{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:47:08Z","timestamp":1791247628582,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T00:00:00Z","timestamp":1115251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1007\/s00125-005-1747-x","type":"journal-article","created":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T08:53:20Z","timestamp":1115196800000},"page":"1088-1092","source":"Crossref","is-referenced-by-count":86,"title":["Increased plasma adiponectin concentrations are associated with microangiopathy in type 1 diabetic subjects"],"prefix":"10.1007","volume":"48","author":[{"given":"S.","family":"Hadjadj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Aubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fumeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tichet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Roussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"SURGENE and DESIR study groups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,5,5]]},"reference":[{"key":"1747_CR1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0161-6420(94)31354-6","volume":"101","author":"R Klein","year":"1994","unstructured":"Klein R, Klein BE, Jensen SC, Moss SE (1994) The relation of socioeconomic factors to the incidence of proliferative diabetic retinopathy and loss of vision. Ophthalmology 101:68\u201376","journal-title":"Ophthalmology"},{"key":"1747_CR2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.7326\/0003-4819-121-12-199412150-00002","volume":"121","author":"TV Pergener","year":"1994","unstructured":"Pergener TV, Brancati FL, Whelton PK, Klag MJ (1994) End-stage renal disease attributable to diabetes. Ann Intern Med 121:912\u2013918","journal-title":"Ann Intern Med"},{"key":"1747_CR3","first-page":"507","volume":"25","author":"S Halimi","year":"1999","unstructured":"Halimi S, Zmirou D, Benhamou PY et al (1999) Huge progression of diabetes prevalence and incidence among dialysed patients in mainland France and overseas French territories. A second national survey six years apart. (UREMIDIAB 2 study). Diabetes Metab 25:507\u2013512","journal-title":"Diabetes Metab"},{"key":"1747_CR4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/bmj.313.7060.779","volume":"313","author":"P Rossing","year":"1996","unstructured":"Rossing P, Hougaard P, Borch-Johnsen K, Parving HH (1996) Predictors of mortality in insulin dependent diabetes: 10 year observational follow up study. BMJ 313:779\u2013784","journal-title":"BMJ"},{"key":"1747_CR5","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s001250050988","volume":"41","author":"J Tuomilheto","year":"1998","unstructured":"Tuomilheto J, Borch-Johnsen K, Molarius A et al (1998) Incidence of cardiovascular disease in type 1 (insulin-dependent) diabetic subjects with and without diabetic nephropathy in Finland. Diabetologia 41:784\u2013790","journal-title":"Diabetologia"},{"key":"1747_CR6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0140-6736(93)90167-F","volume":"341","author":"J Yip","year":"1993","unstructured":"Yip J, Mattock M, Sehti M, Morocutti A, Viberti G (1993) Insulin resistance in family members of insulin-dependent diabetic patients with microalbuminuria. Lancet 341:369\u2013370","journal-title":"Lancet"},{"key":"1747_CR7","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s001250050806","volume":"40","author":"S Cosmo De","year":"1997","unstructured":"De Cosmo S, Bacci S, Piras GP et al (1997) High prevalence of risk factors for cardiovascular disease in parents of IDDM patients with albuminuria. Diabetologia 40:1191\u20131196","journal-title":"Diabetologia"},{"key":"1747_CR8","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s00109-002-0378-7","volume":"80","author":"O Ukkola","year":"2002","unstructured":"Ukkola O, Santaniemi M (2002) Adiponectin: a link between excess adiposity and associated comorbidities? J Mol Med 80:696\u2013702","journal-title":"J Mol Med"},{"key":"1747_CR9","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","volume":"7","author":"T Yamauchi","year":"2001","unstructured":"Yamauchi T, Kamon J, Waki H et al (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941\u2013946","journal-title":"Nat Med"},{"key":"1747_CR10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0140-6736(02)09335-2","volume":"360","author":"RS Lindsay","year":"2002","unstructured":"Lindsay RS, Funahashi T, Hanson RL et al (2002) Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 360:57\u201358","journal-title":"Lancet"},{"key":"1747_CR11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/01.ATV.0000048856.22331.50","volume":"23","author":"M Kumada","year":"2003","unstructured":"Kumada M, Kihara S, Sumitsuji S et al (2003) Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23:85\u201389","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1747_CR12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1681\/ASN.V123541","volume":"12","author":"S Hadjadj","year":"2001","unstructured":"Hadjadj S, Belloum R, Bouhanick B et al (2001) Prognostic value of angiotensin-I converting enzyme I\/D polymorphism for nephropathy in type 1 diabetes mellitus: a prospective study. J Am Soc Nephrol 12:541\u2013549","journal-title":"J Am Soc Nephrol"},{"key":"1747_CR13","first-page":"427","volume":"22","author":"Y Gallois","year":"1996","unstructured":"Gallois Y, Vol S, Caces E, Balkau B, and the DESIR Study Group (1996) Distribution of fasting serum insulin, measured by enzyme immunoassay, in an unselected population of 4,032 individuals, references values, according to age and sex. Diabetes Metab 22:427\u2013431","journal-title":"Diabetes Metab"},{"key":"1747_CR14","first-page":"54","volume":"18","author":"B Bouhanick","year":"1992","unstructured":"Bouhanick B, Berrut G, Chameau A-M et al (1992) Predictive value of testing random urine sample to detect microalbuminuria in diabetic subjects during outpatient visit. Diabetes Metab 18:54\u201358","journal-title":"Diabetes Metab"},{"key":"1747_CR15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/clinchem\/33.2.209","volume":"33","author":"M Marre","year":"1987","unstructured":"Marre M, Claudel JP, Ciret P, Luis N, Suarez L, Passa P (1987) Laser immunonephelometry for routine quantification of urinary albumin excretion. Clin Chem 33:209\u2013213","journal-title":"Clin Chem"},{"key":"1747_CR16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","volume":"16","author":"DW Cockcroft","year":"1976","unstructured":"Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31\u201341","journal-title":"Nephron"},{"key":"1747_CR17","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.2337\/diab.39.9.1116","volume":"39","author":"TJ Orchard","year":"1990","unstructured":"Orchard TJ, Dorman JS, Maser RE et al (1990) Prevalence in complications in IDDM by sex and duration. Pittsburgh Epidemiology of Diabetes Complications Study II. Diabetes 39:1116\u20131124","journal-title":"Diabetes"},{"key":"1747_CR18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1523-1755.2001.00789.x","volume":"60","author":"N Chaturvedi","year":"2001","unstructured":"Chaturvedi N, Bandinelli S, Mangili R, Penno G, Rottiers RE, Fuller JH (2001) Microalbuminuria in type 1 diabetes: rates, risk factors and glycemic threshold. Kidney Int 60:219\u2013227","journal-title":"Kidney Int"},{"key":"1747_CR19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1043-2760(01)00524-0","volume":"13","author":"AH Berg","year":"2002","unstructured":"Berg AH, Combs TP, Scherer PE (2002) ACRP30\/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 13:84\u201389","journal-title":"Trends Endocrinol Metab"},{"key":"1747_CR20","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1046\/j.1523-1755.2002.00507.x","volume":"62","author":"TJ Orchard","year":"2002","unstructured":"Orchard TJ, Chang YF, Ferrell RE, Petro N, Ellis DE (2002) Nephropathy in type 1 diabetes: a manifestation of insulin resistance and multiple genetic susceptibilities? Further evidence from the Pittsburgh Epidemiology of Diabetes Complications Study. Kidney Int 62:963\u2013970","journal-title":"Kidney Int"},{"key":"1747_CR21","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2337\/diacare.24.2.284","volume":"24","author":"N Chaturvedi","year":"2001","unstructured":"Chaturvedi N, Sjoelie AK, Porta M et al (2001) Markers of insulin resistance are strong risk factors for retinopathy incidence in type 1 diabetes. Diabetes Care 24:284\u2013289","journal-title":"Diabetes Care"},{"key":"1747_CR22","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.2337\/diacare.26.7.2165","volume":"26","author":"MT Schram","year":"2003","unstructured":"Schram MT, Chaturvedi N, Schalkwijk C et al (2003) Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study. Diabetes Care 26:2165\u20132173","journal-title":"Diabetes Care"},{"key":"1747_CR23","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1007\/s00125-003-1194-5","volume":"46","author":"M Saraheimo","year":"2003","unstructured":"Saraheimo M, Teppo AM, Forsblom C, Fagerudd J, Groop PH (2003) Diabetic nephropathy is associated with low-grade inflammation in type 1 diabetic patients. Diabetologia 46:1402\u20131407","journal-title":"Diabetologia"},{"key":"1747_CR24","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1001\/jama.289.14.1799","volume":"289","author":"K Esposito","year":"2003","unstructured":"Esposito K, Pontillo A, Di Palo C et al (2003) Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 289:1799\u20131804","journal-title":"JAMA"},{"key":"1747_CR25","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.2337\/diacare.27.10.2450","volume":"27","author":"GK Shetty","year":"2004","unstructured":"Shetty GK, Economides PA, Horton ES, Mantzoros CS, Veves A (2004) Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care 27:2450\u20132457","journal-title":"Diabetes Care"},{"key":"1747_CR26","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1074\/jbc.M310389200","volume":"279","author":"N Ouchi","year":"2003","unstructured":"Ouchi N, Kobayashi H, Kihara S et al (2003) Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 279:1304\u20131309","journal-title":"J Biol Chem"},{"key":"1747_CR27","doi-asserted-by":"crossref","first-page":"28670","DOI":"10.1074\/jbc.M402558200","volume":"279","author":"R Shibata","year":"2004","unstructured":"Shibata R, Ouchi N, Kihara S, Sato K, Funahashi T, Walsh K (2004) Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling. J Biol Chem 279:28670\u201328674","journal-title":"J Biol Chem"},{"key":"1747_CR28","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1210\/jc.2004-0387","volume":"89","author":"J Malyszko","year":"2004","unstructured":"Malyszko J, Malyszko JS, Brzosko S, Wolczynski S, Mysliwiec M (2004) Adiponectin is related to CD146, a novel marker of endothelial cell activation\/injury in chronic renal failure and peritoneally dialyzed patients. J Clin Endocrinol Metab 89:4620\u20134627","journal-title":"J Clin Endocrinol Metab"},{"key":"1747_CR29","doi-asserted-by":"crossref","first-page":"45021","DOI":"10.1074\/jbc.M307878200","volume":"278","author":"H Chen","year":"2003","unstructured":"Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ (2003) Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 278:45021\u201345026","journal-title":"J Biol Chem"},{"key":"1747_CR30","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2337\/diab.44.7.721","volume":"44","author":"JE Tooke","year":"1995","unstructured":"Tooke JE (1995) Microvascular function in human diabetes. A physiological perspective. Diabetes 44:721\u2013726","journal-title":"Diabetes"},{"key":"1747_CR31","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.2337\/diabetes.49.7.1258","volume":"49","author":"F Chiarelli","year":"2000","unstructured":"Chiarelli F, Cipollone F, Romano F et al (2000) Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration. Diabetes 49:1258\u20131263","journal-title":"Diabetes"},{"key":"1747_CR32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000189293","volume":"74","author":"AL Mattar","year":"1996","unstructured":"Mattar AL, Fujihara CK, Ribeiro MO, de Nucci G, Zatz R (1996) Renal effects of acute and chronic nitric oxide inhibition in experimental diabetes. Nephron 74:136\u2013143","journal-title":"Nephron"},{"key":"1747_CR33","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1007\/s001250051088","volume":"41","author":"H Sugimoto","year":"1998","unstructured":"Sugimoto H, Shikata K, Matsuda M et al (1998) Increased expression of endothelial cell nitric oxide synthase (ecNOS) in afferent and glomerular endothelial cells is involved in glomerular hyperfiltration of diabetic nephropathy. Diabetologia 41:1426\u20131434","journal-title":"Diabetologia"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-005-1747-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-005-1747-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-005-1747-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T14:42:34Z","timestamp":1625928154000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-005-1747-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,5]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["1747"],"URL":"https:\/\/doi.org\/10.1007\/s00125-005-1747-x","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,5]]}}}