{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:30:00Z","timestamp":1770121800110,"version":"3.49.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100013885","name":"Kementerian Kesihatan Malaysia","doi-asserted-by":"publisher","award":["NMRR ID: 17-1929-36614"],"award-info":[{"award-number":["NMRR ID: 17-1929-36614"]}],"id":[{"id":"10.13039\/501100013885","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003782","name":"Institute of Postgraduate Studies, Universiti Sains Malaysia","doi-asserted-by":"publisher","award":["GIPS-PhD 311\/PPSP\/4404814"],"award-info":[{"award-number":["GIPS-PhD 311\/PPSP\/4404814"]}],"id":[{"id":"10.13039\/501100003782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00109-026-02639-z","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:46:59Z","timestamp":1769064419000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of cryptic KMT2A-PTD and other novel fusion genes by transcriptome sequencing alters molecular risk stratification in AML-NK"],"prefix":"10.1007","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-0320","authenticated-orcid":false,"given":"Angeli","family":"Ambayya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rozaimi","family":"Razali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarina","family":"Sulong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee Yee","family":"Yap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena","family":"Selvaratnam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jameela","family":"Sathar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0493-1390","authenticated-orcid":false,"given":"Rosline","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"2639_CR1","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1056\/NEJMra1406184","volume":"373","author":"H D\u00f6hner","year":"2015","unstructured":"D\u00f6hner H, Weisdorf DJ, Bloomfield CD (2015) Acute myeloid leukemia. N Engl J Med 373:1136\u20131152","journal-title":"N Engl J Med"},{"key":"2639_CR2","first-page":"75","volume":"66","author":"S Roychowdhury","year":"2016","unstructured":"Roychowdhury S, Chinnaiyan AM (2016) Translating cancer genomes and transcriptomes for precision oncology. CA Cancer J Clin 66:75\u201388","journal-title":"CA Cancer J Clin"},{"key":"2639_CR3","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1182\/blood-2018-99-115785","volume":"132","author":"MG Shin","year":"2018","unstructured":"Shin MG et al (2018) RNA sequencing based whole transcriptome analysis detected precisely all fusion transcripts in leukemias. Blood 132:1496\u20131496","journal-title":"Blood"},{"key":"2639_CR4","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.1182\/bloodadvances.2020003007","volume":"4","author":"A Stengel","year":"2020","unstructured":"Stengel A et al (2020) Whole transcriptome sequencing detects a large number of novel fusion transcripts in patients with AML and MDS. Blood Adv 4:5393\u20135401","journal-title":"Blood Adv"},{"key":"2639_CR5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1097\/01.moh.0000149608.29685.d1","volume":"12","author":"G Marcucci","year":"2005","unstructured":"Marcucci G, Mr\u00f3zek K, Bloomfield CD (2005) Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics. Curr Opin Hematol 12:68\u201375","journal-title":"Curr Opin Hematol"},{"key":"2639_CR6","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1056\/NEJMoa074306","volume":"358","author":"RF Schlenk","year":"2008","unstructured":"Schlenk RF et al (2008) Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 358:1909\u20131918","journal-title":"N Engl J Med"},{"key":"2639_CR7","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/nature07485","volume":"456","author":"TJ Ley","year":"2008","unstructured":"Ley TJ et al (2008) DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 456:66\u201372","journal-title":"Nature"},{"key":"2639_CR8","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","volume":"562","author":"JW Tyner","year":"2018","unstructured":"Tyner JW et al (2018) Functional genomic landscape of acute myeloid leukaemia. Nature 562:526\u2013531","journal-title":"Nature"},{"key":"2639_CR9","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.cell.2019.09.019","volume":"179","author":"D Wu","year":"2019","unstructured":"Wu D et al (2019) Large-scale whole-genome sequencing of three diverse Asian populations in Singapore. Cell 179:736-749.e15","journal-title":"Cell"},{"key":"2639_CR10","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1007\/s00277-019-03838-0","volume":"98","author":"K Chonabayashi","year":"2019","unstructured":"Chonabayashi K et al (2019) Acute myeloid leukemia with a cryptic NUP98\/PRRX2 rearrangement developing after low-dose methotrexate therapy for rheumatoid arthritis. Ann Hematol 98:2841\u20132843","journal-title":"Ann Hematol"},{"key":"2639_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008463","volume":"15","author":"A Darracq","year":"2019","unstructured":"Darracq A et al (2019) NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes. PLoS Genet 15:e1008463","journal-title":"PLoS Genet"},{"key":"2639_CR12","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/trf.14329","volume":"58","author":"MH Choi","year":"2018","unstructured":"Choi MH et al (2018) The effect of therapeutic leukapheresis on early complications and outcomes in patients with acute leukemia and hyperleukocytosis: a propensity score-matched study. Transfusion (Paris) 58:208\u2013216","journal-title":"Transfusion (Paris)"},{"key":"2639_CR13","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1002\/gcc.22064","volume":"52","author":"N Shiba","year":"2013","unstructured":"Shiba N et al (2013) NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia. Genes Chromosomes Cancer 52:683\u2013693","journal-title":"Genes Chromosomes Cancer"},{"key":"2639_CR14","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3892\/mmr.2012.1183","volume":"7","author":"J-B Zhou","year":"2013","unstructured":"Zhou J-B, Zhang T, Wang B-F, Gao H-Z, Xu X (2013) Identification of a novel gene fusion RNF213-SLC26A11 in chronic myeloid leukemia by RNA-Seq. Mol Med Rep 7:591\u2013597","journal-title":"Mol Med Rep"},{"key":"2639_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003464","volume":"9","author":"CP Giacomini","year":"2013","unstructured":"Giacomini CP et al (2013) Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PLoS Genet 9:e1003464","journal-title":"PLoS Genet"},{"key":"2639_CR16","first-page":"1","volume":"2019","author":"J Wang","year":"2019","unstructured":"Wang J et al (2019) Interfering expression of chimeric transcript SEPT7P2-PSPH promotes cell proliferation in patients with nasopharyngeal carcinoma. J Oncol 2019:1\u201310","journal-title":"J Oncol"},{"key":"2639_CR17","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.1158\/0008-5472.CAN-08-4926","volume":"69","author":"DS Rickman","year":"2009","unstructured":"Rickman DS et al (2009) SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer. Cancer Res 69:2734\u20132738","journal-title":"Cancer Res"},{"key":"2639_CR18","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1182\/blood-2016-08-733196","volume":"129","author":"H D\u00f6hner","year":"2017","unstructured":"D\u00f6hner H et al (2017) Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood 129:424\u2013447","journal-title":"Blood"},{"key":"2639_CR19","doi-asserted-by":"publisher","first-page":"e131","DOI":"10.3324\/haematol.2017.185249","volume":"103","author":"SM Choi","year":"2018","unstructured":"Choi SM, Dewar R, Burke PW, Shao L (2018) Partial tandem duplication of KMT2A (MLL) may predict a subset of myelodysplastic syndrome with unique characteristics and poor outcome. Haematologica 103:e131\u2013e134","journal-title":"Haematologica"},{"key":"2639_CR20","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1080\/10428194.2017.1352091","volume":"59","author":"J Kong","year":"2018","unstructured":"Kong J et al (2018) The initial level of MLL-partial tandem duplication affects the clinical outcomes in patients with acute myeloid leukemia. Leuk Lymphoma 59:967\u2013972","journal-title":"Leuk Lymphoma"},{"key":"2639_CR21","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-062376","volume":"13","author":"W Ye","year":"2023","unstructured":"Ye W et al (2023) Prognostic significance of KMT2A-PTD in patients with acute myeloid leukaemia: a systematic review and meta-analysis. BMJ Open 13:e062376","journal-title":"BMJ Open"},{"key":"2639_CR22","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/j.1365-2141.2006.06301.x","volume":"135","author":"J Basecke","year":"2006","unstructured":"Basecke J, Whelan JT, Griesinger F, Bertrand FE (2006) The MLL partial tandem duplication in acute myeloid leukaemia. Br J Haematol 135:438\u2013449","journal-title":"Br J Haematol"},{"key":"2639_CR23","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/pbc.21318","volume":"50","author":"A Shimada","year":"2008","unstructured":"Shimada A et al (2008) Tandem duplications of MLL and FLT3 are correlated with poor prognoses in pediatric acute myeloid leukemia: a study of the Japanese AML Cooperative Study Group. Pediatr Blood Cancer 50:264\u2013269","journal-title":"Pediatr Blood Cancer"},{"key":"2639_CR24","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","volume":"374","author":"E Papaemmanuil","year":"2016","unstructured":"Papaemmanuil E et al (2016) Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med 374:2209\u20132221","journal-title":"N Engl J Med"},{"key":"2639_CR25","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0268-960X(03)00040-7","volume":"18","author":"K Mr\u00f3zek","year":"2004","unstructured":"Mr\u00f3zek K, Heerema NA, Bloomfield CD (2004) Cytogenetics in acute leukemia. Blood Rev 18:115\u2013136","journal-title":"Blood Rev"},{"key":"2639_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051203","volume":"7","author":"H Wen","year":"2012","unstructured":"Wen H et al (2012) New fusion transcripts identified in normal karyotype acute myeloid leukemia. PLoS One 7:e51203","journal-title":"PLoS One"},{"key":"2639_CR27","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11352.2","volume":"6","author":"F Ruffl\u00e9","year":"2017","unstructured":"Ruffl\u00e9 F et al (2017) New chimeric rnas in acute myeloid leukemia. F1000Res 6:1302","journal-title":"F1000Res"},{"key":"2639_CR28","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.gde.2017.10.002","volume":"48","author":"Z Li","year":"2018","unstructured":"Li Z, Qin F, Li H (2018) Chimeric rnas and their implications in cancer. Curr Opin Genet Dev 48:36\u201343","journal-title":"Curr Opin Genet Dev"},{"key":"2639_CR29","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11460-011-0148-9","volume":"6","author":"C Ye","year":"2011","unstructured":"Ye C, Liu L, Wang X, Zhang X (2011) Observations on potential novel transcripts from RNA-seq data. Front Electr Electron Eng China 6:275\u2013282","journal-title":"Front Electr Electron Eng China"},{"key":"2639_CR30","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.bbcan.2017.12.003","volume":"1869","author":"X Dai","year":"2018","unstructured":"Dai X, Theobard R, Cheng H, Xing M, Zhang J (2018) Fusion genes: a promising tool combating against cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1869:149\u2013160","journal-title":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"},{"key":"2639_CR31","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1002\/gcc.22745","volume":"58","author":"B Johansson","year":"2019","unstructured":"Johansson B et al (2019) Most gene fusions in cancer are stochastic events. Genes Chromosomes Cancer 58:607\u2013611","journal-title":"Genes Chromosomes Cancer"},{"key":"2639_CR32","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.18632\/oncotarget.12343","volume":"8","author":"Q Liao","year":"2017","unstructured":"Liao Q, Wang B, Li X, Jiang G (2017) Mirnas in acute myeloid leukemia. Oncotarget 8:3666\u20133682","journal-title":"Oncotarget"},{"key":"2639_CR33","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1126\/science.1231776","volume":"338","author":"JT Lee","year":"2012","unstructured":"Lee JT (2012) Epigenetic regulation by long noncoding RNAs. Science 338:1435\u20131439","journal-title":"Science"},{"key":"2639_CR34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrg2521","volume":"10","author":"TR Mercer","year":"2009","unstructured":"Mercer TR, Dinger ME, Mattick JS (2009) Long non-coding RNAs: insights into functions. Nat Rev Genet 10:155\u2013159","journal-title":"Nat Rev Genet"},{"key":"2639_CR35","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40164-016-0059-9","volume":"5","author":"S Wei","year":"2015","unstructured":"Wei S, Wang K (2015) Long noncoding RNAs: pivotal regulators in acute myeloid leukemia. Exp Hematol Oncol 5:30","journal-title":"Exp Hematol Oncol"},{"key":"2639_CR36","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1038\/cdd.2017.99","volume":"24","author":"N Furth","year":"2017","unstructured":"Furth N, Aylon Y (2017) The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway. Cell Death Differ 24:1488\u20131501","journal-title":"Cell Death Differ"},{"key":"2639_CR37","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0961-0","volume":"31","author":"M Gholami","year":"2014","unstructured":"Gholami M et al (2014) The expression analysis of LATS2 gene in de novo AML patients. Med Oncol 31:961","journal-title":"Med Oncol"},{"key":"2639_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01458-3","volume":"3","author":"B Gajendran","year":"2020","unstructured":"Gajendran B et al (2020) A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3. Commun Biol 3:732","journal-title":"Commun Biol"},{"key":"2639_CR39","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1002\/cbf.3830","volume":"41","author":"S Kumari","year":"2023","unstructured":"Kumari S, Rehman A, Chandra P, Singh KK (2023) Functional role of SAP18 protein: from transcriptional repression to splicing regulation. Cell Biochem Funct 41:738\u2013751","journal-title":"Cell Biochem Funct"},{"key":"2639_CR40","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.jtho.2020.02.023","volume":"15","author":"W Li","year":"2020","unstructured":"Li W, Liu Y, Li W, Chen L, Ying J (2020) Intergenic breakpoints identified by DNA sequencing confound targetable kinase fusion detection in NSCLC. J Thorac Oncol 15:1223\u20131231","journal-title":"J Thorac Oncol"},{"key":"2639_CR41","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1159\/000495956","volume":"51","author":"L-H Wang","year":"2018","unstructured":"Wang L-H, Wu C-F, Rajasekaran N, Shin YK (2018) Loss of tumor suppressor gene function in human cancer: an overview. Cell Physiol Biochem 51:2647\u20132693","journal-title":"Cell Physiol Biochem"},{"key":"2639_CR42","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0092-8674(00)80216-0","volume":"89","author":"Y Zhang","year":"1997","unstructured":"Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (1997) Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89:357\u2013364","journal-title":"Cell"},{"key":"2639_CR43","doi-asserted-by":"publisher","first-page":"136","DOI":"10.7150\/jca.1.136","volume":"1","author":"W Sun","year":"2010","unstructured":"Sun W, Y J (2010) Functional mechanisms for human tumor suppressors. J Cancer 1:136\u2013140","journal-title":"J Cancer"},{"key":"2639_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.770428","volume":"11","author":"Y Feng","year":"2021","unstructured":"Feng Y et al (2021) Homeobox genes in cancers: from carcinogenesis to recent therapeutic intervention. Front Oncol 11:770428","journal-title":"Front Oncol"},{"issue":"1","key":"2639_CR45","first-page":"19","volume":"12","author":"SF Ngiow","year":"2016","unstructured":"Ngiow SF, Abdullah M, Lim J, Cheong S-K, Seow H-F (2016) Subtractive hybridization identifies stem cell-associated genes in an acute myeloid leukemia with poor prognosis. Malays J Med Health Sci 12(1):19\u201331","journal-title":"Malays J Med Health Sci"},{"key":"2639_CR46","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1093\/neuonc\/noac231","volume":"25","author":"R Yang","year":"2023","unstructured":"Yang R et al (2023) Homeobox A3 and KDM6A cooperate in transcriptional control of aerobic glycolysis and glioblastoma progression. Neuro Oncol 25:635\u2013647","journal-title":"Neuro Oncol"},{"key":"2639_CR47","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1158\/0008-5472.CAN-09-2189","volume":"70","author":"BM Costa","year":"2010","unstructured":"Costa BM et al (2010) Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. Cancer Res 70:453\u2013462","journal-title":"Cancer Res"},{"key":"2639_CR48","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/cbf.3293","volume":"35","author":"S Chen","year":"2017","unstructured":"Chen S, Yu J, Lv X, Zhang L (2017) HOXA9 is critical in the proliferation, differentiation, and malignancy of leukaemia cells both in vitro and in vivo. Cell Biochem Funct 35:433\u2013440","journal-title":"Cell Biochem Funct"},{"key":"2639_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/genes10080621","author":"S-L Chen","year":"2019","unstructured":"Chen S-L et al (2019) The role of the HOXA gene family in acute myeloid leukemia. Genes (Basel). https:\/\/doi.org\/10.3390\/genes10080621","journal-title":"Genes (Basel)"},{"key":"2639_CR50","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1182\/blood.V94.2.519.414k20_519_528","volume":"94","author":"GM Crooks","year":"1999","unstructured":"Crooks GM et al (1999) Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors. Blood 94:519\u2013528","journal-title":"Blood"},{"key":"2639_CR51","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.cell.2011.03.014","volume":"145","author":"T Nagano","year":"2011","unstructured":"Nagano T, Fraser P (2011) No-nonsense functions for long noncoding RNAs. Cell 145:178\u2013181","journal-title":"Cell"},{"key":"2639_CR52","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1101\/gad.1800909","volume":"23","author":"JE Wilusz","year":"2009","unstructured":"Wilusz JE, Sunwoo H, Spector DL (2009) Long noncoding RNAs: functional surprises from the RNA world. Genes Dev 23:1494\u20131504","journal-title":"Genes Dev"},{"key":"2639_CR53","doi-asserted-by":"publisher","unstructured":"Chen X, Yan CC, Zhang X, You Z-H (2016) Long non-coding RNAs and complex diseases: from experimental results to computational models. Brief Bioinform bbw060.\u00a0https:\/\/doi.org\/10.1093\/bib\/bbw060","DOI":"10.1093\/bib\/bbw060"},{"key":"2639_CR54","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1093\/bfgp\/ely031","volume":"18","author":"X Chen","year":"2019","unstructured":"Chen X et al (2019) Computational models for lncRNA function prediction and functional similarity calculation. Brief Funct Genomics 18:58\u201382","journal-title":"Brief Funct Genomics"},{"key":"2639_CR55","doi-asserted-by":"publisher","first-page":"6161","DOI":"10.1002\/jcp.27393","volume":"234","author":"C Zhao","year":"2019","unstructured":"Zhao C et al (2019) Long noncoding RNA NEAT1 modulates cell proliferation and apoptosis by regulating miR-23a-3p\/SMC1A in acute myeloid leukemia. J Cell Physiol 234:6161\u20136172","journal-title":"J Cell Physiol"},{"key":"2639_CR56","doi-asserted-by":"publisher","first-page":"18679","DOI":"10.1073\/pnas.1422050112","volume":"111","author":"R Garzon","year":"2014","unstructured":"Garzon R et al (2014) Expression and prognostic impact of lncRNAs in acute myeloid leukemia. Proc Natl Acad Sci U S A 111:18679\u201318684","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2639_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-016-0059-9","volume":"5","author":"S Wei","year":"2015","unstructured":"Wei S, Wang K (2015) Long noncoding RNAs: pivotal regulators in acute myeloid leukemia. Exp Hematol Oncol 5:30","journal-title":"Exp Hematol Oncol"},{"key":"2639_CR58","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1182\/blood-2018-99-111115","volume":"132","author":"M Griffioen","year":"2018","unstructured":"Griffioen M et al (2018) Whole transcriptome RNA sequencing as a comprehensive diagnostic tool for acute myeloid leukemia. Blood 132:2762\u20132762","journal-title":"Blood"},{"key":"2639_CR59","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41375-020-0762-8","volume":"35","author":"W Arindrarto","year":"2021","unstructured":"Arindrarto W et al (2021) Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing. Leukemia 35:47\u201361","journal-title":"Leukemia"},{"key":"2639_CR60","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1842-9","volume":"20","author":"BJ Haas","year":"2019","unstructured":"Haas BJ et al (2019) Accuracy assessment of fusion transcript detection via read-mapping and de novo fusion transcript assembly-based methods. Genome Biol 20:213","journal-title":"Genome Biol"},{"key":"2639_CR61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008463","volume":"15","author":"A Darracq","year":"2019","unstructured":"Darracq A et al (2019) NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes. PLoS Genet 15:e1008463","journal-title":"PLoS Genet"},{"key":"2639_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102766","volume":"12","author":"S Mohanty","year":"2020","unstructured":"Mohanty S et al (2020) Targeted inhibition of the NUP98-NSD1 fusion oncogene in acute myeloid leukemia. Cancers (Basel) 12:2766","journal-title":"Cancers (Basel)"},{"key":"2639_CR63","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/gcc.10219","volume":"37","author":"C Steudel","year":"2003","unstructured":"Steudel C et al (2003) Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia. Genes Chromosomes Cancer 37:237\u2013251","journal-title":"Genes Chromosomes Cancer"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-026-02639-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00109-026-02639-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-026-02639-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T01:02:59Z","timestamp":1770080579000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00109-026-02639-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2639"],"URL":"https:\/\/doi.org\/10.1007\/s00109-026-02639-z","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"12 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Incorrect author affiliation for Sarina Sulong.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and was approved by the Medical Research Ethics Committee of the Ministry of Health of Malaysia (NMRR 17-1929-36614) and Universiti Sains Malaysia (USM\/JEPeM\/21010107).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all subjects in this study, as approved by the Ministry of Health, Malaysia (NMRR 17-1929-36614).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}