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Damit hat sich auch die Herangehensweise an die immuntherapeutische Behandlung dieser Krankheitsgruppe fundamental ver\u00e4ndert, ebenso wie das Verst\u00e4ndnis der zugrunde liegenden Pathophysiologie und der ausl\u00f6senden Faktoren. Die noch immer wachsende Zahl neuer Autoantik\u00f6rper erfordert ein regelm\u00e4\u00dfiges Update \u00fcber den Stand der Antik\u00f6rperdiagnostik, die H\u00e4ufigkeit assoziierter Tumoren sowie das antik\u00f6rperspezifische Spektrum klinischer Symptome, die von Wesens\u00e4nderungen und kognitiven St\u00f6rungen \u00fcber epileptische Anf\u00e4lle und Bewegungsst\u00f6rungen bis hin zu vegetativen und Bewusstseinsst\u00f6rungen f\u00fchren. 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