{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T06:29:34Z","timestamp":1794378574276,"version":"4.9.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00109-026-02647-z","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T08:26:13Z","timestamp":1771835173000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Piezo1\/PI3K-induced autophagy dysregulation in PDLSCs under mechanical stress during root resorption"],"prefix":"10.1007","volume":"104","author":[{"given":"Kuan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-0306","authenticated-orcid":false,"given":"Yujiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"2647_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108803","volume":"114","author":"C Wang","year":"2019","unstructured":"Wang C, Wang Y, Liu N et al (2019) Effect of tumor necrosis factor \u03b1 on ability of SHED to promote osteoclastogenesis during physiological root resorption. Biomed Pharmacother 114:108803","journal-title":"Biomed Pharmacother"},{"key":"2647_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.850826","volume":"10","author":"M Xiao","year":"2022","unstructured":"Xiao M, Qian H, Lv J et al (2022) Advances in the study of the mechanisms of physiological root resorption in deciduous teeth. Front Pediatr 10:850826","journal-title":"Front Pediatr"},{"key":"2647_CR3","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5326341","volume":"2019","author":"Y Chen","year":"2019","unstructured":"Chen Y, Yang K, Zhou Z et al (2019) Mechanical stress modulates the RANKL\/OPG system of periodontal ligament stem cells via \u03b17 nAChR in human deciduous teeth: an in vitro study. Stem Cells Int 2019:5326341","journal-title":"Stem Cells Int"},{"issue":"9","key":"2647_CR4","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s00109-024-02466-0","volume":"102","author":"T Di","year":"2024","unstructured":"Di T, Chen Y, Zhou Z et al (2024) Effect of \u03b17 nAChR-autophagy axis of deciduous tooth pulp stem cells in regulating IL-1\u03b2 in the process of physiological root resorption of deciduous teeth. J Mol Med (Berl) 102(9):1135\u20131149","journal-title":"J Mol Med (Berl)"},{"key":"2647_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ydbio.2024.02.008","volume":"510","author":"T Di","year":"2024","unstructured":"Di T, Guo M, Xu J et al (2024) Circadian clock genes REV-ERB\u03b1 regulates the secretion of IL-1\u03b2 in deciduous tooth pulp stem cells by regulating autophagy in the process of physiological root resorption of deciduous teeth. Dev Biol 510:8\u201316","journal-title":"Dev Biol"},{"issue":"2","key":"2647_CR6","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1152\/physrev.00057.2021","volume":"102","author":"S Earley","year":"2022","unstructured":"Earley S, Santana LF, Lederer WJ (2022) The physiological sensor channels TRP and piezo: Nobel Prize in Physiology or Medicine 2021. Physiol Rev 102(2):1153\u20131158","journal-title":"Physiol Rev"},{"issue":"11","key":"2647_CR7","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/s41580-024-00773-5","volume":"25","author":"B Xiao","year":"2024","unstructured":"Xiao B (2024) Mechanisms of mechanotransduction and physiological roles of PIEZO channels. Nat Rev Mol Cell Biol 25(11):886\u2013903","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2647_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02804-y","volume":"24","author":"S Shi","year":"2022","unstructured":"Shi S, Kang XJ, Zhou Z et al (2022) Excessive mechanical stress-induced intervertebral disc degeneration is related to Piezo1 overexpression triggering the imbalance of autophagy\/apoptosis in human nucleus pulpous. Arthritis Res Ther 24(1):119","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"2647_CR9","doi-asserted-by":"publisher","first-page":"4735","DOI":"10.1021\/acsbiomaterials.3c00419","volume":"9","author":"Y Wu","year":"2023","unstructured":"Wu Y, Xu X, Liu F et al (2023) Three-dimensional matrix stiffness activates the Piezo1-AMPK-autophagy axis to regulate the cellular osteogenic differentiation. ACS Biomater Sci Eng 9(8):4735\u20134746","journal-title":"ACS Biomater Sci Eng"},{"issue":"2","key":"2647_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14365","volume":"30","author":"ZQ Zhang","year":"2024","unstructured":"Zhang ZQ, Lu Y, Zhang H et al (2024) Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting PIEZO1\/calpain\/autophagy signaling pathway in the basal forebrain. CNS Neurosci Ther 30(2):e14365","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"2647_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23482-5","volume":"12","author":"H Atcha","year":"2021","unstructured":"Atcha H, Jairaman A, Holt JR et al (2021) Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun 12(1):3256","journal-title":"Nat Commun"},{"issue":"1","key":"2647_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51211-1","volume":"15","author":"S Baratchi","year":"2024","unstructured":"Baratchi S, Danish H, Chheang C et al (2024) Piezo1 expression in neutrophils regulates shear-induced NETosis. Nat Commun 15(1):7023","journal-title":"Nat Commun"},{"issue":"90","key":"2647_CR13","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adf4699","volume":"8","author":"L Ran","year":"2023","unstructured":"Ran L, Ye T, Erbs E et al (2023) KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation. Sci Immunol 8(90):eadf4699","journal-title":"Sci Immunol"},{"issue":"7772","key":"2647_CR14","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41586-019-1485-8","volume":"573","author":"AG Solis","year":"2019","unstructured":"Solis AG, Bielecki P, Steach HR et al (2019) Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature 573(7772):69\u201374","journal-title":"Nature"},{"issue":"1","key":"2647_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-05631-0","volume":"25","author":"M Xiao","year":"2025","unstructured":"Xiao M, Yue Q, Qin Z et al (2025) Unbalanced occlusal loading elicited remodeling responses in growing rat temporomandibular joints and Notch1\/Hes1 signaling pathway expression. BMC Oral Health 25(1):267","journal-title":"BMC Oral Health"},{"issue":"1","key":"2647_CR16","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ajodo.2019.06.021","volume":"158","author":"H Turkkahraman","year":"2020","unstructured":"Turkkahraman H, Yuan X, Salmon B et al (2020) Root resorption and ensuing cementum repair by Wnt\/\u03b2-catenin dependent mechanism. Am J Orthod Dentofacial Orthop 158(1):16\u201327","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"1","key":"2647_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-022-00398-4","volume":"23","author":"DH Alsawaf","year":"2022","unstructured":"Alsawaf DH, Almaasarani SG, Hajeer MY et al (2022) The effectiveness of the early orthodontic correction of functional unilateral posterior crossbite in the mixed dentition period: a systematic review and meta-analysis. Prog Orthod 23(1):5","journal-title":"Prog Orthod"},{"key":"2647_CR18","doi-asserted-by":"publisher","unstructured":"Dos Santos C C O, Da Rosa Moreira Bastos R T, Bellini-Pereira S A, et al. Spontaneous changes in mandibular incisor crowding from mixed to permanent dentition: a systematic review [J]. Prog Orthod, 2023, 24(1): 15. https:\/\/doi.org\/10.1186\/s40510-023-00466-3","DOI":"10.1186\/s40510-023-00466-3"},{"issue":"12","key":"2647_CR19","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1111\/joor.13376","volume":"49","author":"M Shiramizu","year":"2022","unstructured":"Shiramizu M, Hasegawa Y, Yoneda H et al (2022) Factors affecting masticatory performance during the mixed dentition period. J Oral Rehabil 49(12):1144\u20131154","journal-title":"J Oral Rehabil"},{"key":"2647_CR20","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.physbeh.2018.06.037","volume":"194","author":"N Almotairy","year":"2018","unstructured":"Almotairy N, Kumar A, Trulsson M et al (2018) Development of the jaw sensorimotor control and chewing - a systematic review. Physiol Behav 194:456\u2013465","journal-title":"Physiol Behav"},{"key":"2647_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2019.104540","volume":"108","author":"S Negishi","year":"2019","unstructured":"Negishi S, Richards LC, Kasai K (2019) Relation of dietary preference to masticatory movement and masticatory exercises in Japanese children. Arch Oral Biol 108:104540","journal-title":"Arch Oral Biol"},{"key":"2647_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7604144","volume":"2022","author":"A Heidari","year":"2022","unstructured":"Heidari A, Mokhtari S, Hamrah MH et al (2022) Investigating the factors affecting the need for unilateral space maintainer for first primary molars in late mixed dentition. BioMed Res Int 2022:7604144","journal-title":"BioMed Res Int"},{"key":"2647_CR23","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjad066","author":"R Ovsenik","year":"2024","unstructured":"Ovsenik R, Marolt Mu\u0161i\u010d M, Primo\u017ei\u010d J (2024) Changes in the swallowing pattern and tongue posture during the transition from deciduous to mixed dentition-a longitudinal ultrasonography study. Eur J Orthod. https:\/\/doi.org\/10.1093\/ejo\/cjad066","journal-title":"Eur J Orthod"},{"issue":"3","key":"2647_CR24","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.ajodo.2021.02.014","volume":"160","author":"AA Rajbhoj","year":"2021","unstructured":"Rajbhoj AA, Parchake P, Begnoni G et al (2021) Dental changes in humans with untreated normal occlusion throughout lifetime: a systematic scoping review [J]. Am J Orthod Dentofacial Orthop 160(3):340\u201362.e3","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"5","key":"2647_CR25","first-page":"51","volume":"47","author":"DA Al-Dulaimy","year":"2023","unstructured":"Al-Dulaimy DA, Al-Khannaq MRA, Nahidh M et al (2023) Assessment of dental arch forms in a sample of children [J]. J Clin Pediatr Dent 47(5):51\u201356","journal-title":"J Clin Pediatr Dent"},{"key":"2647_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/children10101708","author":"ME Cabrera-Dom\u00ednguez","year":"2023","unstructured":"Cabrera-Dom\u00ednguez ME, Dom\u00ednguez-Reyes A, Galan-Gonzalez AF (2023) Evolution of the terminal plane from deciduous to mixed dentition. Children. https:\/\/doi.org\/10.3390\/children10101708","journal-title":"Children"},{"issue":"3","key":"2647_CR27","first-page":"203","volume":"21","author":"MM Grippaudo","year":"2020","unstructured":"Grippaudo MM, Quinzi V, Manai A et al (2020) Orthodontic treatment need and timing: assessment of evolutive malocclusion conditions and associated risk factors [J]. Eur J Paediatr Dent 21(3):203\u2013208","journal-title":"Eur J Paediatr Dent"},{"issue":"1","key":"2647_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02011-y","volume":"9","author":"G Huang","year":"2024","unstructured":"Huang G, Yang X, Yu Q et al (2024) Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K\/AKT\/mTOR pathway. Signal Transduct Target Ther 9(1):306","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"2647_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03928-5","volume":"15","author":"C Liu","year":"2024","unstructured":"Liu C, Khairullina L, Qin Y et al (2024) Adipose stem cell exosomes promote mitochondrial autophagy through the PI3K\/AKT\/mTOR pathway to alleviate keloids. Stem Cell Res Ther 15(1):305","journal-title":"Stem Cell Res Ther"},{"issue":"803","key":"2647_CR30","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.ade3599","volume":"16","author":"CY Tsai","year":"2023","unstructured":"Tsai CY, Sakakibara S, Kuan YD et al (2023) Opposing roles of RUBCN isoforms in autophagy and memory B cell generation. Sci Signal 16(803):eade3599","journal-title":"Sci Signal"},{"issue":"1","key":"2647_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02735-7","volume":"22","author":"Y Xue","year":"2024","unstructured":"Xue Y, Cheng X, Ma ZQ et al (2024) Polystyrene nanoplastics induce apoptosis, autophagy, and steroidogenesis disruption in granulosa cells to reduce oocyte quality and fertility by inhibiting the PI3K\/AKT pathway in female mice. J Nanobiotechnology 22(1):460","journal-title":"J Nanobiotechnology"},{"issue":"1","key":"2647_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41739-z","volume":"14","author":"F Zhi","year":"2023","unstructured":"Zhi F, Li B, Zhang C et al (2023) NLRP6 potentiates PI3K\/AKT signalling by promoting autophagic degradation of p85\u03b1 to drive tumorigenesis. Nat Commun 14(1):6069","journal-title":"Nat Commun"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-026-02647-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00109-026-02647-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-026-02647-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:04:10Z","timestamp":1771877050000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00109-026-02647-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2647"],"URL":"https:\/\/doi.org\/10.1007\/s00109-026-02647-z","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"assertion":[{"value":"16 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal studies were approved by the Institutional Review Board (IRB) of the Fourth Military Medical University (IACUC-2024005). Human sample collection protocols were reviewed and approved by the Institutional Review Board (IRB) of the Third Affiliated Hospital of the Fourth Military Medical University (IRB-REV-2021004). Written informed consent was obtained from all donors, specifying the use of discarded tissues for research purposes only.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"47"}}