{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T19:44:36Z","timestamp":1794080676848,"version":"4.8.0"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFC2704702"],"award-info":[{"award-number":["2022YFC2704702"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015640","name":"Tongji Hospital","doi-asserted-by":"publisher","award":["2024B27"],"award-info":[{"award-number":["2024B27"]}],"id":[{"id":"10.13039\/501100015640","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00109-025-02629-7","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:37:00Z","timestamp":1766065020000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Oxidative stress, mitochondrial dysfunction, and ferroptosis in the placenta of gestational diabetes mellitus"],"prefix":"10.1007","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1345-1498","authenticated-orcid":false,"given":"Xuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoshuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencheng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-5574","authenticated-orcid":false,"given":"Ling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"issue":"10448","key":"2629_CR1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/S0140-6736(24)00827-4","volume":"404","author":"MF Hivert","year":"2024","unstructured":"Hivert MF, Backman H, Benhalima K, Catalano P, Desoye G, Immanuel J et al (2024) Pathophysiology from preconception, during pregnancy, and beyond. Lancet 404(10448):158\u2013174. https:\/\/doi.org\/10.1016\/S0140-6736(24)00827-4","journal-title":"Lancet"},{"issue":"10448","key":"2629_CR2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0140-6736(24)00825-0","volume":"404","author":"A Sweeting","year":"2024","unstructured":"Sweeting A, Hannah W, Backman H, Catalano P, Feghali M, Herman WH et al (2024) Epidemiology and management of gestational diabetes. Lancet 404(10448):175\u2013192. https:\/\/doi.org\/10.1016\/S0140-6736(24)00825-0","journal-title":"Lancet"},{"key":"2629_CR3","doi-asserted-by":"publisher","unstructured":"American Diabetes Association Professional Practice Committee. 15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes-2025. Diabetes Care. 2025;48(Suppl 1):S306-S320. https:\/\/doi.org\/10.2337\/dc25-S015.","DOI":"10.2337\/dc25-S015"},{"key":"2629_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-067946","volume":"377","author":"W Ye","year":"2022","unstructured":"Ye W, Luo C, Huang J, Li C, Liu Z, Liu F (2022) Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis. BMJ 377:e067946","journal-title":"BMJ"},{"key":"2629_CR5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1361","volume":"369","author":"E Vounzoulaki","year":"2020","unstructured":"Vounzoulaki E, Khunti K, Abner SC, Tan BK, Davies MJ, Gillies CL (2020) Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis. BMJ 369:m1361","journal-title":"BMJ"},{"issue":"21","key":"2629_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111491","volume":"25","author":"Y Luo","year":"2024","unstructured":"Luo Y, Meng X, Cui L, Wang S (2024) Circadian regulation of lipid metabolism during pregnancy. Int J Mol Sci 25(21):11491","journal-title":"Int J Mol Sci"},{"issue":"23","key":"2629_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312722","volume":"22","author":"C Stern","year":"2021","unstructured":"Stern C, Schwarz S, Moser G, Cvitic S, Jantscher-Krenn E, Gauster M et al (2021) Placental endocrine activity: adaptation and disruption of maternal glucose metabolism in pregnancy and the influence of fetal sex. Int J Mol Sci 22(23):12722. https:\/\/doi.org\/10.3390\/ijms222312722","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2629_CR8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1210\/endrev\/bnac003","volume":"43","author":"A Sweeting","year":"2022","unstructured":"Sweeting A, Wong J, Murphy HR, Ross GP (2022) A clinical update on gestational diabetes mellitus. Endocr Rev 43(5):763\u2013793","journal-title":"Endocr Rev"},{"key":"2629_CR9","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.placenta.2020.11.012","volume":"104","author":"M Lu","year":"2021","unstructured":"Lu M, Sferruzzi-Perri AN (2021) Placental mitochondrial function in response to gestational exposures. Placenta 104:124\u2013137","journal-title":"Placenta"},{"issue":"1","key":"2629_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/1440-1681.13172","volume":"47","author":"JJ Fisher","year":"2020","unstructured":"Fisher JJ, Bartho LA, Perkins AV, Holland OJ (2020) Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy. Clin Exp Pharmacol Physiol 47(1):176\u2013184","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"1","key":"2629_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02766-0","volume":"22","author":"X Chen","year":"2024","unstructured":"Chen X, Tao X, Wang M, Cannon RD, Chen B, Yu X et al (2024) Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3\/FAM3A axis in gestational diabetes mellitus. J Nanobiotechnol 22(1):509","journal-title":"J Nanobiotechnol"},{"issue":"2","key":"2629_CR12","doi-asserted-by":"publisher","first-page":"176","DOI":"10.2174\/1570161118666200616144512","volume":"19","author":"S Bedell","year":"2021","unstructured":"Bedell S, Hutson J, de Vrijer B, Eastabrook G (2021) Effects of maternal obesity and gestational diabetes mellitus on the placenta: current knowledge and targets for therapeutic interventions. Curr Vasc Pharmacol 19(2):176\u2013192. https:\/\/doi.org\/10.2174\/1570161118666200616144512","journal-title":"Curr Vasc Pharmacol"},{"issue":"4","key":"2629_CR13","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3390\/nu13041303","volume":"13","author":"C Diceglie","year":"2021","unstructured":"Diceglie C, Anelli GM, Martelli C, Serati A, Lo Dico A, Lisso F et al (2021) Placental antioxidant defenses and autophagy-related genes in maternal obesity and gestational diabetes mellitus. Nutrients 13(4):1303","journal-title":"Nutrients"},{"issue":"21","key":"2629_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111641","volume":"25","author":"J Torres-Torres","year":"2024","unstructured":"Torres-Torres J, Monroy-Mu\u00f1oz IE, Perez-Duran J, Solis-Paredes JM, Camacho-Martinez ZA, Baca D et al (2024) Cellular and molecular pathophysiology of gestational diabetes. Int J Mol Sci 25(21):11641. https:\/\/doi.org\/10.3390\/ijms252111641","journal-title":"Int J Mol Sci"},{"issue":"10","key":"2629_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12101812","volume":"12","author":"R Saucedo","year":"2023","unstructured":"Saucedo R, Ortega-Camarillo C, Ferreira-Hermosillo A, D\u00edaz-Vel\u00e1zquez MF, Meixueiro-Calder\u00f3n C, Valencia-Ortega J (2023) Role of oxidative stress and inflammation in gestational diabetes mellitus. Antioxidants 12(10):1812. https:\/\/doi.org\/10.3390\/antiox12101812","journal-title":"Antioxidants"},{"issue":"1","key":"2629_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010106","volume":"11","author":"CSM Ruano","year":"2022","unstructured":"Ruano CSM, Miralles F, M\u00e9hats C, Vaiman D (2022) The impact of oxidative stress of environmental origin on the onset of placental diseases. Antioxidants 11(1):106","journal-title":"Antioxidants"},{"issue":"18","key":"2629_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221810122","volume":"22","author":"EH Joo","year":"2021","unstructured":"Joo EH, Kim YR, Kim N, Jung JE, Han SH, Cho HY (2021) Effect of endogenic and exogenic oxidative stress triggers on adverse pregnancy outcomes: preeclampsia, fetal growth restriction, gestational diabetes mellitus and preterm birth. Int J Mol Sci 22(18):10122. https:\/\/doi.org\/10.3390\/ijms221810122","journal-title":"Int J Mol Sci"},{"issue":"7","key":"2629_CR18","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.tem.2024.02.002","volume":"35","author":"CXW Zhang","year":"2024","unstructured":"Zhang CXW, Candia AA, Sferruzzi-Perri AN (2024) Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity. Trends Endocrinol Metab 35(7):638\u2013647","journal-title":"Trends Endocrinol Metab"},{"issue":"2","key":"2629_CR19","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1530\/REP-22-0278","volume":"166","author":"Z Sultana","year":"2023","unstructured":"Sultana Z, Qiao Y, Maiti K, Smith R (2023) Involvement of oxidative stress in placental dysfunction, the pathophysiology of fetal death and pregnancy disorders. Reproduction 166(2):R25\u2013R38","journal-title":"Reproduction"},{"issue":"4","key":"2629_CR20","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1021\/acs.jproteome.3c00735","volume":"23","author":"ZR Ren","year":"2024","unstructured":"Ren ZR, Luo SS, Qin XY, Huang HF, Ding GL (2024) Sex-specific alterations in placental proteomics induced by intrauterine hyperglycemia. J Proteome Res 23(4):1272\u20131284","journal-title":"J Proteome Res"},{"key":"2629_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2022.101098","volume":"87","author":"JR Prins","year":"2022","unstructured":"Prins JR, Schoots MH, Wessels JI, Campmans-Kuijpers MJE, Navis GJ, van Goor H et al (2022) The influence of the dietary exposome on oxidative stress in pregnancy complications. Mol Aspects Med 87:101098. https:\/\/doi.org\/10.1016\/j.mam.2022.101098","journal-title":"Mol Aspects Med"},{"issue":"1","key":"2629_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010129","volume":"11","author":"ELSS de Mendon\u00e7a","year":"2022","unstructured":"de Mendon\u00e7a ELSS, Fragoso MBT, de Oliveira JM, Xavier JA, Goulart MOF, de Oliveira ACM (2022) Gestational diabetes mellitus: the crosslink among inflammation, nitroxidative stress, intestinal microbiota and alternative therapies. Antioxidants 11(1):129. https:\/\/doi.org\/10.3390\/antiox11010129","journal-title":"Antioxidants"},{"issue":"7","key":"2629_CR23","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.3390\/nu13072284","volume":"13","author":"C Chatzakis","year":"2021","unstructured":"Chatzakis C, Sotiriadis A, Tsakmaki E, Papagianni M, Paltoglou G, Dinas K et al (2021) The effect of dietary supplements on oxidative stress in pregnant women with gestational diabetes mellitus: a network meta-analysis. Nutrients 13(7):2284","journal-title":"Nutrients"},{"issue":"10","key":"2629_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13101234","volume":"13","author":"L Annesi","year":"2024","unstructured":"Annesi L, Tossetta G, Borghi C, Piani F (2024) The role of xanthine oxidase in pregnancy complications: a systematic review. Antioxidants (Basel) 13(10):1234","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"2629_CR25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12958-024-01259-x","volume":"22","author":"A Ibrahim","year":"2024","unstructured":"Ibrahim A, Khoo MI, Ismail EHE, Hussain NHN, Zin AAM, Noordin L et al (2024) Oxidative stress biomarkers in pregnancy: a systematic review. Reprod Biol Endocrinol 22(1):93","journal-title":"Reprod Biol Endocrinol"},{"issue":"4","key":"2629_CR26","doi-asserted-by":"publisher","first-page":"746","DOI":"10.3390\/nu14040746","volume":"14","author":"A Lopez-Ya\u00f1ez Blanco","year":"2022","unstructured":"Lopez-Ya\u00f1ez Blanco A, D\u00edaz-L\u00f3pez KM, Vilchis-Gil J, Diaz-Garcia H, Gomez-Lopez J, Medina-Bravo P et al (2022) Diet and maternal obesity are associated with increased oxidative stress in newborns: a cross-sectional study. Nutrients 14(4):746","journal-title":"Nutrients"},{"issue":"4","key":"2629_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/biology12040527","volume":"12","author":"A Rasool","year":"2023","unstructured":"Rasool A, Mahmoud T, O\u2019Tierney-Ginn P (2023) Lipid aldehydes 4-hydroxynonenal and 4-hydroxyhexenal exposure differentially impact lipogenic pathways in human placenta. Biology (Basel) 12(4):527. https:\/\/doi.org\/10.3390\/biology12040527","journal-title":"Biology (Basel)"},{"issue":"8","key":"2629_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13080979","volume":"13","author":"JM Toledano","year":"2024","unstructured":"Toledano JM, Puche-Juarez M, Galvez-Navas JM, Moreno-Fernandez J, Diaz-Castro J, Ochoa JJ (2024) Pregnancy disorders: a potential role for mitochondrial altered homeostasis. Antioxidants 13(8):979","journal-title":"Antioxidants"},{"issue":"1","key":"2629_CR29","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/s10020-024-01007-2","volume":"30","author":"X Zhou","year":"2024","unstructured":"Zhou X, Jiang Y, Wang Z, Wei L, Zhang H, Fang C et al (2024) Chemerin alleviates the placental oxidative stress and improves fetal overgrowth of gestational diabetes mellitus mice induced by high fat diet. Mol Med 30(1):239","journal-title":"Mol Med"},{"issue":"12","key":"2629_CR30","doi-asserted-by":"publisher","first-page":"5496","DOI":"10.7150\/ijbs.113728","volume":"21","author":"Y Peng","year":"2025","unstructured":"Peng Y, Zhao H, Chen J, Wang CC, Zhang T, Yeung TC et al (2025) PGK1 regulates oxidative stress in gestational diabetes mellitus through the estradiol-Keap1-Nrf2 pathway. Int J Biol Sci 21(12):5496\u20135513. https:\/\/doi.org\/10.7150\/ijbs.113728","journal-title":"Int J Biol Sci"},{"issue":"4","key":"2629_CR31","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1152\/physrev.00039.2024","volume":"105","author":"ILMH Aye","year":"2025","unstructured":"Aye ILMH, Tong S, Charnock-Jones DS, Smith GCS (2025) The human placenta and its role in reproductive outcomes revisited. Physiol Rev 105(4):2305\u20132376","journal-title":"Physiol Rev"},{"issue":"16","key":"2629_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169395","volume":"23","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Lu Y, Jin L (2022) Iron metabolism and ferroptosis in physiological and pathological pregnancy. Int J Mol Sci 23(16):9395","journal-title":"Int J Mol Sci"},{"issue":"11","key":"2629_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12111918","volume":"12","author":"C Garc\u00eda-Montero","year":"2023","unstructured":"Garc\u00eda-Montero C, Fraile-Martinez O, De Leon-Oliva D, Boaru DL, Garcia-Puente LM, De Le\u00f3n-Luis JA et al (2023) Exploring the role of mediterranean and westernized diets and their main nutrients in the modulation of oxidative stress in the placenta: a narrative review. Antioxidants 12(11):1918","journal-title":"Antioxidants"},{"key":"2629_CR34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.placenta.2024.01.012","volume":"147","author":"YM Lai","year":"2024","unstructured":"Lai YM, Tan GC, Shah SA, Abd Rahman R, Mohd Saleh MF, Mansor S et al (2024) Non-hypertensive gestational diabetes mellitus: placental histomorphology and its association with perinatal outcomes. Placenta 147:21\u201327","journal-title":"Placenta"},{"key":"2629_CR35","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.placenta.2021.04.005","volume":"116","author":"E Ehlers","year":"2021","unstructured":"Ehlers E, Talton OO, Schust DJ, Schulz LC (2021) Placental structural abnormalities in gestational diabetes and when they develop: a scoping review. Placenta 116:58\u201366","journal-title":"Placenta"},{"issue":"6","key":"2629_CR36","doi-asserted-by":"publisher","first-page":"808","DOI":"10.4239\/wjd.v14.i6.808","volume":"14","author":"HZ Ma","year":"2023","unstructured":"Ma HZ, Chen Y, Guo HH, Wang J, Xin XL, Li YC et al (2023) Effect of resveratrol in gestational diabetes mellitus and its complications. World J Diabetes 14(6):808\u2013819. https:\/\/doi.org\/10.4239\/wjd.v14.i6.808","journal-title":"World J Diabetes"},{"issue":"17","key":"2629_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179681","volume":"25","author":"NI Basri","year":"2024","unstructured":"Basri NI, Murthi P, Abd Rahman R (2024) Hydroxychloroquine as an adjunct therapy for diabetes in pregnancy. Int J Mol Sci 25(17):9681","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2629_CR38","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12884-023-05524-6","volume":"23","author":"R Sa","year":"2023","unstructured":"Sa R, Ma J, Yang J, Li DF, Du J, Jia JC et al (2023) High TXNIP expression accelerates the migration and invasion of the GDM placenta trophoblast. BMC Pregnancy Childbirth 23(1):235","journal-title":"BMC Pregnancy Childbirth"},{"issue":"2","key":"2629_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021314","volume":"25","author":"TH Chen","year":"2024","unstructured":"Chen TH, Wang HC, Chang CJ, Lee SY (2024) Mitochondrial glutathione in cellular redox homeostasis and disease manifestation. Int J Mol Sci 25(2):1314","journal-title":"Int J Mol Sci"},{"issue":"9","key":"2629_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9090794","volume":"9","author":"C Santos-Rosendo","year":"2020","unstructured":"Santos-Rosendo C, Bugatto F, Gonz\u00e1lez-Dom\u00ednguez A, Lechuga-Sancho AM, M MR, Visiedo F (2020) Placental adaptive changes to protect function and decrease oxidative damage in metabolically healthy maternal obesity. Antioxidants (Basel) 9(9):794","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"2629_CR41","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3390\/nu14030628","volume":"14","author":"C Hogan","year":"2022","unstructured":"Hogan C, Perkins AV (2022) Selenoproteins in the human placenta: how essential is selenium to a healthy start to life? Nutrients 14(3):628","journal-title":"Nutrients"},{"key":"2629_CR42","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.freeradbiomed.2025.06.007","volume":"237","author":"K Etchegaray-Armijo","year":"2025","unstructured":"Etchegaray-Armijo K, Bustos-Arriagada E, Navarro-Rosenblatt D, Vera C, Garmendia ML, Sobrevia L et al (2025) Biomarkers of oxidative stress in maternal plasma, umbilical cord and placenta of patients with gestational diabetes: a systematic review and meta-analysis. Free Radic Biol Med 237:650\u2013665. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.06.007","journal-title":"Free Radic Biol Med"},{"key":"2629_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2024.148746","volume":"928","author":"A Shamsad","year":"2024","unstructured":"Shamsad A, Gautam T, Singh R, Banerjee M (2024) Association of mRNA expression and polymorphism of antioxidant glutathione-S-transferase (GSTM1 and GSTT1) genes with the risk of gestational diabetes mellitus (GDM). Gene 928:148746","journal-title":"Gene"},{"issue":"3","key":"2629_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032240","volume":"24","author":"C Giommi","year":"2023","unstructured":"Giommi C, Lomb\u03cc M, Montik N, Paolucci M, Notarstefano V, Delli Carpini G et al (2023) Gestational diabetes mellitus and small-for-gestational-age: an insight into the placental molecular biomarkers. Int J Mol Sci 24(3):2240. https:\/\/doi.org\/10.3390\/ijms24032240","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2629_CR45","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1113\/JP280593","volume":"599","author":"JJ Fisher","year":"2021","unstructured":"Fisher JJ, Vanderpeet CL, Bartho LA, McKeating DR, Cuffe JSM, Holland OJ et al (2021) Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus. J Physiol 599(4):1291\u20131305. https:\/\/doi.org\/10.1113\/JP280593","journal-title":"J Physiol"},{"issue":"1","key":"2629_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165967","volume":"1867","author":"JF Hebert","year":"2021","unstructured":"Hebert JF, Myatt L (2021) Placental mitochondrial dysfunction with metabolic diseases: therapeutic approaches. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867(1):165967","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"2629_CR47","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.placenta.2020.01.015","volume":"98","author":"AN Sferruzzi-Perri","year":"2020","unstructured":"Sferruzzi-Perri AN, Lopez-Tello J, Napso T, Yong HEJ (2020) Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy: lessons from animal models. Placenta 98:43\u201351","journal-title":"Placenta"},{"issue":"7","key":"2629_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13070858","volume":"13","author":"C Mand\u00f2","year":"2024","unstructured":"Mand\u00f2 C, Castiglioni S, Novielli C, Anelli GM, Serati A, Parisi F et al (2024) Placental bioenergetics and antioxidant homeostasis in maternal obesity and gestational diabetes. Antioxidants 13(7):858","journal-title":"Antioxidants"},{"issue":"10","key":"2629_CR49","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.3390\/biom10101359","volume":"10","author":"J Tozour","year":"2020","unstructured":"Tozour J, Hughes F, Carrier A, Vieau D, Delahaye F (2020) Prenatal hyperglycemia exposure and cellular stress, a sugar-coated view of early programming of metabolic diseases. Biomolecules 10(10):1359","journal-title":"Biomolecules"},{"issue":"15","key":"2629_CR50","doi-asserted-by":"publisher","first-page":"8572","DOI":"10.3390\/ijms23158572","volume":"23","author":"S Wang","year":"2022","unstructured":"Wang S, Ning J, Huai J, Yang H (2022) Hyperglycemia in pregnancy-associated oxidative stress augments altered placental glucose transporter 1 trafficking via AMPK\u03b1\/p38MAPK signaling cascade. Int J Mol Sci 23(15):8572","journal-title":"Int J Mol Sci"},{"key":"2629_CR51","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.placenta.2024.10.021","volume":"158","author":"KL Milan","year":"2024","unstructured":"Milan KL, Gayatri V, Kriya K, Sanjushree N, Vishwanathan Palanivel S, Anuradha M et al (2024) Mir-142-5p mediated Nrf2 dysregulation in gestational diabetes mellitus and its impact on placental angiogenesis. Placenta 158:192\u2013199","journal-title":"Placenta"},{"key":"2629_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102883","volume":"67","author":"PM Psefteli","year":"2023","unstructured":"Psefteli PM, Morris JK, Ehler E, Smith L, Bowe J, Mann GE et al (2023) Sulforaphane induced NRF2 activation in obese pregnancy attenuates developmental redox imbalance and improves early-life cardiovascular function in offspring. Redox Biol 67:102883. https:\/\/doi.org\/10.1016\/j.redox.2023.102883","journal-title":"Redox Biol"},{"issue":"5","key":"2629_CR53","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1093\/humupd\/dmaa014","volume":"26","author":"K Peoc\u2019h","year":"2020","unstructured":"Peoc\u2019h K, Puy V, Fournier T (2020) Haem oxygenases play a pivotal role in placental physiology and pathology. Hum Reprod Update 26(5):634\u2013649","journal-title":"Hum Reprod Update"},{"issue":"1","key":"2629_CR54","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s10020-020-00205-y","volume":"26","author":"S Jiang","year":"2020","unstructured":"Jiang S, Teague AM, Tryggestad JB, Lyons TJ, Chernausek SD (2020) Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis. Mol Med 26(1):76","journal-title":"Mol Med"},{"issue":"3","key":"2629_CR55","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201611R","volume":"37","author":"X Zhou","year":"2023","unstructured":"Zhou X, Zhang H, Jiang Y, Wei L, Chen Y, Zhang J et al (2023) The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta. FASEB J 37(3):e22806. https:\/\/doi.org\/10.1096\/fj.202201611R","journal-title":"FASEB J"},{"issue":"12","key":"2629_CR56","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1631\/jzus.B2000432","volume":"21","author":"X Zhou","year":"2020","unstructured":"Zhou X, Li JQ, Wei LJ, He MZ, Jia J, Zhang JY et al (2020) Silencing of DsbA-L gene impairs the PPAR\u03b3 agonist function of improving insulin resistance in a high-glucose cell model. J Zhejiang Univ Sci B 21(12):990\u2013998","journal-title":"J Zhejiang Univ Sci B"},{"issue":"1","key":"2629_CR57","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.apsb.2021.05.011","volume":"12","author":"PK Oduro","year":"2022","unstructured":"Oduro PK, Zheng X, Wei J, Yang Y, Wang Y, Zhang H et al (2022) The cGAS-STING signaling in cardiovascular and metabolic diseases: future novel target option for pharmacotherapy. Acta Pharm Sin B 12(1):50\u201375. https:\/\/doi.org\/10.1016\/j.apsb.2021.05.011","journal-title":"Acta Pharm Sin B"},{"issue":"10","key":"2629_CR58","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1093\/jmcb\/mjab066","volume":"13","author":"J Bai","year":"2021","unstructured":"Bai J, Liu F (2021) cGAS-STING signaling and function in metabolism and kidney diseases. J Mol Cell Biol 13(10):728\u2013738","journal-title":"J Mol Cell Biol"},{"issue":"16","key":"2629_CR59","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1042\/CS20220150","volume":"137","author":"S Nair","year":"2023","unstructured":"Nair S, Ormazabal V, Carrion F, Handberg A, McIntyre HD, Salomon C (2023) Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes. Clin Sci (Lond) 137(16):1311\u20131332","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"2629_CR60","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000326RR","volume":"35","author":"AM Valent","year":"2021","unstructured":"Valent AM, Choi H, Kolahi KS, Thornburg KL (2021) Hyperglycemia and gestational diabetes suppress placental glycolysis and mitochondrial function and alter lipid processing. FASEB J 35(3):e21423","journal-title":"FASEB J"},{"issue":"8","key":"2629_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13081007","volume":"13","author":"SC Hung","year":"2024","unstructured":"Hung SC, Chan TF, Chan HC, Wu CY, Chan ML, Jhuang JY et al (2024) Lysophosphatidylcholine impairs the mitochondria homeostasis leading to trophoblast dysfunction in gestational diabetes mellitus. Antioxidants 13(8):1007","journal-title":"Antioxidants"},{"issue":"21","key":"2629_CR62","doi-asserted-by":"publisher","first-page":"11534","DOI":"10.3390\/ijms252111534","volume":"25","author":"KM Siemers","year":"2024","unstructured":"Siemers KM, Joss-Moore LA, Baack ML (2024) Gestational diabetes-like fuels impair mitochondrial function and long-chain fatty acid uptake in human trophoblasts. Int J Mol Sci 25(21):11534","journal-title":"Int J Mol Sci"},{"key":"2629_CR63","doi-asserted-by":"publisher","DOI":"10.1113\/JP285935","author":"RA Grismaldo","year":"2024","unstructured":"Grismaldo RA, Lu\u00e9vano-Mart\u00ednez LA, Reyes M, Garc\u00eda-M\u00e1rquez G, Garc\u00eda-Rivas G, Sobrevia L (2024) Placental mitochondrial impairment and its association with maternal metabolic dysfunction. J Physiol. https:\/\/doi.org\/10.1113\/JP285935","journal-title":"J Physiol"},{"issue":"12","key":"2629_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165948","volume":"1866","author":"L Sobrevia","year":"2020","unstructured":"Sobrevia L, Valero P, Grismaldo A, Villalobos-Labra R, Pardo F, Subiabre M et al (2020) Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866(12):165948","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"2629_CR65","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.placenta.2021.09.015","volume":"115","author":"UK Kolac","year":"2021","unstructured":"Kolac UK, Kurek Eken M, \u00dcn\u00fcbol M, Donmez Yalcin G, Yalcin A (2021) The effect of gestational diabetes on the expression of mitochondrial fusion proteins in placental tissue. Placenta 115:106\u2013114","journal-title":"Placenta"},{"issue":"1","key":"2629_CR66","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-000923","volume":"8","author":"J Abbade","year":"2020","unstructured":"Abbade J, Klemetti MM, Farrell A, Ermini L, Gillmore T, Sallais J et al (2020) Increased placental mitochondrial fusion in gestational diabetes mellitus: an adaptive mechanism to optimize feto-placental metabolic homeostasis? BMJ Open Diabetes Res Care 8(1):e000923. https:\/\/doi.org\/10.1136\/bmjdrc-2019-000923","journal-title":"BMJ Open Diabetes Res Care"},{"issue":"1","key":"2629_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13105-022-00927-z","volume":"79","author":"N Phengpol","year":"2023","unstructured":"Phengpol N, Thongnak L, Lungkaphin A (2023) The programming of kidney injury in offspring affected by maternal overweight and obesity: role of lipid accumulation, inflammation, oxidative stress, and fibrosis in the kidneys of offspring. J Physiol Biochem 79(1):1\u201317","journal-title":"J Physiol Biochem"},{"issue":"3","key":"2629_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030719","volume":"12","author":"JF Hebert","year":"2023","unstructured":"Hebert JF, Myatt L (2023) Metformin impacts human syncytiotrophoblast mitochondrial function from pregnancies complicated by obesity and gestational diabetes mellitus in a sexually dimorphic manner. Antioxidants 12(3):719. https:\/\/doi.org\/10.3390\/antiox12030719","journal-title":"Antioxidants"},{"key":"2629_CR69","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.placenta.2023.04.011","volume":"137","author":"AM Parsons","year":"2023","unstructured":"Parsons AM, Rajendran RR, Whitcomb LA, Bouma GJ, Chicco AJ (2023) Characterization of trophoblast mitochondrial function and responses to testosterone treatment in ACH-3P cells. Placenta 137:70\u201377","journal-title":"Placenta"},{"issue":"1","key":"2629_CR70","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41420-024-01867-x","volume":"10","author":"H Chen","year":"2024","unstructured":"Chen H, Chen Y, Zheng Q (2024) The regulated cell death at the maternal-fetal interface: beneficial or detrimental? Cell Death Discov 10(1):100","journal-title":"Cell Death Discov"},{"issue":"1","key":"2629_CR71","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05192-5","volume":"81","author":"J Zaugg","year":"2024","unstructured":"Zaugg J, Lopez-Tello J, Musial B, Vaughan OR, Fowden AL, Albrecht C et al (2024) Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations. Cell Mol Life Sci 81(1):151. https:\/\/doi.org\/10.1007\/s00018-024-05192-5","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"2629_CR72","doi-asserted-by":"publisher","first-page":"7311","DOI":"10.1096\/fj.201903054R","volume":"34","author":"J Zaugg","year":"2020","unstructured":"Zaugg J, Melhem H, Huang X, Wegner M, Baumann M, Surbek D et al (2020) Gestational diabetes mellitus affects placental iron homeostasis: mechanism and clinical implications. FASEB J 34(6):7311\u20137329. https:\/\/doi.org\/10.1096\/fj.201903054R","journal-title":"FASEB J"},{"issue":"3","key":"2629_CR73","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1093\/ajcn\/nqab162","volume":"114","author":"X Zhang","year":"2021","unstructured":"Zhang X, Wu M, Zhong C, Huang L, Zhang Y, Chen R et al (2021) Association between maternal plasma ferritin concentration, iron supplement use, and the risk of gestational diabetes: a prospective cohort study. Am J Clin Nutr 114(3):1100\u20131106. https:\/\/doi.org\/10.1093\/ajcn\/nqab162","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"2629_CR74","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/dom.14886","volume":"25","author":"L Liu","year":"2023","unstructured":"Liu L, Yan F, Yan H, Wang Z (2023) Impact of iron supplementation on gestational diabetes mellitus: a literature review. Diabetes Obes Metab 25(2):342\u2013353","journal-title":"Diabetes Obes Metab"},{"key":"2629_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2023.104182","volume":"161","author":"S Mohandas","year":"2024","unstructured":"Mohandas S, Milan KL, Anuradha M, Ramkumar KM (2024) Exploring lactoferrin as a novel marker for disease pathology and ferroptosis regulation in gestational diabetes. J Reprod Immunol 161:104182","journal-title":"J Reprod Immunol"},{"issue":"11","key":"2629_CR76","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.70027","volume":"16","author":"H Mo","year":"2024","unstructured":"Mo H, Wen J, Qu C, Liu X (2024) Associations of maternal serum ferritin levels across gestation with gestational diabetes mellitus: a longitudinal cohort study. J Diabetes 16(11):e70027","journal-title":"J Diabetes"},{"issue":"1","key":"2629_CR77","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00394-023-03250-5","volume":"63","author":"T Li","year":"2024","unstructured":"Li T, Zhang J, Li P (2024) Ferritin and iron supplements in gestational diabetes mellitus: less or more? Eur J Nutr 63(1):67\u201378","journal-title":"Eur J Nutr"},{"issue":"3","key":"2629_CR78","doi-asserted-by":"publisher","DOI":"10.3390\/biology10030184","volume":"10","author":"JY Lee","year":"2021","unstructured":"Lee JY, Kim WK, Bae KH, Lee SC, Lee EW (2021) Lipid metabolism and ferroptosis. Biology 10(3):184","journal-title":"Biology"},{"issue":"15","key":"2629_CR79","doi-asserted-by":"publisher","first-page":"5826","DOI":"10.7150\/thno.100080","volume":"14","author":"S Li","year":"2024","unstructured":"Li S, Zhang G, Hu J, Tian Y, Fu X (2024) Ferroptosis at the nexus of metabolism and metabolic diseases. Theranostics 14(15):5826\u20135852","journal-title":"Theranostics"},{"issue":"20","key":"2629_CR80","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012286","volume":"23","author":"KB Kuentzel","year":"2022","unstructured":"Kuentzel KB, Bradi\u0107 I, Mihali\u010d ZN, Korbelius M, Rainer S, Pirchheim A et al (2022) Dysregulation of placental lipid hydrolysis by high-fat\/high-cholesterol feeding and gestational diabetes mellitus in mice. Int J Mol Sci 23(20):12286. https:\/\/doi.org\/10.3390\/ijms232012286","journal-title":"Int J Mol Sci"},{"issue":"11","key":"2629_CR81","doi-asserted-by":"publisher","first-page":"8839","DOI":"10.1002\/jcp.29727","volume":"235","author":"D Han","year":"2020","unstructured":"Han D, Jiang L, Gu X, Huang S, Pang J, Wu Y et al (2020) SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK\/mTOR pathway and promoting GPX4 levels. J Cell Physiol 235(11):8839\u20138851. https:\/\/doi.org\/10.1002\/jcp.29727","journal-title":"J Cell Physiol"},{"issue":"9","key":"2629_CR82","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3526","volume":"25","author":"J Jiang","year":"2023","unstructured":"Jiang J, Gao H, Zhou W, Cai H, Liao L, Wang C (2023) Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes mellitus by regulating glutathione peroxidase 4 DNA methylation. J Gene Med 25(9):e3526","journal-title":"J Gene Med"},{"issue":"9","key":"2629_CR83","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1111\/jdi.70115","volume":"16","author":"D Xia","year":"2025","unstructured":"Xia D, Zhang Y, Zhang C, Wang H (2025) Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K\/Akt\/Nrf2 pathway in gestational diabetes mellitus. J Diabetes Investig 16(9):1720\u20131732","journal-title":"J Diabetes Investig"},{"issue":"44","key":"2629_CR84","doi-asserted-by":"publisher","first-page":"27319","DOI":"10.1073\/pnas.2009201117","volume":"117","author":"O Beharier","year":"2020","unstructured":"Beharier O, Tyurin VA, Goff JP, Guerrero-Santoro J, Kajiwara K, Chu T et al (2020) PLA2G6 guards placental trophoblasts against ferroptotic injury. Proc Natl Acad Sci U S A 117(44):27319\u201327328. https:\/\/doi.org\/10.1073\/pnas.2009201117","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"2629_CR85","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26178719","volume":"26","author":"MZ Assani","year":"2025","unstructured":"Assani MZ, Boldeanu L, Manolea MM, Boldeanu MV, Silo\u0219i I, Assani AD et al (2025) From molecular insights to clinical management of gestational diabetes mellitus-a narrative review. Int J Mol Sci 26(17):8719. https:\/\/doi.org\/10.3390\/ijms26178719","journal-title":"Int J Mol Sci"},{"key":"2629_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2025.07.039","author":"GJ Burton","year":"2025","unstructured":"Burton GJ, Jauniaux E, Moffett A (2025) Formation of the placental membranes and pathophysiological origin of associated great obstetrical syndromes. Am J Obstet Gynecol. https:\/\/doi.org\/10.1016\/j.ajog.2025.07.039","journal-title":"Am J Obstet Gynecol"},{"key":"2629_CR87","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1177547","volume":"14","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Gao Q, Li B, Wang Y, Wang Y (2023) Ferroptosis and its potential role in gestational diabetes mellitus: updated evidence from pathogenesis to therapy. Front Endocrinol (Lausanne) 14:1177547","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"2629_CR88","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.255737","volume":"135","author":"K Kajiwara","year":"2022","unstructured":"Kajiwara K, Beharier O, Chng CP, Goff JP, Ouyang Y, St Croix CM et al (2022) Ferroptosis induces membrane blebbing in placental trophoblasts. J Cell Sci 135(5):jcs255737. https:\/\/doi.org\/10.1242\/jcs.255737","journal-title":"J Cell Sci"},{"issue":"2","key":"2629_CR89","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","volume":"21","author":"FJ Bock","year":"2020","unstructured":"Bock FJ, Tait SWG (2020) Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol 21(2):85\u2013100","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"2629_CR90","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","volume":"25","author":"SJ Dixon","year":"2024","unstructured":"Dixon SJ, Olzmann JA (2024) The cell biology of ferroptosis. Nat Rev Mol Cell Biol 25(6):424\u2013442","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"2629_CR91","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41581-023-00689-x","volume":"19","author":"H Bay\u0131r","year":"2023","unstructured":"Bay\u0131r H, Dixon SJ, Tyurina YY, Kellum JA, Kagan VE (2023) Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney. Nat Rev Nephrol 19(5):315\u2013336","journal-title":"Nat Rev Nephrol"},{"key":"2629_CR92","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.freeradbiomed.2022.05.024","volume":"187","author":"Q Li","year":"2022","unstructured":"Li Q, Liao J, Chen W, Zhang K, Li H, Ma F et al (2022) NAC alleviative ferroptosis in diabetic nephropathy via maintaining mitochondrial redox homeostasis through activating SIRT3-SOD2\/Gpx4 pathway. Free Radic Biol Med 187:158\u2013170. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.05.024","journal-title":"Free Radic Biol Med"},{"key":"2629_CR93","first-page":"413","volume":"57","author":"Y Wang","year":"2023","unstructured":"Wang Y, He X, Xue M, Sun W, He Q, Jin J (2023) Germacrone protects renal tubular cells against ferroptotic death and ROS release by re-activating mitophagy in diabetic nephropathy. Free Radic Res 57:413\u2013429","journal-title":"Free Radic Res"},{"issue":"19","key":"2629_CR94","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1016\/j.devcel.2024.09.004","volume":"59","author":"J Khatun","year":"2024","unstructured":"Khatun J, Gelles JD, Chipuk JE (2024) Dynamic death decisions: how mitochondrial dynamics shape cellular commitment to apoptosis and ferroptosis. Dev Cell 59(19):2549\u20132565","journal-title":"Dev Cell"},{"issue":"1","key":"2629_CR95","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.molmed.2024.08.007","volume":"31","author":"Y Li","year":"2025","unstructured":"Li Y, Li Z, Ran Q, Wang P (2025) Sterols in ferroptosis: from molecular mechanisms to therapeutic strategies. Trends Mol Med 31(1):36\u201349","journal-title":"Trends Mol Med"},{"issue":"2","key":"2629_CR96","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","volume":"31","author":"D Tang","year":"2021","unstructured":"Tang D, Chen X, Kang R, Kroemer G (2021) Ferroptosis: molecular mechanisms and health implications. Cell Res 31(2):107\u2013125","journal-title":"Cell Res"},{"issue":"12","key":"2629_CR97","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24096","volume":"35","author":"Y Yang","year":"2021","unstructured":"Yang Y, Pan Z, Guo F, Wang H, Long W, Wang H et al (2021) Placental metabolic profiling in gestational diabetes mellitus: an important role of fatty acids. J Clin Lab Anal 35(12):e24096. https:\/\/doi.org\/10.1002\/jcla.24096","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"2629_CR98","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s13668-025-00636-1","volume":"14","author":"P van der Pligt","year":"2025","unstructured":"van der Pligt P, Wadley GD, Lee IL, Ebrahimi S, Spiteri S, Dennis K et al (2025) Antioxidant supplementation for management of gestational diabetes mellitus in pregnancy: a systematic review and meta-analysis of randomised controlled trials. Curr Nutr Rep 14(1):45","journal-title":"Curr Nutr Rep"},{"issue":"6","key":"2629_CR99","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1016\/j.ajcnut.2023.09.025","volume":"118","author":"K Demircan","year":"2023","unstructured":"Demircan K, Jensen RC, Chillon TS, Jensen TK, Sun Q, Bonnema SJ et al (2023) Serum selenium, selenoprotein P, and glutathione peroxidase 3 during early and late pregnancy in association with gestational diabetes mellitus: prospective Odense child cohort. Am J Clin Nutr 118(6):1224\u20131234. https:\/\/doi.org\/10.1016\/j.ajcnut.2023.09.025","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"2629_CR100","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.tem.2024.03.004","volume":"35","author":"K Demircan","year":"2024","unstructured":"Demircan K, Chillon TS, Bang J, Gladyshev VN, Schomburg L (2024) Selenium, diabetes, and their intricate sex-specific relationship. Trends Endocrinol Metab 35(9):781\u2013792","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"2629_CR101","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","volume":"8","author":"S Sun","year":"2023","unstructured":"Sun S, Shen J, Jiang J, Wang F, Min J (2023) Targeting ferroptosis opens new avenues for the development of novel therapeutics. Signal Transduct Target Ther 8(1):372","journal-title":"Signal Transduct Target Ther"},{"issue":"16","key":"2629_CR102","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.3390\/nu15163624","volume":"15","author":"K Jaworsky","year":"2023","unstructured":"Jaworsky K, DeVillez P, Alexander JM, Basu A (2023) Effects of an eating pattern including colorful fruits and vegetables on management of gestational diabetes: a randomized controlled trial. Nutrients 15(16):3624","journal-title":"Nutrients"},{"key":"2629_CR103","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.freeradbiomed.2022.12.003","volume":"194","author":"SA Mason","year":"2023","unstructured":"Mason SA, Parker L, van der Pligt P, Wadley GD (2023) Vitamin C supplementation for diabetes management: a comprehensive narrative review. Free Radic Biol Med 194:255\u2013283. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.12.003","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"2629_CR104","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.3390\/nu13041267","volume":"13","author":"CL Shen","year":"2021","unstructured":"Shen CL, Ramamoorthy S, Kaur G, Dufour JM, Wang R, Mo H et al (2021) Dietary annatto-extracted tocotrienol reduces inflammation and oxidative stress, and improves macronutrient metabolism in obese mice: a metabolic profiling study. Nutrients 13(4):1267","journal-title":"Nutrients"},{"issue":"6","key":"2629_CR105","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062862","volume":"22","author":"F Cimmino","year":"2021","unstructured":"Cimmino F, Catapano A, Trinchese G, Cavaliere G, Culurciello R, Fogliano C et al (2021) Dietary micronutrient management to treat mitochondrial dysfunction in diet-induced obese mice. Int J Mol Sci 22(6):2862. https:\/\/doi.org\/10.3390\/ijms22062862","journal-title":"Int J Mol Sci"},{"issue":"20","key":"2629_CR106","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.3390\/nu15204421","volume":"15","author":"JS Lai","year":"2023","unstructured":"Lai JS, Godfrey KM, Ong CN, Tan KH, Yap F, Chong YS et al (2023) Perinatal plasma carotenoids and vitamin E concentrations with glycemia and insulin resistance in women during and after pregnancy. Nutrients 15(20):4421","journal-title":"Nutrients"},{"issue":"17","key":"2629_CR107","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179688","volume":"25","author":"A Perna","year":"2024","unstructured":"Perna A, Venditti N, Merolla F, Fusco S, Guerra G, Zoroddu S et al (2024) Nutraceuticals in pregnancy: a special focus on probiotics. Int J Mol Sci 25(17):9688. https:\/\/doi.org\/10.3390\/ijms25179688","journal-title":"Int J Mol Sci"},{"issue":"11","key":"2629_CR108","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1080\/14712598.2024.2409880","volume":"24","author":"DE de Albuquerque Lemos","year":"2024","unstructured":"de Albuquerque Lemos DE, de Brito Alves JL, de Souza EL (2024) Probiotic therapy as a promising strategy for gestational diabetes mellitus management. Expert Opin Biol Ther 24(11):1207\u20131219. https:\/\/doi.org\/10.1080\/14712598.2024.2409880","journal-title":"Expert Opin Biol Ther"},{"key":"2629_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113656","volume":"155","author":"H Wang","year":"2022","unstructured":"Wang H, Chen X, Miao X, Lu K, He M, Wu X (2022) Dendrobium mixture improves gestational diabetes mellitus through regulating Nrf2\/HO1 signaling pathway. Biomed Pharmacother 155:113656. https:\/\/doi.org\/10.1016\/j.biopha.2022.113656","journal-title":"Biomed Pharmacother"},{"issue":"7","key":"2629_CR110","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s12272-020-01242-1","volume":"43","author":"N Wang","year":"2020","unstructured":"Wang N, Dong X, Shi D, Li N, Zhang Q (2020) Cryptotanshinone ameliorates placental oxidative stress and inflammation in mice with gestational diabetes mellitus. Arch Pharm Res 43(7):755\u2013764","journal-title":"Arch Pharm Res"},{"issue":"2","key":"2629_CR111","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020341","volume":"12","author":"I Ramli","year":"2023","unstructured":"Ramli I, Posadino AM, Giordo R, Fenu G, Fardoun M, Iratni R et al (2023) Effect of resveratrol on pregnancy, prenatal complications and pregnancy-associated structure alterations. Antioxidants 12(2):341","journal-title":"Antioxidants"},{"issue":"1","key":"2629_CR112","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1080\/10717544.2020.1775722","volume":"27","author":"S Du","year":"2020","unstructured":"Du S, Lv Y, Li N, Huang X, Liu X, Li H et al (2020) Biological investigations on therapeutic effect of chitosan encapsulated nano resveratrol against gestational diabetes mellitus rats induced by streptozotocin. Drug Deliv 27(1):953\u2013963. https:\/\/doi.org\/10.1080\/10717544.2020.1775722","journal-title":"Drug Deliv"},{"key":"2629_CR113","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2024.101850","volume":"75","author":"K Xiao Liang","year":"2024","unstructured":"Xiao Liang K (2024) Interplay of mitochondria and diabetes: unveiling novel therapeutic strategies. Mitochondrion 75:101850","journal-title":"Mitochondrion"},{"issue":"6","key":"2629_CR114","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1113\/JP286178","volume":"602","author":"Z Wang","year":"2024","unstructured":"Wang Z, Camm EJ, Nuzzo AM, Spiroski AM, Skeffington KL, Ashmore TJ et al (2024) In vivo mitochondria-targeted protection against uterine artery vascular dysfunction and remodelling in rodent hypoxic pregnancy. J Physiol 602(6):1211\u20131225. https:\/\/doi.org\/10.1113\/JP286178","journal-title":"J Physiol"},{"issue":"5","key":"2629_CR115","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11050812","volume":"11","author":"C Di Fabrizio","year":"2022","unstructured":"Di Fabrizio C, Giorgione V, Khalil A, Murdoch CE (2022) Antioxidants in pregnancy: do we really need more trials? Antioxidants 11(5):812","journal-title":"Antioxidants"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-025-02629-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00109-025-02629-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-025-02629-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T15:05:13Z","timestamp":1766070313000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00109-025-02629-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":115,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2629"],"URL":"https:\/\/doi.org\/10.1007\/s00109-025-02629-7","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"4 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}