{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:40:06Z","timestamp":1788928806266,"version":"build-2803163510"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T00:00:00Z","timestamp":1449532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s00115-015-0030-8","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T05:53:06Z","timestamp":1449640386000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Amyotrophe Lateralsklerose","Amyotrophic lateral sclerosis"],"prefix":"10.1007","volume":"87","author":[{"given":"A.","family":"H\u00fcbers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Ludolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rosenbohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. H.","family":"Pinkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Weishaupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,8]]},"reference":[{"key":"30_CR1","first-page":"74","volume":"9","author":"TJ Anderson","year":"2013","unstructured":"Anderson TJ, Macaskill MR (2013) Eye movements in patients with neurodegenerative disorders. Nature reviews. Neurology 9:74\u201385","journal-title":"Neurology"},{"key":"30_CR2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/21678421.2014.974617","volume":"16","author":"S Ash","year":"2015","unstructured":"Ash S, Olm C, Mcmillan CT et al (2015) Deficits in sentence expression in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 16:31\u201339","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"30_CR3","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/brain\/aws004","volume":"135","author":"BF Boeve","year":"2012","unstructured":"Boeve BF, Boylan KB, Graff-Radford NR et al (2012) Characterization of frontotemporal dementia and\/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72. Brain 135:765\u2013783","journal-title":"Brain"},{"key":"30_CR4","first-page":"708","volume":"9","author":"H Braak","year":"2013","unstructured":"Braak H, Brettschneider J, Ludolph AC et al (2013) Amyotrophic lateral sclerosis \u2013 a model of corticofugal axonal spread. Nature reviews. Neurology 9:708\u2013714","journal-title":"Neurology"},{"key":"30_CR5","first-page":"364","volume":"96","author":"A Braum\u00fchl","year":"1932","unstructured":"Braum\u00fchl A (1932) Pick\u2019s disease and amyotrophic lateral sclerosis. Allg Zeitschrift Fur Psychiatr Psychol Med 96:364\u2013366","journal-title":"Allg Zeitschrift Fur Psychiatr Psychol Med"},{"key":"30_CR6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","volume":"74","author":"J Brettschneider","year":"2013","unstructured":"Brettschneider J, Del Tredici K, Toledo JB et al (2013) Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Ann Neurol 74:20\u201338","journal-title":"Ann Neurol"},{"key":"30_CR7","doi-asserted-by":"crossref","first-page":"e90452","DOI":"10.1371\/journal.pone.0090452","volume":"9","author":"Y Carlomagno","year":"2014","unstructured":"Carlomagno Y, Zhang Y, Davis M et al (2014) Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins. PloS One 9:e90452","journal-title":"PloS One"},{"key":"30_CR8","first-page":"147","volume":"1","author":"AL Chen","year":"2010","unstructured":"Chen AL, Riley DE, King SA et al (2010) The disturbance of gaze in progressive supranuclear palsy: implications for pathogenesis. Front Neurol 1:147","journal-title":"Front Neurol"},{"key":"30_CR9","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1212\/WNL.0b013e31824e8f53","volume":"78","author":"A Chio","year":"2012","unstructured":"Chio A, Ilardi A, Cammarosano S et al (2012) Neurobehavioral dysfunction in ALS has a negative effect on outcome and use of PEG and NIV. Neurology 78:1085\u20131089","journal-title":"Neurology"},{"key":"30_CR10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/hmg\/ddt498","volume":"23","author":"DK Choksi","year":"2014","unstructured":"Choksi DK, Roy B, Chatterjee S et al (2014) TDP-43 Phosphorylation by casein kinase Iepsilon promotes oligomerization and enhances toxicity in vivo. Hum Mol Genet 23:1025\u20131035","journal-title":"Hum Mol Genet"},{"key":"30_CR11","doi-asserted-by":"crossref","unstructured":"Cirulli ET, Lasseigne BN, Petrovski S et al (2015) Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science 347:1436\u20131441","DOI":"10.1126\/science.aaa3650"},{"key":"30_CR12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/21678421.2012.756525","volume":"14","author":"D Czell","year":"2013","unstructured":"Czell D, Andersen PM, Neuwirth C et al (2013) Progressive aphasia as the presenting symptom in a patient with amyotrophic lateral sclerosis with a novel mutation in the OPTN gene. Amyotroph Lateral Scler Frontotemporal Degener 14:138\u2013140","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"30_CR13","doi-asserted-by":"crossref","unstructured":"DeJesus-Hernandez M, Mackenzie IR, Boeve BF et al (2011) Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 72:245\u2013256","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"30_CR14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1212\/WNL.53.5.1059","volume":"53","author":"JC Desport","year":"1999","unstructured":"Desport JC, Preux PM, Truong TC et al (1999) Nutritional status is a prognostic factor for survival in ALS patients. Neurology 53:1059\u20131063","journal-title":"Neurology"},{"key":"30_CR15","unstructured":"Dornbl\u00fcth O (1889) An anatomical investigation of a case of amyotrophic lateral sclerosis. Neur Zbl 13"},{"key":"30_CR16","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/21678421.2013.823999","volume":"14","author":"J Dorst","year":"2013","unstructured":"Dorst J, Cypionka J, Ludolph AC (2013) High-caloric food supplements in the treatment of amyotrophic lateral sclerosis: A prospective interventional study. Amyotroph Lateral Scler Frontotemporal Degener 14:533\u2013536","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"4","key":"30_CR17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00415-015-7646-2","volume":"262","author":"J Dorst","year":"2015","unstructured":"Dorst J, Dupuis L, Petri S et al (2015) Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis: a prospective observational study. J Neurol 262(4):849\u2013858","journal-title":"J Neurol"},{"key":"30_CR18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00415-010-5805-z","volume":"258","author":"J Dorst","year":"2011","unstructured":"Dorst J, Kuhnlein P, Hendrich C et al (2011) Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis. J Neurol 258:613\u2013617","journal-title":"J Neurol"},{"key":"30_CR19","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1212\/01.wnl.0000285080.70324.27","volume":"70","author":"L Dupuis","year":"2008","unstructured":"Dupuis L, Corcia P, Fergani A et al (2008) Dyslipidemia is a protective factor in amyotrophic lateral sclerosis. Neurology 70:1004\u20131009","journal-title":"Neurology"},{"key":"30_CR20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s00415-012-6654-8","volume":"260","author":"P Fathinia","year":"2013","unstructured":"Fathinia P, Hermann A, Reuner U et al (2013) Parkinson\u2019s disease-like midbrain hyperechogenicity is frequent in amyotrophic lateral sclerosis. J Neurol 260:454\u2013457","journal-title":"J Neurol"},{"key":"30_CR21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1055\/s-0034-1374583","volume":"41","author":"E Feneberg","year":"2014","unstructured":"Feneberg E, H\u00fcbers A, Weishaupt JH et al (2014) Genetik und Neurochemische Biomarker bei Amyotropher Lateralsklerose und Frontotemporaler Lob\u00e4rdegeneration. Akt Neurol 41:239\u2013247","journal-title":"Akt Neurol"},{"key":"30_CR22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nn.4000","volume":"18","author":"A Freischmidt","year":"2015","unstructured":"Freischmidt A, Wieland T, Richter B et al (2015) Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci 18:631\u2013636","journal-title":"Nat Neurosci"},{"key":"30_CR23","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.biopsych.2013.01.031","volume":"74","author":"D Galimberti","year":"2013","unstructured":"Galimberti D, Fenoglio C, Serpente M et al (2013) Autosomal dominant frontotemporal lobar degeneration due to the C9ORF72 hexanucleotide repeat expansion: late-onset psychotic clinical presentation. Biol Psychiatry 74:384\u2013391","journal-title":"Biol Psychiatry"},{"key":"30_CR24","doi-asserted-by":"crossref","unstructured":"Gitcho MA, Baloh RH, Chakraverty S et al (2008) TDP-43 A315T mutation in familial motor neuron disease. Ann Neurol 63:535\u2013538","DOI":"10.1002\/ana.21344"},{"key":"30_CR25","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S1474-4422(13)70026-7","volume":"12","author":"LH Goldstein","year":"2013","unstructured":"Goldstein LH, Abrahams S (2013) Changes in cognition and behaviour in amyotrophic lateral sclerosis: nature of impairment and implications for assessment. Lancet Neurol 12:368\u2013380","journal-title":"Lancet Neurol"},{"key":"30_CR26","first-page":"1014","volume":"50","author":"H Ichikawa","year":"2010","unstructured":"Ichikawa H (2010) Language disorders in ALS\/FTLD. Clin Neurol 50:1014\u20131016","journal-title":"Clin Neurol"},{"key":"30_CR27","doi-asserted-by":"crossref","first-page":"e007659","DOI":"10.1136\/bmjopen-2015-007659","volume":"5","author":"C Iglesias","year":"2015","unstructured":"Iglesias C, Sangari S, El Mendili MM et al (2015) Electrophysiological and spinal imaging evidences for sensory dysfunction in amyotrophic lateral sclerosis. BMJ Open 5:e007659","journal-title":"BMJ Open"},{"key":"30_CR28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-510X(96)00297-3","volume":"146","author":"K Iwanaga","year":"1997","unstructured":"Iwanaga K, Hayashi S, Oyake M et al (1997) Neuropathology of sporadic amyotrophic lateral sclerosis of long duration. J Neurol Sci 146:139\u2013143","journal-title":"J Neurol Sci"},{"key":"30_CR29","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1083\/jcb.200908115","volume":"187","author":"JS Ju","year":"2009","unstructured":"Ju JS, Fuentealba RA, Miller SE et al (2009) Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol 187:875\u2013888","journal-title":"J Cell Biol"},{"key":"30_CR30","doi-asserted-by":"crossref","unstructured":"Kabashi E, Valdmanis PN, Dion P et al (2008) TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nat Genet 40:572\u2013574","DOI":"10.1038\/ng.132"},{"key":"30_CR31","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/brain\/awu090","volume":"137","author":"J Kassubek","year":"2014","unstructured":"Kassubek J, Muller HP, Del Tredici K et al (2014) Diffusion tensor imaging analysis of sequential spreading of disease in amyotrophic lateral sclerosis confirms patterns of TDP-43 pathology. Brain 137:1733\u20131740","journal-title":"Brain"},{"key":"30_CR32","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ng.2853","volume":"46","author":"HJ Kim","year":"2014","unstructured":"Kim HJ, Raphael AR, Ladow ES et al (2014) Therapeutic modulation of eIF2alpha phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nat Genet 46:152\u2013160","journal-title":"Nat Genet"},{"key":"30_CR33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S1097-2765(00)00040-X","volume":"6","author":"MF Kleijnen","year":"2000","unstructured":"Kleijnen MF, Shih AH, Zhou P et al (2000) The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Mol Cell 6:409\u2013419","journal-title":"Mol Cell"},{"key":"30_CR34","doi-asserted-by":"crossref","unstructured":"Kwiatkowski TJ Jr, Bosco DA, Leclerc AL et al (2009) Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 323:1205\u20131208","DOI":"10.1126\/science.1166066"},{"key":"30_CR35","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1001\/archneur.1982.00510230010003","volume":"39","author":"A Leveille","year":"1982","unstructured":"Leveille A, Kiernan J, Goodwin JA et al (1982) Eye movements in amyotrophic lateral sclerosis. Arch Neurol 39:684\u2013686","journal-title":"Arch Neurol"},{"key":"30_CR36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.neuron.2013.07.033","volume":"79","author":"SC Ling","year":"2013","unstructured":"Ling SC, Polymenidou M, Cleveland DW (2013) Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron 79:416\u2013438","journal-title":"Neuron"},{"key":"30_CR37","author":"A Ludolph","year":"2015","unstructured":"Ludolph A, Drory V, Hardiman O et al (2015) A revision of the El Escorial criteria \u2013 2015. Amyotroph Lateral Scler Frontotemporal Degener. doi:10.3109\/21678421.2015.1049183 (Epub ahead of print)","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"30_CR38","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/21678421.2014.959451","volume":"16","author":"D Lule","year":"2015","unstructured":"Lule D, Burkhardt C, Abdulla S et al (2015) The edinburgh cognitive and Behavioural Amyotrophic lateral sclerosis screen: a cross-sectional comparison of established screening tools in a German-Swiss population. Amyotroph Lateral Scler Frontotemporal Degener 16:16\u201323","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"30_CR39","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00415-005-0907-8","volume":"252","author":"D Lule","year":"2005","unstructured":"Lule D, Kurt A, Jurgens R et al (2005) Emotional responding in amyotrophic lateral sclerosis. J Neurol 252:1517\u20131524","journal-title":"J Neurol"},{"key":"30_CR40","doi-asserted-by":"crossref","unstructured":"Maruyama H, Morino H, Ito H et al (2010) Mutations of optineurin in amyotrophic lateral sclerosis. Nature 465:223\u2013226","DOI":"10.1038\/nature08971"},{"key":"30_CR41","first-page":"284","volume":"96","author":"JR Mendell","year":"1971","unstructured":"Mendell JR, Chase TN, Engel WK (1971) Amyotrophic lateral sclerosis: metabolism of central monoamines and treatment with L-dopa. Trans Am Neurol Assoc 96:284\u2013286","journal-title":"Trans Am Neurol Assoc"},{"key":"30_CR42","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","volume":"314","author":"M Neumann","year":"2006","unstructured":"Neumann M, Sampathu DM, Kwong LK et al (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314:130\u2013133","journal-title":"Science"},{"key":"30_CR43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/14660820500514974","volume":"7","author":"S Piepers","year":"2006","unstructured":"Piepers S, Van Den Berg JP, Kalmijn S et al (2006) Effect of non-invasive ventilation on survival, quality of life, respiratory function and cognition: a review of the literature. Amyotroph Lateral Scler 7:195\u2013200","journal-title":"Amyotroph Lateral Scler"},{"key":"30_CR44","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/mds.22762","volume":"24","author":"PF Pradat","year":"2009","unstructured":"Pradat PF, Bruneteau G, Munerati E et al (2009) Extrapyramidal stiffness in patients with amyotrophic lateral sclerosis. Mov Disord 24:2143\u20132148","journal-title":"Mov Disord"},{"issue":"Pt B","key":"30_CR45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.expneurol.2014.07.021","volume":"262","author":"J Ravits","year":"2014","unstructured":"Ravits J (2014) Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis. Exp Neurol 262(Pt B):121\u2013126","journal-title":"Exp Neurol"},{"key":"30_CR46","doi-asserted-by":"crossref","unstructured":"Renton AE, Majounie E, Waite A et al (2011) A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 72:257\u2013268","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"30_CR47","doi-asserted-by":"crossref","unstructured":"Rosen DR, Siddique T, Patterson D et al (1993) Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362:59\u201362","DOI":"10.1038\/362059a0"},{"key":"30_CR48","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/s00415-005-0739-6","volume":"252","author":"H Schreiber","year":"2005","unstructured":"Schreiber H, Gaigalat T, Wiedemuth-Catrinescu U et al (2005) Cognitive function in bulbar- and spinal-onset amyotrophic lateral sclerosis. A longitudinal study in 52 patients. J Neurol 252:772\u2013781","journal-title":"J Neurol"},{"key":"30_CR49","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s13311-015-0338-x","volume":"12","author":"EL Scotter","year":"2015","unstructured":"Scotter EL, Chen HJ, Shaw CE (2015) TDP-43 Proteinopathy and ALS: insights into disease mechanisms and therapeutic targets. Neurotherapeutics 12:352\u2013363","journal-title":"Neurotherapeutics"},{"key":"30_CR50","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ana.410380109","volume":"38","author":"S Shaunak","year":"1995","unstructured":"Shaunak S, Orrell RW, O\u2019sullivan E et al (1995) Oculomotor function in amyotrophic lateral sclerosis: evidence for frontal impairment. Ann Neurol 38:38\u201344","journal-title":"Ann Neurol"},{"key":"30_CR51","doi-asserted-by":"crossref","unstructured":"Sreedharan J, Blair IP, Tripathi VB et al (2008) TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science 319:1668\u20131672","DOI":"10.1126\/science.1154584"},{"key":"30_CR52","doi-asserted-by":"crossref","first-page":"13171","DOI":"10.1074\/jbc.M110.197483","volume":"286","author":"H Suzuki","year":"2011","unstructured":"Suzuki H, Lee K, Matsuoka M (2011) TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage. J Biol Chem 286:13171\u201313183","journal-title":"J Biol Chem"},{"key":"30_CR53","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/s00415-015-7672-0","volume":"262","author":"A Truini","year":"2015","unstructured":"Truini A, Biasiotta A, Onesti E et al (2015) Small-fibre neuropathy related to bulbar and spinal-onset in patients with ALS. J Neurol 262:1014\u20131018","journal-title":"J Neurol"},{"key":"30_CR54","doi-asserted-by":"crossref","first-page":"e93932","DOI":"10.1371\/journal.pone.0093932","volume":"9","author":"H Uenal","year":"2014","unstructured":"Uenal H, Rosenbohm A, Kufeldt J et al (2014) Incidence and geographical variation of amyotrophic lateral sclerosis (ALS) in Southern Germany \u2013 completeness of the ALS registry Swabia. PloS One 9:e93932","journal-title":"PloS One"},{"key":"30_CR55","doi-asserted-by":"crossref","unstructured":"Vance C, Rogelj B, Hortobagyi T et al (2009) Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type\u00a06. Science 323:1208\u20131211","DOI":"10.1126\/science.1165942"},{"key":"30_CR56","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3109\/07853890.2012.665471","volume":"44","author":"T Langenhove Van","year":"2012","unstructured":"Van Langenhove T, Van Der Zee J, Van Broeckhoven C (2012) The molecular basis of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum. Ann Med 44:817\u2013828","journal-title":"Ann Med"},{"key":"30_CR57","doi-asserted-by":"crossref","first-page":"15024","DOI":"10.1073\/pnas.1206362109","volume":"109","author":"IF Wang","year":"2012","unstructured":"Wang IF, Guo BS, Liu YC et al (2012) Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. Proc Natl Acad Sci U S A 109:15024\u201315029","journal-title":"Proc Natl Acad Sci U S A"},{"key":"30_CR58","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1212\/WNL.0b013e31821e553a","volume":"76","author":"J Weis","year":"2011","unstructured":"Weis J, Katona I, Muller-Newen G et al (2011) Small-fiber neuropathy in patients with ALS. Neurology 76:2024\u20132029","journal-title":"Neurology"},{"key":"30_CR59","doi-asserted-by":"crossref","first-page":"e15878","DOI":"10.1371\/journal.pone.0015878","volume":"5","author":"C Yang","year":"2010","unstructured":"Yang C, Tan W, Whittle C et al (2010) The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism. PloS One 5:e15878","journal-title":"PloS One"},{"key":"30_CR60","doi-asserted-by":"crossref","first-page":"230578","DOI":"10.1155\/2014\/230578","volume":"2014","author":"K Yoshizawa","year":"2014","unstructured":"Yoshizawa K, Yasuda N, Fukuda M et al (2014) Syntactic comprehension in patients with amyotrophic lateral sclerosis. Behav Neurol 2014:230578","journal-title":"Behav Neurol"}],"container-title":["Der Nervenarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-015-0030-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00115-015-0030-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-015-0030-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T05:15:03Z","timestamp":1558588503000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00115-015-0030-8"}},"subtitle":["Eine Multisystemdegeneration","Multisystem degeneration"],"short-title":[],"issued":{"date-parts":[[2015,12,8]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["30"],"URL":"https:\/\/doi.org\/10.1007\/s00115-015-0030-8","relation":{},"ISSN":["0028-2804","1433-0407"],"issn-type":[{"value":"0028-2804","type":"print"},{"value":"1433-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,8]]}}}