{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:12:40Z","timestamp":1791180760944,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T00:00:00Z","timestamp":1115078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1007\/s00125-005-1765-8","type":"journal-article","created":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T09:28:34Z","timestamp":1115112514000},"page":"1059-1065","source":"Crossref","is-referenced-by-count":78,"title":["Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse"],"prefix":"10.1007","volume":"48","author":[{"given":"H.","family":"Poirier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rouault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cl\u00e9ment","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Niot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-C.","family":"Monnot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guerre-Millo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Besnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,5,3]]},"reference":[{"key":"1765_CR1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/sj.ijo.0802641","volume":"28","author":"YW Wang","year":"2004","unstructured":"Wang YW, Jones PJ (2004) Conjugated linoleic acid and obesity control: efficacy and mechanisms. Int J Obes Relat Metab Disord 28: 941\u2013955","journal-title":"Int J Obes Relat Metab Disord"},{"key":"1765_CR2","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.2337\/diabetes.49.9.1534","volume":"49","author":"N Tsuboyama-Kasaoka","year":"2000","unstructured":"Tsuboyama-Kasaoka N, Takahashi M, Tanemura K et al (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49:1534\u20131542","journal-title":"Diabetes"},{"key":"1765_CR3","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1194\/jlr.M20008-JLR200","volume":"43","author":"L Cl\u00e9ment","year":"2002","unstructured":"Cl\u00e9ment L, Poirier H, Niot I et al (2002) Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J Lipid Res 43:1400\u20131409","journal-title":"J Lipid Res"},{"key":"1765_CR4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/oby.2004.68","volume":"12","author":"C Malpuech-Brugere","year":"2004","unstructured":"Malpuech-Brugere C, Verboeket-van de Venne WP, Mensink RP et al (2004) Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obes Res 12:591\u2013598","journal-title":"Obes Res"},{"key":"1765_CR5","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1093\/jn\/133.10.3181","volume":"133","author":"AH Terpstra","year":"2003","unstructured":"Terpstra AH, Javadi M, Beynen AC et al (2003) Dietary conjugated linoleic acids as free fatty acids and triacylglycerols similarly affect body composition and energy balance in mice. J Nutr 133:3181\u20133186","journal-title":"J Nutr"},{"key":"1765_CR6","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1194\/jlr.R300011-JLR200","volume":"44","author":"TM Larsen","year":"2003","unstructured":"Larsen TM, Toubro S, Astrup A (2003) Efficacy and safety of dietary supplements containing CLA for the treatment of obesity: evidence from animal and human studies. J Lipid Res 44:2234\u20132241","journal-title":"J Lipid Res"},{"key":"1765_CR7","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.2337\/diacare.25.9.1516","volume":"25","author":"U Riserus","year":"2002","unstructured":"Riserus U, Arner P, Brismar K et al (2002) Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 25:1516\u20131521","journal-title":"Diabetes Care"},{"key":"1765_CR8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1097-2765(05)00010-9","volume":"6","author":"I Shimomura","year":"2000","unstructured":"Shimomura I, Matsuda M, Hammer RE et al (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob\/ob mice. Mol Cell 6:77\u201386","journal-title":"Mol Cell"},{"key":"1765_CR9","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1101\/gad.12.20.3182","volume":"12","author":"I Shimomura","year":"1998","unstructured":"Shimomura I, Hammer RE, Richardson JA et al (1998) Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 12:3182\u20133194","journal-title":"Genes Dev"},{"key":"1765_CR10","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1172\/JCI119839","volume":"100","author":"CF Burant","year":"1997","unstructured":"Burant CF, Sreenan S, Hirano K et al (1997) Troglitazone action is independent of adipose tissue. J Clin Invest 100:2900\u20132908","journal-title":"J Clin Invest"},{"key":"1765_CR11","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1101\/gad.12.20.3168","volume":"12","author":"J Moitra","year":"1998","unstructured":"Moitra J, Mason MM, Olive M et al (1998) Life without white fat: a transgenic mouse. Genes Dev 12:3168\u20133181","journal-title":"Genes Dev"},{"key":"1765_CR12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1172\/JCI7901","volume":"105","author":"O Gavrilova","year":"2000","unstructured":"Gavrilova O, Marcus-Samuels B, Graham D et al (2000) Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 105:271\u2013278","journal-title":"J Clin Invest"},{"key":"1765_CR13","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","volume":"7","author":"T Yamauchi","year":"2001","unstructured":"Yamauchi T, Kamon J, Waki H et al (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Med 7:941\u2013946","journal-title":"Nature Med"},{"key":"1765_CR14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/43448","volume":"401","author":"I Shimomura","year":"1999","unstructured":"Shimomura I, Hammer RE, Ikemoto S et al (1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401:73\u201376","journal-title":"Nature"},{"key":"1765_CR15","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1210\/endo.139.3.5812","volume":"139","author":"V Poitout","year":"1998","unstructured":"Poitout V, Rouault C, Guerre-Millo M et al (1998) Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans. Endocrinology 139:822\u2013826","journal-title":"Endocrinology"},{"key":"1765_CR16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2337\/diabetes.50.2.315","volume":"50","author":"I Briaud","year":"2001","unstructured":"Briaud I, Harmon JS, Kelpe CL et al (2001) Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes 50:315\u2013321","journal-title":"Diabetes"},{"key":"1765_CR17","first-page":"99","volume":"26","author":"JL Delsal","year":"1944","unstructured":"Delsal JL (1944) Nouveau proc\u00e9d\u00e9 d\u2019extraction des lipides du s\u00e9rum par le m\u00e9thylal. Application aux microdosages du cholest\u00e9rol total, des phospholipides et des prot\u00e9ines [Article in French]. Bull Soc Chim Biol (Paris) 26:99\u2013105","journal-title":"Bull Soc Chim Biol (Paris)"},{"key":"1765_CR18","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/jn\/134.4.861","volume":"134","author":"P Degrace","year":"2004","unstructured":"Degrace P, Demizieux L, Gresti J, Chardigny JM, Sebedio JL, Clouet P (2004) Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL\/6J mice fed the conjugated trans-10, cis-12-isomer of linoleic acid. J Nutr 134:861\u2013867","journal-title":"J Nutr"},{"key":"1765_CR19","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1172\/JCI119824","volume":"100","author":"TG Kirchgessner","year":"1997","unstructured":"Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS (1997) Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest 100:2777\u20132782","journal-title":"J Clin Invest"},{"key":"1765_CR20","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1006\/bbrc.2001.6307","volume":"290","author":"M Fasshauer","year":"2002","unstructured":"Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2002) Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun 290:1084\u20131089","journal-title":"Biochem Biophys Res Commun"},{"key":"1765_CR21","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0006-291X(03)00090-1","volume":"301","author":"M Fasshauer","year":"2003","unstructured":"Fasshauer M, Kralisch S, Klier M et al (2003) Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 301:1045\u20131050","journal-title":"Biochem Biophys Res Commun"},{"key":"1765_CR22","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2337\/diabetes.52.7.1655","volume":"52","author":"M Iwaki","year":"2003","unstructured":"Iwaki M, Matsuda M, Maeda N et al (2003) Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52:1655\u20131663","journal-title":"Diabetes"},{"key":"1765_CR23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1388-1981(01)00155-X","volume":"1533","author":"JM Peters","year":"2001","unstructured":"Peters JM, Park Y, Gonzalez FJ, Pariza MW (2001) Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice. Biochim Biophys Acta 1533:233\u2013242","journal-title":"Biochim Biophys Acta"},{"key":"1765_CR24","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/nm788","volume":"8","author":"T Yamauchi","year":"2002","unstructured":"Yamauchi T, Kamon J, Minokoshi Y et al (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8:1288\u20131295","journal-title":"Nat Med"},{"key":"1765_CR25","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1194\/jlr.M300001-JLR200","volume":"44","author":"JM Brown","year":"2003","unstructured":"Brown JM, Boysen MS, Jensen SS et al (2003) Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. J Lipid Res 44:1287\u20131300","journal-title":"J Lipid Res"},{"key":"1765_CR26","doi-asserted-by":"crossref","first-page":"26735","DOI":"10.1074\/jbc.M401766200","volume":"279","author":"JM Brown","year":"2004","unstructured":"Brown JM, Boysen MS, Chung S et al (2004) Conjugated linoleic acid (CLA) induces human adipocyte delipidation: autocrine\/paracrine regulation of MEK\/ERK signaling by adipocytokines. J Biol Chem 279:26735\u201326747","journal-title":"J Biol Chem"},{"key":"1765_CR27","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.1128\/MCB.23.20.7222-7229.2003","volume":"23","author":"ED Rosen","year":"2003","unstructured":"Rosen ED, Kulkarni RN, Sarraf P et al (2003) Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 23:7222\u20137229","journal-title":"Mol Cell Biol"},{"key":"1765_CR28","first-page":"R1172","volume":"276","author":"JP DeLany","year":"1999","unstructured":"DeLany JP, Blohm F, Truett AA, Scimeca JA, West DB (1999) Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol 276:R1172\u2013R1179","journal-title":"Am J Physiol"},{"key":"1765_CR29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1677\/jme.0.0240297","volume":"24","author":"S Bonner-Weir","year":"2000","unstructured":"Bonner-Weir S (2000) Islet growth and development in the adult. J Mol Endocrinol 24:297\u2013302","journal-title":"J Mol Endocrinol"},{"key":"1765_CR30","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s11745-000-0586-y","volume":"35","author":"EA Medina","year":"2000","unstructured":"Medina EA, Horn WF, Keim NL et al (2000) Conjugated linoleic acid supplementation in humans: effects on circulating leptin concentrations and appetite. Lipids 35:783\u2013788","journal-title":"Lipids"},{"key":"1765_CR31","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1007\/s00125-004-1421-8","volume":"47","author":"U Riserus","year":"2004","unstructured":"Riserus U, Vessby B, Arner P, Zethelius B (2004) Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 47:1016\u20131019","journal-title":"Diabetologia"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-005-1765-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-005-1765-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-005-1765-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T11:44:42Z","timestamp":1558611882000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-005-1765-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,3]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["1765"],"URL":"https:\/\/doi.org\/10.1007\/s00125-005-1765-8","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,3]]}}}