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Eine genaue Kenntnis der Risikofaktoren f\u00fcr das Wiederauftreten depressiver Episoden kann durch die Implementierung fr\u00fchzeitiger und zielgerichteter Interventionen rezidivierende Krankheitsverl\u00e4ufe verhindern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ziel der Arbeit<\/jats:title>\n                    <jats:p>Aufstellung der verschiedenen Faktoren, die das Risiko f\u00fcr Rezidive und R\u00fcckf\u00e4lle in der Depression erh\u00f6hen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material und Methoden<\/jats:title>\n                    <jats:p>Narrative Literatur\u00fcbersicht.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Risikofaktoren f\u00fcr depressive Rezidive und R\u00fcckf\u00e4lle sind vor allem klinische Faktoren n\u00e4mlich die Anzahl fr\u00fcherer depressiver Episoden, ein junges Ersterkrankungsalter und bestehende Residualsymptome. Umweltbedingte Faktoren umfassen Misshandlungserfahrungen in der Kindheit sowie aktuelle Stressoren. Auch intrapsychische Faktoren wie erh\u00f6hter Neurotizismus oder dysfunktionale Kognitionen beg\u00fcnstigen R\u00fcckf\u00e4lle und Rezidive. Biologische Faktoren sind funktionelle und strukturelle Gehirnver\u00e4nderungen, immunologische Dysregulation sowie genetische Pr\u00e4dispositionen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diskussion<\/jats:title>\n                    <jats:p>In der klinischen Praxis ist der bisherige Krankheitsverlauf der zentrale Pr\u00e4diktor f\u00fcr die individuelle Risikoprognose. Therapeutische Interventionen sollten verst\u00e4rkt auf die Vollremission residualer Symptome abzielen durch kombinierte pharmakologische und psychotherapeutische Behandlung. Die Vulnerabilit\u00e4t f\u00fcr rezidivierende depressive Episoden ist multifaktoriell bedingt, und die Indikationsstellung zur Rezidivprophylaxe sollte dies abbilden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00115-026-01945-8","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T14:46:55Z","timestamp":1770302815000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vulnerabilit\u00e4tsfaktoren depressiver Rezidive und R\u00fcckf\u00e4lle","Vulnerability factors of depressive relapses and recurrences"],"prefix":"10.1007","author":[{"given":"Lea","family":"Teutenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilo","family":"Kircher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"1945_CR1","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.cpr.2011.09.003","volume":"31","author":"S Beshai","year":"2011","unstructured":"Beshai\u00a0S, Dobson\u00a0KS, Bockting\u00a0CLH, Quigley\u00a0L (2011) Relapse and recurrence prevention in depression: Current research and future prospects. 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Keine der angegebenen Finanzierungsquellen und Beziehungen stehen mit der vorliegenden Arbeit in Zusammenhang. L.\u00a0Teutenberg gibt an, dass keine Interessenskonflikte bestehen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}