{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:56:27Z","timestamp":1763564187187,"version":"3.37.3"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Unfallchirurg"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00113-021-01016-4","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T07:03:31Z","timestamp":1627887811000},"page":"247-254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Implementation of a\u00a0standardized clinical test kit for diagnostics of periprosthetic infections in the clinical routine","Implementierung eines standardisierten Test-Kits zur Diagnostik von periprothetischen Infektionen in der klinischen Routine"],"prefix":"10.1007","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-308X","authenticated-orcid":false,"given":"Y.","family":"Gramlich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Br\u00fcning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Breuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Klug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"1016_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s11999-009-0945-0","volume":"468","author":"KJ Bozic","year":"2010","unstructured":"Bozic\u00a0KJ, Kurtz\u00a0SM, Lau\u00a0E et\u00a0al (2010) The epidemiology of revision total knee arthroplasty in the United States. Clin Orthop Relat Res 468:45\u201351","journal-title":"Clin Orthop Relat Res"},{"key":"1016_CR2","doi-asserted-by":"publisher","first-page":"635","DOI":"10.2106\/JBJS.18.00632","volume":"101","author":"AV Carli","year":"2019","unstructured":"Carli\u00a0AV, Abdelbary\u00a0H, Ahmadzai\u00a0N et\u00a0al (2019) Diagnostic accuracy of serum, synovial, and tissue testing for chronic periprosthetic joint infection after hip and knee replacements: a systematic review. J\u00a0Bone Joint Surg Am 101:635\u2013649","journal-title":"J Bone Joint Surg Am"},{"volume-title":"Revisionsendoprothetik der H\u00fcftpfanne","year":"2008","key":"1016_CR3","unstructured":"Wirtz\u00a0DC, Rader\u00a0C, Reichel\u00a0H (eds) (2008) Revisionsendoprothetik der H\u00fcftpfanne. Heiko Reichel, Heidelberg"},{"key":"1016_CR4","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1055\/s-0042-109830","volume":"154","author":"B Fink","year":"2016","unstructured":"Fink\u00a0B, Lass\u00a0R (2016) Diagnostischer Algorithmus der schmerzhaften H\u00fcfttotalendoprothese. Z\u00a0Orthop Unfall 154:527\u2013544","journal-title":"Z Orthop Unfall"},{"key":"1016_CR5","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.arth.2013.09.024","volume":"29","author":"T Gehrke","year":"2014","unstructured":"Gehrke\u00a0T, Parvizi\u00a0J (2014) Proceedings of the international consensus meeting on periprosthetic joint infection. J\u00a0Arthroplasty 29:4","journal-title":"J Arthroplasty"},{"key":"1016_CR6","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s12178-018-9513-0","volume":"11","author":"K Goswami","year":"2018","unstructured":"Goswami\u00a0K, Parvizi\u00a0J, Maxwell Courtney\u00a0P (2018) Current recommendations for the diagnosis of acute and chronic PJI for hip and knee-cell counts, alpha-defensin, leukocyte esterase, next-generation sequencing. Curr Rev Musculoskelet Med 11:428\u2013438","journal-title":"Curr Rev Musculoskelet Med"},{"issue":"7","key":"1016_CR7","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1007\/s00264-018-4066-9","volume":"43","author":"Y Gramlich","year":"2019","unstructured":"Gramlich\u00a0Y, Walter\u00a0G, Klug\u00a0A, Harbering\u00a0J, Kemmerer\u00a0M, Hoffmann\u00a0R (2019) Procedure for single-stage implant retention for chronic periprosthetic infection using topical degradable calcium-based antibiotics. Int Orthop 43(7):1559\u20131566. https:\/\/doi.org\/10.1007\/s00264-018-4066-9","journal-title":"Int Orthop"},{"key":"1016_CR8","volume-title":"Klinischer Nutzen des Alpha-Defensin-ELISA im Vergleich mit etablierten Markern zur Detektion eines periprothetischen Infektes","author":"YBC Gramlich","year":"2019","unstructured":"Gramlich\u00a0YBC (2019) Klinischer Nutzen des Alpha-Defensin-ELISA im Vergleich mit etablierten Markern zur Detektion eines periprothetischen Infektes"},{"key":"1016_CR9","first-page":"019","volume":"18","author":"Y Gramlich","year":"2019","unstructured":"Gramlich\u00a0Y, Johnson\u00a0T, Kemmerer\u00a0M et al (2019) Salvage procedure for chronic periprosthetic knee infection: the application of DAIR results in better remission rates and infection-free survivorship when used with topical degradable calcium-based antibiotics. Knee Surg Sports Traumatol Arthrosc 18:19\u20135627","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"1016_CR10","first-page":"DocWI27-1114","volume-title":"Two-stage hip revision arthroplasty for periprosthetic joint infection without the use of spacer or cemented implants. Submitted Journal of Arthroplasty","author":"Y Gramlich","year":"2018","unstructured":"Gramlich\u00a0Y, Walter\u00a0G, Hagebusch\u00a0P et al (2018) Two-stage hip revision arthroplasty for periprosthetic joint infection without the use of spacer or cemented implants. Submitted Journal of Arthroplasty. German Medical Science GMS Publishing House;, D\u00fcsseldorf, p DocWI27-1114"},{"issue":"7","key":"1016_CR11","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1007\/s00264-018-4066-9","volume":"43","author":"Y Gramlich","year":"2019","unstructured":"Gramlich\u00a0Y, Walter\u00a0G, Klug\u00a0A, Harbering\u00a0J, Kemmerer\u00a0M, Hoffmann\u00a0R (2019) Procedure for single-stage implant retention for chronic periprosthetic infection using topical degradable calcium-based antibiotics. Int Orthop 43(7):1559\u20131566. https:\/\/doi.org\/10.1007\/s00264-018-4066-9","journal-title":"Int Orthop"},{"key":"1016_CR12","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1302\/0301-620X.100B6.BJJ-2017-1563.R1","volume":"100-b","author":"BA Marson","year":"2018","unstructured":"Marson\u00a0BA, Deshmukh\u00a0SR, Grindlay\u00a0DJC et al (2018) Alpha-defensin and the Synovasure lateral flow device for the diagnosis of prosthetic joint infection: a\u00a0systematic review and meta-analysis. Bone Joint\u00a0J 100-b:703\u2013711","journal-title":"Bone Joint J"},{"key":"1016_CR13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1302\/0301-620X.103B1.BJJ-2020-1381.R1","volume":"103-b","author":"M Mcnally","year":"2021","unstructured":"Mcnally\u00a0M, Sousa\u00a0R, Wouthuyzen-Bakker\u00a0M et al (2021) The EBJIS definition of periprosthetic joint infection. Bone Joint\u00a0J 103-b:18\u201325","journal-title":"Bone Joint J"},{"issue":"4","key":"1016_CR14","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s00132-020-03940-6","volume":"50","author":"H M\u00fchlhofer","year":"2021","unstructured":"M\u00fchlhofer\u00a0H, Renz\u00a0N, Zahar\u00a0A et\u00a0al (2021) Diagnostik der periprothetischen Infektion. Orthop\u00e4de 50(4):312\u2013325. https:\/\/doi.org\/10.1007\/s00132-020-03940-6","journal-title":"Orthop\u00e4de"},{"key":"1016_CR15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1749-799X-3-31","volume":"3","author":"M M\u00fcller","year":"2008","unstructured":"M\u00fcller\u00a0M, Morawietz\u00a0L, Hasart\u00a0O et al (2008) Diagnosis of periprosthetic infection following total hip arthroplasty\u2014evaluation of the diagnostic values of pre- and intraoperative parameters and the associated strategy to preoperatively select patients with a\u00a0high probability of joint infection. J\u00a0Orthop Surg Res 3:31","journal-title":"J Orthop Surg Res"},{"key":"1016_CR16","volume-title":"Infections of the musculoskeletal system: basic principles, prevention, diagnosis and treatment","author":"PE Ochsner","year":"2014","unstructured":"Ochsner\u00a0PE, Borens\u00a0O, Bodler\u00a0P\u2011M (2014) Infections of the musculoskeletal system: basic principles, prevention, diagnosis and treatment"},{"key":"1016_CR17","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/cis803","volume":"56","author":"D Osmon","year":"2013","unstructured":"Osmon\u00a0D, Berbari\u00a0E, Berendt\u00a0A et\u00a0al (2013) Infectious diseases society of A: diagnosis and management of prosthetic joint infection: clinical practice guidelines by the infectious diseases society of america. Clin Infect Dis 56:e1\u2013e25","journal-title":"Clin Infect Dis"},{"key":"1016_CR18","first-page":"347","volume":"114","author":"C Otto-Lambertz","year":"2017","unstructured":"Otto-Lambertz\u00a0C, Yagdiran\u00a0A, Wallscheid\u00a0F et al (2017) Periprosthetic infection in joint replacement: diagnosis and treatment. Dtsch Arztebl Int 114:347","journal-title":"Dtsch Arztebl Int"},{"key":"1016_CR19","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1016\/j.arth.2014.03.009","volume":"29","author":"J Parvizi","year":"2014","unstructured":"Parvizi\u00a0J, Gehrke\u00a0T (2014) Definition of periprosthetic joint infection. J\u00a0Arthroplasty 29:1331","journal-title":"J Arthroplasty"},{"issue":"5","key":"1016_CR20","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/jor.24293","volume":"37","author":"EM Schwarz","year":"2018","unstructured":"Schwarz\u00a0EM, Parvizi\u00a0J, Gehrke\u00a0T, Aiyer\u00a0A, Battenberg\u00a0A, Brown\u00a0SA, Callaghan\u00a0JJ, Citak\u00a0M, Egol\u00a0K, Garrigues\u00a0GE, Ghert\u00a0M, Goswami\u00a0K, Green\u00a0A, Hammound\u00a0S, Kates\u00a0SL, McLaren\u00a0AC, Mont\u00a0MA, Namdari\u00a0S, Obremskey\u00a0WT, O\u2019Toole\u00a0R, Raikin\u00a0S, Restrepo\u00a0C, Ricciardi\u00a0B, Saeed\u00a0K, Sanchez-Sotelo\u00a0J, Shohat\u00a0N, Tan\u00a0T, Thirukumaran\u00a0CP, Winters\u00a0B (2018) International Consensus Meeting on Musculoskeletal Infection: Research Priorities from the General Assembly Questions. J\u00a0Orthop Res 37(5):997\u20131006. https:\/\/doi.org\/10.1002\/jor.24293","journal-title":"J Orthop Res"},{"key":"1016_CR21","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1007\/s11999-011-1822-1","volume":"469","author":"J Parvizi","year":"2011","unstructured":"Parvizi\u00a0J, Suh\u00a0D\u2011H, Jafari\u00a0SM et al (2011) Aseptic loosening of total hip arthroplasty: infection always should be ruled out. Clin Orthop Relat Res 469:1401\u20131405","journal-title":"Clin Orthop Relat Res"},{"key":"1016_CR22","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.arth.2018.02.078","volume":"33","author":"J Parvizi","year":"2018","unstructured":"Parvizi\u00a0J, Tan\u00a0TL, Goswami\u00a0K et al (2018) The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria. J\u00a0Arthroplasty 33:1309\u201313142","journal-title":"J Arthroplasty"},{"key":"1016_CR23","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.arth.2018.02.078","volume":"33","author":"J Parvizi","year":"2018","unstructured":"Parvizi\u00a0J, Tan\u00a0TL, Goswami\u00a0K et al (2018) The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria. J\u00a0Arthroplasty 33:1309\u20131314.e2","journal-title":"J Arthroplasty"},{"key":"1016_CR24","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.arth.2018.02.078","volume":"33","author":"J Parvizi","year":"2018","unstructured":"Parvizi\u00a0J, Tan\u00a0TL, Goswami\u00a0K et al (2018) The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria. J\u00a0Arthroplasty 33:1309\u20131314","journal-title":"J Arthroplasty"},{"key":"1016_CR25","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1007\/s11999-011-2102-9","volume":"469","author":"J Parvizi","year":"2011","unstructured":"Parvizi\u00a0J, Zmistowski\u00a0B, Berbari\u00a0EF et\u00a0al (2011) New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res 469:2992\u20132994","journal-title":"Clin Orthop Relat Res"},{"key":"1016_CR26","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1051\/sicotj\/2016038","volume":"3","author":"SN Qasim","year":"2017","unstructured":"Qasim\u00a0SN, Swann\u00a0A, Ashford\u00a0R (2017) The DAIR (debridement, antibiotics and implant retention) procedure for infected total knee replacement - a literature review. SICOT J 3:2. https:\/\/doi.org\/10.1051\/sicotj\/2016038","journal-title":"SICOT J."},{"key":"1016_CR27","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.arth.2011.01.019","volume":"27","author":"MR Rasouli","year":"2012","unstructured":"Rasouli\u00a0MR, Harandi\u00a0AA, Adeli\u00a0B et\u00a0al (2012) Revision total knee arthroplasty: infection should be ruled out in all cases. J\u00a0Arthroplasty 27:1239\u20131431","journal-title":"J Arthroplasty"},{"key":"1016_CR28","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.2106\/JBJS.G.01255","volume":"90","author":"MF Schinsky","year":"2008","unstructured":"Schinsky\u00a0MF, Della Valle\u00a0CJ, Sporer\u00a0SM et\u00a0al (2008) Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J\u00a0Bone Joint Surg Am 90:1869\u20131875","journal-title":"J Bone Joint Surg Am"},{"key":"1016_CR29","doi-asserted-by":"publisher","first-page":"S232","DOI":"10.1016\/j.arth.2017.06.005","volume":"32","author":"A Shahi","year":"2017","unstructured":"Shahi\u00a0A, Tan\u00a0TL, Kheir\u00a0MM et\u00a0al (2017) Diagnosing periprosthetic joint infection: and the winner is? J\u00a0Arthroplasty 32:S232\u2013S235","journal-title":"J Arthroplasty"},{"key":"1016_CR30","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s00259-019-4263-9","volume":"46","author":"A Signore","year":"2019","unstructured":"Signore\u00a0A, Sconfienza\u00a0LM, Borens\u00a0O et\u00a0al (2019) Consensus document for the diagnosis of prosthetic joint infections: a\u00a0joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement). Eur J Nucl Med Mol Imaging 46:971\u2013988","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1016_CR31","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.arth.2006.05.008","volume":"21","author":"SM Sporer","year":"2006","unstructured":"Sporer\u00a0SM, Paprosky\u00a0WG (2006) The use of a\u00a0trabecular metal acetabular component and trabecular metal augment for severe acetabular defects. J\u00a0Arthroplasty 21:83\u201386","journal-title":"J Arthroplasty"},{"key":"1016_CR32","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1302\/0301-620X.100B1.BJJ-2017-0630.R1","volume":"100-b","author":"K Suen","year":"2018","unstructured":"Suen\u00a0K, Keeka\u00a0M, Ailabouni\u00a0R et al (2018) Synovasure \u201aquick test\u2018 is not as accurate as the laboratory-based alpha-defensin immunoassay: a\u00a0systematic review and meta-analysis. Bone Joint\u00a0J 100-b:66\u201372","journal-title":"Bone Joint J"},{"key":"1016_CR33","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.arth.2019.03.029","volume":"34","author":"MT Torchia","year":"2019","unstructured":"Torchia\u00a0MT, Austin\u00a0DC, Kunkel\u00a0ST et al (2019) Next-generation sequencing vs culture-based methods for diagnosing periprosthetic joint infection after total knee arthroplasty: a cost-effectiveness analysis. J\u00a0Arthroplasty 34:1333\u20131341","journal-title":"J Arthroplasty"},{"key":"1016_CR34","first-page":"1","volume-title":"Orthop\u00e4die und Unfallchirurgie","author":"G Walter","year":"2019","unstructured":"Walter\u00a0G, Gramlich\u00a0Y (2019) Periprothetische Infektionen. In: Orthop\u00e4die und Unfallchirurgie. Springer, Berlin, Heidelberg, pp\u00a01\u201325"},{"key":"1016_CR35","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s00132-013-2132-y","volume":"43","author":"T Winkler","year":"2014","unstructured":"Winkler\u00a0T, Trampuz\u00a0A, Hardt\u00a0S et\u00a0al (2014) Periprosthetic infection after hip arthroplasty. Orthopade 43:70\u201378","journal-title":"Orthopade"},{"key":"1016_CR36","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1007\/s11999-013-2844-7","volume":"471","author":"R Yu","year":"2013","unstructured":"Yu\u00a0R, Hofstaetter\u00a0JG, Sullivan\u00a0T et\u00a0al (2013) Validity and reliability of the paprosky acetabular defect classification. Clin Orthop Relat Res 471:2259\u20132265","journal-title":"Clin Orthop Relat Res"},{"key":"1016_CR37","unstructured":"Zealand HQSCN (2020) Surgical site infection improvement. https:\/\/www.hqsc.govt.nz\/assets\/Infection-Prevention\/Surgical-Site-Infection-Surveillance\/National_PJI_sampling_guide_Mar_2018.pdf"}],"container-title":["Der Unfallchirurg"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00113-021-01016-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00113-021-01016-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00113-021-01016-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T11:10:15Z","timestamp":1639566615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00113-021-01016-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":37,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1016"],"URL":"https:\/\/doi.org\/10.1007\/s00113-021-01016-4","relation":{},"ISSN":["0177-5537","1433-044X"],"issn-type":[{"type":"print","value":"0177-5537"},{"type":"electronic","value":"1433-044X"}],"subject":[],"published":{"date-parts":[[2021,8,2]]},"assertion":[{"value":"22 April 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Y.\u00a0Gramlich, M.\u00a0Kremer, C.\u00a0Br\u00fcning, J.\u00a0Breuer, L.\u00a0Hofmann, A.\u00a0Klug and R.\u00a0Hoffmann declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional (LAEKHFF71) and\/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. The study was financed by the investigating clinic. The study abides by Good Clinical Practice guidelines. Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The supplement containing this article is not sponsored by industry.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}