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This study has been granted an exemption from requiring written informed consent by the Medical Ethics Committee of Zhujiang Hospital, Southern Medical University. This study complied with the guidelines for human studies and was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. The animal experiment protocol was approved by the Institutional Animal Care and Use Committee of Zhujiang Hospital, Southern Medical University (Document No. LAEC-2020\u2013001) and performed according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"14"}}