{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:45:42Z","timestamp":1780350342946,"version":"3.54.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005296","name":"Universit\u00e4tsklinikum Regensburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005296","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Unfallchirurgie"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Antibiotika (AB) spielen eine wichtige Rolle in der Prophylaxe und Behandlung von Infektionen in der Unfallchirurgie. Dennoch scheint es gerade bei der Infektionsprophylaxe nach offenen Frakturen und auch bei der empirischen Therapie von frakturassoziierten Infektionen (FRI) gro\u00dfe Unterschiede zwischen einzelnen Kliniken zu geben.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methodik<\/jats:title>\n                <jats:p>An deutschen Universit\u00e4ts- und berufsgenossenschaftlichen Kliniken wurde eine Umfrage zu Prophylaxe und empirischer AB-Therapie von FRI durchgef\u00fchrt. Die AB-Regime wurden mit dem Resistenzprofil der Erreger bei 86\u00a0FRI-Patienten verglichen, um die theoretische Wirksamkeit der jeweiligen Therapien zu ermitteln.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Von 71\u00a0Kliniken antworteten insgesamt 44 (62,0\u202f%). Bei geschlossenen Frakturen zeigte sich mit der Verwendung von Cephalosporinen in 95,5\u202f% der Kliniken ein einheitliches Bild. F\u00fcr offene Frakturen wurden 8 verschiedene AB-Regime berichtet, wobei Aminopenicilline\/\u03b2-Lactamase-Inhibitor (BLI) (31,8\u202f%) am h\u00e4ufigsten genannt wurden. F\u00fcr die empirische Therapie der FRI wurden 12\u00a0verschiedene AB-Regime angegeben, am h\u00e4ufigsten Aminopenicilline\/BLI (31,8\u202f%), Cephalosporine (31,8\u202f%) und Ampicillin\/Sulbactam\u202f+\u2009Vancomycin (9,1\u202f%). Hinsichtlich der empirischen Therapie der FRI zeigten sich niedrige Sensibilit\u00e4tsraten f\u00fcr Cephalosporine (65,1\u202f%) bzw. Aminopenicillinen\/BLI (74,4\u202f%). F\u00fcr die Kombination Vancomycin\u202f+\u2009Meropenem ergab sich mit 91,9\u202f% die h\u00f6chste hypothetische Sensibilit\u00e4t.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Diskussion<\/jats:title>\n                <jats:p>Im Abgleich mit dem vorliegenden, einrichtungsspezifischen Keimspektrum erscheint die Kombinationstherapie Vancomycin\u202f+\u2009Meropenem f\u00fcr die empirische Therapie sinnvoll, sollte jedoch Patienten mit mehrfachen Revisionseingriffen oder septischen Infektionsverl\u00e4ufen vorbehalten bleiben, um die Selektion hochresistenter Keime zu vermeiden.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphic abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00113-022-01200-0","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T17:22:46Z","timestamp":1656091366000},"page":"707-714","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antibiotikaeinsatz zu Prophylaxe und empirischer Therapie von frakturassoziierten Infektionen in Deutschland","Antibiotic use for prophylaxis and empirical therapy of fracture-related infections in Germany"],"prefix":"10.1007","volume":"126","author":[{"given":"Susanne","family":"B\u00e4rtl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nike","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegmund","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Hitzenbichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-4650","authenticated-orcid":false,"given":"Volker","family":"Alt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"1200_CR1","unstructured":"AWMF Leitlinie Perioperative Antibiotikaprophylaxe. https:\/\/www.awmf.org\/leitlinien\/aktuelle-leitlinien.html. 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Sci Rep 11:10443. https:\/\/doi.org\/10.1038\/s41598-021-90008-w","journal-title":"Sci Rep"}],"container-title":["Die Unfallchirurgie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00113-022-01200-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00113-022-01200-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00113-022-01200-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:02:19Z","timestamp":1692871339000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00113-022-01200-0"}},"subtitle":["Eine Umfrage an 44\u00a0Kliniken","A\u00a0survey of 44\u00a0hospitals"],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["1200"],"URL":"https:\/\/doi.org\/10.1007\/s00113-022-01200-0","relation":{},"ISSN":["2731-7021","2731-703X"],"issn-type":[{"value":"2731-7021","type":"print"},{"value":"2731-703X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,24]]},"assertion":[{"value":"17 May 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"S.\u00a0B\u00e4rtl, N.\u00a0Walter, S.\u00a0Lang, F.\u00a0Hitzenbichler, M.\u00a0Rupp und V.\u00a0Alt geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. Bez\u00fcglich der Untersuchungen zum Keimspektrum und zu Resistenztestungen in der angef\u00fchrten FRI-Kohorte wird auf die Einhaltung der ethischen Richtlinien in der entsprechenden Studie verwiesen []. F\u00fcr alle weiteren aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}