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Within the German Mental Health Cohort (GEMCO), these mechanisms and their influence on disease trajectories will be investigated longitudinally. Parallelized human and animal projects will enable an in-depth characterization of their neurobiological correlates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By leveraging recent advancement in the modeling of complex, dynamic systems and machine learning techniques, we will be able to integrate human and animal data on the key cognitive\u2013emotional mechanisms and their interplay with stressors and other modifying factors across disease trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gaining a\u00a0deeper understanding of the cognitive\u2013emotional mechanisms in the progression of affective disorders will help to predict symptom changes and course of illness as well as to identify key targets of intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00115-025-01920-9","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:00:42Z","timestamp":1762772442000},"page":"147-153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Key mechanisms of affective disorders","Schl\u00fcsselmechanismen affektiver St\u00f6rungen"],"prefix":"10.1007","volume":"97","author":[{"given":"Philipp","family":"Kanske","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Bernhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Gro\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Culmsee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth J.","family":"Leehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"J\u00fcngling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Straube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Wessing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilo","family":"Kircher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"W\u00f6hr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"1920_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s10608-014-9662-4","volume":"39","author":"A Aldao","year":"2015","unstructured":"Aldao\u00a0A et\u00a0al (2015) Emotion regulation flexibility. 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