{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:37:44Z","timestamp":1756993064520},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T00:00:00Z","timestamp":1292976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1007\/s00115-010-3185-3","type":"journal-article","created":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T17:23:48Z","timestamp":1292865828000},"page":"1006-1011","source":"Crossref","is-referenced-by-count":4,"title":["Restless-legs-Syndrom und kardiovaskul\u00e4res Risiko"],"prefix":"10.1007","volume":"82","author":[{"given":"E.C.","family":"Schulte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Spieler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Winkelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,12,22]]},"reference":[{"key":"3185_CR1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1389-9457(03)00010-8","volume":"4","author":"Allen","year":"2003","unstructured":"Allen RP, Picchietti D, Hening WA et al (2003) Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4:101\u2013119","journal-title":"Sleep Med"},{"key":"3185_CR2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1212\/01.wnl.0000223316.53428.c9","volume":"67","author":"Clemens","year":"2006","unstructured":"Clemens S, Rye D, Hochman S (2006) Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective. Neurology 67:125\u2013130","journal-title":"Neurology"},{"key":"3185_CR3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pediatrneurol.2006.02.006","volume":"35","author":"Cortese","year":"2006","unstructured":"Cortese S, Konofal E, Lecendreux M et al (2006) Restless legs syndrome triggered by heart surgery. Pediatric Neurol 35:223\u2013226","journal-title":"Pediatric Neurol"},{"key":"3185_CR4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cell.2005.09.009","volume":"123","author":"Dasen","year":"2005","unstructured":"Dasen JS, Tice BC, Brenner-Morton S et al (2005) A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity. Cell 123:477\u2013491","journal-title":"Cell"},{"key":"3185_CR5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/jech.2005.039057","volume":"60","author":"Elwood","year":"2006","unstructured":"Elwood P, Hack M, Pickering J et al (2006) Sleep disturbance, stroke, and heart disease events: evidence from the Caerphilly cohort. J Epidemiol Community Health 60:69\u201373","journal-title":"J Epidemiol Community Health"},{"key":"3185_CR6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1440-1819.1997.tb02370.x","volume":"51","author":"Espinar-Sierra","year":"1997","unstructured":"Espinar-Sierra J, Vela-Bueno A, Luque-Otero M (1997) Periodic leg movments in essential hypertension. Psychiatry Clin Neurosciences 51:103\u2013107","journal-title":"Psychiatry Clin Neurosciences"},{"key":"3185_CR7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jpsychores.2004.02.010","volume":"56","author":"Foley","year":"2004","unstructured":"Foley D, Ancoli-Israel S, Britz P et al (2004) Sleep disturbances and chronic disease in older adults: results of the 2003 National Sleep Foundation Sleep in America Survey. J Psychosom Res 56:497\u2013502","journal-title":"J Psychosom Res"},{"key":"3185_CR8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/sleep\/30.6.755","volume":"30","author":"Guggisberg","year":"2007","unstructured":"Guggisberg AG, Hess CW, Mathis J (2007) The significance of the sympathetic nervous system in the pathophysiology of periodic leg movements in sleep. Sleep 30:755\u2013766","journal-title":"Sleep"},{"key":"3185_CR9","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1212\/01.WNL.0000163996.64461.A3","volume":"54","author":"H\u00f6gl","year":"2005","unstructured":"H\u00f6gl B, Kiechl S, Willeit J et al (2005) Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. Neurology 54:1920\u20131924","journal-title":"Neurology"},{"key":"3185_CR10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ehj.2003.10.032","volume":"25","author":"Javaheri","year":"2004","unstructured":"Javaheri S, Abraham WT, Brown C et al (2004) Prevalence of obstructive sleep apnea and periodic limb movements in 45 subjects with heart transplantation. Eur Heart J 25:260\u2013266","journal-title":"Eur Heart J"},{"key":"3185_CR11","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1101\/gad.437307","volume":"21","author":"Junion","year":"2007","unstructured":"Junion G, Bataille L, Jagla T et al (2007) Genome-wide view of cell fate specification: ladybird acts at multiple levels during diversification of muscle and heart precursors. Genes Dev 21:3163\u20133180","journal-title":"Genes Dev"},{"key":"3185_CR12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/46580","volume":"402","author":"Mercader","year":"1999","unstructured":"Mercader N, Leonardo E, Azpiazu N et al (1999) Conserved regulation of proximodistal limb axis development by Meis1\/Hth. Nature 402(6760):425\u2013429","journal-title":"Nature"},{"key":"3185_CR13","first-page":"9","volume":"12","author":"Ochi","year":"2009","unstructured":"Ochi H, Westerfield M (2009) Lbx2 regulates formation of myofibrils. BMC Dev Biol 12:9\u201313","journal-title":"BMC Dev Biol"},{"key":"3185_CR14","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0022-3999(02)00443-9","volume":"53","author":"Ohayon","year":"2002","unstructured":"Ohayon MM, Roth T (2002) Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J Psychosom Res 53:547\u2013554","journal-title":"J Psychosom Res"},{"key":"3185_CR15","unstructured":"Pfeufer A, Noord C van, Marciante KD et al (2010) Genome-wide association study of PR interval. Nat Genet (in press)"},{"key":"3185_CR16","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1212\/01.wnl.0000259036.89411.52","volume":"68","author":"Pennestri","year":"2007","unstructured":"Pennestri MH, Montplaisir J, Colombo R et al (2007) Nocturnal blood pressure changes in patients with restless legs syndrome. Neurology 68:1213\u20131218","journal-title":"Neurology"},{"key":"3185_CR17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1378\/chest.129.1.76","volume":"129","author":"Phillips","year":"2005","unstructured":"Phillips B, Hening W, Britz P et al (2005) Prevalence and correlates of restless legs syndrome. Chest 129:76\u201380","journal-title":"Chest"},{"key":"3185_CR18","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1212\/WNL.54.5.1064","volume":"54","author":"Rothdach","year":"2000","unstructured":"Rothdach AJ, Trenkwalder C, Haberstock J et al (2000) Prevalence and risk factors of RLS in an elderly population: The MEMO Study. Neurology 54:1064\u20131068","journal-title":"Neurology"},{"key":"3185_CR19","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/mds.22486","volume":"24","author":"Schlesinger","year":"2009","unstructured":"Schlesinger I, Erikh I, Avizohar O et al (2009) Cardiovascular risk factors in restless legs syndrome. Mov Disord 24:1587\u20131592","journal-title":"Mov Disord"},{"key":"3185_CR20","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ng.190","volume":"40","author":"Schormair","year":"2008","unstructured":"Schormair B, Kemlink D, Roeske D et al (2008) PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nat Genet 40:946\u2013948","journal-title":"Nat Genet"},{"key":"3185_CR21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/sleep\/30.1.43","volume":"30","author":"Sforza","year":"2007","unstructured":"Sforza E, Pichot V, Cervena K et al (2007) Cardiac variability and heart-rate increment as a marker of sleep fragmentation in patients with a sleep disorder: a preliminary study. Sleep 30:43\u201351","journal-title":"Sleep"},{"key":"3185_CR22","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.clinph.2007.05.006","volume":"118","author":"Siddiqui","year":"2007","unstructured":"Siddiqui F, Strus J, Ming X et al (2007) Rise in blood pressure with periodic limb movements in sleep and wakefulness. Clin Neurophysiol 118:1923\u20131930","journal-title":"Clin Neurophysiol"},{"key":"3185_CR23","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1161\/CIRCRESAHA.108.175489","volume":"103","author":"Stankunas","year":"2008","unstructured":"Stankunas K, Shang C, Twu KY et al (2008) Pbx\/Meis Deficiencies demonstrate multigenetic origins of congenital heart disease. Circ Res 103:702\u2013709","journal-title":"Circ Res"},{"key":"3185_CR24","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.sleep.2008.06.009","volume":"10","author":"Trotti","year":"2009","unstructured":"Trotti LM, Bliwise DL, Greer SA et al (2009) Correlates of PLMs variability over multiple nights and impact upon RLS diagnosis. Sleep Med 10:668\u2013671","journal-title":"Sleep Med"},{"key":"3185_CR25","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/mds.1209","volume":"16","author":"Ulfberg","year":"2001","unstructured":"Ulfberg J, Nystr\u00f6m B, Carter N et al (2001) Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms. Mov Disord 16:1159\u20131163","journal-title":"Mov Disord"},{"key":"3185_CR26","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/mds.870100517","volume":"10","author":"Walters","year":"1995","unstructured":"Walters AS, IRLSSG (1995) Toward a better definition of the restless legs syndrome. Mov Disord 10:634\u2013642","journal-title":"Mov Disord"},{"key":"3185_CR27","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/sleep\/32.5.589","volume":"32","author":"Walters","year":"2009","unstructured":"Walters AS, Rye DB (2009) Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke. Sleep 32:589\u2013597","journal-title":"Sleep"},{"key":"3185_CR28","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/sleep\/22.5.575","volume":"22","author":"Winkelman","year":"1999","unstructured":"Winkelman JW (1999) The evoked heart rates response to periodic leg movements of sleep. Sleep 22:575\u2013580","journal-title":"Sleep"},{"key":"3185_CR29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.sleep.2006.01.004","volume":"7","author":"Winkelman","year":"2006","unstructured":"Winkelman JW, Finn L, Young T (2006) Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort. Sleep Med 7:545\u2013552","journal-title":"Sleep Med"},{"key":"3185_CR30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1212\/01.wnl.0000287072.93277.c9","volume":"70","author":"Winkelman","year":"2008","unstructured":"Winkelman JW, Shahar E, Sharief I et al (2008) Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study. Neurology 70:35\u201342","journal-title":"Neurology"},{"key":"3185_CR31","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ng2099","volume":"39","author":"Winkelmann","year":"2007","unstructured":"Winkelmann J, Schormair B, Lichtner P et al (2007) Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet 39:1000\u20131006","journal-title":"Nat Genet"}],"container-title":["Der Nervenarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-010-3185-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00115-010-3185-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-010-3185-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T06:12:27Z","timestamp":1559887947000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00115-010-3185-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,22]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["3185"],"URL":"https:\/\/doi.org\/10.1007\/s00115-010-3185-3","relation":{},"ISSN":["0028-2804","1433-0407"],"issn-type":[{"value":"0028-2804","type":"print"},{"value":"1433-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,22]]}}}