{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:51:59Z","timestamp":1790009519195,"version":"4.0.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Bloomage Biotechnology Corporation Limited"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Nat"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00114-025-02030-x","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T07:04:35Z","timestamp":1760943875000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gamma-aminobutyric acid attenuates cortisol-induced damage in human colorectal adenocarcinoma cells via Nrf2 signaling"],"prefix":"10.1007","volume":"112","author":[{"given":"Yijie","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"issue":"5","key":"2030_CR1","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.beem.2015.09.001","volume":"29","author":"YJ Bae","year":"2015","unstructured":"Bae YJ, Kratzsch J (2015) Corticosteroid-binding globulin: modulating mechanisms of bioavailability of cortisol and its clinical implications. Best Pract Res Clin Endocrinol Metab 29(5):761\u2013772","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"5","key":"2030_CR2","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","volume":"1865","author":"I Bellezza","year":"2018","unstructured":"Bellezza I et al (2018) Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta 1865(5):721\u2013733","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"2030_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39412-6","volume":"14","author":"C Cai","year":"2023","unstructured":"Cai C, Ma H, Peng J (2023) USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice. Nat Commun 14(1):3648","journal-title":"Nat Commun"},{"issue":"3","key":"2030_CR4","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1152\/physrev.00020.2012","volume":"93","author":"K Chapman","year":"2013","unstructured":"Chapman K, Holmes M, Seckl J (2013) 11\u03b2-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. Physiol Rev 93(3):1139\u20131206","journal-title":"Physiol Rev"},{"key":"2030_CR5","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2024.2367570","author":"Z Chu","year":"2025","unstructured":"Chu Z (2025) Targeting Nrf2 by bioactive peptides alleviate inflammation: expanding the role of gut microbiota and metabolites. Crit Rev Food Sci Nutr. https:\/\/doi.org\/10.1080\/10408398.2024.2367570","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"14","key":"2030_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/nu16142288","volume":"16","author":"C Covello","year":"2024","unstructured":"Covello C, Becherucci G, Di Vincenzo F (2024) Parenteral nutrition, inflammatory bowel disease, and gut barrier: an intricate plot. Nutrients 16(14):2288","journal-title":"Nutrients"},{"key":"2030_CR7","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2024.2408447","author":"X Cui","year":"2025","unstructured":"Cui X, Wei W, Hu Y, Zhang Z (2025) Dietary inflammation and vascular calcification: a comprehensive review of the associations, underlying mechanisms, and prevention strategies. Crit Rev Food Sci Nutr. https:\/\/doi.org\/10.1080\/10408398.2024.2408447","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2030_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101506","volume":"34","author":"A Daiber","year":"2020","unstructured":"Daiber A, Kr\u00f6ller-Sch\u00f6n S, Oelze M, Hahad OL et al (2020) Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases. Redox Biol 34:101506","journal-title":"Redox Biol"},{"issue":"2","key":"2030_CR9","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","volume":"19","author":"F Di Vincenzo","year":"2024","unstructured":"Di Vincenzo F, Del Gaudio A, Petito V (2024) Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review. Intern Emerg Med 19(2):275\u2013293","journal-title":"Intern Emerg Med"},{"issue":"10263","key":"2030_CR10","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/S0140-6736(20)31548-8","volume":"396","author":"AC Ford","year":"2020","unstructured":"Ford AC, Sperber AD, Corsetti M (2020) Irritable bowel syndrome. Lancet 396(10263):1675\u20131688","journal-title":"Lancet"},{"key":"2030_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.718093","volume":"8","author":"M Fortea","year":"2021","unstructured":"Fortea M, Albert-Bayo M, Abril-Gil M et al (2021) Present and future therapeutic approaches to barrier dysfunction. Front Nutr 8:718093","journal-title":"Front Nutr"},{"key":"2030_CR12","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ecl.2013.10.005","volume":"43","author":"EB Geer","year":"2014","unstructured":"Geer EB, Islam J, Buettner C (2014) Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism. Endocrinol Metab Clin North Am 43:75\u2013102","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"1","key":"2030_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0079-6107(02)00037-8","volume":"81","author":"L Gonz\u00e1lez-Mariscal","year":"2003","unstructured":"Gonz\u00e1lez-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003) Tight junction proteins. Prog Biophys Mol Biol 81(1):1\u201344","journal-title":"Prog Biophys Mol Biol"},{"key":"2030_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/encyclopedia2040111","volume":"2","author":"P Hussar","year":"2022","unstructured":"Hussar P (2022) Apoptosis regulators Bcl-2 and caspase-3. Encyclopedia 2:1624\u20131636","journal-title":"Encyclopedia"},{"issue":"11","key":"2030_CR15","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.3109\/10715762.2012.717692","volume":"46","author":"G Jena","year":"2012","unstructured":"Jena G, Trivedi PP, Sandala B (2012) Oxidative stress in ulcerative colitis: an old concept but a new concern. Free Radic Res 46(11):1339\u20131345","journal-title":"Free Radic Res"},{"issue":"1","key":"2030_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-021-00330-w","volume":"54","author":"XB Jia","year":"2021","unstructured":"Jia XB, Zhang Q, Xu L et al (2021) Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells through the ROS\/p38 MAPK pathway. Biol Res 54(1):7","journal-title":"Biol Res"},{"key":"2030_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11624","volume":"7","author":"E Kobayashi","year":"2016","unstructured":"Kobayashi E, Suzuki T, Funayama R et al (2016) Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun 7:11624","journal-title":"Nat Commun"},{"issue":"6","key":"2030_CR18","first-page":"591","volume":"62","author":"PC Konturek","year":"2011","unstructured":"Konturek PC, Brzozowski T, Konturek SJ (2011) Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options [J]. Journal of Physiology and Pharmacology\u202f: an Official Journal of the Polish Physiological Society 62(6):591\u2013599","journal-title":"Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society"},{"key":"2030_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/978-1-4939-2895-8_5","volume":"872","author":"T Kuo","year":"2015","unstructured":"Kuo T, McQueen A, Chen TC, Wang JC (2015) Regulation of glucose homeostasis by glucocorticoids. Adv Exp Med Biol 872:99\u2013126","journal-title":"Adv Exp Med Biol"},{"issue":"20","key":"2030_CR20","doi-asserted-by":"publisher","first-page":"4491","DOI":"10.1113\/JP281951","volume":"601","author":"SJ Leigh","year":"2023","unstructured":"Leigh SJ, Uhlig F, Wilmes L (2023) The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota-gut-brain axis perspective. J Physiol 601(20):4491\u20134538","journal-title":"J Physiol"},{"key":"2030_CR21","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cbi.2013.12.005","volume":"209","author":"L Li","year":"2014","unstructured":"Li L, Dong H, Song E, Xu X (2014) Nrf2\/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K\/AKT signaling. Chem Biol Interact 209:56\u201367","journal-title":"Chem Biol Interact"},{"key":"2030_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92574-5","volume":"11","author":"P Lian","year":"2021","unstructured":"Lian P, Braber S, Varasteh S et al (2021) Hypoxia and heat stress affect epithelial integrity in a Caco-2\/HT-29 co-culture. Sci Rep 11:13186","journal-title":"Sci Rep"},{"issue":"1","key":"2030_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-024-01496-9","volume":"24","author":"B Macura","year":"2024","unstructured":"Macura B, Kiecka A, Szczepanik M (2024) Intestinal permeability disturbances: causes, diseases and therapy. Clin Exp Med 24(1):232","journal-title":"Clin Exp Med"},{"issue":"5","key":"2030_CR24","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3390\/ijerph21050533","volume":"21","author":"PC Mandiola","year":"2024","unstructured":"Mandiola PC, Leiva C, Moya-Salazar MJ et al (2024) Healthy habits, physical activity, stress, and food consumption trends in Chilean adults with irritable bowel syndrome during the COVID-19 pandemic. Int J Environ Res Public Health 21(5):533","journal-title":"Int J Environ Res Public Health"},{"issue":"18","key":"2030_CR25","doi-asserted-by":"publisher","first-page":"9254","DOI":"10.1039\/D4FO01446D","volume":"15","author":"MS Matos","year":"2024","unstructured":"Matos MS, \u00c1vila-G\u00e1lvez M\u00c1, Gonz\u00e1lez-Sarr\u00edas A et al (2024) Unveiling the anti-inflammatory potential of 11\u03b2,13-dihydrolactucin for application in inflammatory bowel disease management. Food Funct 15(18):9254\u20139271","journal-title":"Food Funct"},{"key":"2030_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153712","volume":"91","author":"KB Megha","year":"2021","unstructured":"Megha KB, Joseph X, Akhil V, Mohanan PV (2021) Cascade of immune mechanism and consequences of inflammatory disorders. Phytomedicine 91:153712","journal-title":"Phytomedicine"},{"key":"2030_CR27","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5767535","author":"S Mohammadpour","year":"2024","unstructured":"Mohammadpour S, Torshizi Esfahani A, Sarpash S (2024) Hippo signaling pathway in colorectal cancer: modulation by various signals and therapeutic potential. Anal Cell Pathol. https:\/\/doi.org\/10.1155\/2024\/5767535","journal-title":"Anal Cell Pathol"},{"issue":"6","key":"2030_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12061187","volume":"12","author":"M Perrelli","year":"2024","unstructured":"Perrelli M, Goparaju P, Postolache TT (2024) Stress and the CRH system, norepinephrine, depression, and type 2 diabetes. Biomedicines 12(6):1187","journal-title":"Biomedicines"},{"key":"2030_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1482214","volume":"15","author":"P Qi","year":"2024","unstructured":"Qi P, Chen X, Tian J et al (2024) The gut homeostasis-immune system axis: novel insights into rheumatoid arthritis pathogenesis and treatment. Front Immunol 15:1482214","journal-title":"Front Immunol"},{"key":"2030_CR30","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41574-019-0228-0","volume":"15","author":"G Russell","year":"2019","unstructured":"Russell G, Lightman S (2019) The human stress response. Nat Rev Endocrinol 15:525\u2013534","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"2030_CR31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jcmgh.2016.10.004","volume":"3","author":"A Shawki","year":"2016","unstructured":"Shawki A, McCole DF (2016) Mechanisms of intestinal epithelial barrier dysfunction by adherent-invasive Escherichia coli. Cell Mol Gastroenterol Hepatol 3(1):41\u201350","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"9","key":"2030_CR32","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3390\/diseases12090220","volume":"12","author":"A Sic","year":"2024","unstructured":"Sic A, Cvetkovic K, Manchanda E, Knezevic NN (2024) Neurobiological implications of chronic stress and metabolic dysregulation in inflammatory bowel diseases [J]. Diseases 12(9):220","journal-title":"Diseases"},{"issue":"1","key":"2030_CR33","doi-asserted-by":"publisher","first-page":"G7","DOI":"10.1152\/ajpgi.2001.280.1.G7","volume":"280","author":"JD S\u00f6derholm","year":"2001","unstructured":"S\u00f6derholm JD, Perdue MH (2001) Stress and gastrointestinal tract. Part II. Stress and intestinal barrier function. Am J Physiol Gastrointest Liver Physiol 280(1):G7\u2013G13","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"13","key":"2030_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137394","volume":"25","author":"E Szczepanska-Sadowska","year":"2024","unstructured":"Szczepanska-Sadowska E, Czarzasta K, Bogacki-Rychlik W, Kowara M (2024) The interaction of vasopressin with hormones of the hypothalamo-pituitary-adrenal axis: the significance for therapeutic strategies in cardiovascular and metabolic diseases. Int J Mol Sci 25(13):7394","journal-title":"Int J Mol Sci"},{"key":"2030_CR35","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41574-019-0185-7","volume":"15","author":"A T\u00e9blick","year":"2019","unstructured":"T\u00e9blick A, Peeters B, Langouche L et al (2019) Adrenal function and dysfunction in critically ill patients. Nat Rev Endocrinol 15:417\u2013427","journal-title":"Nat Rev Endocrinol"},{"key":"2030_CR36","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.genhosppsych.2024.07.013","volume":"90","author":"NS Thomas","year":"2024","unstructured":"Thomas NS, Gillespie NA, Kendler KS, Oldehinkel AJ (2024) Comorbidity and sex differences in functional disorders and internalizing disorders. Gen Hosp Psychiatry 90:91\u201398","journal-title":"Gen Hosp Psychiatry"},{"key":"2030_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01545","volume":"10","author":"S Timmermans","year":"2019","unstructured":"Timmermans S, Souffriau J, Libert C (2019) A general introduction to glucocorticoid biology. Front Immunol 10:1545","journal-title":"Front Immunol"},{"issue":"17","key":"2030_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/cells13171436","volume":"13","author":"A Verma","year":"2024","unstructured":"Verma A, Inslicht SS, Bhargava A (2024) Gut-brain axis: role of microbiome, metabolomics, hormones, and stress in mental health disorders. Cells 13(17):1436","journal-title":"Cells"},{"key":"2030_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06243-0","volume":"7","author":"Y Wang","year":"2024","unstructured":"Wang Y, Fu X, Zeng L et al (2024a) Activation of Nrf2\/HO-1 signaling pathway exacerbates cholestatic liver injury. Commun Biol 7:621","journal-title":"Commun Biol"},{"issue":"12","key":"2030_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103654","volume":"23","author":"H Wang","year":"2024","unstructured":"Wang H, Cai Y, Wu W, Zhang M (2024) Exploring the role of gut microbiome in autoimmune diseases: a comprehensive review. Autoimmun Rev 23(12):103654","journal-title":"Autoimmun Rev"},{"key":"2030_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1365871","volume":"15","author":"A Warren","year":"2024","unstructured":"Warren A, Nyavor Y, Beguelin A (2024) Dangers of the chronic stress response in the context of the microbiota-gut-immune-brain axis and mental health: a narrative review. Front Immunol 15:1365871","journal-title":"Front Immunol"},{"key":"2030_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2024.104368","author":"Y Xiao","year":"2024","unstructured":"Xiao Y, Gao X, Yuan J (2024) Substituting ethoxyquin with tea polyphenols and propyl gallate enhanced feed oxidative stability, broiler hepatic antioxidant capacity and gut health. Poult Sci. https:\/\/doi.org\/10.1016\/j.psj.2024.104368","journal-title":"Poult Sci"},{"issue":"6","key":"2030_CR43","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1016\/j.clnu.2024.05.016","volume":"43","author":"J Ying","year":"2024","unstructured":"Ying J, Ye D, Luo P, Liu B et al (2024) Lifestyle and genetic predisposition are associated with incident irritable bowel syndrome: a population-based prospective cohort study [J]. Clin Nutr 43(6):1544\u20131550","journal-title":"Clin Nutr"},{"key":"2030_CR44","doi-asserted-by":"crossref","unstructured":"Yue Y, Ke Y, Zheng J, Wang et al (2024) Microbiota-derived tryptophan metabolism and AMPK\/mTOR pathway mediate antidepressant-like effect of Shugan Hewei Decoction .\u00a0Front Pharmacol 15: 1466336.","DOI":"10.3389\/fphar.2024.1466336"},{"key":"2030_CR45","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","volume":"34","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Liu J, Duan H, Li R et al (2021) Activation of Nrf2\/HO-1 signaling: an important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress. J Adv Res 34:43\u201363","journal-title":"J Adv Res"},{"key":"2030_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-024-00571-z","volume":"10","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Li X, Lu S et al (2024a) Stress triggers gut dysbiosis via CRH-CRHR1-mitochondria pathway. NPJ Biofilms Microbiomes 10:93","journal-title":"NPJ Biofilms Microbiomes"},{"key":"2030_CR47","unstructured":"Zhang L, Wang HL, Zhang YF, et al (2024) Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon.\u00a0Cell Metab"},{"key":"2030_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-0167-x","volume":"6","author":"D Zheng","year":"2020","unstructured":"Zheng D, Liwinski T, Elinav E (2020) Inflammasome activation and regulation: toward a better understanding of complex mechanisms. Cell Discov 6:36","journal-title":"Cell Discov"},{"key":"2030_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300467","volume":"21","author":"Z Zou","year":"2024","unstructured":"Zou Z, Xiao N, Chen Z et al (2024) Yeast extract peptides alleviate depression in chronic restraint stress rats by alleviating hippocampal neuronal apoptosis and dysbiosis of the gut microbiota. Mol Nutr Food Res 21:e2300467","journal-title":"Mol Nutr Food Res"}],"container-title":["The Science of Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00114-025-02030-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00114-025-02030-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00114-025-02030-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:57:02Z","timestamp":1768474622000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00114-025-02030-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2030"],"URL":"https:\/\/doi.org\/10.1007\/s00114-025-02030-x","relation":{},"ISSN":["0028-1042","1432-1904"],"issn-type":[{"value":"0028-1042","type":"print"},{"value":"1432-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]},"assertion":[{"value":"8 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical Approval is not applicable for this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"There are no human subjects in this article and informed consent is not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This article does not contain any studies with human or animal subjects.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"82"}}