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Zu den wichtigsten Entit\u00e4ten z\u00e4hlen das DRESS-Syndrom (\u201edrug reaction with eosinophilia and systemic symptoms\u201c), das Stevens-Johnson-Syndrom (SJS) und die toxische epidermale Nekrolyse (TEN, Lyell-Syndrom), die Serumkrankheit, medikamenteninduzierte eosinophile Pneumonien sowie Hypersensitivit\u00e4tspneumonitiden. Pulmonale Manifestationen sind dabei h\u00e4ufig und k\u00f6nnen den klinischen Verlauf entscheidend beeinflussen. Dieser \u00dcbersichtsartikel erl\u00e4utert die immunologischen Grundlagen, die Pathogenese und \u00c4tiologie der medikamenteninduzierten Hyperreaktivit\u00e4tserkrankungen, beschreibt ihre klinische Relevanz und stellt die typischen thorakalen Manifestationen und Bildmuster in der Computertomographie (CT) des Thorax dar. Im Vordergrund steht die Bedeutung der radiologischen Diagnostik bei der fr\u00fchzeitigen Erkennung und Differenzierung dieser potenziell lebensbedrohlichen Krankheitsbilder.<\/jats:p>","DOI":"10.1007\/s00117-026-01565-y","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:45:33Z","timestamp":1771242333000},"page":"199-206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Medikamenteninduzierte Hyperreaktivit\u00e4tserkrankungen","Drug-induced hypersensitivity reactions"],"prefix":"10.1007","volume":"66","author":[{"given":"Justus E.","family":"Roos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Ebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"issue":"3\u20134","key":"1565_CR1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1159\/000453265","volume":"171","author":"W Pichler","year":"2016","unstructured":"Pichler\u00a0W, Hausmann\u00a0O (2016) Classification of Drug Hypersensitivity into Allergic, p\u2011i, and Pseudo-Allergic Forms. 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