{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T13:28:55Z","timestamp":1749475735296},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00115-018-0586-1","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T13:41:36Z","timestamp":1535031696000},"page":"1131-1139","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuronale Plastizit\u00e4t und Neuromodulation in der Kinderneurologie"],"prefix":"10.1007","volume":"89","author":[{"given":"N. H.","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"M\u00fcnchau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Mall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"586_CR1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1146\/annurev.neuro.051508.135516","volume":"32","author":"DE Feldman","year":"2009","unstructured":"Feldman DE (2009) Synaptic mechanisms for plasticity in neocortex. Annu Rev Neurosci 32:33\u201355","journal-title":"Annu Rev Neurosci"},{"issue":"2","key":"586_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1113\/jphysiol.1973.sp010273","volume":"232","author":"TV Bliss","year":"1973","unstructured":"Bliss TV, Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J\u00a0Physiol (Lond) 232(2):331\u2013356","journal-title":"J Physiol (Lond)"},{"issue":"1","key":"586_CR3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ejpn.2016.07.007","volume":"21","author":"FY Ismail","year":"2017","unstructured":"Ismail FY, Fatemi A, Johnston MV (2017) Cerebral plasticity: windows of opportunity in the developing brain. Eur J Paediatr Neurol 21(1):23\u201348","journal-title":"Eur J Paediatr Neurol"},{"issue":"2","key":"586_CR4","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1055\/s-2004-815834","volume":"35","author":"V Mall","year":"2004","unstructured":"Mall V, Berweck S, Fietzek UM, Glocker FX, Oberhuber U, Walther M et\u00a0al (2004) Low level of intracortical inhibition in children shown by transcranial magnetic stimulation. Neuropediatrics 35(2):120\u2013125","journal-title":"Neuropediatrics"},{"issue":"10","key":"586_CR5","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00702-016-1609-3","volume":"123","author":"F Mainberger","year":"2016","unstructured":"Mainberger F, Langer S, Mall V, Jung NH (2016) Impaired synaptic plasticity in RASopathies: a\u00a0mini-review. J\u00a0Neural Transm 123(10):1133\u20131138","journal-title":"J Neural Transm"},{"issue":"6","key":"586_CR6","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.clinph.2015.02.001","volume":"126","author":"PM Rossini","year":"2015","unstructured":"Rossini PM, Burke D, Chen R, Cohen LG, Daskalakis Z, Di Iorio R et al (2015) Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee. Clin Neurophysiol 126(6):1071\u20131107","journal-title":"Clin Neurophysiol"},{"issue":"11","key":"586_CR7","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1016\/j.clinph.2017.09.007","volume":"128","author":"YZ Huang","year":"2017","unstructured":"Huang YZ, Lu MK, Antal A, Classen J, Nitsche M, Ziemann U et al (2017) Plasticity induced by non-invasive transcranial brain stimulation: a position paper. Clin Neurophysiol 128(11):2318\u20132329","journal-title":"Clin Neurophysiol"},{"issue":"2","key":"586_CR8","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.neuron.2004.12.033","volume":"45","author":"YZ Huang","year":"2005","unstructured":"Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC (2005) Theta burst stimulation of the human motor cortex. Neuron 45(2):201\u2013206","journal-title":"Neuron"},{"issue":"Pt 3","key":"586_CR9","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1093\/brain\/123.3.572","volume":"123","author":"K Stefan","year":"2000","unstructured":"Stefan K, Kunesch E, Cohen LG, Benecke R, Classen J (2000) Induction of plasticity in the human motor cortex by paired associative stimulation. Brain 123(Pt 3):572\u2013584","journal-title":"Brain"},{"issue":"12","key":"586_CR10","doi-asserted-by":"publisher","first-page":"e0168410","DOI":"10.1371\/journal.pone.0168410","volume":"11","author":"NH Jung","year":"2016","unstructured":"Jung NH, Gleich B, Gattinger N, Hoess C, Haug C, Siebner HR et al (2016) Quadri-pulse theta burst stimulation using ultra-high frequency bursts \u2013 A new protocol to induce changes in cortico-spinal excitability in human motor cortex. PLoS ONE 11(12):e168410","journal-title":"PLoS ONE"},{"key":"586_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.pediatrneurol.2016.12.009","volume":"68","author":"CH Allen","year":"2017","unstructured":"Allen CH, Kluger BM, Buard I (2017) Safety of transcranial magnetic stimulation in children: a systematic review of the literature. Pediatr Neurol 68:3\u201317","journal-title":"Pediatr Neurol"},{"issue":"12","key":"586_CR12","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/j.clinph.2009.08.016","volume":"120","author":"S Rossi","year":"2009","unstructured":"Rossi S, Hallett M, Rossini PM, Pascual-Leone A (2009) Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol 120(12):2008\u20132039","journal-title":"Clin Neurophysiol"},{"issue":"10","key":"586_CR13","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1111\/dmcn.12209","volume":"55","author":"H Juenger","year":"2013","unstructured":"Juenger H, Kuhnke N, Braun C, Ummenhofer F, Wilke M, Walther M et al (2013) Two types of exercise-induced neuroplasticity in congenital hemiparesis: a\u00a0transcranial magnetic stimulation, functional MRI, and magnetoencephalography study. Dev Med Child Neurol 55(10):941\u2013951","journal-title":"Dev Med Child Neurol"},{"issue":"18","key":"586_CR14","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1212\/WNL.0000000000002646","volume":"86","author":"A Kirton","year":"2016","unstructured":"Kirton A, Andersen J, Herrero M, Nettel-Aguirre A, Carsolio L, Damji O et al (2016) Brain stimulation and constraint for perinatal stroke hemiparesis: the PLASTIC CHAMPS Trial. Neurology 86(18):1659\u20131667","journal-title":"Neurology"},{"key":"586_CR15","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev-genom-091212-153523","volume":"14","author":"KA Rauen","year":"2013","unstructured":"Rauen KA (2013) The RASopathies. Annu Rev Genomics Hum Genet 14:355\u2013369","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"4","key":"586_CR16","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1097\/MOP.0b013e32834881dd","volume":"23","author":"M Zenker","year":"2011","unstructured":"Zenker M (2011) Clinical manifestations of mutations in RAS and related intracellular signal transduction factors. Curr Opin Pediatr 23(4):443\u2013451","journal-title":"Curr Opin Pediatr"},{"issue":"6871","key":"586_CR17","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/nature711","volume":"415","author":"RM Costa","year":"2002","unstructured":"Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M et\u00a0al (2002) Mechanism for the learning deficits in a\u00a0mouse model of neurofibromatosis type 1. Nature 415(6871):526\u2013530","journal-title":"Nature"},{"issue":"21","key":"586_CR18","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1016\/j.cub.2005.09.043","volume":"15","author":"W Li","year":"2005","unstructured":"Li W, Cui Y, Kushner SA, Brown RA, Jentsch JD, Frankland PW et al (2005) The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a\u00a0mouse model of neurofibromatosis type 1. Curr Biol 15(21):1961\u20131967","journal-title":"Curr Biol"},{"issue":"12","key":"586_CR19","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1038\/nn.3863","volume":"17","author":"YS Lee","year":"2014","unstructured":"Lee YS, Ehninger D, Zhou M, Oh JY, Kang M, Kwak C et\u00a0al (2014) Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nat Neurosci 17(12):1736\u20131743","journal-title":"Nat Neurosci"},{"key":"586_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/1471-2377-13-131","volume":"13","author":"F Mainberger","year":"2013","unstructured":"Mainberger F, Jung NH, Zenker M, Wahllander U, Freudenberg L, Langer S et\u00a0al (2013) Lovastatin improves impaired synaptic plasticity and phasic alertness in patients with neurofibromatosis type 1. BMC Neurol 13:131","journal-title":"BMC Neurol"},{"issue":"12","key":"586_CR21","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1016\/j.clinph.2013.04.343","volume":"124","author":"F Mainberger","year":"2013","unstructured":"Mainberger F, Zenker M, Jung NH, Delvendahl I, Brandt A, Freudenberg L et\u00a0al (2013) Impaired motor cortex plasticity in patients with Noonan syndrome. Clin Neurophysiol 124(12):2439\u20132444","journal-title":"Clin Neurophysiol"},{"key":"586_CR22","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders","author":"AP Association","year":"2013","unstructured":"Association AP (2013) Diagnostic and statistical manual of mental disorders, 5.\u00a0Aufl. American Psychiatric Association, Washington, DC.","edition":"5"},{"issue":"3","key":"586_CR23","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/aur.239","volume":"5","author":"M Elsabbagh","year":"2012","unstructured":"Elsabbagh M, Divan G, Koh YJ, Kim YS, Kauchali S, Marcin C et\u00a0al (2012) Global prevalence of autism and other pervasive developmental disorders. Autism Res 5(3):160\u2013179","journal-title":"Autism Res"},{"issue":"6","key":"586_CR24","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/ng.3303","volume":"47","author":"N Krumm","year":"2015","unstructured":"Krumm N, Turner TN, Baker C, Vives L, Mohajeri K, Witherspoon K et\u00a0al (2015) Excess of rare, inherited truncating mutations in autism. Nat Genet 47(6):582\u2013588","journal-title":"Nat Genet"},{"issue":"9","key":"586_CR25","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nrn3992","volume":"16","author":"T Bourgeron","year":"2015","unstructured":"Bourgeron T (2015) From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat Rev Neurosci 16(9):551\u2013563","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"586_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/dmcn.12012","volume":"55","author":"NH Jung","year":"2013","unstructured":"Jung NH, Janzarik WG, Delvendahl I, Munchau A, Biscaldi M, Mainberger F et al (2013) Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome. Dev Med Child Neurol 55(1):83\u201389","journal-title":"Dev Med Child Neurol"},{"issue":"Pt 9","key":"586_CR27","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1093\/brain\/awp088","volume":"132","author":"SH Mostofsky","year":"2009","unstructured":"Mostofsky SH, Powell SK, Simmonds DJ, Goldberg MC, Caffo B, Pekar JJ (2009) Decreased connectivity and cerebellar activity in autism during motor task performance. Brain 132(Pt 9):2413\u20132425","journal-title":"Brain"},{"issue":"7321","key":"586_CR28","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nature09582","volume":"468","author":"HT Chao","year":"2010","unstructured":"Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J et al (2010) Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 468(7321):263\u2013269","journal-title":"Nature"},{"issue":"7","key":"586_CR29","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00787-013-0475-x","volume":"23","author":"M Biscaldi","year":"2014","unstructured":"Biscaldi M, Rauh R, Irion L, Jung NH, Mall V, Fleischhaker C et al (2014) Deficits in motor abilities and developmental fractionation of imitation performance in high-functioning autism spectrum disorders. Eur Child Adolesc Psychiatry 23(7):599\u2013610","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"586_CR30","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013","unstructured":"American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders. American Psychiatric Association, Washington, DC"},{"issue":"2","key":"586_CR31","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0733-8619(05)70311-X","volume":"15","author":"J Jankovic","year":"1997","unstructured":"Jankovic J (1997) Tourette syndrome. Phenomenology and classification of tics. Neurol Clin 15(2):267\u2013275","journal-title":"Neurol Clin"},{"issue":"8","key":"586_CR32","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1002\/mds.23053","volume":"25","author":"J Paszek","year":"2010","unstructured":"Paszek J, Pollok B, Biermann-Ruben K, Muller-Vahl K, Roessner V, Thomalla G et al (2010) Is it a\u00a0tic? \u2013 Twenty seconds to make a\u00a0diagnosis. Mov Disord 25(8):1106\u20131108","journal-title":"Mov Disord"},{"issue":"5","key":"586_CR33","doi-asserted-by":"publisher","first-page":"e98417","DOI":"10.1371\/journal.pone.0098417","volume":"9","author":"VC Brandt","year":"2014","unstructured":"Brandt VC, Niessen E, Ganos C, Kahl U, Baumer T, Munchau A (2014) Altered synaptic plasticity in Tourette\u2019s syndrome and its relationship to motor skill learning. PLoS ONE 9(5):e98417","journal-title":"PLoS ONE"},{"issue":"Pt 2","key":"586_CR34","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/brain\/awv307","volume":"139","author":"C Delorme","year":"2016","unstructured":"Delorme C, Salvador A, Valabregue R, Roze E, Palminteri S, Vidailhet M et\u00a0al (2016) Enhanced habit formation in Gilles de la Tourette syndrome. Brain 139(Pt 2):605\u2013615","journal-title":"Brain"},{"issue":"1","key":"586_CR35","doi-asserted-by":"publisher","first-page":"e27850","DOI":"10.1371\/journal.pone.0027850","volume":"7","author":"S Franzkowiak","year":"2012","unstructured":"Franzkowiak S, Pollok B, Biermann-Ruben K, Sudmeyer M, Paszek J, Thomalla G et al (2012) Motor-cortical interaction in Gilles de la Tourette syndrome. PLoS ONE 7(1):e27850","journal-title":"PLoS ONE"},{"issue":"43","key":"586_CR36","doi-asserted-by":"publisher","first-page":"15376","DOI":"10.1523\/JNEUROSCI.2271-11.2011","volume":"31","author":"N Arai","year":"2011","unstructured":"Arai N, Muller-Dahlhaus F, Murakami T, Bliem B, Lu MK, Ugawa Y et al (2011) State-dependent and timing-dependent bidirectional associative plasticity in the human SMA-M1 network. J\u00a0Neurosci 31(43):15376\u201315383","journal-title":"J Neurosci"},{"key":"586_CR37","unstructured":"T\u00fcbing J, Gigla B, Brandt VC, Verrel J, Weissbach A, Beste C et\u00a0al. (im Druck) Associative plasticity in supplementary motor area \u2013 motor cortex pathways in Tourette syndrome. Scientific Reports"},{"key":"586_CR38","doi-asserted-by":"publisher","DOI":"10.15761\/bem.1000136","author":"N Gattinger","year":"2018","unstructured":"Gattinger N, Jung NH, Mall V, Gleich B (2018) Transcranial magnetic stimulation devices for biphasic and polyphasic ultra-high frequency protocols. Biol Eng Med. \n                    https:\/\/doi.org\/10.15761\/bem.1000136","journal-title":"Biol. Eng. Med."}],"container-title":["Der Nervenarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00115-018-0586-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-018-0586-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-018-0586-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T14:22:55Z","timestamp":1567693375000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00115-018-0586-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["586"],"URL":"https:\/\/doi.org\/10.1007\/s00115-018-0586-1","relation":{},"ISSN":["0028-2804","1433-0407"],"issn-type":[{"value":"0028-2804","type":"print"},{"value":"1433-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,23]]},"assertion":[{"value":"23 August 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"N.\u00a0H.\u00a0Jung, A.\u00a0M\u00fcnchau und V.\u00a0Mall geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Dieser Beitrag beinhaltet keine von den Autoren durchgef\u00fchrten Studien an Menschen oder Tieren.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}