{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:51:12Z","timestamp":1767340272069},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsmedizin Rostock"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die limbisch pr\u00e4dominante altersassoziierte TDP-43(Transactivation response(TAR)-DNA-binding protein 43 kDa)-Enzephalopathie (LATE) wurde k\u00fcrzlich als eigene neuropathologische Entit\u00e4t im Demenzspektrum charakterisiert. Neuropathologische Ver\u00e4nderungen im Sinne von LATE wurden zuvor bereits als Komorbidit\u00e4t der Alzheimer-Krankheit (AD) beschrieben und sp\u00e4testens seit 2008 auch als ein von der AD unabh\u00e4ngiger autoptischer Befund. Die Konzeptualisierung von LATE r\u00fcckt nun die pathogenetische Bedeutung von limbischem TDP-43 als alternative oder komorbide Ursache einer der klinischen AD \u00e4hnlichen amnestischen Demenz in das Bewusstsein. LATE k\u00f6nnte divergierende klinische und Biomarkerbefunde erkl\u00e4ren, bei denen eine ausgepr\u00e4gte mnestische St\u00f6rung ohne Amyloid- und Tau-Ver\u00e4nderungen im Sinne einer AD-Pathologie nachweisbar ist. Ob LATE eine eigenst\u00e4ndige neuropathologische Entit\u00e4t darstellt oder eine regionale Auspr\u00e4gung innerhalb des Spektrums der bekannten TDP-43-assoziierten neurodegenerativen Erkrankungen ist aktuell Gegenstand kontroverser Diskussionen. Die weitere, gezielte Erforschung von TDP-43-Proteinopathien ist davon unabh\u00e4ngig ein vielversprechender Forschungsansatz, um Wissensl\u00fccken in der Alzheimer- und Demenzforschung zu schlie\u00dfen. So k\u00f6nnte ganz praktisch die Anreicherung eines amnestischen Ph\u00e4notyps in klinischen Studien zu amyloidzentrierten Therapien durch das erh\u00f6hte Risiko limbischer TDP-43-Komorbidit\u00e4t den Nachweis der klinischen Wirksamkeit erschweren. Dieser Artikel stellt den aktuellen Stand der Diskussion zu LATE vor und illustriert das Konzept und daraus abgeleitete klinische \u00dcberlegungen an einem Fallbeispiel.<\/jats:p>","DOI":"10.1007\/s00115-020-00922-z","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T07:06:19Z","timestamp":1589439979000},"page":"18-26","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["LATE: Nicht jede Demenz ist Alzheimer \u2013 Diskussion einer neuen Krankheitsentit\u00e4t am Fallbeispiel"],"prefix":"10.1007","volume":"92","author":[{"given":"Doreen","family":"G\u00f6r\u00df","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Kilimann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Dyrba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Nitsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Krause","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Teipel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"issue":"3","key":"922_CR1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","volume":"7","author":"MS Albert","year":"2011","unstructured":"Albert\u00a0MS, DeKosky\u00a0ST, Dickson\u00a0D et al (2011) The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. 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