechanisms and clinical implications. Front Endocrinol 15:1406046","journal-title":"Front Endocrinol"},{"issue":"12","key":"2548_CR7","doi-asserted-by":"publisher","first-page":"210110","DOI":"10.1098\/rsob.210110","volume":"11","author":"T Molina","year":"2021","unstructured":"Molina T, Fabre P, Dumont NA (2021) Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases. Open Biol 11(12):210110","journal-title":"Open Biol"},{"key":"2548_CR8","doi-asserted-by":"publisher","first-page":"101682","DOI":"10.1016\/j.arr.2022.101682","volume":"80","author":"W Chen","year":"2022","unstructured":"Chen W, You W, Valencak TG, Shan T (2022) Bidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease. Ageing Res Rev 80:101682","journal-title":"Ageing Res Rev"},{"issue":"4","key":"2548_CR9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22(4):266\u2013282","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"22","key":"2548_CR10","doi-asserted-by":"publisher","first-page":"7038","DOI":"10.1111\/febs.16059","volume":"289","author":"J Liu","year":"2022","unstructured":"Liu J, Kang R, Tang D (2022) Signaling pathways and defense mechanisms of ferroptosis. FEBS J 289(22):7038\u20137050","journal-title":"FEBS J"},{"issue":"9","key":"2548_CR11","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1038\/s41590-021-00993-3","volume":"22","author":"P Li","year":"2021","unstructured":"Li P, Jiang M, Li K, Li H, Zhou Y, Xiao X et al (2021) Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity. Nat Immunol 22(9):1107\u20131117","journal-title":"Nat Immunol"},{"key":"2548_CR12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3389\/fnins.2020.00267","volume":"14","author":"X Song","year":"2020","unstructured":"Song X, Long D (2020) Nrf2 and ferroptosis: a new research direction for neurodegenerative diseases. Front Neurosci 14:267","journal-title":"Front Neurosci"},{"issue":"2","key":"2548_CR13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/cac2.12250","volume":"42","author":"L Zhao","year":"2022","unstructured":"Zhao L, Zhou X, Xie F, Zhang L, Yan H, Huang J et al (2022) Ferroptosis in cancer and cancer immunotherapy. Cancer Commun (London, England) 42(2):88\u2013116","journal-title":"Cancer Commun (London, England)"},{"issue":"19","key":"2548_CR14","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1161\/CIRCULATIONAHA.122.060257","volume":"147","author":"W Cai","year":"2023","unstructured":"Cai W, Liu L, Shi X, Liu Y, Wang J, Fang X et al (2023) Alox15\/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis. Circulation 147(19):1444\u20131460","journal-title":"Circulation"},{"issue":"12","key":"2548_CR15","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","volume":"82","author":"D Liang","year":"2022","unstructured":"Liang D, Minikes AM, Jiang X (2022) Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell 82(12):2215\u20132227","journal-title":"Mol Cell"},{"issue":"1","key":"2548_CR16","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41392-020-00216-5","volume":"5","author":"D Li","year":"2020","unstructured":"Li D, Li Y (2020) The interaction between ferroptosis and lipid metabolism in cancer. Signal Transduct Target Ther 5(1):108","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"2548_CR17","doi-asserted-by":"publisher","first-page":"2240707","DOI":"10.1080\/07853890.2023.2240707","volume":"55","author":"L Cai","year":"2023","unstructured":"Cai L, Shi L, Peng Z, Sun Y, Chen J (2023) Ageing of skeletal muscle extracellular matrix and mitochondria: finding a potential link. Ann Med 55(2):2240707","journal-title":"Ann Med"},{"key":"2548_CR18","doi-asserted-by":"publisher","first-page":"1049936","DOI":"10.3389\/fimmu.2022.1049936","volume":"13","author":"S Zhang","year":"2022","unstructured":"Zhang S, Sun Z, Jiang X, Lu Z, Ding L, Li C et al (2022) Ferroptosis increases obesity: crosstalk between adipocytes and the neuroimmune system. Front Immunol 13:1049936","journal-title":"Front Immunol"},{"key":"2548_CR19","doi-asserted-by":"publisher","first-page":"1248934","DOI":"10.3389\/fendo.2023.1248934","volume":"14","author":"D Zhou","year":"2023","unstructured":"Zhou D, Lu P, Mo X, Yang B, Chen T, Yao Y et al (2023) Ferroptosis and metabolic syndrome and complications: association, mechanism, and translational applications. Front Endocrinol 14:1248934","journal-title":"Front Endocrinol"},{"issue":"7","key":"2548_CR20","doi-asserted-by":"publisher","first-page":"e13659","DOI":"10.1111\/acel.13659","volume":"21","author":"Y Wu","year":"2022","unstructured":"Wu Y, Wu Y, Yang Y, Yu J, Wu J, Liao Z et al (2022) Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis. Aging Cell 21(7):e13659","journal-title":"Aging Cell"},{"issue":"1","key":"2548_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13018-025-05544-2","volume":"20","author":"W Xu","year":"2025","unstructured":"Xu W, Lv S, Wang X, Song C, Xi C, Yan J (2025) Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation. J Orthop Surg Res 20(1):117","journal-title":"J Orthop Surg Res"},{"key":"2548_CR22","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.maturitas.2022.09.001","volume":"168","author":"C Flor-Rufino","year":"2023","unstructured":"Flor-Rufino C, Barrachina-Igual J, P\u00e9rez-Ros P, Pablos-Monz\u00f3 A, Sanz-Requena R, Mart\u00ednez-Arnau FM (2023) Fat infiltration and muscle hydration improve after high-intensity resistance training in women with sarcopenia. A randomized clinical trial. Maturitas 168:29\u201336","journal-title":"Maturitas"},{"issue":"4","key":"2548_CR23","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1002\/jcsm.13518","volume":"15","author":"KZ Zhang","year":"2024","unstructured":"Zhang KZ, Li JW, Xu JS, Shen ZK, Lin YS, Zhao C et al (2024) RBP4 promotes denervation-induced muscle atrophy through STRA6-dependent pathway. J Cachexia Sarcopenia Muscle 15(4):1601\u20131615","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"24","key":"2548_CR24","doi-asserted-by":"publisher","first-page":"e70234","DOI":"10.1096\/fj.202400381R","volume":"38","author":"K Yin","year":"2024","unstructured":"Yin K, Zhang C, Deng Z, Wei X, Xiang T, Yang C et al (2024) FAPs orchestrate homeostasis of muscle physiology and pathophysiology. FASEB J: Off Publ Fed Am Soc Exp Biol 38(24):e70234","journal-title":"FASEB J: Off Publ Fed Am Soc Exp Biol"},{"issue":"12","key":"2548_CR25","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1177\/03635465231190389","volume":"51","author":"R Iio","year":"2023","unstructured":"Iio R, Manaka T, Takada N, Orita K, Nakazawa K, Hirakawa Y et al (2023) Parathyroid hormone inhibits fatty infiltration and muscle atrophy after rotator cuff tear by browning of fibroadipogenic progenitors in a rodent model. Am J Sports Med 51(12):3251\u20133260","journal-title":"Am J Sports Med"},{"issue":"4","key":"2548_CR26","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.stemcr.2024.02.010","volume":"19","author":"K Wang","year":"2024","unstructured":"Wang K, Yang J, An Y, Wang J, Tan S, Xu H et al (2024) MST1\/2 regulates fibro\/adipogenic progenitor fate decisions in skeletal muscle regeneration. Stem Cell Rep 19(4):501\u2013514","journal-title":"Stem Cell Rep"},{"issue":"1","key":"2548_CR27","first-page":"221436022412985","volume":"12","author":"MW Hogarth","year":"2025","unstructured":"Hogarth MW, Kurukunda MP, Ismat K, Uapinyoying P, Jaiswal JK (2025) Exploring the therapeutic potential of fibroadipogenic progenitors in muscle disease. J Neuromuscul Dis 12(1):22143602241298544","journal-title":"J Neuromuscul Dis"},{"issue":"23","key":"2548_CR28","doi-asserted-by":"publisher","first-page":"12935","DOI":"10.3390\/ijms252312935","volume":"25","author":"Z Xu","year":"2024","unstructured":"Xu Z, Wu J, Li Y, Zhou J, Zhang Y, Qiao M et al (2024) A single-cell atlas of porcine skeletal muscle reveals mechanisms that regulate intramuscular adipogenesis. Int J Mol Sci 25(23):12935. https:\/\/doi.org\/10.3390\/ijms252312935","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2548_CR29","doi-asserted-by":"publisher","first-page":"62","DOI":"10.33594\/000000121","volume":"53","author":"AF Pagano","year":"2019","unstructured":"Pagano AF, Arc-Chagnaud C, Brioche T, Chopard A, Py G (2019) Muscle resting and TGF-\u03b2 inhibitor treatment prevent fatty infiltration following skeletal muscle injury. Cell Physiol Biochem 53(1):62\u201375","journal-title":"Cell Physiol Biochem"},{"issue":"8","key":"2548_CR30","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/s41556-018-0151-y","volume":"20","author":"L Madaro","year":"2018","unstructured":"Madaro L, Passafaro M, Sala D, Etxaniz U, Lugarini F, Proietti D et al (2018) Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis. Nat Cell Biol 20(8):917\u2013927","journal-title":"Nat Cell Biol"},{"issue":"11","key":"2548_CR31","doi-asserted-by":"publisher","first-page":"114925","DOI":"10.1016\/j.celrep.2024.114925","volume":"43","author":"BR Pryce","year":"2024","unstructured":"Pryce BR, Oles A, Talbert EE, Romeo MJ, Vaena S, Sharma S et al (2024) Muscle inflammation is regulated by NF-\u03baB from multiple cells to control distinct states of wasting in cancer cachexia. Cell Rep 43(11):114925","journal-title":"Cell Rep"},{"key":"2548_CR32","doi-asserted-by":"publisher","first-page":"122742","DOI":"10.1016\/j.lfs.2024.122742","volume":"350","author":"Y Sun","year":"2024","unstructured":"Sun Y, Xu Z, You W, Zhou Y, Nong Q, Chen W et al (2024) Lipidomics and single-cell RNA sequencing reveal lipid and cell dynamics of porcine glycerol-injured skeletal muscle regeneration model. Life Sci 350:122742","journal-title":"Life Sci"},{"issue":"8","key":"2548_CR33","first-page":"1147","volume":"39","author":"L Li","year":"2024","unstructured":"Li L, Li D, Zhu J, Wang Y, Zhao F, Cheng J et al (2024) Downregulation of TGF-\u03b21 in fibro-adipogenic progenitors initiates muscle ectopic mineralization. J Bone Miner Res 39(8):1147\u20131161","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2548_CR34","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1038\/cdd.2017.132","volume":"24","author":"G Morozzi","year":"2017","unstructured":"Morozzi G, Beccafico S, Bianchi R, Riuzzi F, Bellezza I, Giambanco I et al (2017) Oxidative stress-induced S100B accumulation converts myoblasts into brown adipocytes via an NF-\u03baB\/YY1\/miR-133 axis and NF-\u03baB\/YY1\/BMP-7 axis. Cell Death Differ 24(12):2077\u20132088","journal-title":"Cell Death Differ"},{"issue":"2","key":"2548_CR35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3390\/biomedicines13020265","volume":"13","author":"AD Alatawi","year":"2025","unstructured":"Alatawi AD, Venkatesan K, Asseri K, Paulsamy P, Alqifari SF, Ahmed R et al (2025) Targeting ferroptosis in rare neurological disorders including pediatric conditions: innovations and therapeutic challenges. Biomedicines 13(2):265. https:\/\/doi.org\/10.3390\/biomedicines13020265","journal-title":"Biomedicines"},{"key":"2548_CR36","doi-asserted-by":"publisher","unstructured":"Zhang X, Deng Z, Xu X, Zhu J, Huang Z, Ye Y et al (2025) Tetrahedral framework nucleic acid-based delivery of DJ-1-saRNA prevent retinal ischaemia-reperfusion injury via inhibiting ferroptosis. Cell Proliferation e13820. https:\/\/doi.org\/10.1111\/cpr.13820","DOI":"10.1111\/cpr.13820"},{"issue":"1","key":"2548_CR37","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s10565-024-09980-4","volume":"41","author":"L Huang","year":"2025","unstructured":"Huang L, Han L, Liang S, Han G (2025) Molecular mechanism of ZC3H13 -mediated ferroptosis in doxorubicin resistance of triple negative breast cancer. Cell Biol Toxicol 41(1):52","journal-title":"Cell Biol Toxicol"},{"issue":"3","key":"2548_CR38","doi-asserted-by":"publisher","first-page":"e70116","DOI":"10.1002\/mco2.70116","volume":"6","author":"D Guo","year":"2025","unstructured":"Guo D, Cai S, Deng L, Xu W, Fu S, Lin Y et al (2025) Ferroptosis in pulmonary disease and lung cancer: molecular mechanisms, crosstalk regulation, and therapeutic strategies. MedComm 6(3):e70116","journal-title":"MedComm"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-025-02548-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00109-025-02548-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-025-02548-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T06:26:51Z","timestamp":1749104811000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00109-025-02548-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,3]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["2548"],"URL":"https:\/\/doi.org\/10.1007\/s00109-025-02548-7","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,3]]},"assertion":[{"value":"27 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethics committee of the Local Animal Care Committee (approval number: AD2024060). All experiments related to animals were conducted abiding by the National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}