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Das Konzept der \u201eimmunometabolischen Depression\u201c (IMD) beschreibt eine Subgruppe mit zus\u00e4tzlichen metabolischen und inflammatorischen Auff\u00e4lligkeiten wie Adipositas, Insulinresistenz und erh\u00f6htem CRP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ziel der Arbeit<\/jats:title>\n                    <jats:p>Zusammenfassung aktueller Erkenntnisse zur AD, ihrer \u00dcberlappung mit immunometabolischen Mechanismen und therapeutischer Implikationen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material und Methoden<\/jats:title>\n                    <jats:p>Narratives Review auf Basis einer PubMed-Recherche (\u201eatypical depression\u201c, \u201eimmunometabolic depression\u201c) sowie erg\u00e4nzender \u00dcbersichtsarbeiten.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Atypische depressive Syndrome sind mit erh\u00f6hter systemischer Inflammation und metabolischer Dysregulation assoziiert. F\u00fcr Bupropion und Monoaminooxidase-Hemmer bestehen Hinweise auf eine spezifische Wirksamkeit bei AD, jedoch bei begrenzter Evidenz. Bei immunometabolischen Auff\u00e4lligkeiten (z.\u202fB. Erh\u00f6hung des C-reaktiven Proteins) werden antiinflammatorische Substanzen (z.\u202fB. Infliximab) und metabolisch wirksame Medikamente (z.\u202fB. orale Antidiabetika) als potenzielle Therapieoptionen diskutiert, wobei Statine bislang keine konsistenten antidepressiven Effekte zeigten. K\u00f6rperliche Aktivit\u00e4t und Ern\u00e4hrungsumstellung wirken zus\u00e4tzlich g\u00fcnstig.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diskussion<\/jats:title>\n                    <jats:p>Das Konzept der IMD k\u00f6nnte k\u00fcnftig stratifizierte Therapieans\u00e4tze erm\u00f6glichen. Derzeit fehlt jedoch eine eindeutige Evidenz und es existieren keine spezifisch zugelassenen Behandlungen. Zudem erschwert die h\u00e4ufige Fluktuation zwischen atypischen und melancholischen Syndromen die klinische Abgrenzung.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00115-026-01947-6","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T14:35:22Z","timestamp":1770734122000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunometabolische Mechanismen bei atypischer Depression","Immunometabolic mechanisms in atypical depression"],"prefix":"10.1007","author":[{"given":"Marco","family":"Kramer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Juckel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"1947_CR1","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1176\/appi.ajp.2015.14020181","volume":"172","author":"BA Arnow","year":"2015","unstructured":"Arnow\u00a0BA, Blasey\u00a0C, Williams\u00a0LM et\u00a0al (2015) Depression Subtypes in Predicting Antidepressant Response: A Report From the iSPOT\u2011D Trial. 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