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The gene and locus regulate fruit weight by increasing pericarp cell size and its function on fruit weight appears to be conserved in other crops.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      Fruit weight is a quantitative trait that was under strong selection during the domestication of fruit and vegetable crops such as tomato (\n                      <jats:italic>Solanum lycopersicum<\/jats:italic>\n                      ). While numerous fruit weight QTLs have been identified, only three tomato fruit weight genes have been cloned. In this study, we utilized a genetically diverse tomato panel, the Varitome collection, to identify additional genetic loci that control fruit weight. We mapped and fine mapped two fruit weight QTLs on chromosome 6,\n                      <jats:italic>fw6.1<\/jats:italic>\n                      and\n                      <jats:italic>fw6.2<\/jats:italic>\n                      , by using Genome Wide Association studies (GWAS) and linkage mapping in bi-parental populations. We identified a member of the\n                      <jats:italic>Cell Size Regulator<\/jats:italic>\n                      family,\n                      <jats:italic>CSR-like1<\/jats:italic>\n                      , as the likely candidate underlying\n                      <jats:italic>fw6.2<\/jats:italic>\n                      . The near isogenic lines (NILs) carrying the derived allele of\n                      <jats:italic>fw6.2<\/jats:italic>\n                      produced heavier fruits with larger fruit pericarp cells than lines with wildtype (WT) allele. Transgenic downregulation of\n                      <jats:italic>CSR-like1<\/jats:italic>\n                      led to a decrease in fruit weight and pericarp cells, supporting the role of this gene at the\n                      <jats:italic>fw6.2<\/jats:italic>\n                      locus. The haplotype analysis implied that the\n                      <jats:italic>CSR-like1<\/jats:italic>\n                      -Derived (\n                      <jats:italic>CSR-like1<\/jats:italic>\n                      -D) allele was selected in the transition from the fully wild\n                      <jats:italic>S. pimpinellifolium<\/jats:italic>\n                      to the earliest\n                      <jats:italic>S. lycopersicum cerasiforme<\/jats:italic>\n                      accessions\n                      <jats:italic>.<\/jats:italic>\n                      Four single nucleotide polymorphisms (SNPs) were identified in the regulatory region of\n                      <jats:italic>CSR-like1<\/jats:italic>\n                      that were conserved in the accessions carrying\n                      <jats:italic>CSR-like1<\/jats:italic>\n                      -WT and were significantly associated with lower fruit weight and pericarp cell size at the locus. Moreover, a pepper GWAS identified a\n                      <jats:italic>CSR-like1<\/jats:italic>\n                      ortholog that was associated with fruit weight. Together, our findings established\n                      <jats:italic>CSR-like1<\/jats:italic>\n                      as a novel fruit weight gene likely conserved in other crops in the Solanaceae family.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00122-026-05177-x","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:16:51Z","timestamp":1772723811000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fruit weight regulation by a paralog of Cell Size Regulator (CSR) in tomato and other crops"],"prefix":"10.1007","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3891-9712","authenticated-orcid":false,"given":"Qian","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5184-8587","authenticated-orcid":false,"given":"Lara","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-1193","authenticated-orcid":false,"given":"Manoj","family":"Sapkota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Sai","family":"Karnatam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-8104","authenticated-orcid":false,"given":"Yanbing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-9193","authenticated-orcid":false,"given":"Padma","family":"Nimmakayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-7143","authenticated-orcid":false,"given":"Umesh K.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4963-7427","authenticated-orcid":false,"given":"Esther","family":"van der Knaap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"5177_CR1","unstructured":"Alexander DH, Shringarpure SS, Novembre J and Lange K (2015) Admixture 1.3 software manual. 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