{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:53:51Z","timestamp":1790942031999,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nervenarzt"],"DOI":"10.1007\/s00115-026-02019-5","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:56:42Z","timestamp":1790938602000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relevance of the negative valence system, the cognitive system, and their interactions for understanding aggression in mental disorders","Relevanz des negativen Valenzsystems, des kognitiven Systems und ihrer Wechselwirkungen f\u00fcr das Verst\u00e4ndnis von Aggression bei psychischen St\u00f6rungen"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9177-9010","authenticated-orcid":false,"given":"Katja","family":"Bertsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Wagels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Neukel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya","family":"Chechko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Ende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Frodl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schmahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph W.","family":"Korn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"2019_CR1","unstructured":"RdoC Matrix. National Institute of Mental Health (NIMH). Available online at: https:\/\/www.nimh.nih.gov\/research\/research-funded-by-nimh\/rdoc (accessed Mai\u00a022, 2026)."},{"key":"2019_CR2","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1007\/s00115-021-01166-1","volume":"92","author":"CW Korn","year":"2021","unstructured":"Korn\u00a0CW, Wolf\u00a0RC (2021) Negative Valenzsysteme im System der Research Domain Criteria. Nervenarzt 92:868\u2013877","journal-title":"Nervenarzt"},{"issue":"7","key":"2019_CR3","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1176\/appi.ajp.2010.09091379","volume":"167","author":"T Insel","year":"2010","unstructured":"Insel\u00a0T et\u00a0al (2010) Research domain criteria (RDoC): Toward a\u00a0new classification framework for research on mental disorders. The American Journal of Psychiatry 167(7):748\u2013751","journal-title":"The American Journal of Psychiatry"},{"key":"2019_CR4","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s00115-024-01632-6","volume":"95","author":"MG Halil","year":"2024","unstructured":"Halil\u00a0MG et\u00a0al (2024) The German Center for Mental Health: Innovative translational research to promote prevention, targeted intervention and resilience. Nervenarzt 95:450\u2013457","journal-title":"Nervenarzt"},{"key":"2019_CR5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ijpsycho.2015.03.008","volume":"98","author":"E Verona","year":"2015","unstructured":"Verona\u00a0E, Bresin\u00a0K (2015) Aggression proneness: transdiagnostic processes involving negative valence and cognitive systems. International Journal of Psychophysiology 98:321\u2013329","journal-title":"International Journal of Psychophysiology"},{"key":"2019_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-020-01208-6","volume":"22","author":"K Bertsch","year":"2020","unstructured":"Bertsch\u00a0K et\u00a0al (2020) Understanding brain mechanisms of reactive aggression. Current Psychiatry Reports 22:81","journal-title":"Current Psychiatry Reports"},{"key":"2019_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2024.1328839","volume":"15","author":"JC Hutten","year":"2024","unstructured":"Hutten\u00a0JC et\u00a0al (2024) Neuropsychological assessment of aggressive offenders: a\u00a0Delphi consensus study. Frontiers in Psychology 15:1328839","journal-title":"Frontiers in Psychology"},{"key":"2019_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2022.102204","volume":"98","author":"A Flechsenhar","year":"2022","unstructured":"Flechsenhar\u00a0A et\u00a0al (2022) The (un)learning of social functions and its significance for mental health. Clinical Psychology Review 98:102204","journal-title":"Clinical Psychology Review"},{"issue":"2","key":"2019_CR9","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.ijpsycho.2015.04.018","volume":"98","author":"LM Gatzke-Kopp","year":"2015","unstructured":"Gatzke-Kopp\u00a0LM et\u00a0al (2015) \u201cHow does reactivity to frustrative non-reward increase risk for externalizing symptoms?\u201d. International Journal of Psychophysiology 98(2):300\u2013309","journal-title":"International Journal of Psychophysiology"},{"issue":"2","key":"2019_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3758\/s13415-011-0083-5","volume":"12","author":"TA Niendam","year":"2012","unstructured":"Niendam\u00a0TA et\u00a0al (2012) Meta-analytic evidence for a\u00a0superordinate cognitive control network subserving dierse executive functions. Cognitive, Affective, and Behavioral Neuroscience 12(2):241\u2013268","journal-title":"Cognitive, Affective, and Behavioral Neuroscience"},{"issue":"1","key":"2019_CR11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1177\/0146167290161002","volume":"16","author":"KA Dodge","year":"1990","unstructured":"Dodge\u00a0KA, Crick\u00a0NR (1990) Social information-processing bases of aggressive behavior in children. Personality and Social Psychology Bulletin 16(1):8\u201322","journal-title":"Personality and Social Psychology Bulletin"},{"issue":"4","key":"2019_CR12","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/ab.21432","volume":"38","author":"L Berkowitz","year":"2012","unstructured":"Berkowitz\u00a0L (2012) \u201cA\u00a0Different View of Anger: The Cognitive-Neoassociation Conception of the Relation of Anger to Aggression\u201d. Aggressive Behavior 38(4):322\u2013333","journal-title":"Aggressive Behavior"},{"issue":"2","key":"2019_CR13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1080\/02699931.2014.911146","volume":"29","author":"BM Wilkowski","year":"2015","unstructured":"Wilkowski\u00a0BM et\u00a0al (2015) Learning to keep your cool: reducing aggression through the experimental modification of cognitive control. Cognition and Emotion 29(2):251\u2013265","journal-title":"Cognition and Emotion"},{"issue":"156","key":"2019_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.03.008","volume":"15","author":"A Sebastian","year":"2019","unstructured":"Sebastian\u00a0A et\u00a0al (2019) Violent offending in borderline personality disorder and attention deficit\/hyperactivity disorder. Neuropharmacology 15(156):107565","journal-title":"Neuropharmacology"},{"issue":"5","key":"2019_CR15","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1093\/scan\/nsv154","volume":"11","author":"M Achterberg","year":"2016","unstructured":"Achterberg\u00a0M et\u00a0al (2016) Control your anger! The neural basis of aggression regulation in response to negative social feedback. Social, Cognitive, and Affective Neuroscience 11(5):712\u2013720","journal-title":"Social, Cognitive, and Affective Neuroscience"},{"key":"2019_CR16","doi-asserted-by":"crossref","unstructured":"Hernandez-Pena, L. et\u00a0al. (2026). Future directions in aggression research: the contribution of technology-integrated operationalizations. Review of General Psychology, 10892680251412856.","DOI":"10.31234\/osf.io\/xegu2_v1"},{"issue":"2","key":"2019_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1467-6494.1967.tb01430.x","volume":"35","author":"SP Taylor","year":"1967","unstructured":"Taylor\u00a0SP (1967) Aggressive behavior and physiological arousal as a function of provocation and the tendency to inhibit aggression. Journal of Personality 35(2):297\u2013310","journal-title":"Journal of Personality"},{"issue":"1","key":"2019_CR18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1037\/emo0000435","volume":"19","author":"G Gilam","year":"2019","unstructured":"Gilam\u00a0G et\u00a0al (2019) The anger-infused Ultimatum Game: A reliable and valid paradigm to induce and assess anger. Emotion 19(1):84\u201396","journal-title":"Emotion"},{"issue":"5","key":"2019_CR19","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1037\/0022-3514.79.5.748","volume":"79","author":"KD Williams","year":"2000","unstructured":"Williams\u00a0KD et\u00a0al (2000) Cyberostracism: Effects of being ignored over the Internet. Journal of Personality and Social Psychology 79(5):748\u2013762","journal-title":"Journal of Personality and Social Psychology"},{"key":"2019_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1006\/nimg.2002.1179","volume":"17","author":"AR Hariri","year":"2002","unstructured":"Hariri\u00a0AR et\u00a0al (2002) The amygdala response to emotional stimuli: a comparision of faces and scenes. Neuroimage 17:317\u2013323","journal-title":"Neuroimage"},{"key":"2019_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2024.1288743","volume":"15","author":"J Koch","year":"2024","unstructured":"Koch\u00a0J et\u00a0al (2024) A\u00a0quasi-experimental study in sibling dyads: differential provocation-aggression patterns in the interactive taylor aggression paradigm. Frontiers in Psychology 15:1288743","journal-title":"Frontiers in Psychology"},{"issue":"1","key":"2019_CR22","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.neuropsychologia.2007.07.015","volume":"46","author":"DJ Simmonds","year":"2008","unstructured":"Simmonds\u00a0DJ et\u00a0al (2008) Meta-analysis of Go\/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent. Neuropsychologia 46(1):224\u2013232","journal-title":"Neuropsychologia"},{"issue":"7","key":"2019_CR23","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/s41562-019-0603-9","volume":"3","author":"CW Korn","year":"2019","unstructured":"Korn\u00a0CW, Bach\u00a0DR (2019) Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex. Nature Human Behavior 3(7):733\u2013745","journal-title":"Nature Human Behavior"},{"issue":"7","key":"2019_CR24","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.biopsych.2017.01.018","volume":"82","author":"CW Korn","year":"2017","unstructured":"Korn\u00a0CW et\u00a0al (2017) Amygdala Lesions Reduce Anxiety-like Behavior in a\u00a0Human Benzodiazepine-Sensitive Approach-Avoidance Conflict Test. Biological Psychiatry 82(7):522\u2013531","journal-title":"Biological Psychiatry"},{"issue":"4","key":"2019_CR25","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1037\/abn0000258","volume":"126","author":"R Kotov","year":"2017","unstructured":"Kotov\u00a0R et\u00a0al (2017) The Hierarchical Taxonomy of Psychopathology (HiTOP): A dimensional alternative to traditional nosologies. Journal of Abnormal Psychology 126(4):454\u2013477","journal-title":"Journal of Abnormal Psychology"},{"issue":"11","key":"2019_CR26","doi-asserted-by":"publisher","first-page":"e816","DOI":"10.1016\/S2589-7500(22)00152-2","volume":"4","author":"TU Hauser","year":"2022","unstructured":"Hauser\u00a0TU et\u00a0al (2022) The promise of a\u00a0model-based psychiatry: building computational models of mental ill health. Lancet Digit Health 4(11):e816\u2013e828","journal-title":"Lancet Digit Health"},{"issue":"1","key":"2019_CR27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41386-020-0746-4","volume":"46","author":"QJM Huys","year":"2021","unstructured":"Huys\u00a0QJM et\u00a0al (2021) Advances in the computational understanding dof mental illness. Neuropsychopharmacology 46(1):3\u201319","journal-title":"Neuropsychopharmacology"}],"container-title":["Der Nervenarzt"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-026-02019-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00115-026-02019-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00115-026-02019-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:56:44Z","timestamp":1790938604000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00115-026-02019-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":27,"alternative-id":["2019"],"URL":"https:\/\/doi.org\/10.1007\/s00115-026-02019-5","relation":{},"ISSN":["0028-2804","1433-0407"],"issn-type":[{"value":"0028-2804","type":"print"},{"value":"1433-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"assertion":[{"value":"1 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"K.\u00a0Bertsch, L.\u00a0Wagels, C.\u00a0Neukel, N.\u00a0Chechko, G.\u00a0Ende, T.\u00a0Frodl, M.\u00a0Hanke, C.\u00a0Schmahl and C.W.\u00a0Korn declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For this article no studies with human participants or animals were performed by any of the authors. All studies mentioned were in accordance with the ethical standards indicated in each case.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}}]}}