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Offensichtlich ist der gr\u00f6\u00dfte Teil der Wirkung, die in klinischen Studien in den Antidepressivagruppen gefunden wird, auf Faktoren zur\u00fcckf\u00fchren, die nicht spezifisch f\u00fcr die Antidepressivatherapie sind. Im Artikel wird dargelegt, welche Faktoren zu dieser hohen Effektivit\u00e4t von Placebointerventionen bei Antidepressiva beitragen.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methodik<\/jats:title>\n            <jats:p>Es wird ein narrativer Literatur\u00fcberblick mit besonderer Ber\u00fccksichtigung der Placeboeffekte in Studien zu Antidepressiva vorgestellt.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Ergebnisse<\/jats:title>\n            <jats:p>Bei Depressionen findet sich auch im Vergleich zu anderen psychischen St\u00f6rungen ein besonders starker Placeboeffekt. Die St\u00e4rke dieses Effekts l\u00e4sst sich modulieren durch hilfreiche vs. nichthilfreiche Instruktionen, durch Beteiligung der Patienten am Entscheidungsprozess, aber auch durch pers\u00f6nliche Zuwendung, insbesondere wenn die Behandler als kompetent und warmherzig wahrgenommen werden. Auch das Auftreten dezenter Nebenwirkungen kann Placeboeffekte verst\u00e4rken. Placeboeffekte zeigen sich dabei nicht nur in subjektiven Patientenberichten, sondern auch durch nachweisbare neurochemische Ver\u00e4nderungen im K\u00f6rper.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Schlussfolgerung<\/jats:title>\n            <jats:p>Behandler tragen durch ihr eigenes Verhalten wesentlich zur Effektivit\u00e4t antidepressiver Behandlungen bei. Gleichzeitig muss der insgesamt doch eher geringe Abstand zwischen Verum- und Placebobehandlungen bei Depressionen eine kritische Beleuchtung der Bewertung des Kosten-Nutzen-Verh\u00e4ltnisses am Einzelfall nach sich ziehen. Studiendesigns zur Evaluation von Antidepressiva sind gefordert, die die komplexen Wechselwirkungen zwischen der eigentlichen Medikamentenwirkung und Placeboeffekten besser darstellen.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00115-024-01784-5","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T20:27:15Z","timestamp":1734035235000},"page":"128-137","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Placeboeffekte bei der Therapie mit Antidepressiva","Placebo effect in the treatment with antidepressants"],"prefix":"10.1007","volume":"96","author":[{"given":"Winfried","family":"Rief","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"1784_CR1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s12160-016-9772-1","volume":"50","author":"H Bartley","year":"2016","unstructured":"Bartley\u00a0H, Faasse\u00a0K, Horne\u00a0R et\u00a0al (2016) You can\u2019t always get what you want: the influence of choice on nocebo and placebo responding. 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