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Derzeit inkludiert die mpMRT die kontrastmittelverst\u00e4rkte und diffusionsgewichtete MRT. F\u00fcr eine umfassendere Charakterisierung der Schl\u00fcsselprozesse der Krebsentstehung sind zus\u00e4tzliche MRT-Methoden, welche funktionelle Vorg\u00e4nge auf zellul\u00e4rer und molekularer Ebene erfassen, notwendig. Im Rahmen von pr\u00e4klinischen Studien werden MRT-Methoden, welche eine kontrastmittelfreie Evaluierung der Schl\u00fcsselprozesse auf metabolischer und molekularer Ebene erm\u00f6glichen, f\u00fcr zuk\u00fcnftige klinische Anwendungen entwickelt.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Fragestellung<\/jats:title>\n            <jats:p>Wie sieht die mpMRT der Brust in Zukunft aus?<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Material und Methoden<\/jats:title>\n            <jats:p>Systematische Literaturanalyse fokussiert auf pr\u00e4klinische Forschung in Bezug auf mpMRT sowie Entwicklung und Modifizierung von nichtinvasiven MRT-Methoden.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Ergebnisse<\/jats:title>\n            <jats:p>Einige vielversprechende MRT-Methoden f\u00fcr die Mammadiagnostik, die funktionelle als auch metabolische Fragen beantworten k\u00f6nnen, sind BOLD (\u201eblood oxygen level dependent\u201c), IVIM (\u201eintravoxel incoherent motion\u201c), DMI (Deuterium-MRT) und CEST (\u201echemical exchange saturation transfer\u201c). Eine Kombination, und somit ein multiparametrischer Ansatz, erm\u00f6glicht die nichtinvasive Differenzierung der Subtypen sowie die fr\u00fche Evaluierung des Therapieansprechens und ist somit entscheidend f\u00fcr den weiteren Verlauf der Krankheit.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Schlussfolgerung<\/jats:title>\n            <jats:p>Standardisierung der Quantifizierung sowie Verbesserung und Erweiterung der MRT-Methoden erm\u00f6glichen solch eine multiparametrische, funktionelle und metabolische Einsch\u00e4tzung des Tumors. Viele davon werden zun\u00e4chst in der Pr\u00e4klinik entwickelt, bevor die Translation in die Klinik erfolgen kann.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00117-024-01390-1","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T06:17:28Z","timestamp":1732861048000},"page":"162-169","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multiparametrische Magnetresonanztomographie der Brust","Multiparametric magnetic resonance imaging of the breast"],"prefix":"10.1007","volume":"65","author":[{"given":"Daniela","family":"Prinz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvester J.","family":"Bartsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Ehret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Friske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Pinker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Helbich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"1390_CR1","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/s00117-016-0129-3","volume":"56","author":"K Pinker","year":"2016","unstructured":"Pinker\u00a0K, Marino\u00a0MA, Meyer-Baese\u00a0A, Helbich\u00a0TH (2016) Multiparametrische und molekulare Bildgebung von Brusttumoren mit MRT und PET-MRT. 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T.H.\u00a0Helbich gibt an Teil des Rednerb\u00fcros der European Society of Breast Imaging (EUSOBI) (aktiv) zu sein und Kooperationen mit Bracco, Siemens Healthineers, Guerbet, Novomed, Bruker und BD hat. D.\u00a0Prinz, S.J.\u00a0Bartsch, V.\u00a0Ehret und J.\u00a0Friske geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle nationalen Richtlinien zur Haltung und zum Umgang mit Labortieren wurden eingehalten und die notwendigen Zustimmungen der zust\u00e4ndigen Beh\u00f6rden liegen vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}