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Au\u00dferdem fand eine eingehende Anamnese der aktuellen Symptomatik sowie die systematische retrospektive Erfragung der Akutsymptomatik bis 4\u00a0Wochen nach best\u00e4tigter Infektion statt. Die Einteilung der Subtypen erfolgte gem\u00e4\u00df o.\u202fg. Leitlinie anhand der Anamnese, Vorbefunden sowie ausgew\u00e4hlter Patientenfrageb\u00f6gen. Zus\u00e4tzlich wurde ein 5.\u00a0Subtyp aus der vorangegangenen Leitlinie \u201eLong\/Post-COVID\u201c (Stand 05.03.2023) erg\u00e4nzt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Insgesamt wurden 157 Patient<jats:italic>innen<\/jats:italic> zwischen August 2020 und M\u00e4rz 2022 eingeschlossen. Die Vorstellung erfolgte im Median\u00a09,4\u00a0Monate (IQR\u202f=\u20095,3) nach der Infektion, wobei das mediane Alter 49,9 Jahre (IQR\u202f=\u200917,2) betrug und 68\u202f% weiblich waren, bei einer Hospitalisierungsrate von insgesamt 26\u202f%. Subtyp\u00a01 (Post-intensive-care-Syndrom) wies die h\u00f6chste M\u00e4nnerquote und den h\u00f6chsten Body-Mass-Index (BMI) sowie den gr\u00f6\u00dften Anstieg subjektiver Wortfindungsst\u00f6rungen (70\u202f%) auf. In Subtyp\u00a02 (Folgekrankheiten) dominierten kognitive Beeintr\u00e4chtigungen und die h\u00f6chsten Depressionswerte. Subtyp\u00a03 (Fatigue und Belastungsintoleranz) war am h\u00e4ufigsten (44\u202f%), hatte den gr\u00f6\u00dften Frauenanteil, die meisten Symptome und die st\u00e4rkste subjektive Fatigue. Subtyp\u00a04 (Exazerbation einer Grunderkrankung) wies vor allem affektive Symptome auf. Subtyp\u00a05 (Beschwerden ohne Alltagsrelevanz) hatte die niedrigsten Werte f\u00fcr Depression, Fatigue und BMI. Neurologische und psychische Erkrankungen waren \u00fcberall h\u00e4ufig vorbestehend.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Diskussion<\/jats:title>\n                <jats:p>Das Management eines PCC kann durch eine standardisierte Subtypeneinteilung, die individuelle und fr\u00fchzeitige Behandlungskonzepte erm\u00f6glicht, verbessert werden. Risikopatient<jats:italic>innen<\/jats:italic> sollten identifiziert und \u00fcber Risikofaktoren sowie Pr\u00e4ventionsstrategien aufgekl\u00e4rt werden. K\u00f6rperliche Aktivit\u00e4t und Reduzierung kardiovaskul\u00e4rer Risikofaktoren sind essenziell. Bei kognitiven Defiziten und gleichzeitiger affektiver Symptomatik sollte zeitnah eine psychotherapeutische Anbindung und medikament\u00f6se Behandlung mit selektiven Serotonin-Wiederaufnahme-Hemmern (SSRI) erfolgen.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00115-024-01753-y","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T13:01:50Z","timestamp":1728046910000},"page":"1091-1103","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Post-COVID-19-Zustand\u00a0\u2013 klinische Ph\u00e4notypisierung in der Praxis","Post-COVID-19 condition\u2014Clinical phenotyping in practice"],"prefix":"10.1007","volume":"95","author":[{"given":"Karen","family":"Humkamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Sofia","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Reetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Walders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"1753_CR1","doi-asserted-by":"publisher","first-page":"e0300570","DOI":"10.1371\/journal.pone.0300570","volume":"19","author":"KM Andersen","year":"2024","unstructured":"Andersen\u00a0KM, Khan\u00a0FL, Park\u00a0PW et\u00a0al (2024) Using a\u00a0data-driven approach to define post-COVID conditions in US electronic health record data. 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Die Daten sind auf begr\u00fcndete Anfrage verf\u00fcgbar.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}