{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T16:40:48Z","timestamp":1706805648675},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Unfallchirurgie"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die vasookklusiven Krisen der Sichelzellkrankheit gehen mit Knochennekrosen einher, welche eine endogene Keimbesiedlung und somit eine Osteomyelitis beg\u00fcnstigen. Dies bringt eine gro\u00dfe Herausforderung f\u00fcr die Eradikation und Frakturversorgung mit sich.<\/jats:p><jats:p>Ein 22-j\u00e4hriger Patienten mit Sichelzellkrankheit erlitt eine mehrfragment\u00e4re Humerusschaftfraktur. Im Rahmen der operativen Versorgung entleerte sich Pus im Frakturbereich, und es zeigte sich in der weiterf\u00fchrenden Diagnostik eine Osteomyelitis mit dem Nachweis von <jats:italic>Klebsiella aerogenes<\/jats:italic>. F\u00fcnf Monate vor dem Unfall kam es zu einer Septik\u00e4mie durch <jats:italic>Klebsiella aerogenes<\/jats:italic> aufgrund einer vasookklusiven Krise. Diese gehen geh\u00e4uft mit Knochennekrosen und endogener Keimbesiedelung einher. Die Eradikation der Keime und die Frakturversorgung werden zu einer Herausforderung. Eine erfolgreiche Therapieoption sind wiederholte operative Eingriffe mit Segmenttransfer.<\/jats:p>","DOI":"10.1007\/s00113-023-01334-9","type":"journal-article","created":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T11:01:30Z","timestamp":1685876490000},"page":"146-150","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infizierte, pathologische Humerusfraktur bei Sichelzellan\u00e4mie\u00a0\u2013 noch ein Einzelfall?","Infectious, pathologic humeral fracture in a\u00a0patient with sickle cell disease\u2014A\u00a0rare case?"],"prefix":"10.1007","volume":"127","author":[{"given":"Tobias Malte","family":"Ballhause","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Linke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"H\u00e4ttich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till Orla","family":"Klatte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Heinz","family":"Frosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Mader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,4]]},"reference":[{"issue":"4","key":"1334_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/ejh.13212","volume":"102","author":"A Piccin","year":"2019","unstructured":"Piccin\u00a0A et\u00a0al (2019) Insight into the complex pathophysiology of sickle cell anaemia and possible treatment. 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Pediatr Blood Cancer 67(4):e28130","journal-title":"Pediatr Blood Cancer"},{"issue":"9","key":"1334_CR5","first-page":"e20.00002","volume":"4","author":"H Al Farii","year":"2020","unstructured":"Al Farii\u00a0H, Zhou\u00a0S, Albers\u00a0A (2020) Management of osteomyelitis in sickle cell disease: review article. J\u00a0Am Acad Orthop Surg Glob Res Rev 4(9):e20.00002","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"issue":"10","key":"1334_CR6","doi-asserted-by":"publisher","first-page":"e28517","DOI":"10.1002\/pbc.28517","volume":"67","author":"CM Kao","year":"2020","unstructured":"Kao\u00a0CM et\u00a0al (2020) Microbiology and radiographic features of osteomyelitis in children and adolescents with sickle cell disease. 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Semin Plast Surg 23(2):80\u201389","journal-title":"Semin Plast Surg"},{"key":"1334_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26550","author":"JB Kunz","year":"2017","unstructured":"Kunz\u00a0JB et al (2017) The epidemiology of sickle cell disease in Germany following recent large-scale immigration. 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F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor. <i>Einwilligung zur Ver\u00f6ffentlichung:<\/i> Die schriftliche Einwilligungskl\u00e4rung zur Publikation der medizinischen Daten des Patienten liegt vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}