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Unterschiedliche Studien enthalten Hinweise, dass je nach Therapieform, das Risiko, an einer Demenz zu erkranken, weiter erh\u00f6ht, aber auch gesenkt werden kann. Der aktuelle Forschungsstand wird in diesem systematischen Review zusammengefasst.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Die Auswirkungen einer Langzeittherapie mit Lithium, Valproat, Carbamazepin und Antipsychotika auf die Entstehung einer Demenz und kognitiver Beeintr\u00e4chtigungen bei Patient*innen mit bipolarer St\u00f6rung werden untersucht.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methoden<\/jats:title>\n                <jats:p>Es wurde eine systematische Literaturrecherche in der PubMed-Datenbank von den beiden Autor*innen im Zeitraum Mai bis Juli 2022 durchgef\u00fchrt. Placebokontrollierte Studien, Metaanalysen, prospektive Studien mit Kontrollsubstanz, Fall-Kontroll-Studien, Kohortenstudien, systematische Reviews und randomisierte kontrollierte Studien wurden eingeschlossen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Der Gro\u00dfteil der verf\u00fcgbaren Studien sieht in der Langzeittherapie mit Lithium einen protektiven Effekt auf das Ged\u00e4chtnis und damit das Entstehen einer Demenz. F\u00fcr Valproat hingegen wird ein eher negativer Einfluss beschrieben. Bei Antipsychotika ist die derzeitige Datenlage nicht aussagekr\u00e4ftig genug, aber auch hier wird ein eher neutraler bis negativer Einfluss mit der Langzeiteinnahme assoziiert.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Diskussion<\/jats:title>\n                <jats:p>Lithium sollte, auch aufgrund des neuroprotektiven Effekts, in der Erhaltungstherapie der bipolaren St\u00f6rung empfohlen werden. Der Einsatz von Valproat hingegen sollte in dieser Indikation kritisch gesehen werden. Antipsychotika sind bez\u00fcglich dieser Fragestellung noch nicht hinreichend untersucht, sodass keine generelle Empfehlung ausgesprochen werden kann.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00115-023-01454-y","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T18:02:38Z","timestamp":1678903358000},"page":"417-424","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Auswirkungen von Lithium, Valproat, Carbamazepin und Antipsychotika auf die Kognition bei bipolarer St\u00f6rung\u00a0\u2013 ein systematisches Review","Effects of lithium, valproic acid, carbamazepine and antipsychotic agents on cognition in bipolar disorders\u2014A systematic review"],"prefix":"10.1007","volume":"94","author":[{"given":"Sophie","family":"Leopold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnim","family":"Quante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"1454_CR1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1192\/bjp.bp.115.180059","volume":"209","author":"OP Almeida","year":"2016","unstructured":"Almeida\u00a0OP, Mccaul\u00a0K, Hankey\u00a0GJ et al (2016) Risk of dementia and death in community-dwelling older men with bipolar disorder. 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