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Disrupted PSAP trafficking may lead to amyloid protein aggregation with implications for neurodegenerative diseases. In Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD), PSAP shows altered expression patterns and pathological co-localization with amyloid aggregates.\n                    <jats:italic>PSAP<\/jats:italic>\n                    variants are linked to multiple neurodegenerative diseases, including synucleinopathies, Gaucher\u2019s disease, and metachromatic leukodystrophy. Its levels are elevated in blood and cerebrospinal fluid in some individuals with AD or PD and are upregulated by stress conditions such as nerve injury and cold adaptation, but not by exercise. Prosaptides, short peptides derived from PSAP, show protective effects in models of oxidative stress, CNS injury, and metabolic disorders. Pharmacological stabilization of PSAP interactions with progranulin has shown promise in neurodegenerative disease models. These findings suggest PSAP plays an important role in maintaining brain health and may hold therapeutic potential. Here, we provide a comprehensive overview of PSAP\u2019s role in CNS health and disease, metabolic stress, and exercise adaptation.\n                  <\/jats:p>","DOI":"10.1007\/s00109-026-02643-3","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T04:21:17Z","timestamp":1770006077000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prosaposin in CNS health and disease, metabolic stress and exercise adaptation"],"prefix":"10.1007","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3056-8878","authenticated-orcid":false,"given":"Hash Brown","family":"Taha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"2643_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01087-1","volume":"14","author":"Z Zhang","year":"2021","unstructured":"Zhang Z et al (2021) Role of lysosomes in physiological activities, diseases, and therapy. 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