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Klinische Versuche in der Psychiatrie, 1940\u20131980\u201c hei\u00dft der Bericht einer Untersuchungskommission, die die Regierung des Schweizer Kantons Thurgau 2016 eingesetzt hatte, nachdem mehrere Presseartikel ab 2012 die Arzneimittelpr\u00fcfungen von Roland Kuhn, dem ehemaligen \u00e4rztlichen Direktor der kantonalen Anstalt in M\u00fcnsterlingen, skandalisiert hatten. Der Bericht problematisiert \u201eaus heutiger Sicht\u201c \u201efeine Diskrepanzen, in allt\u00e4glichen Grenz\u00fcberschreitungen\u201c. Solche Grenz\u00fcberschreitungen wurden vor allem in fehlender, unzureichender oder nicht belegter Aufkl\u00e4rung und Einwilligung der Patienten gesehen sowie bei der Anwendung der Pr\u00fcfsubstanzen, die zwischen (meist) akzeptierter oder nicht abgelehnter Einnahme und getarnter oder (selten) angedrohter Applikation per Injektion variierte. Damit zeigt der Bericht einerseits die erhebliche Entwicklung des normativen Kontextes der Behandlung psychisch Kranker in den letzten 70\u00a0Jahren und vermag andererseits durch seine detaillierten Schilderungen, heutige Therapeuten f\u00fcr den aktuellen Kontext zu sensibilisieren. Es ist aber vor allem die Geschichte des verantwortlichen Psychiaters Roland Kuhn, des arzneimittelpr\u00fcfenden Entdeckers der antidepressiven Wirkung des Imipramin. Diese Entdeckungsgeschichte wird aus sehr unterschiedlichen Perspektiven beurteilt und damit auch relativiert und ist zwischen der Beobachtung eines \u201eProvinzpsychiaters\u201c und ihrer Nobelpreisw\u00fcrdigkeit angesiedelt; dabei scheinen kritisch bewertete Z\u00fcge der Eigenart von Kuhns Pers\u00f6nlichkeit auch die gelegentlich negative Tonlage des Kommissionsberichtes beeinflusst zu haben. Festzuhalten ist, dass Kuhn mit seiner qualitativen psychopathologischen Einzelfallbeobachtung die antidepressive Wirkung einer Pr\u00fcfsubstanz entdeckt hat, die als Hypothese durch nachfolgende quantitative statistische Methoden verifiziert wurde.<\/jats:p>","DOI":"10.1007\/s00115-022-01296-0","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T09:06:23Z","timestamp":1651827983000},"page":"243-249","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Allt\u00e4gliche Grenz\u00fcberschreitungen: zur Skandalisierung der klinischen Arzneimittelpr\u00fcfungen des Psychiaters Roland Kuhn","Everyday transgressions of borderlines: the scandalization of clinical drug trials of the psychiatrist Roland Kuhn"],"prefix":"10.1007","volume":"94","author":[{"given":"Hanfried","family":"Helmchen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"1296_CR1","first-page":"48","volume":"45","author":"H Steinberg","year":"2012","unstructured":"Steinberg\u00a0H, Himmerich\u00a0H (2012) Roland Kuhn - 100th birthday of an innovator of clinical psychopharmacology. 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