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Insbesondere f\u00fcr die Alzheimer-Erkrankung existieren validierte Biomarker, die die Diagnose untermauern und bei der diagnostischen Abgrenzung anderer Demenz\u00e4tiologien hilfreich sein k\u00f6nnen. W\u00e4hrend unauff\u00e4llige Liquorbefunde mit negativen Demenz- und Destruktionsmarkern die \u00fcberwiegende Mehrzahl neurodegenerativer Demenzursachen mit hoher diagnostischer Sicherheit ausschlie\u00dfen, stellen in der klinischen Praxis vor allem \u00fcberlappende Biomarkerprofile bei prim\u00e4r neurodegenerativen Demenzursachen ein substanzielles Problem bei der Befundinterpretation dar. Deshalb bedarf die Liquorbefundinterpretation stets einer kontextualisierten Betrachtung unter W\u00fcrdigung der klinischen Symptomatik und Verlaufscharakteristika des entsprechenden demenziellen Syndroms. Au\u00dferdem stellen auch Mischbefunde eine h\u00e4ufige diagnostische Herausforderung dar, f\u00fcr deren Interpretation es profunder Kenntnisse im Bereich von Pr\u00e4analytik, m\u00f6glicher Liquorbefundkonstellationen und nat\u00fcrlich der verschiedenen in Betracht kommenden Demenz\u00e4tiologien bedarf. Auch Liquorbiomarker f\u00fcr Synukleinopathien, Tauopathien sowie TDP43(Transactive response DNA binding protein 43 kDa)-Proteinopathien sind Gegenstand aktueller Untersuchungen, wenngleich diese noch nicht den Weg in die klinische Routinediagnostik gefunden haben.<\/jats:p>","DOI":"10.1007\/s00115-022-01339-6","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T05:02:36Z","timestamp":1654578156000},"page":"1236-1242","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostischer und differenzialdiagnostischer Stellenwert der Liquordiagnostik bei neurodegenerativen Demenzerkrankungen","Prognostic and diagnostic value of cerebrospinal fluid analysis in neurodegenerative dementia diseases"],"prefix":"10.1007","volume":"93","author":[{"given":"R.","family":"Hau\u00dfmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Homeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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