{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:17:03Z","timestamp":1775744223621,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Leipzig"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund und Ziele<\/jats:title>\n                <jats:p>Sch\u00e4delbasismetastasen sind eine seltene Manifestation onkologischer Erkrankungen. Wenn Hirnnerven beteiligt sind, k\u00f6nnen schon kleine L\u00e4sionen erhebliche funktionelle Beeintr\u00e4chtigungen hervorrufen. Spezifische klinische Charakteristika wie neurologische Symptome, assoziierte Prim\u00e4rtumoren, Prognose und optimale Therapie der Erkrankung sind schlecht definiert und sollen in dieser Arbeit systematisch dargestellt werden.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methoden<\/jats:title>\n                <jats:p>Mit einem monozentrischen retrospektiven Ansatz wurden Sch\u00e4delbasismetastasen bei Patienten, die im Zeitraum von 2006 bis 2018 behandelt wurden, detailliert hinsichtlich klinischer Charakteristika, der durchgef\u00fchrten Therapie und des weiteren Erkrankungsverlaufs analysiert.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Insgesamt 45\u00a0Patienten mit Sch\u00e4delbasismetastasen und Hirnnervenausf\u00e4llen wurden erfasst. Die h\u00e4ufigsten Prim\u00e4rtumoren waren Prostatakarzinom (27\u202f%), Mammakarzinom (22\u202f%) und multiples Myelom (16\u202f%). Die am h\u00e4ufigsten betroffenen Hirnnerven waren Nervus trigeminus (42\u202f%), Nervus oculomotorius (33\u202f%) und Nervus facialis (27\u202f%). 84\u202f% aller Patienten wiesen au\u00dferhalb der Sch\u00e4delbasis liegende weitere Knochenmetastasen auf. Eine durale Infiltration oder eine Meningeosis neoplastica lagen bei je 13\u202f% der Patienten vor. Nach Bestrahlung waren 61\u202f% der Patienten hinsichtlich der auf die Sch\u00e4delbasismetastase zur\u00fcckzuf\u00fchrenden Symptome klinisch stabil, bei 22\u202f% hatten sich die Symptome gebessert. Das mediane Gesamt\u00fcberleben betrug 8\u00a0Monate (Spanne: 0,4\u201351\u00a0Monate). Bei Patienten, die mit einer dosiseskalierten Bestrahlung behandelt wurden, bestand eine  l\u00e4ngere \u00dcberlebenszeit (16,4\u00a0Monate vs. 4,7\u00a0Monate). Dieser Effekt persistierte auch in der multivariaten Analyse unter Ber\u00fccksichtigung der Faktoren Karnofsky-Index, Metastasenanzahl, Prim\u00e4rtumor und Bestrahlungsdosis (HR 0,37, <jats:italic>p<\/jats:italic>\u202f=\u20090,02).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Diskussion<\/jats:title>\n                <jats:p>Sch\u00e4delbasismetastasen mit Hirnnervenausf\u00e4llen haben ein vielgestaltiges Bild und oft eine schlechte Prognose. Um potenziell eine \u00dcberlebenszeitverbesserung zu erreichen, sind pr\u00e4zise Diagnostik und Therapie Voraussetzung. Prospektive kontrollierte Untersuchungen sind notwendig.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00115-021-01229-3","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T13:02:48Z","timestamp":1642078968000},"page":"812-818","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sch\u00e4delbasismetastasen mit Hirnnervenaffektionen","Skull base metastases with cranial nerve deficits"],"prefix":"10.1007","volume":"93","author":[{"given":"J.","family":"Hoppe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kalckreuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Metelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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