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Der Beitrag beleuchtet neuroanatomische und -physiologische Grundelemente der Wirkungsweisen manualmedizinischer Diagnostik und Therapie. Anhand neuester Literatur und Betrachtung verschiedener wissenschaftlicher Leitlinien wird die evidenzbasierte Wirksamkeit manualmedizinischer Verfahren dargestellt, im Einzelnen: akute und chronische Lumbalgie, zervikogener Kopfschmerz, Schulter- und Nackenschmerzen, radikul\u00e4rer Armschmerz, dysfunktionelle thorakale Schmerzsyndrome, Erkrankungen der Rotatorenmanschette, Karpaltunnelsyndrom und Plantarfasziitis. Fallbeispiele veranschaulichen die klinische Vorgehensweise. Die Begrifflichkeit, die Provenienz und die klinische Pr\u00e4senz der \u201eOsteopathie\u201c werden ausf\u00fchrlich gew\u00fcrdigt, und die nationalen und internationalen Vereinigungen und Gesellschaften der manuellen Medizin (Deutsche Gesellschaft f\u00fcr Manuelle Medizin [DGMM], European Scientific Society of Manual Medicine [ESSOMM], F\u00e9d\u00e9ration Internationale de Medicine Manuelle [FIMM]) werden lexikalisch dargestellt. Abschlie\u00dfend finden sich Kontraindikationen und ein Ausblick auf die Erfordernisse und M\u00f6glichkeiten der wissenschaftlichen Schmerzanalyse, wie sie in der Pr\u00e4ambel der Leitlinie \u201eSpezifischer Kreuzschmerz\u201c der Deutschen Gesellschaft f\u00fcr Orthop\u00e4die und Orthop\u00e4dische Chirurgie (DGOOC) postuliert werden.<\/jats:p>","DOI":"10.1007\/s00113-021-01004-8","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T08:02:49Z","timestamp":1621411369000},"page":"433-445","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Manuelle Medizin, manuelle Therapie","Manual medicine, manual treatment"],"prefix":"10.1007","volume":"124","author":[{"given":"Hermann","family":"Locher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"1004_CR1","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/s0079-6123(00)29026-2","volume":"129","author":"L Arendt-Nielsen","year":"2000","unstructured":"Arendt-Nielsen\u00a0L, Laursen\u00a0RJ, Drewes\u00a0AM (2000) Referred pain as an indicator for neural plasticity. 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