{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:34:47Z","timestamp":1771054487087,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008131","name":"Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008131","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Die transiente epileptische Amnesie (TEA) ist ein seltenes Ph\u00e4nomen bei Temporallappenepilepsien, das h\u00e4ufig nicht erkannt oder als transiente globale Amnesie (TGA) fehldiagnostiziert wird. Als Ursache werden iktale und postiktale St\u00f6rungen der Ged\u00e4chtnisbildung postuliert, was auch durch das Ansprechen auf Antiepileptika gest\u00fctzt wird. Angesichts der zunehmenden Zahl neu auftretender Epilepsien im h\u00f6heren Lebensalter ist auch mit einer Zunahme der TEA zu rechnen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Analyse typischer Merkmale der TEA in einer monozentrischen Fallserie.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Mittels interner Datenbankanalyse wurden unter 7899\u00a0Patient*innen \u00fcber einen Zeitraum von 8\u00a0Jahren 10\u00a0Patient*innen mit TEA identifiziert. Klinische Merkmale sowie Befunde der Zusatzdiagnostik wurden retrospektiv untersucht. Die Daten sind als Mittelwert\u202f\u00b1\u2009SD angegeben.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Bei allen 10\u00a0Patient*innen wurde die Diagnose einer Temporallappenepilepsie gestellt. Das Lebensalter bei Erstmanifestation der TEA lag bei 59,1\u202f\u00b1\u20096,7\u00a0Jahren, die Diagnose wurde mit einer Latenz von 21,9\u202f\u00b1\u200926,3\u00a0Monaten gestellt. Eine TEA-Episode dauerte 56\u202f\u00b1\u200937\u202fmin an und trat pro Jahr 16\u202f\u00b1\u20099,9-mal auf; 6\u00a0von 10\u00a0Patient*innen berichteten \u00fcber h\u00e4ufiges Auftreten direkt nach dem Erwachen. Bei 9\u00a0von 10\u00a0Patient*innen wurde \u00fcber weitere Anfallstypen bzw. weitere semiologische Elemente w\u00e4hrend der TEA berichtet. Hinweise auf neuropsychologische St\u00f6rungen temporaler Funktionen ergaben sich bei 8\u00a0von 10\u00a0Patient*innen, Hinweise auf eine depressive St\u00f6rung bei 6\u00a0von 10\u00a0Patient*innen. Im Schlaf aktivierte epilepsietypische Aktivit\u00e4t wurde bei 4\u00a0Patient*innen temporal links sowie bei 2\u00a0Patient*innen temporal beidseits nachgewiesen. Bei 3\u00a0Patient*innen wurden mittels Kernspintomographie typische Auff\u00e4lligkeiten im Bereich der temporomesialen Strukturen (bei 2\u00a0links, bei 1\u00a0rechts) nachgewiesen. Eine antiepileptische Therapie verbesserte die Anfallskontrolle bei 7\u00a0von 10\u00a0Patient*innen (Anfallsfreiheit bei 6\u00a0Patienten), bei 3\u00a0Patienten ist die therapeutische Wirkung unbekannt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Diskussion<\/jats:title>\n                <jats:p>TEA sind selten, treten im h\u00f6heren Erwachsenenalter auf und werden erst nach etwa 2\u00a0Jahren korrekt als epileptisches Ph\u00e4nomen diagnostiziert. Die gr\u00fcndliche Erfassung von Begleitsymptomen, die Umst\u00e4nde und das rezidivierende Auftreten sowie Hinweise auf eine Temporallappenepilepsie in den apparativen Zusatzuntersuchungen erm\u00f6glichen die Differenzierung zur TGA.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00115-022-01364-5","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T12:02:48Z","timestamp":1659528168000},"page":"1193-1205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Transiente epileptische Amnesie\u00a0\u2013 ein seltenes Ph\u00e4nomen bei Temporallappenepilepsien","Transient epileptic amnesia\u2014A rare phenomenon in temporal lobe epilepsies"],"prefix":"10.1007","volume":"93","author":[{"given":"Jan","family":"Pukropski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randi","family":"von Wrede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Helmstaedter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Surges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"1364_CR1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAINCOMMS\/FCAB038","author":"J Baker","year":"2021","unstructured":"Baker\u00a0J, Savage\u00a0S, Milton\u00a0F et\u00a0al (2021) The syndrome of transient epileptic amnesia: a\u00a0combined series of 115\u00a0cases and literature review. 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C.\u00a0Helmstaedter hat Honorare f\u00fcr eingeladene Vortr\u00e4ge von Eisai, UCB, GW und Precisis GmbH erhalten; Lizenzgeb\u00fchren von UCB und Eisai; Honorar von Florey Institute Melbourne Beratung Australian Epilepsy Project; Honorar f\u00fcr editorielle Arbeit bei der Zeitschrift \u201eSeizure\u201c des Verlags Elsevier. Rainer Surges hat Honorare f\u00fcr Vortr\u00e4ge oder als Berater von Arvelle, Angelini, Bial, Desitin, Eisai, LivaNova, Novartis, Precisis GmbH, UCB Pharma, UnEEG und Zogenix erhalten. Randi von Wrede hat Honorare als Rednerin, Beraterin oder Reiseunterst\u00fctzung von Apocare, Arvelle, Cerbomed, Desitin, GW Pharmaceuticals\u2014part of Jazz Pharmaceuticals, Eisai und UCB erhalten.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Dieser Beitrag beinhaltet keine prospektiven Studien an Menschen oder Tieren.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}