{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:12:23Z","timestamp":1775157143935,"version":"3.50.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s00115-023-01538-9","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:04:05Z","timestamp":1693227845000},"page":"892-903","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Das Exposom im Fokus pr\u00e4ventiver Ma\u00dfnahmen f\u00fcr die Alzheimer- und Parkinson-Erkrankung","The exposome in the context of preventive measures for Alzheimer\u2019s and Parkinson\u2019s diseases"],"prefix":"10.1007","volume":"94","author":[{"given":"Eva","family":"Sch\u00e4ffer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Piel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"issue":"1","key":"1538_CR1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/jamaneurol.2017.3299","volume":"75","author":"ER Dorsey","year":"2018","unstructured":"Dorsey\u00a0ER, Bloem\u00a0BR (2018) The Parkinson pandemic\u2014A call to action. JAMA Neurol 75(1):9\u201310","journal-title":"JAMA Neurol"},{"issue":"2","key":"1538_CR2","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","volume":"7","author":"E Nichols","year":"2022","unstructured":"Nichols\u00a0E, Steinmetz\u00a0JD, Vollset\u00a0SE, Fukutaki\u00a0K, Chalek\u00a0J, Abd-Allah\u00a0F et al (2022) Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019. Lancet Public Health 7(2):e105\u2013e125","journal-title":"Lancet Public Health"},{"issue":"10113","key":"1538_CR3","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","volume":"390","author":"G Livingston","year":"2017","unstructured":"Livingston\u00a0G, Sommerlad\u00a0A, Orgeta\u00a0V, Costafreda\u00a0SG, Huntley\u00a0J, Ames\u00a0D et\u00a0al (2017) Dementia prevention, intervention, and care. Lancet 390(10113):2673\u20132734","journal-title":"Lancet"},{"key":"1538_CR4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/B978-0-12-803678-5.00117-X","volume-title":"International encyclopedia of public health","author":"AH Outwater","year":"2017","unstructured":"Outwater\u00a0AH, Leshabari\u00a0SC, Nolte\u00a0E (2017) Disease prevention: an overview. In: Quah\u00a0SR (Hrsg) International encyclopedia of public health, 2.\u00a0Aufl. Academic Press, Oxford, S\u00a0338\u2013349 (https:\/\/www.sciencedirect.com\/science\/article\/pii\/B978012803678500117X)","edition":"2"},{"issue":"140","key":"1538_CR5","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1183\/16000617.0034-2016","volume":"25","author":"V Siroux","year":"2016","unstructured":"Siroux\u00a0V, Agier\u00a0L, Slama\u00a0R (2016) The exposome concept: a\u00a0challenge and a\u00a0potential driver for environmental health research. Eur Respir Rev 25(140):124\u2013129","journal-title":"Eur Respir Rev"},{"issue":"8","key":"1538_CR6","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1158\/1055-9965.EPI-05-0456","volume":"14","author":"CP Wild","year":"2005","unstructured":"Wild\u00a0CP (2005) Complementing the genome with an \u201cExposome\u201d: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev 14(8):1847\u20131850","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"11","key":"1538_CR7","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1474-4422(17)30299-5","volume":"16","author":"GBD 2015 Neurological Disorders Collaborator Group","year":"2017","unstructured":"GBD 2015 Neurological Disorders Collaborator Group (2017) Global, regional, and national burden of neurological disorders during 1990\u20132015: a\u00a0systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol 16(11):877\u2013897","journal-title":"Lancet Neurol"},{"issue":"12","key":"1538_CR8","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/mds.26431","volume":"30","author":"D Berg","year":"2015","unstructured":"Berg\u00a0D, Postuma\u00a0RB, Adler\u00a0CH, Bloem\u00a0BR, Chan\u00a0P, Dubois\u00a0B et\u00a0al (2015) MDS research criteria for prodromal Parkinson\u2019s disease: MDS criteria for prodromal PD. Mov Disord 30(12):1600\u20131611","journal-title":"Mov Disord"},{"issue":"9","key":"1538_CR9","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.tips.2009.06.005","volume":"30","author":"F Cicchetti","year":"2009","unstructured":"Cicchetti\u00a0F, Drouin-Ouellet\u00a0J, Gross\u00a0RE (2009) Environmental toxins and Parkinson\u2019s disease: what have we learned from pesticide-induced animal models? Trends Pharmacol Sci 30(9):475\u2013483","journal-title":"Trends Pharmacol Sci"},{"key":"1538_CR10","doi-asserted-by":"crossref","first-page":"135032","DOI":"10.1016\/j.neulet.2020.135032","volume":"730","author":"Y Pu","year":"2020","unstructured":"Pu\u00a0Y, Chang\u00a0L, Qu\u00a0Y, Wang\u00a0S, Tan\u00a0Y, Wang\u00a0X et\u00a0al (2020) Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP. Neurosci Lett 730:135032","journal-title":"Neurosci Lett"},{"key":"1538_CR11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuro.2018.02.013","volume":"65","author":"ME Johnson","year":"2018","unstructured":"Johnson\u00a0ME, Stringer\u00a0A, Bobrovskaya\u00a0L (2018) Rotenone induces gastrointestinal pathology and microbiota alterations in a\u00a0rat model of Parkinson\u2019s disease. Neurotoxicology 65:174\u2013185","journal-title":"Neurotoxicology"},{"key":"1538_CR12","doi-asserted-by":"crossref","first-page":"124556","DOI":"10.1016\/j.jhazmat.2020.124556","volume":"408","author":"L Leino","year":"2021","unstructured":"Leino\u00a0L, Tall\u00a0T, Helander\u00a0M, Saloniemi\u00a0I, Saikkonen\u00a0K, Ruuskanen\u00a0S et al (2021) Classification of the glyphosate target enzyme (5-enolpyruvylshikimate-3-phosphate synthase) for assessing sensitivity of organisms to the herbicide. J\u00a0Hazard Mater 408:124556","journal-title":"J Hazard Mater"},{"issue":"4","key":"1538_CR13","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1001\/jamaneurol.2020.5011","volume":"78","author":"S Martinez","year":"2021","unstructured":"Martinez\u00a0S, Yaffe\u00a0K, Li\u00a0Y, Byers\u00a0AL, Peltz\u00a0CB, Barnes\u00a0DE (2021) Agent Orange exposure and dementia diagnosis in US veterans of the Vietnam era. JAMA Neurol 78(4):473\u2013477","journal-title":"JAMA Neurol"},{"key":"1538_CR14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.envres.2014.04.027","volume":"133","author":"SW Yi","year":"2014","unstructured":"Yi\u00a0SW, Hong\u00a0JS, Ohrr\u00a0H, Yi\u00a0JJ (2014) Agent Orange exposure and disease prevalence in Korean Vietnam veterans: the Korean veterans health study. Environ Res 133:56\u201365","journal-title":"Environ Res"},{"issue":"3","key":"1538_CR15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1001\/jamaneurol.2013.6030","volume":"71","author":"JR Richardson","year":"2014","unstructured":"Richardson\u00a0JR, Roy\u00a0A, Shalat\u00a0SL, von Stein\u00a0RT, Hossain\u00a0MM, Buckley\u00a0B et\u00a0al (2014) Elevated serum pesticide levels and risk for Alzheimer disease. JAMA Neurol 71(3):284\u2013290","journal-title":"JAMA Neurol"},{"issue":"3","key":"1538_CR16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3390\/ijerph16030337","volume":"16","author":"LG Gunnarsson","year":"2019","unstructured":"Gunnarsson\u00a0LG, Bodin\u00a0L (2019) Occupational exposures and neurodegenerative diseases\u2011A systematic literature review and meta-analyses. Int J Environ Res Public Health 16(3):337","journal-title":"Int J Environ Res Public Health"},{"key":"1538_CR17","doi-asserted-by":"crossref","first-page":"32222","DOI":"10.1038\/srep32222","volume":"6","author":"D Yan","year":"2016","unstructured":"Yan\u00a0D, Zhang\u00a0Y, Liu\u00a0L, Yan\u00a0H (2016) Pesticide exposure and risk of Alzheimer\u2019s disease: a\u00a0systematic review and meta-analysis. Sci Rep 6:32222","journal-title":"Sci Rep"},{"key":"1538_CR18","doi-asserted-by":"crossref","first-page":"837579","DOI":"10.3389\/ftox.2022.837579","volume":"4","author":"M Nabi","year":"2022","unstructured":"Nabi\u00a0M, Tabassum\u00a0N (2022) Role of environmental toxicants on neurodegenerative disorders. Front Toxicol 4:837579","journal-title":"Front Toxicol"},{"issue":"3","key":"1538_CR19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.taap.2012.11.016","volume":"266","author":"EA Lock","year":"2013","unstructured":"Lock\u00a0EA, Zhang\u00a0J, Checkoway\u00a0H (2013) Solvents and Parkinson disease: a\u00a0systematic review of toxicological and epidemiological evidence. Toxicol Appl Pharmacol 266(3):345\u2013355","journal-title":"Toxicol Appl Pharmacol"},{"key":"1538_CR20","doi-asserted-by":"crossref","first-page":"105312","DOI":"10.1016\/j.nbd.2021.105312","volume":"153","author":"BR De Miranda","year":"2021","unstructured":"De Miranda\u00a0BR, Castro\u00a0SL, Rocha\u00a0EM, Bodle\u00a0CR, Johnson\u00a0KE, Greenamyre\u00a0JT (2021) The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a\u00a0rat model of Parkinson\u2019s disease. Neurobiol Dis 153:105312","journal-title":"Neurobiol Dis"},{"key":"1538_CR21","first-page":"e231168","volume":"15","author":"SM Goldman","year":"2023","unstructured":"Goldman\u00a0SM, Weaver\u00a0FM, Stroupe\u00a0KT, Cao\u00a0L, Gonzalez\u00a0B, Colletta\u00a0K et\u00a0al (2023) Risk of Parkinson disease among service members at marine corps base camp Lejeune. JAMA Neurol 15:e231168","journal-title":"JAMA Neurol"},{"key":"1538_CR22","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.envres.2018.10.008","volume":"168","author":"CY Hu","year":"2019","unstructured":"Hu\u00a0CY, Fang\u00a0Y, Li\u00a0FL, Dong\u00a0B, Hua\u00a0XG, Jiang\u00a0W et al (2019) Association between ambient air pollution and Parkinson\u2019s disease: systematic review and meta-analysis. Environ Res 168:448\u2013459","journal-title":"Environ Res"},{"issue":"2","key":"1538_CR23","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3233\/JAD-200483","volume":"77","author":"P Fu","year":"2020","unstructured":"Fu\u00a0P, Yung\u00a0KKL (2020) Air pollution and Alzheimer\u2019s disease: a\u00a0systematic review and meta-analysis. J\u00a0Alzheimers Dis 77(2):701\u2013714","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"1538_CR24","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/mds.28922","volume":"37","author":"H Murata","year":"2022","unstructured":"Murata\u00a0H, Barnhill\u00a0LM, Bronstein\u00a0JM (2022) Air pollution and the risk of Parkinson\u2019s disease: a\u00a0review. Mov Disord 37(5):894\u2013904","journal-title":"Mov Disord"},{"issue":"1","key":"1538_CR25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3233\/JAD-170658","volume":"61","author":"EG Cleary","year":"2018","unstructured":"Cleary\u00a0EG, Cifuentes\u00a0M, Grinstein\u00a0G, Brugge\u00a0D, Shea\u00a0TB (2018) Association of low-level ozone with cognitive decline in older adults. J\u00a0Alzheimers Dis 61(1):67\u201378","journal-title":"J Alzheimers Dis"},{"issue":"12","key":"1538_CR26","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S1474-4422(16)30230-7","volume":"15","author":"A Ascherio","year":"2016","unstructured":"Ascherio\u00a0A, Schwarzschild\u00a0MA (2016) The epidemiology of Parkinson\u2019s disease: risk factors and prevention. Lancet Neurol 15(12):1257\u20131272","journal-title":"Lancet Neurol"},{"issue":"15","key":"1538_CR27","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.3390\/nu14153240","volume":"14","author":"J Haas","year":"2022","unstructured":"Haas\u00a0J, Berg\u00a0D, Bosy-Westphal\u00a0A, Schaeffer\u00a0E (2022) Parkinson\u2019s disease and sugar intake\u2014Reasons for and consequences of a\u00a0still unclear craving. Nutrients 14(15):3240","journal-title":"Nutrients"},{"key":"1538_CR28","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3389\/fnagi.2019.00344","volume":"11","author":"M Ettcheto","year":"2019","unstructured":"Ettcheto\u00a0M, Olloquequi\u00a0J, S\u00e1nchez-L\u00f3pez\u00a0E, Busquets\u00a0O, Cano\u00a0A, Manzine\u00a0PR et al (2019) Benzodiazepines and related drugs as a\u00a0risk factor in Alzheimer\u2019s disease dementia. Front Aging Neurosci 11:344","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"1538_CR29","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.2146\/ajhp160381","volume":"75","author":"JD Picton","year":"2018","unstructured":"Picton\u00a0JD, Marino\u00a0AB, Nealy\u00a0KL (2018) Benzodiazepine use and cognitive decline in the elderly. Am J Health Syst Pharm 75(1):e6\u2013e12","journal-title":"Am J Health Syst Pharm"},{"issue":"3","key":"1538_CR30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/mds.27924","volume":"35","author":"TH Mertsalmi","year":"2020","unstructured":"Mertsalmi\u00a0TH, Pekkonen\u00a0E, Scheperjans\u00a0F (2020) Antibiotic exposure and risk of Parkinson\u2019s disease in Finland: a\u00a0nationwide case-control study. Mov Disord 35(3):431\u2013442","journal-title":"Mov Disord"},{"issue":"Pt 11","key":"1538_CR31","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1093\/brain\/awh617","volume":"128","author":"T Brandt","year":"2005","unstructured":"Brandt\u00a0T, Schautzer\u00a0F, Hamilton\u00a0DA, Br\u00fcning\u00a0R, Markowitsch\u00a0HJ, Kalla\u00a0R et\u00a0al (2005) Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. Brain 128(Pt 11):2732\u20132741","journal-title":"Brain"},{"issue":"6","key":"1538_CR32","doi-asserted-by":"crossref","first-page":"e663","DOI":"10.1097\/MAO.0000000000003540","volume":"43","author":"HS Cohen","year":"2022","unstructured":"Cohen\u00a0HS, Lincoln\u00a0CM, Pavlik\u00a0VN, Sangi-Haghpeykar\u00a0H (2022) Changes in measures of vestibular and balance function and hippocampus volume in Alzheimer\u2019s disease and mild cognitive impairment. Otol Neurotol 43(6):e663\u2013e670","journal-title":"Otol Neurotol"},{"key":"1538_CR33","doi-asserted-by":"crossref","first-page":"986302","DOI":"10.3389\/fneur.2022.986302","volume":"13","author":"PF Smith","year":"2022","unstructured":"Smith\u00a0PF (2022) Recent developments in the understanding of the interactions between the vestibular system, memory, the hippocampus, and the striatum. Front Neurol 13:986302","journal-title":"Front Neurol"},{"key":"1538_CR34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neubiorev.2019.04.001","volume":"117","author":"Z Jafari","year":"2020","unstructured":"Jafari\u00a0Z, Kolb\u00a0BE, Mohajerani\u00a0MH (2020) Noise exposure accelerates the risk of cognitive impairment and Alzheimer\u2019s disease: adulthood, gestational, and prenatal mechanistic evidence from animal studies. Neurosci Biobehav Rev 117:110\u2013128","journal-title":"Neurosci Biobehav Rev"},{"issue":"19","key":"1538_CR35","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1056\/NEJMoa1908483","volume":"381","author":"DF Mackay","year":"2019","unstructured":"Mackay\u00a0DF, Russell\u00a0ER, Stewart\u00a0K, MacLean\u00a0JA, Pell\u00a0JP, Stewart\u00a0W (2019) Neurodegenerative disease mortality among former professional soccer players. N\u00a0Engl J Med 381(19):1801\u20131808","journal-title":"N Engl J Med"},{"issue":"10","key":"1538_CR36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/biomedicines8100389","volume":"8","author":"A Jarrahi","year":"2020","unstructured":"Jarrahi\u00a0A, Braun\u00a0M, Ahluwalia\u00a0M, Gupta\u00a0RV, Wilson\u00a0M, Munie\u00a0S et\u00a0al (2020) Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions. Biomedicines 8(10):389","journal-title":"Biomedicines"},{"issue":"4","key":"1538_CR37","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3233\/JAD-200282","volume":"76","author":"KM Bakulski","year":"2020","unstructured":"Bakulski\u00a0KM, Seo\u00a0YA, Hickman\u00a0RC, Brandt\u00a0D, Vadari\u00a0HS, Hu\u00a0H et\u00a0al (2020) Heavy metals exposure and Alzheimer\u2019s disease and related dementias. J\u00a0Alzheimers Dis 76(4):1215\u20131242","journal-title":"J Alzheimers Dis"},{"issue":"12","key":"1538_CR38","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1289\/ehp.9102","volume":"114","author":"S Coon","year":"2006","unstructured":"Coon\u00a0S, Stark\u00a0A, Peterson\u00a0E, Gloi\u00a0A, Kortsha\u00a0G, Pounds\u00a0J et al (2006) Whole-body lifetime occupational lead exposure and risk of Parkinson\u2019s disease. Environ Health Perspect 114(12):1872\u20131876","journal-title":"Environ Health Perspect"},{"issue":"18","key":"1538_CR39","doi-asserted-by":"crossref","first-page":"18032","DOI":"10.1007\/s11356-019-05104-2","volume":"26","author":"CN Amadi","year":"2019","unstructured":"Amadi\u00a0CN, Offor\u00a0SJ, Frazzoli\u00a0C, Orisakwe\u00a0OE (2019) Natural antidotes and management of metal toxicity. Environ Sci Pollut Res Int 26(18):18032\u201318052","journal-title":"Environ Sci Pollut Res Int"},{"issue":"4","key":"1538_CR40","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1212\/01.WNL.0000151960.28687.93","volume":"64","author":"H Chen","year":"2005","unstructured":"Chen\u00a0H, Zhang\u00a0SM, Schwarzschild\u00a0MA, Hern\u00e1n\u00a0MA, Ascherio\u00a0A (2005) Physical activity and the risk of Parkinson disease. Neurology 64(4):664\u2013669","journal-title":"Neurology"},{"issue":"Pt 2","key":"1538_CR41","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/brain\/awu323","volume":"138","author":"F Yang","year":"2015","unstructured":"Yang\u00a0F, Trolle Lagerros\u00a0Y, Bellocco\u00a0R, Adami\u00a0HO, Fang\u00a0F, Pedersen\u00a0NL et\u00a0al (2015) Physical activity and risk of Parkinson\u2019s disease in the Swedish national march cohort. Brain 138(Pt 2):269\u2013275","journal-title":"Brain"},{"issue":"4","key":"1538_CR42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1212\/WNL.0b013e3181ea1597","volume":"75","author":"Q Xu","year":"2010","unstructured":"Xu\u00a0Q, Park\u00a0Y, Huang\u00a0X, Hollenbeck\u00a0A, Blair\u00a0A, Schatzkin\u00a0A et\u00a0al (2010) Physical activities and future risk of Parkinson disease. Neurology 75(4):341\u2013348","journal-title":"Neurology"},{"issue":"1","key":"1538_CR43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1017\/S0033291708003681","volume":"39","author":"M Hamer","year":"2009","unstructured":"Hamer\u00a0M, Chida\u00a0Y (2009) Physical activity and risk of neurodegenerative disease: a\u00a0systematic review of prospective evidence. Psychol Med 39(1):3\u201311","journal-title":"Psychol Med"},{"issue":"3","key":"1538_CR44","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1212\/WNL.0b013e318225ab66","volume":"77","author":"JE Ahlskog","year":"2011","unstructured":"Ahlskog\u00a0JE (2011) Does vigorous exercise have a\u00a0neuroprotective effect in Parkinson disease? Neurology 77(3):288\u2013294","journal-title":"Neurology"},{"key":"1538_CR45","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neubiorev.2021.05.025","volume":"128","author":"D Ruiz-Gonz\u00e1lez","year":"2021","unstructured":"Ruiz-Gonz\u00e1lez\u00a0D, Hern\u00e1ndez-Mart\u00ednez\u00a0A, Valenzuela\u00a0PL, Morales\u00a0JS, Soriano-Maldonado\u00a0A (2021) Effects of physical exercise on plasma brain-derived neurotrophic factor in neurodegenerative disorders: a\u00a0systematic review and meta-analysis of randomized controlled trials. Neurosci Biobehav Rev 128:394\u2013405","journal-title":"Neurosci Biobehav Rev"},{"issue":"7","key":"1538_CR46","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3390\/cells8070691","volume":"8","author":"O Mee-Inta","year":"2019","unstructured":"Mee-Inta\u00a0O, Zhao\u00a0ZW, Kuo\u00a0YM (2019) Physical exercise inhibits inflammation and microglial activation. Cells 8(7):691","journal-title":"Cells"},{"key":"1538_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.637010","author":"M Clauss","year":"2021","unstructured":"Clauss\u00a0M, G\u00e9rard\u00a0P, Mosca\u00a0A, Leclerc\u00a0M (2021) Interplay between exercise and gut microbiome in the context of human health and performance. Front Nutr. https:\/\/doi.org\/10.3389\/fnut.2021.637010","journal-title":"Front Nutr"},{"issue":"5","key":"1538_CR48","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/nu10050642","volume":"10","author":"M Kujawska","year":"2018","unstructured":"Kujawska M, Jodynis-Liebert J (2018) Polyphenols in Parkinson\u2019s disease: a\u00a0systematic review of in vivo studies. Nutrients 10(5):642","journal-title":"Nutrients"},{"issue":"1","key":"1538_CR49","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s13668-018-0222-5","volume":"7","author":"H Gardener","year":"2018","unstructured":"Gardener\u00a0H, Caunca\u00a0MR (2018) Mediterranean diet in preventing neurodegenerative diseases. Curr Nutr Rep 7(1):10\u201320","journal-title":"Curr Nutr Rep"},{"key":"1538_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00052","author":"SC Dyall","year":"2015","unstructured":"Dyall\u00a0SC (2015) Long-chain omega\u20113 fatty acids and the brain: a\u00a0review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci. https:\/\/doi.org\/10.3389\/fnagi.2015.00052","journal-title":"Front Aging Neurosci"},{"issue":"20","key":"1538_CR51","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1001\/jama.283.20.2674","volume":"283","author":"GW Ross","year":"2000","unstructured":"Ross\u00a0GW, Abbott\u00a0RD, Petrovitch\u00a0H, Morens\u00a0DM, Grandinetti\u00a0A, Tung\u00a0KH et\u00a0al (2000) Association of coffee and caffeine intake with the risk of Parkinson disease. JAMA 283(20):2674\u20132679","journal-title":"JAMA"},{"issue":"1","key":"1538_CR52","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13024-021-00427-6","volume":"16","author":"VTE Aho","year":"2021","unstructured":"Aho\u00a0VTE, Houser\u00a0MC, Pereira\u00a0PAB, Chang\u00a0J, Rudi\u00a0K, Paulin\u00a0L et al (2021) Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson\u2019s disease. Mol Neurodegeneration 16(1):6","journal-title":"Mol Neurodegeneration"},{"issue":"1","key":"1538_CR53","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.parkreldis.2013.09.023","volume":"20","author":"F Kamel","year":"2014","unstructured":"Kamel\u00a0F, Goldman\u00a0SM, Umbach\u00a0DM, Chen\u00a0H, Richardson\u00a0G, Barber\u00a0MR et\u00a0al (2014) Dietary fat intake, pesticide use, and Parkinson\u2019s disease. Parkinsonism Relat Disord 20(1):82\u201387","journal-title":"Parkinsonism Relat Disord"},{"key":"1538_CR54","doi-asserted-by":"crossref","first-page":"110609","DOI":"10.1016\/j.nut.2019.110609","volume":"71","author":"EE Mart\u00ednez Leo","year":"2020","unstructured":"Mart\u00ednez Leo\u00a0EE, Segura Campos\u00a0MR (2020) Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases. Nutrition 71:110609","journal-title":"Nutrition"},{"issue":"1","key":"1538_CR55","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1038\/s41467-021-22354-2","volume":"12","author":"S Sabia","year":"2021","unstructured":"Sabia\u00a0S, Fayosse\u00a0A, Dumurgier\u00a0J, van Hees\u00a0VT, Paquet\u00a0C, Sommerlad\u00a0A et\u00a0al (2021) Association of sleep duration in middle and old age with incidence of dementia. Nat Commun 12(1):2289","journal-title":"Nat Commun"},{"issue":"5","key":"1538_CR56","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ana.25459","volume":"85","author":"SJ Schreiner","year":"2019","unstructured":"Schreiner\u00a0SJ, Imbach\u00a0LL, Werth\u00a0E, Poryazova\u00a0R, Baumann-Vogel\u00a0H, Valko\u00a0PO et al (2019) Slow-wave sleep and motor progression in Parkinson disease. Ann Neurol 85(5):765\u2013770","journal-title":"Ann Neurol"},{"issue":"8","key":"1538_CR57","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","volume":"11","author":"JM Tarasoff-Conway","year":"2015","unstructured":"Tarasoff-Conway\u00a0JM, Carare\u00a0RO, Osorio\u00a0RS, Glodzik\u00a0L, Butler\u00a0T, Fieremans\u00a0E et al (2015) Clearance systems in the brain\u2014Implications for Alzheimer disease. Nat Rev Neurol 11(8):457\u2013470","journal-title":"Nat Rev Neurol"},{"key":"1538_CR58","volume-title":"World Alzheimer report 2014: dementia and risk reduction. An analysis of protective and modifiable factors","author":"M Prince","year":"2014","unstructured":"Prince\u00a0M, Albanese\u00a0E, Guerchet\u00a0M, Prina\u00a0M (2014) World Alzheimer report 2014: dementia and risk reduction. An analysis of protective and modifiable factors"},{"issue":"6","key":"1538_CR59","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/mds.25863","volume":"29","author":"D Zhang","year":"2014","unstructured":"Zhang\u00a0D, Jiang\u00a0H, Xie\u00a0J (2014) Alcohol intake and risk of Parkinson\u2019s disease: a\u00a0meta-analysis of observational studies. Mov Disord 29(6):819\u2013822","journal-title":"Mov Disord"},{"key":"1538_CR60","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1471-2377-13-190","volume":"13","author":"AK Eriksson","year":"2013","unstructured":"Eriksson\u00a0AK, L\u00f6fving\u00a0S, Callaghan\u00a0RC, Allebeck\u00a0P (2013) Alcohol use disorders and risk of Parkinson\u2019s disease: findings from a\u00a0Swedish national cohort study 1972\u20132008. BMC Neurol 13:190","journal-title":"BMC Neurol"},{"issue":"6","key":"1538_CR61","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/mds.27720","volume":"34","author":"C Marras","year":"2019","unstructured":"Marras\u00a0C, Canning\u00a0CG, Goldman\u00a0SM (2019) Environment, lifestyle, and Parkinson\u2019s disease: implications for prevention in the next decade. Mov Disord 34(6):801\u2013811","journal-title":"Mov Disord"},{"issue":"3 Suppl","key":"1538_CR62","first-page":"S122","volume":"10","author":"TC Durazzo","year":"2014","unstructured":"Durazzo\u00a0TC, Mattsson\u00a0N, Weiner\u00a0MW, Alzheimer\u2019s Disease Neuroimaging Initiative (2014) Smoking and increased Alzheimer\u2019s disease risk: a\u00a0review of potential mechanisms. Alzheimers Dement 10(3 Suppl):S122\u2013S145","journal-title":"Alzheimers Dement"},{"issue":"10","key":"1538_CR63","doi-asserted-by":"crossref","first-page":"e1056","DOI":"10.1212\/WNL.0000000000200871","volume":"99","author":"H Li","year":"2022","unstructured":"Li\u00a0H, Li\u00a0S, Yang\u00a0H, Zhang\u00a0Y, Zhang\u00a0S, Ma\u00a0Y et\u00a0al (2022) Association of ultraprocessed food consumption with risk of dementia: a\u00a0prospective cohort study. Neurology 99(10):e1056\u2013e1066","journal-title":"Neurology"},{"issue":"3","key":"1538_CR64","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1474-4422(04)00681-7","volume":"3","author":"S Craft","year":"2004","unstructured":"Craft\u00a0S, Watson\u00a0GS (2004) Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol 3(3):169\u2013178","journal-title":"Lancet Neurol"},{"issue":"10","key":"1538_CR65","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1136\/jnnp-2020-323646","volume":"91","author":"BM Jacobs","year":"2020","unstructured":"Jacobs\u00a0BM, Belete\u00a0D, Bestwick\u00a0J, Blauwendraat\u00a0C, Bandres-Ciga\u00a0S, Heilbron\u00a0K et al (2020) Parkinson\u2019s disease determinants, prediction and gene-environment interactions in the UK Biobank. J\u00a0Neurol Neurosurg Psychiatry 91(10):1046\u20131054","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1538_CR66","volume-title":"Risk reduction of cognitive decline and dementia: WHO guidelines","author":"World Health Organization","year":"2019","unstructured":"World Health Organization (2019) Risk reduction of cognitive decline and dementia: WHO guidelines (Licence: CC BY-NC-SA 3.0 IGO)"},{"key":"1538_CR67","doi-asserted-by":"publisher","unstructured":"Furlong M, Tanner CM, Goldman SM, Bhudhikanok GS, Blair A, Chade A et\u00a0al (2015) Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson\u2019s disease. Environ Int 75:144\u2013150. https:\/\/doi.org\/10.1016\/j.envint.2014.11.002","DOI":"10.1016\/j.envint.2014.11.002"}],"container-title":["Der Nervenarzt"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-023-01538-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00115-023-01538-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-023-01538-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T08:03:31Z","timestamp":1697184211000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00115-023-01538-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["1538"],"URL":"https:\/\/doi.org\/10.1007\/s00115-023-01538-9","relation":{},"ISSN":["0028-2804","1433-0407"],"issn-type":[{"value":"0028-2804","type":"print"},{"value":"1433-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,28]]},"assertion":[{"value":"24 July 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"E.\u00a0Sch\u00e4ffer und J.\u00a0Piel geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}