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Written informed consent was obtained from all participants in accordance with the principles outlined in the Declaration of Helsinki. Clinical trial number: not applicable. All animal experiments were approved by the Institutional Animal Care and Use Committee of Chang Gung University (IACUC approval nos. CGU110-185 and CGU113-097) and conducted in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"57"}}