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Die Rekrutierung erfolgte aus den Kliniken f\u00fcr Neurologie, Neurochirurgie und Psychiatrie des Universit\u00e4tsklinikums Carl Gustav Carus in Dresden. NPH-typische Bildbefunde wurden anhand vorliegender MRT- bzw. CT-Schnittbilder erhoben. Relevante soziodemografische, klinische, kognitive und liquordiagnostische Parameter wurden mittels Aktendurchsicht erfasst. Die Patienten wurden hinsichtlich des Liquorbefundes gem\u00e4\u00df ATN-Klassifikation kategorisiert.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>\n                      Im Beobachtungszeitraum wurden 33\u00a0Patienten (14\u00a0weiblich, 19\u00a0m\u00e4nnlich, Durchschnittsalter\u00a074,6\u202f\u00b1\u20098,1\u00a0Jahre) mit iNPH-Verdacht analysiert. 19\u00a0Patienten (57,6\u202f%) wiesen eine komplette und 14\u00a0Patienten (42,4\u202f%) eine inkomplette Hakim-Trias auf. Die Differenz des MoCA-Scores vor und nach Liquorablass unterschied zwischen Patienten mit und ohne Ansprechen im Liquorablass (F[1;22]\u202f=\u20095,725;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090,026). Es bestand ein Trend, dass Patienten mit pathologischem Corpus-callosum-Winkel und auff\u00e4lligem Evans-Index (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090,052) sowie Patienten mit pathologischem Corpus-callosum-Winkel, Evans-Index und kompletter Hakim-Trias (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090,055) h\u00e4ufiger ansprechen. Der durchschnittliche Fazekas-Score betrug\u00a01,7. Es bestand kein Zusammenhang zwischen Fazekas-Score und Ansprechen auf den Liquorablass. Insgesamt wurden bei 25\u00a0Patienten (75,8\u202f%) Demenz- und Destruktionsmarker bestimmt. Gem\u00e4\u00df ATN-Klassifikation wurden 20\u00a0Patienten (80\u202f%) als A\n                      <jats:sup>+<\/jats:sup>\n                      T\n                      <jats:sup>\u2212<\/jats:sup>\n                      , 3 (12,0\u202f%) als A\n                      <jats:sup>+<\/jats:sup>\n                      T\n                      <jats:sup>+<\/jats:sup>\n                      und 2 (8,0\u202f%) als A\n                      <jats:sup>\u2212<\/jats:sup>\n                      T\n                      <jats:sup>\u2212<\/jats:sup>\n                      klassifiziert. A\n                      <jats:sup>+<\/jats:sup>\n                      T\n                      <jats:sup>+<\/jats:sup>\n                      - und A\n                      <jats:sup>+<\/jats:sup>\n                      T\n                      <jats:sup>\u2212<\/jats:sup>\n                      -Patienten sprachen nicht h\u00e4ufiger auf den Liquorablass an (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090,600).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diskussion<\/jats:title>\n                    <jats:p>Die kombinierte Bestimmung von CCW und Evans-Index sowie deren Kontextualisierung mit klinischen Charakteristika verbessern m\u00f6glicherweise die prognostische Einsch\u00e4tzung eines Ansprechens im Liquorablassversuch. Insbesondere eine komorbide Amyloidpathologie, aber auch eine zerebrale Mikroangiopathie stellen h\u00e4ufige Kopathologien beim iNPH dar, wobei der Einfluss einer komorbiden Amyloidpathologie auf das Ansprechen im Liquorablassversuch noch ungekl\u00e4rt ist.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00115-025-01808-8","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T10:29:16Z","timestamp":1740738556000},"page":"686-695","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beobachtungsstudie zur Koinzidenz von Alzheimer-Erkrankung und idiopathischem Normaldruckhydrozephalus: Analyse von Koinzidenz, deren Einfluss auf das Ansprechen im Liquorablassversuch und zerebrovaskul\u00e4rer Kopathologie","Observational study on the coincidence of Alzheimer\u2019s disease and idiopathic normal pressure hydrocephalus: analysis of coincidence, the influence on response to cerebrospinal fluid drainage and cerebrovascular copathology"],"prefix":"10.1007","volume":"96","author":[{"given":"M.","family":"Beeke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Petzold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Frenzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Donix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Rei\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Hau\u00dfmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"1808_CR1","volume-title":"S1-Leitlinie Normaldruckhydrozephalus","author":"W Paulus","year":"2018","unstructured":"Paulus\u00a0W, Krauss\u00a0J (2018) S1-Leitlinie Normaldruckhydrozephalus"},{"issue":"10","key":"1808_CR2","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1055\/a-2212-7899","volume":"91","author":"M Beeke","year":"2023","unstructured":"Beeke\u00a0M et\u00a0al (2023) Correction: Coincidence of normal pressure hydrocephalus and Alzheimer;s disease: therapeutic implications and open questions. 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