{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:44:22Z","timestamp":1791110662225,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T00:00:00Z","timestamp":1163030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2006,12,28]]},"DOI":"10.1007\/s00125-006-0467-1","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T11:32:35Z","timestamp":1162985555000},"page":"131-141","source":"Crossref","is-referenced-by-count":32,"title":["Amelioration of glucose tolerance by hepatic inhibition of nuclear factor \u03baB in db\/db mice"],"prefix":"10.1007","volume":"50","author":[{"given":"Y.","family":"Tamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ogihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kumashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nomiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kawamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Watada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,11,9]]},"reference":[{"issue":"Suppl 3","key":"467_CR1","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1038\/sj.ijo.0802491","volume":"27","author":"G Perseghin","year":"2003","unstructured":"Perseghin G, Petersen K, Shulman GI (2003) Cellular mechanism of insulin resistance: potential links with inflammation. Int J Obes Relat Metab Disord 27 (Suppl 3):S6\u2013S11","journal-title":"Int J Obes Relat Metab Disord"},{"issue":"Suppl 3","key":"467_CR2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.1365-2362.32.s3.3.x","volume":"32","author":"G Boden","year":"2002","unstructured":"Boden G, Shulman GI (2002) Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32 (Suppl 3):14\u201323","journal-title":"Eur J Clin Invest"},{"key":"467_CR3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1172\/JCI10583","volume":"106","author":"GI Shulman","year":"2000","unstructured":"Shulman GI (2000) Cellular mechanisms of insulin resistance. J Clin Invest 106:171\u2013176","journal-title":"J Clin Invest"},{"key":"467_CR4","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1126\/science.1061620","volume":"293","author":"M Yuan","year":"2001","unstructured":"Yuan M, Konstantopoulos N, Lee J et al (2001) Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293:1673\u20131677","journal-title":"Science"},{"key":"467_CR5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1172\/JCI11559","volume":"108","author":"JK Kim","year":"2001","unstructured":"Kim JK, Kim YJ, Fillmore JJ et al (2001) Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 108:437\u2013446","journal-title":"J Clin Invest"},{"key":"467_CR6","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1172\/JCI0214955","volume":"109","author":"RS Hundal","year":"2002","unstructured":"Hundal RS, Petersen KF, Mayerson AB et al (2002) Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest 109:1321\u20131326","journal-title":"J Clin Invest"},{"key":"467_CR7","doi-asserted-by":"crossref","first-page":"48115","DOI":"10.1074\/jbc.M209459200","volume":"277","author":"Z Gao","year":"2002","unstructured":"Gao Z, Hwang D, Bataille F et al (2002) Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem 277:48115\u201348121","journal-title":"J Biol Chem"},{"key":"467_CR8","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1210\/jc.2003-030435","volume":"88","author":"M Gurnell","year":"2003","unstructured":"Gurnell M, Savage DB, Chatterjee VK, O\u2019Rahilly S (2003) The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation. J Clin Endocrinol Metab 88:2412\u20132421","journal-title":"J Clin Endocrinol Metab"},{"key":"467_CR9","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/414821a","volume":"414","author":"DE Moller","year":"2001","unstructured":"Moller DE (2001) New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414:821\u2013827","journal-title":"Nature"},{"key":"467_CR10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nm1185","volume":"11","author":"MC Arkan","year":"2005","unstructured":"Arkan MC, Hevener AL, Greten FR et al (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191\u2013198","journal-title":"Nat Med"},{"key":"467_CR11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm1166","volume":"11","author":"D Cai","year":"2005","unstructured":"Cai D, Yuan M, Frantz DF et al (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11:183\u2013190","journal-title":"Nat Med"},{"key":"467_CR12","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1172\/JCI483","volume":"101","author":"Y Iimuro","year":"1998","unstructured":"Iimuro Y, Nishiura T, Hellerbrand C et al (1998) NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 101:802\u2013811","journal-title":"J Clin Invest"},{"key":"467_CR13","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1172\/JCI0215880","volume":"110","author":"K Miyake","year":"2002","unstructured":"Miyake K, Ogawa W, Matsumoto M, Nakamura T, Sakaue H, Kasuga M (2002) Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. J Clin Invest 110:1483\u20131491","journal-title":"J Clin Invest"},{"key":"467_CR14","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1126\/science.1092341","volume":"303","author":"RR Banerjee","year":"2004","unstructured":"Banerjee RR, Rangwala SM, Shapiro JS et al (2004) Regulation of fasted blood glucose by resistin. Science 303:1195\u20131198","journal-title":"Science"},{"key":"467_CR15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2004.09.013","volume":"119","author":"J Lin","year":"2004","unstructured":"Lin J, Wu PH, Tarr PT et al (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119:121\u2013135","journal-title":"Cell"},{"key":"467_CR16","first-page":"417","volume":"6","author":"MJ FitzGerald","year":"1995","unstructured":"FitzGerald MJ, Webber EM, Donovan JR, Fausto N (1995) Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration. Cell Growth Differ 6:417\u2013427","journal-title":"Cell Growth Differ"},{"key":"467_CR17","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/hep.510250514","volume":"25","author":"CA Bradham","year":"1997","unstructured":"Bradham CA, Stachlewitz RF, Gao W et al (1997) Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology 25:1128\u20131135","journal-title":"Hepatology"},{"key":"467_CR18","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1073\/pnas.97.17.9443","volume":"97","author":"H Watada","year":"2000","unstructured":"Watada H, Mirmira RG, Kalamaras J, German MS (2000) Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins. Proc Natl Acad Sci USA 97:9443\u20139448","journal-title":"Proc Natl Acad Sci USA"},{"key":"467_CR19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0003-2697(74)90248-6","volume":"60","author":"JV Passonneau","year":"1974","unstructured":"Passonneau JV, Lauderdale VR (1974) A comparison of three methods of glycogen measurement in tissues. Anal Biochem 60:405\u2013412","journal-title":"Anal Biochem"},{"key":"467_CR20","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.2337\/diabetes.50.10.2287","volume":"50","author":"UJ Desai","year":"2001","unstructured":"Desai UJ, Slosberg ED, Boettcher BR et al (2001) Phenotypic correction of diabetic mice by adenovirus-mediated glucokinase expression. Diabetes 50:2287\u20132295","journal-title":"Diabetes"},{"key":"467_CR21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbrc.2004.06.019","volume":"320","author":"T Nomiyama","year":"2004","unstructured":"Nomiyama T, Igarashi Y, Taka H et al (2004) Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1. Biochem Biophys Res Commun 320:639\u2013647","journal-title":"Biochem Biophys Res Commun"},{"key":"467_CR22","doi-asserted-by":"crossref","first-page":"21693","DOI":"10.1074\/jbc.M302684200","volume":"278","author":"T Ogihara","year":"2003","unstructured":"Ogihara T, Watada H, Kanno R et al (2003) p38 MAPK is involved in activin A- and hepatocyte growth factor-mediated expression of pro-endocrine gene neurogenin 3 in AR42J-B13 cells. J Biol Chem 278:21693\u201321700","journal-title":"J Biol Chem"},{"key":"467_CR23","doi-asserted-by":"crossref","first-page":"6865","DOI":"10.1073\/pnas.121455098","volume":"98","author":"JC Webster","year":"2001","unstructured":"Webster JC, Oakley RH, Jewell CM, Cidlowski JA (2001) Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance. Proc Natl Acad Sci USA 98:6865\u20136870","journal-title":"Proc Natl Acad Sci USA"},{"key":"467_CR24","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.2337\/diabetes.52.12.2905","volume":"52","author":"H Ono","year":"2003","unstructured":"Ono H, Shimano H, Katagiri H et al (2003) Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement. Diabetes 52:2905\u20132913","journal-title":"Diabetes"},{"key":"467_CR25","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1073\/pnas.95.4.1776","volume":"95","author":"WH Martin","year":"1998","unstructured":"Martin WH, Hoover DJ, Armento SJ et al (1998) Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo. Proc Natl Acad Sci USA 95:1776\u20131781","journal-title":"Proc Natl Acad Sci USA"},{"key":"467_CR26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/35093050","volume":"413","author":"JC Yoon","year":"2001","unstructured":"Yoon JC, Puigserver P, Chen G et al (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413:131\u2013138","journal-title":"Nature"},{"key":"467_CR27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/35093131","volume":"413","author":"S Herzig","year":"2001","unstructured":"Herzig S, Long F, Jhala US et al (2001) CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413:179\u2013183","journal-title":"Nature"},{"key":"467_CR28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nm980","volume":"10","author":"H Inoue","year":"2004","unstructured":"Inoue H, Ogawa W, Ozaki M et al (2004) Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat Med 10:168\u2013174","journal-title":"Nat Med"},{"key":"467_CR29","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2337\/diabetes.49.6.896","volume":"49","author":"PA Lochhead","year":"2000","unstructured":"Lochhead PA, Salt IP, Walker KS, Hardie DG, Sutherland C (2000) 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. Diabetes 49:896\u2013903","journal-title":"Diabetes"},{"key":"467_CR30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1097-2765(05)00015-8","volume":"6","author":"MD Michael","year":"2000","unstructured":"Michael MD, Kulkarni RN, Postic C et al (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6:87\u201397","journal-title":"Mol Cell"},{"key":"467_CR31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1097-2765(05)00010-9","volume":"6","author":"I Shimomura","year":"2000","unstructured":"Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob\/ob mice. Mol Cell 6:77\u201386","journal-title":"Mol Cell"},{"key":"467_CR32","doi-asserted-by":"crossref","first-page":"9151","DOI":"10.1073\/pnas.91.19.9151","volume":"91","author":"A Valera","year":"1994","unstructured":"Valera A, Pujol A, Pelegrin M, Bosch F (1994) Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 91:9151\u20139154","journal-title":"Proc Natl Acad Sci USA"},{"key":"467_CR33","doi-asserted-by":"crossref","first-page":"23301","DOI":"10.1074\/jbc.M200964200","volume":"277","author":"Y Sun","year":"2002","unstructured":"Sun Y, Liu S, Ferguson S, Wang L et al (2002) Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice. J Biol Chem 277:23301\u201323307","journal-title":"J Biol Chem"},{"key":"467_CR34","doi-asserted-by":"crossref","first-page":"31615","DOI":"10.1074\/jbc.273.47.31615","volume":"273","author":"KY Trinh","year":"1998","unstructured":"Trinh KY, O\u2019Doherty RM, Anderson P, Lange AJ, Newgard CB (1998) Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. J Biol Chem 273:31615\u201331620","journal-title":"J Biol Chem"},{"key":"467_CR35","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.2337\/diabetes.50.11.2591","volume":"50","author":"RH Bandsma","year":"2001","unstructured":"Bandsma RH, Wiegman CH, Herling AW et al (2001) Acute inhibition of glucose-6-phosphate translocator activity leads to increased de novo lipogenesis and development of hepatic steatosis without affecting VLDL production in rats. Diabetes 50:2591\u20132597","journal-title":"Diabetes"},{"key":"467_CR36","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nm1044","volume":"10","author":"SH Koo","year":"2004","unstructured":"Koo SH, Satoh H, Herzig S et al (2004) PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med 10:530\u2013534","journal-title":"Nat Med"},{"key":"467_CR37","doi-asserted-by":"crossref","first-page":"31847","DOI":"10.1074\/jbc.M003656200","volume":"275","author":"M Waltner-Law","year":"2000","unstructured":"Waltner-Law M, Daniels MC, Sutherland C, Granner DK (2000) NF-kappa B inhibits glucocorticoid and cAMP-mediated expression of the phosphoenolpyruvate carboxykinase gene. J Biol Chem 275:31847\u201331856","journal-title":"J Biol Chem"},{"key":"467_CR38","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/BJ20040160","volume":"382","author":"R Grempler","year":"2004","unstructured":"Grempler R, Kienitz A, Werner T et al (2004) Tumour necrosis factor alpha decreases glucose-6-phosphatase gene expression by activation of nuclear factor kappaB. Biochem J 382:471\u2013479","journal-title":"Biochem J"},{"key":"467_CR39","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0026-0495(97)90197-9","volume":"46","author":"S Metzger","year":"1997","unstructured":"Metzger S, Begleibter N, Barash V et al (1997) Tumor necrosis factor inhibits the transcriptional rate of glucose-6-phosphatase in vivo and in vitro. Metabolism 46:579\u2013583","journal-title":"Metabolism"},{"key":"467_CR40","doi-asserted-by":"crossref","first-page":"642","DOI":"10.2337\/diabetes.52.3.642","volume":"52","author":"H Daitoku","year":"2003","unstructured":"Daitoku H, Yamagata K, Matsuzaki H, Hatta M, Fukamizu A (2003) Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 52:642\u2013649","journal-title":"Diabetes"},{"key":"467_CR41","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nm1050","volume":"10","author":"XY Zhou","year":"2004","unstructured":"Zhou XY, Shibusawa N, Naik K et al (2004) Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med 10:633\u2013637","journal-title":"Nat Med"},{"key":"467_CR42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","volume":"1","author":"J Lin","year":"2005","unstructured":"Lin J, Handschin C, Spiegelman BM (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1:361\u2013370","journal-title":"Cell Metab"},{"key":"467_CR43","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1371\/journal.pbio.0030101","volume":"3","author":"TC Leone","year":"2005","unstructured":"Leone TC, Lehman JJ, Finck BN et al (2005) PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol 3:e101","journal-title":"PLoS Biol"},{"key":"467_CR44","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1210\/me.2003-0283","volume":"18","author":"C Opherk","year":"2004","unstructured":"Opherk C, Tronche F, Kellendonk C et al (2004) Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Mol Endocrinol 18:1346\u20131353","journal-title":"Mol Endocrinol"},{"key":"467_CR45","doi-asserted-by":"crossref","first-page":"31475","DOI":"10.1074\/jbc.272.50.31475","volume":"272","author":"JE Friedman","year":"1997","unstructured":"Friedman JE, Sun Y, Ishizuka T et al (1997) Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db\/db transgenic mice. J Biol Chem 272:31475\u201331481","journal-title":"J Biol Chem"},{"key":"467_CR46","doi-asserted-by":"crossref","first-page":"8944","DOI":"10.1128\/JVI.70.12.8944-8960.1996","volume":"70","author":"A Lieber","year":"1996","unstructured":"Lieber A, He CY, Kirillova I, Kay MA (1996) Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol 70:8944\u20138960","journal-title":"J Virol"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-006-0467-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-006-0467-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-006-0467-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T23:31:51Z","timestamp":1587252711000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-006-0467-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,9]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12,28]]}},"alternative-id":["467"],"URL":"https:\/\/doi.org\/10.1007\/s00125-006-0467-1","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,9]]}}}