{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:13:43Z","timestamp":1786979623245,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s00115-017-0300-8","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T09:48:36Z","timestamp":1489398516000},"page":"451-458","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neurobiologische Grundlagen der Sexualit\u00e4t und ihrer Probleme","Neurobiological foundations underlying normal and disturbed sexuality"],"prefix":"10.1007","volume":"88","author":[{"given":"T. H. C.","family":"Kr\u00fcger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kneer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"300_CR1","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1038\/npp.2011.66","volume":"36","author":"B Abler","year":"2011","unstructured":"Abler B, Seeringer A, Hartmann A et al (2011) Neural correlates of antidepressant-related sexual dysfunction: A\u00a0placebo-controlled fMRI study on healthy males under subchronic paroxetine and bupropion. Neuropsychopharmacology 36:1837\u20131847","journal-title":"Neuropsychopharmacology"},{"key":"300_CR2","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.neuroscience.2008.09.044","volume":"158","author":"B Arnow","year":"2009","unstructured":"Arnow B, Millheiser L, Garrett A et\u00a0al (2009) Women with hypoactive sexual desire disorder compared to normal females: a\u00a0functional magnetic resonance imaging study. Neuroscience 158:484\u2013502","journal-title":"Neuroscience"},{"key":"300_CR3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.tins.2006.03.004","volume":"29","author":"J Balthazart","year":"2006","unstructured":"Balthazart J, Ball GF (2006) Is brain estradiol a\u00a0hormone or a\u00a0neurotransmitter? Trends Neurosci 29:241\u2013249","journal-title":"Trends Neurosci."},{"key":"300_CR4","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0149-7634(00)00024-5","volume":"24","author":"J Bancroft","year":"2000","unstructured":"Bancroft J, Janssen E (2000) The dual control model of male sexual response: a theoretical approach to centrally mediated erectile dysfunction. Neurosci Biobehav Rev 24:571\u2013579","journal-title":"Neurosci Biobehav Rev"},{"key":"300_CR5","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1111\/j.1743-6109.2011.02376.x","volume":"8","author":"F Bianchi-Demicheli","year":"2011","unstructured":"Bianchi-Demicheli F, Cojan Y, Waber L et al (2011) Neural bases of hypoactive sexual desire disorder in women: an event-related fMRI study. J\u00a0Sex Med 8:2546\u20132559","journal-title":"J Sex Med"},{"key":"300_CR6","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1161\/HYPERTENSIONAHA.116.08188","volume":"68","author":"AH Boal","year":"2016","unstructured":"Boal AH, Smith DJ, Mccallum L et\u00a0al (2016) Monotherapy with major antihypertensive drug classes and risk of hospital admissions for mood disordersnovelty and significance. Hypertension 68:1132\u20131138","journal-title":"Hypertension"},{"key":"300_CR7","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1530\/REP-10-0033","volume":"140","author":"M Egli","year":"2010","unstructured":"Egli M, Leeners B, Kr\u00fcger TH (2010) Prolactin secretion patterns: basic mechanisms and clinical implications for reproduction. Reproduction 140:643\u2013654","journal-title":"Reproduction"},{"key":"300_CR8","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1056\/NEJMoa1206168","volume":"369","author":"JS Finkelstein","year":"2013","unstructured":"Finkelstein JS, Lee H, Burnett-Bowie SA et al (2013) Gonadal steroids and body composition, strength, and sexual function in men. N\u00a0Engl J Med 369:1011\u20131022","journal-title":"N Engl J Med"},{"key":"300_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.pneurobio.2012.05.004","volume":"98","author":"J Georgiadis","year":"2012","unstructured":"Georgiadis J, Kringelbach ML (2012) The human sexual response cycle: Brain imaging evidence linking sex to other pleasures. Prog Neurobiol 98:49\u201381","journal-title":"Prog. Neurobiol."},{"key":"300_CR10","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1007\/s10508-016-0768-5","volume":"45","author":"A Guillamon","year":"2016","unstructured":"Guillamon A, Junque C, G\u00f3mez-Gil E (2016) A review of the status of brain structure research in transsexualism. Arch Sex Behav 45:1615\u20131648","journal-title":"Arch Sex Behav"},{"key":"300_CR11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/070674370304800411","volume":"48","author":"P Haake","year":"2003","unstructured":"Haake P, Schedlowski M, Exton MS et\u00a0al (2003) Acute neuroendocrine response to sexual stimulation in sexual offenders. Can J Psychiatry 48:265\u2013271","journal-title":"Can J Psychiatry"},{"key":"300_CR12","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1001\/jamainternmed.2015.8565","volume":"176","author":"L Jaspers","year":"2016","unstructured":"Jaspers L, Feys F, Bramer WM et al (2016) Efficacy and safety of flibanserin for the treatment of hypoactive sexual desire disorder in women: a systematic review and meta-analysis. JAMA Intern Med 176:453\u2013462","journal-title":"JAMA Intern Med"},{"key":"300_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1177\/0269881115609072","volume":"30","author":"S K\u00f6hler","year":"2016","unstructured":"K\u00f6hler S, Cierpinsky K, Kronenberg G et\u00a0al (2016) The serotonergic system in the neurobiology of depression: relevance for novel antidepressants. J\u00a0Psychopharmacol (Oxford) 30:13\u201322","journal-title":"J Psychopharmacol. (Oxford)"},{"key":"300_CR14","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1677\/joe.0.1770057","volume":"177","author":"TH Kr\u00fcger","year":"2003","unstructured":"Kr\u00fcger TH, Haake P, Chereath D et\u00a0al (2003) Specificity of the neuroendocrine response to orgasm during sexual arousal in men. J\u00a0Endocrinol 177:57\u201364","journal-title":"J Endocrinol"},{"key":"300_CR15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0149-7634(01)00036-7","volume":"26","author":"TH Kr\u00fcger","year":"2002","unstructured":"Kr\u00fcger TH, Haake P, Hartmann U et al (2002) Orgasm-induced prolactin secretion: Feedback control of sexual drive? Neurosci Biobehav Rev 26:31\u201344","journal-title":"Neurosci Biobehav Rev"},{"key":"300_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1677\/joe.0.1790357","volume":"179","author":"TH Kruger","year":"2003","unstructured":"Kruger TH, Haake P, Haverkamp J et\u00a0al (2003) Effects of acute prolactin manipulation on sexual drive and function in males. J\u00a0Endocrinol 179:357\u2013365","journal-title":"J Endocrinol"},{"key":"300_CR17","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.1111\/j.1460-9568.2006.05215.x","volume":"24","author":"TH Kr\u00fcger","year":"2006","unstructured":"Kr\u00fcger TH, Schiffer B, Eikermann M et\u00a0al (2006) Serial neurochemical measurement of cerebrospinal fluid during the human sexual response cycle. Eur J Neurosci 24:3445\u20133452","journal-title":"Eur J Neurosci"},{"key":"300_CR18","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1743-6109.2012.02824.x","volume":"10","author":"CG McMahon","year":"2013","unstructured":"McMahon CG, Jannini E, Waldinger M et\u00a0al (2013) Standard operating procedures in the disorders of orgasm and ejaculation. J\u00a0Sex Med 10:204\u2013229","journal-title":"J Sex Med"},{"key":"300_CR19","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nrn3044","volume":"12","author":"A Meyer-Lindenberg","year":"2011","unstructured":"Meyer-Lindenberg A, Domes G, Kirsch P et al (2011) Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci 12:524\u2013538","journal-title":"Nat Rev Neurosci"},{"key":"300_CR20","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1177\/0306624X10392191","volume":"56","author":"V Moulier","year":"2012","unstructured":"Moulier V, Fonteille V, Pelegrini-Issac M et al (2012) A pilot study of the effects of gonadotropin-releasing hormone agonist therapy on brain activation pattern in a\u00a0man with pedophilia. Int J Offender Ther Comp Criminol 56:50\u201360","journal-title":"Int J Offender Ther Comp Criminol"},{"key":"300_CR21","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/hbm.20435","volume":"29","author":"T Paul","year":"2008","unstructured":"Paul T, Schiffer B, Zwarg T et\u00a0al (2008) Brain response to visual sexual stimuli in heterosexual and homosexual males. Hum Brain Mapp 29:726\u2013735","journal-title":"Hum Brain Mapp"},{"key":"300_CR22","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1017\/S1092852915000486","volume":"21","author":"AL Pehrson","year":"2016","unstructured":"Pehrson AL, Jeyarajah T, Sanchez C (2016) Regional distribution of serotonergic receptors: a\u00a0systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS Spectr 21:162\u2013183","journal-title":"CNS Spectr"},{"key":"300_CR23","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1111\/j.1743-6109.2009.01309.x","volume":"6","author":"JG Pfaus","year":"2009","unstructured":"Pfaus JG (2009) Pathways of sexual desire. J\u00a0Sex Med 6:1506\u20131533","journal-title":"J Sex Med"},{"key":"300_CR24","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1002\/hbm.22262","volume":"35","author":"TB Poeppl","year":"2014","unstructured":"Poeppl TB, Langguth B, Laird AR et al (2014) The functional neuroanatomy of male psychosexual and physiosexual arousal: a quantitative meta-analysis. Hum Brain Mapp 35:1404\u20131421","journal-title":"Hum Brain Mapp"},{"key":"300_CR25","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.neuroimage.2006.08.002","volume":"33","author":"J Ponseti","year":"2006","unstructured":"Ponseti J, Bosinski HA, Wolff S et\u00a0al (2006) A functional endophenotype for sexual orientation in humans. Neuroimage 33:825\u2013833","journal-title":"Neuroimage"},{"key":"300_CR26","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1001\/archgenpsychiatry.2011.130","volume":"69","author":"J Ponseti","year":"2012","unstructured":"Ponseti J, Granert O, Jansen O et\u00a0al (2012) Assessment of pedophilia using hemodynamic brain response to sexual stimuli. Arch Gen Psychiatry 69:187\u2013194","journal-title":"Arch Gen Psychiatry"},{"key":"300_CR27","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/1097-0193(200011)11:3<162::AID-HBM30>3.0.CO;2-A","volume":"11","author":"J Redout\u00e9","year":"2000","unstructured":"Redout\u00e9 J, Stol\u00e9ru S, Gr\u00e9goire MC et\u00a0al (2000) Brain processing of visual sexual stimuli in human males. Hum Brain Mapp 11:162\u2013177","journal-title":"Hum Brain Mapp"},{"key":"300_CR28","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1111\/j.1743-6109.2008.01094.x","volume":"6","author":"B Schiffer","year":"2009","unstructured":"Schiffer B, Gizewski E, Kruger T (2009) Reduced neuronal responsiveness to visual sexual stimuli in a\u00a0pedophile treated with a\u00a0long-acting LH-RH agonist. J\u00a0Sex Med 6:892\u2013894","journal-title":"J Sex Med"},{"key":"300_CR29","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/JCP.0b013e3181a5233f","volume":"29","author":"A Serretti","year":"2009","unstructured":"Serretti A, Chiesa A (2009) Treatment-emergent sexual dysfunction related to antidepressants: a\u00a0meta-analysis. J\u00a0Clin Psychopharmacol 29:259\u2013266","journal-title":"J Clin Psychopharmacol"},{"key":"300_CR30","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0925-4927(03)00068-4","volume":"124","author":"S Stol\u00e9ru","year":"2003","unstructured":"Stol\u00e9ru S, Redout\u00e9 J, Costes N et\u00a0al (2003) Brain processing of visual sexual stimuli in men with hypoactive sexual desire disorder. Psychiatry Res 124:67\u201386","journal-title":"Psychiatry Res"},{"key":"300_CR31","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.neuroimage.2008.01.040","volume":"40","author":"M Walter","year":"2008","unstructured":"Walter M, Bermpohl F, Mouras H et\u00a0al (2008) Distinguishing specific sexual and general emotional effects in fMRI \u2013 subcortical and cortical arousal during erotic picture viewing. Neuroimage 40:1482\u20131494","journal-title":"Neuroimage"},{"key":"300_CR32","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1212\/WNL.0b013e31827b915c","volume":"80","author":"D Weintraub","year":"2013","unstructured":"Weintraub D, Papay K, Siderowf A et al (2013) Screening for impulse control symptoms in patients with de novo Parkinson disease: a\u00a0case-control study. Neurology 80:176\u2013180","journal-title":"Neurology"},{"key":"300_CR33","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.fertnstert.2013.05.041","volume":"100","author":"TL Woodard","year":"2013","unstructured":"Woodard TL, Nowak NT, Balon R et al (2013) Brain activation patterns in women with acquired hypoactive sexual desire disorder and women with normal sexual function: a\u00a0cross-sectional pilot study. Fertil Steril 100:1068\u20131076","journal-title":"Fertil Steril"},{"key":"300_CR34","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/378068a0","volume":"378","author":"J-N Zhou","year":"1995","unstructured":"Zhou J\u2011N, Hofman MA, Gooren LJ et al (1995) A sex difference in the human brain and its relation to transsexuality. Nature 378:68\u201370","journal-title":"Nature"}],"container-title":["Der Nervenarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00115-017-0300-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-017-0300-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-017-0300-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T13:23:50Z","timestamp":1568899430000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00115-017-0300-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,13]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["300"],"URL":"https:\/\/doi.org\/10.1007\/s00115-017-0300-8","relation":{},"ISSN":["0028-2804","1433-0407"],"issn-type":[{"value":"0028-2804","type":"print"},{"value":"1433-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,13]]}}}