{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:46:32Z","timestamp":1782733592625,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Hintergrund<\/jats:title>\n                    <jats:p>Geschlechtschromosomale Aberrationen betreffen etwa 1,5\u00a0pro 1000 Individuen, wobei somatisch wenig ausgepr\u00e4gte Ph\u00e4notypen unerkannt bleiben k\u00f6nnen. Auch bei bekannter Diagnose gilt es, das erh\u00f6hte Risiko neuropsychiatrischer Manifestationen spezifisch in der psychiatrischen Versorgung zu adressieren.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodik<\/jats:title>\n                    <jats:p>Die narrative \u00dcbersicht analysiert aktuelle Literatur zu neuropsychiatrischen Manifestationen geschlechtschromosomaler Syndrome mit Fokus auf die vier h\u00e4ufigsten Formen (Klinefelter\u2011, Turner\u2011, XYY- und Triple-X-Syndrom).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Geschlechtschromosomale Aberrationen zeigen charakteristische neuropsychiatrische Manifestationen. H\u00e4ufige psychiatrische Manifestationen umfassen Aufmerksamkeitsdefizit\u2011\/Hyperaktivit\u00e4tsst\u00f6rung, Autismusspektrumst\u00f6rungen, Angstst\u00f6rungen, affektive und psychotische St\u00f6rungen. Kognitive Beeintr\u00e4chtigungen betreffen die Mehrheit der Betroffenen und manifestieren sich in sprachlichen Entwicklungsst\u00f6rungen, exekutiven Dysfunktionen oder in visuell-r\u00e4umlichen Defiziten. Schwere intellektuelle Beeintr\u00e4chtigungen sind selten (&lt;\u202f5\u201310\u202f%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerung<\/jats:title>\n                    <jats:p>Erh\u00f6hte klinische Aufmerksamkeit f\u00fcr neuropsychiatrische Manifestationen geschlechtschromosomaler Aberrationen erm\u00f6glicht eine fr\u00fchzeitigere Diagnosestellung und Zugang zu entwicklungsf\u00f6rdernden, psycho(pharmako)logischen und endokrinologischen Behandlungsans\u00e4tzen zur Verbesserung der Lebensqualit\u00e4t und gesellschaftlichen Teilhabe Betroffener.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00115-026-01977-0","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:33:15Z","timestamp":1780392795000},"page":"326-338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuropsychiatrische Manifestationen\u00a0geschlechtschromosomaler Aberrationen\u00a0\u2013 klinische und therapeutische Aspekte der neurologisch-psychiatrischen Versorgung","Neuropsychiatric manifestations of sex chromosome aberrations\u2014Clinical and therapeutic aspects of neuropsychiatric care"],"prefix":"10.1007","volume":"97","author":[{"given":"Heiko","family":"Paland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Philipsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva C.","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"1977_CR1","doi-asserted-by":"publisher","unstructured":"Berglund\u00a0A, Stochholm\u00a0K, Gravholt\u00a0CH (2020) The epidemiology of sex chromosome abnormalities. 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