{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:32:04Z","timestamp":1792794724431,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Capsular contracture (CC) is the most common complication associated with implant-based breast surgery, with particularly high risk in patients undergoing alloplastic reconstruction surgery followed by radiation therapy. Revision surgery, the only currently effective treatment, carries a high risk of recurrent CC and secondary complications. This work assessed the prophylactic potential of human adipose-derived mesenchymal stem cells (hAD-MSCs) in a novel animal model of radiation-induced CC. A total of 36 female C57Bl\/6 mice were randomly assigned to three groups: (1) IMP (silicone implants only), (2) IMP\u2009+\u2009RAD (silicone implants and irradiation therapy to promote CC), and (3) IMP\u2009+\u2009RAD\u2009+\u2009MSCs (silicone implants, irradiation therapy, and local administration of hAD-MSCs). On day 42 post-implantation, animals were euthanized and capsular tissue was subjected to histological and gene expression analyses. In addition, serum transforming growth factor beta (TGF-\u03b2) levels were measured. Targeted radiotherapy induced significant CC. In contrast, on day 42 post-irradiation, the capsular thickness in the IMP\u2009+\u2009RAD\u2009+\u2009MSCs group was significantly lower, comparable to that of non-irradiated mice. hAD-MSC treatment also resulted in a significant downregulation of pro-fibrotic and pro-inflammatory genes in the capsular tissue. In this study conducted in a murine model, hAD-MSCs demonstrated significant prophylactic potential in preventing radiation-induced CC. Further research is necessary to investigate the underlying mechanisms and to assess the efficacy and safety of this approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key messages<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\u00a0Radiotherapy increased capsular thickness and expression of pro-inflammatory and fibrotic genes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u00a0Stem cells restored capsular thickness to levels comparable to non-irradiated mice.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u00a0Stem cells downregulated both pro-fibrotic and pro-inflammatory genes in capsule tissue.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u00a0Findings highlight the potential of stem cells in preventing radiation-induced capsular contracture.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00109-025-02576-3","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T08:13:43Z","timestamp":1754036023000},"page":"1169-1178","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adipose-derived mesenchymal stem cells for the prevention of capsular contracture"],"prefix":"10.1007","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8441-1397","authenticated-orcid":false,"given":"Orel","family":"Govrin-Yehudain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Korzets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosef","family":"Zkika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Castel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Y.","family":"Brzezinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Reuveni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoad","family":"Govrin-Yehudain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Gur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Solodeev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Barnea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"2576_CR1","doi-asserted-by":"publisher","unstructured":"Susini P, Nisi G, Pierazzi DM, et al. 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TLVMC\u2014IL\u20142203\u2014111\u20144). The study \u201cFat samples for use in current and future medical laboratory research\u201d was approved by the ethics committee of Tel Aviv Sourasky Medical Center, Israel (approval no. 0369\u201312-TLV, 1\/2020). All procedures were performed in accordance with the Declaration of Helsinki. Patients or their guardians\/legally authorized representatives\/next of kin provided written informed consent for participation in the study and\/or the use of samples.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors confirm their consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Yoav Barnea participates in educational lectures for Johnson (Mentor) Corporation. All other authors have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}