{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:37:17Z","timestamp":1767911837610,"version":"3.49.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T00:00:00Z","timestamp":1442620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00115-015-4407-5","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T11:05:02Z","timestamp":1442487902000},"page":"1248-1254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Zerebrale Amyloidangiopathie und Demenz","Cerebral amyloid angiopathy and dementia"],"prefix":"10.1007","volume":"86","author":[{"given":"P.","family":"Berlit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Keyvani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kr\u00e4mer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,9,19]]},"reference":[{"key":"4407_CR1","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1161\/01.STR.0000131809.35202.1b","volume":"35","author":"Jeerakathil","year":"2004","unstructured":"Jeerakathil T, Wolf PA, Beiser A et al (2004) Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study. Stroke 35:1831","journal-title":"Stroke"},{"key":"4407_CR2","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/jnnp.2007.121913","volume":"79","author":"Sveinbjornsdottir","year":"2008","unstructured":"Sveinbjornsdottir S, Sigurdsson S, Aspelund T et al (2008) Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and location. J Neurol Neurosurg Psychiatry 79:1002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4407_CR3","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/01.wnl.0000307750.41970.d9","volume":"70","author":"Vernooij","year":"2008","unstructured":"Vernooij MW, Lugt A van der, Ikram MA et al (2008) Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 70:1208","journal-title":"Neurology"},{"key":"4407_CR4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11883-012-0254-z","volume":"14","author":"Auriel","year":"2012","unstructured":"Auriel E, Greenberg SM (2012) The pathophysiology and clinical presentation of cerebral amyloid angiopathy. Curr Atheroscler Rep 14:343\u2013350","journal-title":"Curr Atheroscler Rep"},{"key":"4407_CR5","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1212\/WNL.46.6.1592","volume":"46","author":"Ellis","year":"1996","unstructured":"Ellis RJ, Olichney JM, Thal LJ et al (1996) Cerebral amyloid angiopathy in the brains of patients with Alzheimer\u2019s disease: the CERAD experience, Part XV. Neurology 46:1592","journal-title":"Neurology"},{"key":"4407_CR6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1212\/WNL.0b013e3182452928","volume":"78","author":"Poels","year":"2012","unstructured":"Poels MM, Ikram MA, Lugt A van der et al (2012) Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology 78:326","journal-title":"Neurology"},{"key":"4407_CR7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ana.23566","volume":"72","author":"Dumas","year":"2012","unstructured":"Dumas A, Dierksen GA, Gurol ME et al (2012) Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy. Ann Neurol 72:76","journal-title":"Ann Neurol"},{"key":"4407_CR8","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1212\/01.wnl.0000435291.49598.54","volume":"81","author":"Peca","year":"2013","unstructured":"Peca S, McCreary CR, Donaldson E et al (2013) Neurovascular decoupling is associated with severity of cerebral amyloid angiopathy. Neurology 81:1659","journal-title":"Neurology"},{"key":"4407_CR9","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.HYP.31.6.1223","volume":"31","author":"Thrift","year":"1998","unstructured":"Thrift AG, McNeil JJ, Forbes A, Donnan GA (1998) Three important subgroups of hypertensive persons at greater risk of intracerebral hemorrhage. Hypertension 31:1223\u20131229","journal-title":"Hypertension"},{"key":"4407_CR10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/ana.20596","volume":"58","author":"Rosand","year":"2005","unstructured":"Rosand J, Muzikansky A, Kumar A et al (2005) Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Ann Neurol 58:459","journal-title":"Ann Neurol"},{"key":"4407_CR11","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1161\/01.STR.28.7.1418","volume":"28","author":"Greenberg","year":"1997","unstructured":"Greenberg SM, Vonsattel JP (1997) Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy. Stroke 28:1418","journal-title":"Stroke"},{"key":"4407_CR12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1055\/s-2006-944313","volume":"75","author":"Koennecke","year":"2007","unstructured":"Koennecke H-C, Kauert A (2007) Intrazerebrale Blutungen. Fortschr Neurol Psychiatr 75:107\u2013122","journal-title":"Fortschr Neurol Psychiatr"},{"key":"4407_CR13","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1212\/WNL.55.7.947","volume":"55","author":"Rosand","year":"2000","unstructured":"Rosand J, Hylek EM, O\u2019Donnell HC, Greenberg SM (2000) Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study. Neurology 55:947","journal-title":"Neurology"},{"key":"4407_CR14","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S1474-4422(04)00825-7","volume":"3","author":"McCarron","year":"2004","unstructured":"McCarron MO, Nicoll JA (2004) Cerebral amyloid angiopathy and thrombolysis related intracerebral haemorrhage. Lancet Neurol 3:484\u2013492","journal-title":"Lancet Neurol"},{"key":"4407_CR15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1212\/WNL.45.4.649","volume":"45","author":"Sloan","year":"1995","unstructured":"Sloan MA, Price TR, Petito CK et al (1995) Clinical features and pathogenesis of intracerebral hemorrhage after rt-PA and heparin therapy for acute myocardial infarction: the Thrombolysis in Myocardial Infarction (TIMI) II Pilot and Randomized Clinical Trial combined experience. Neurology 45:649","journal-title":"Neurology"},{"key":"4407_CR16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/neup.12152","volume":"35","author":"Mattila","year":"2015","unstructured":"Mattila OS, Sairanen T, Laakso E et al (2015) Cerebral amyloid angiopathy related hemorrhage after stroke thrombolysis: case report and literature review. Neuropathology 35:70\u201374","journal-title":"Neuropathology"},{"key":"4407_CR17","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/ana.22072","volume":"68","author":"Ly","year":"2010","unstructured":"Ly JV, Rowe CC, Villemagne VL et al (2010) Cerebral beta-amyloid detected by predisposes to recombinant tissue plasminogen activator-related hemorrhage. Ann Neurol 68:959\u2013962","journal-title":"Ann Neurol"},{"key":"4407_CR18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/jnnp-2012-303379","volume":"84","author":"Charidimou","year":"2013","unstructured":"Charidimou A, Kakar P, Fox Z, Werring DJ (2013) Cerebral microbleeds and the risk of intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry 84:277\u2013280","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"4407_CR19","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1212\/WNL.0b013e3181eee40f","volume":"75","author":"Biffi","year":"2010","unstructured":"Biffi A, Halpin A, Towfighi A et al (2010) Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy. Neurology 75:693","journal-title":"Neurology"},{"key":"4407_CR20","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archneurol.2009.42","volume":"66","author":"Vernooij","year":"2009","unstructured":"Vernooij MW, Haag MD, Lugt A van der et al (2009) Use of antithrombotic drugs and the presence of cerebral microbleeds: the Rotterdam Scan Study. Arch Neurol 66:714\u2013720","journal-title":"Arch Neurol"},{"key":"4407_CR21","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1161\/STROKEAHA.109.576975","volume":"41","author":"Thoonsen","year":"2010","unstructured":"Thoonsen H, Richard E, Bentham P et al (2010) Aspirin in Alzheimer\u2019s disease: increased risk of intracerebral hemorrhage: cause for concern? Stroke 41:2690\u20132692","journal-title":"Stroke"},{"key":"4407_CR22","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1161\/STROKEAHA.113.002267","volume":"44","author":"Cheng","year":"2013","unstructured":"Cheng AL, Batool S, McCreary CR et al (2013) Susceptibility-weighted imaging is more reliable than T2*-weighted gradient-recalled echo MRI for detecting microbleeds. Stroke 44(10):2782","journal-title":"Stroke"},{"key":"4407_CR23","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1212\/WNL.0b013e3181dad605","volume":"74","author":"Linn","year":"2010","unstructured":"Linn J, Halpin A, Demaerel P et al (2010) Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. Neurology 74:1346","journal-title":"Neurology"},{"key":"4407_CR24","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1161\/STROKEAHA.112.657759","volume":"43","author":"Charidimou","year":"2012","unstructured":"Charidimou A, Peeters A, Fox Z et al (2012) Spectrum of transient focal neurological episodes in cerebral amyloid angiopathy: multicentre magnetic resonance imaging cohort study and meta-analysis. Stroke 43:2324","journal-title":"Stroke"},{"key":"4407_CR25","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1212\/WNL.0b013e3182a08f2c","volume":"81","author":"Charidimou","year":"2013","unstructured":"Charidimou A, J\u00e4ger RH, Fox Z et al (2013) Prevalence and mechanisms of cortical superficial siderosis in cerebral amyloid angiopathy. Neurology 81:626","journal-title":"Neurology"},{"key":"4407_CR26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1212\/WNL.0b013e318227b250","volume":"77","author":"Hermann","year":"2011","unstructured":"Hermann DM, Keyvani K, Nes J van de et al (2011) Brain-reactive \u03b2-amyloid antibodies in primary CNS angiitis with cerebral amyloid angiopathy. Neurology 77:503","journal-title":"Neurology"},{"key":"4407_CR27","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ana.23857","volume":"73","author":"Piazza","year":"2013","unstructured":"Piazza F, Greenberg SM, Savoiardo M et al (2013) Anti-amyloid \u03b2 autoantibodies in cerebral amyloid angiopathy-related inflammation: implications for amyloid-modifying therapies. Ann Neurol 73:449","journal-title":"Ann Neurol"},{"key":"4407_CR28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.semarthrit.2014.02.001","volume":"44","author":"Danve","year":"2014","unstructured":"Danve A, Grafe M, Deodhar A (2014) Amyloid beta-related angiitis--a case report and comprehensive review of literature of 94 cases. Semin Arthritis Rheum 44:86\u201392","journal-title":"Semin Arthritis Rheum"},{"key":"4407_CR29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1468-1331.2009.02940.x","volume":"17","author":"Hirohata","year":"2010","unstructured":"Hirohata M, Yoshita M, Ishida C et al (2010) Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy. Eur J Neurol 17:823\u2013829","journal-title":"Eur J Neurol"},{"key":"4407_CR30","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(13)60986-1","volume":"382","author":"Mendelow","year":"2013","unstructured":"Mendelow AD, Gregson BA, Rowan EN et al (2013) Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial. Lancet 382:397\u2013408","journal-title":"Lancet"},{"key":"4407_CR31","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1161\/STROKEAHA.114.005151","volume":"45","author":"Etten","year":"2014","unstructured":"Etten ES van, Auriel E, Haley KE et al (2014) Incidence of symptomatic hemorrhage in patients with lobar microbleeds. Stroke 45:2280\u20132285","journal-title":"Stroke"},{"key":"4407_CR32","doi-asserted-by":"crossref","unstructured":"Hofmeijer J, Kappelle LJ, Klijn CJ (2015) Antithrombotic treatment and intracerebral haemorrhage: between Scylla and Charybdis. Pract Neurol. pii: practneurol-2015-001104. doi:10.1136\/practneurol-2015-001104","DOI":"10.1136\/practneurol-2015-001104"},{"key":"4407_CR33","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/STROKEAHA.114.004130","volume":"45","author":"Romero","year":"2014","unstructured":"Romero JR, Preis SR, Beiser A et al (2014) Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the Framingham Heart Study. Stroke 45:1492\u20131494","journal-title":"Stroke"},{"key":"4407_CR34","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1161\/STROKEAHA.112.657486","volume":"43","author":"Haussen","year":"2012","unstructured":"Haussen DC, Henninger N, Kumar S, Selim M (2012) Statin use and microbleeds in patients with spontaneous intracerebral hemorrhage. Stroke 43(10):2677\u20132681","journal-title":"Stroke"},{"key":"4407_CR35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJM200001273420403","volume":"342","author":"O","year":"2000","unstructured":"O\u2019Donnell HC, Rosand J, Knudsen KA et al (2000) Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. N Engl J Med 342:240","journal-title":"N Engl J Med"},{"key":"4407_CR36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1212\/WNL.0b013e31826043a9","volume":"79","author":"Gurol","year":"2012","unstructured":"Gurol ME, Dierksen G, Betensky R et al (2012) Predicting sites of new hemorrhage with amyloid imaging in cerebral amyloid angiopathy. Neurology 79:320\u2013326","journal-title":"Neurology"},{"key":"4407_CR37","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1212\/WNL.0b013e3182a9f545","volume":"81","author":"Salvarani","year":"2013","unstructured":"Salvarani C, Hunder GG, Morris JM et al (2013) A\u03b2-related angiitis: comparison with CAA without inflammation and primary CNS vasculitis. Neurology 81:1596\u20131603","journal-title":"Neurology"}],"container-title":["Der Nervenarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-015-4407-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00115-015-4407-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-015-4407-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T05:15:06Z","timestamp":1558588506000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00115-015-4407-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,19]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["4407"],"URL":"https:\/\/doi.org\/10.1007\/s00115-015-4407-5","relation":{},"ISSN":["0028-2804","1433-0407"],"issn-type":[{"value":"0028-2804","type":"print"},{"value":"1433-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,19]]}}}