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In vivo, the Tail Cuff method evaluated blood pressure-lowering effects in adrenaline-induced hypertensive rats. Phytochemical profiling was performed via GC-MS, and molecular docking assessed interactions of key compounds with vascular regulation targets (7VFS, 8THK, 3NOS). In vitro, 5\u00a0\u00b5g\/ mL of the extract slightly increased aortic contractility (3.9\u2009\u00b1\u20093.4%), whereas 60\u00a0\u00b5g\/ mL markedly reduced it (89.5\u2009\u00b1\u20093.1%). At 50\u00a0\u00b5g\/ mL, it inhibited phenylephrine-induced GPCR-mediated contractions by 84.9\u2009\u00b1\u20093.8%. In vivo, 40\u00a0mg\/kg of the extract lowered systolic and diastolic pressures to 150 mmHg and 110 mmHg, respectively. GC-MS identified pinocarveol, coumarin, apigenin derivatives, and dicaffeoylquinic acids. Molecular docking revealed strong affinities of apigenin-7-O-neohesperidoside and other compounds to key vascular targets. Both experimental approaches consistently demonstrated vasorelaxant activity, likely linked to polyphenol and flavonoid content.\n                    <jats:italic>M. chamomilla<\/jats:italic>\n                    extract exhibits significant vasorelaxant and antihypertensive effects, mediated through modulation of calcium channels and bioactive polyphenols. These findings support its potential as a therapeutic agent for hypertension and hypoxia-related cardiovascular disorders, warranting further clinical investigation.\n                  <\/jats:p>","DOI":"10.1007\/s00114-025-02065-0","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:28:04Z","timestamp":1768811284000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiovascular effects of Matricaria chamomilla extract: calcium channel modulation and vasorelaxant activity"],"prefix":"10.1007","volume":"113","author":[{"given":"Omonturdiev","family":"Sirojiddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullaev","family":"Izzatullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayibov","family":"Ulugbek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inomjonov","family":"Dolimjon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayibova","family":"Sabina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makhmudov","family":"Rustamjon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aripov","family":"Takhir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine \u0130ncilay","family":"Toruno\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdi Can","family":"Aytar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"2065_CR1","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.13005\/BPJ\/2942","volume":"17","author":"AA Abdullaev","year":"2024","unstructured":"Abdullaev AA, Inamjanov DR, Abduazimova DS et al (2024) S\u00edlybum mari\u00e1num\u2019s impact on physiological alterations and oxidative stress in diabetic rats. 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All authors participated in the work in a substantive way and are prepared to take public responsibility for the work. The text, illustrations, and any other materials included in the manuscript do not infringe upon any existing copyright or other rights of anyone. The authors are agreeing that all materials submitted for evaluation (including text, figures, etc.) retains the property\/copyrights of The Science of Nature. In the case of not acceptable papers, after their rejection the property of all materials will backward to the authors. Reproduction, posting, transmission or other distribution or use of the article or any material contained therein, requires a citation to the journal The Science of Nature.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Animal Ethical Committee of the Institute of Bioorganic Chemistry, AS RUz (Protocol No: 133\/1a\/h; approved on August 4, 2014).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}