{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:28:48Z","timestamp":1785734928401,"version":"3.56.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T00:00:00Z","timestamp":1168905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2007,2,5]]},"DOI":"10.1007\/s00125-006-0563-2","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T16:09:31Z","timestamp":1168963771000},"page":"612-619","source":"Crossref","is-referenced-by-count":64,"title":["Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor"],"prefix":"10.1007","volume":"50","author":[{"given":"H.","family":"Noguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Masui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Futaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,1,16]]},"reference":[{"key":"563_CR1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","volume":"343","author":"AM Shapiro","year":"2000","unstructured":"Shapiro AM, Lakey JR, Ryan EA et al (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230\u2013238","journal-title":"N Engl J Med"},{"key":"563_CR2","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/S0140-6736(05)66383-0","volume":"365","author":"S Matsumoto","year":"2005","unstructured":"Matsumoto S, Okitsu T, Iwanaga Y et al (2005) Insulin independence after living-donor distal pancreatectomy and islet allotransplantation. Lancet 365:1642\u20131644","journal-title":"Lancet"},{"key":"563_CR3","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1111\/j.1600-6143.2006.01499.x","volume":"6","author":"H Noguchi","year":"2006","unstructured":"Noguchi H, Iwanaga Y, Okitsu T et al (2006) Evaluation of islet transplantation from non-heart beating donors. Am J Transplant 6:2476\u20132482","journal-title":"Am J Transplant"},{"key":"563_CR4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00006676-200004000-00008","volume":"20","author":"S Paraskevas","year":"2000","unstructured":"Paraskevas S, Maysinger D, Wang R, Duguid TP, Rosenberg L (2000) Cell loss in isolated human islets occurs by apoptosis. Pancreas 20:270\u2013276","journal-title":"Pancreas"},{"key":"563_CR5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1067\/msy.2001.116413","volume":"130","author":"F Thomas","year":"2001","unstructured":"Thomas F, Wu J, Contreras JL et al (2001) A tripartite anoikis-like mechanism causes early isolated islet apoptosis. Surgery 130:333\u2013338","journal-title":"Surgery"},{"key":"563_CR6","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2337\/diab.45.9.1161","volume":"45","author":"AM Davalli","year":"1996","unstructured":"Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC (1996) Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes 45:1161\u20131167","journal-title":"Diabetes"},{"key":"563_CR7","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/BF00404341","volume":"37","author":"A Rabinovitch","year":"1994","unstructured":"Rabinovitch A, Sorensen O, Suarez-Pinzon WL, Power RF, Rajotte RV, Bleackley RC (1994) Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice: interleukin 2 and interferon gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival. Diabetologia 37:833\u2013837","journal-title":"Diabetologia"},{"key":"563_CR8","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/00007890-199609150-00019","volume":"62","author":"A Faust","year":"1996","unstructured":"Faust A, Rothe H, Schade U, Lampeter E, Kolb H (1996) Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10. Transplantation 62:648\u2013652","journal-title":"Transplantation"},{"key":"563_CR9","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1177\/096368970000900612","volume":"9","author":"T Dobson","year":"2000","unstructured":"Dobson T, Fraga D, Saba C, Bryer-Ash M, Gaber AO, Gerling IC (2000) Human pancreatic islets transfected to produce an inhibitor of TNF are protected against destruction by human leukocytes. Cell Transplant 9:857\u2013865","journal-title":"Cell Transplant"},{"key":"563_CR10","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1097\/00007890-200212150-00003","volume":"74","author":"D Thomas","year":"2002","unstructured":"Thomas D, Yang H, Boffa DJ et al (2002) Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2. Transplantation 74:1489\u20131496","journal-title":"Transplantation"},{"key":"563_CR11","doi-asserted-by":"crossref","first-page":"9862","DOI":"10.1074\/jbc.M207700200","volume":"278","author":"KK Rehman","year":"2003","unstructured":"Rehman KK, Bertera S, Bottino R et al (2003) Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide. J Biol Chem 278:9862\u20139868","journal-title":"J Biol Chem"},{"key":"563_CR12","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.2337\/diabetes.53.11.2815","volume":"53","author":"S Abdelli","year":"2004","unstructured":"Abdelli S, Ansite J, Roduit R et al (2004) Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes 53:2815\u20132823","journal-title":"Diabetes"},{"key":"563_CR13","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.2337\/diabetes.48.10.1907","volume":"48","author":"W Bennet","year":"1999","unstructured":"Bennet W, Sundberg B, Groth CG et al (1999) Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation? Diabetes 48:1907\u20131914","journal-title":"Diabetes"},{"key":"563_CR14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1034\/j.1399-3089.2002.1o040.x","volume":"9","author":"L Badet","year":"2002","unstructured":"Badet L, Titus T, Metzen E et al (2002) The interaction between primate blood and mouse islets induces accelerated clotting with islet destruction. Xenotransplantation 9:91\u201396","journal-title":"Xenotransplantation"},{"key":"563_CR15","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(02)12020-4","volume":"360","author":"L Moberg","year":"2002","unstructured":"Moberg L, Johansson H, Lukinius A et al (2002) Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 360:2039\u20132045","journal-title":"Lancet"},{"key":"563_CR16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2337\/diabetes.47.3.316","volume":"47","author":"R Bottino","year":"1998","unstructured":"Bottino R, Fernandez LA, Ricordi C et al (1998) Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 47:316\u2013323","journal-title":"Diabetes"},{"key":"563_CR17","first-page":"352","volume":"32","author":"MJ Fontaine","year":"2002","unstructured":"Fontaine MJ, Blanchard J, Rastellini C, Lazda V, Herold KC, Pollak R (2002) Pancreatic islets activate portal vein endothelial cells in vitro. Ann Clin Lab Sci 32:352\u2013361","journal-title":"Ann Clin Lab Sci"},{"key":"563_CR18","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/00007890-199806150-00003","volume":"65","author":"S Arita","year":"1998","unstructured":"Arita S, Une S, Ohtsuka S et al (1998) Prevention of primary islet isograft nonfunction in mice with pravastatin. Transplantation 65:1429\u20131433","journal-title":"Transplantation"},{"key":"563_CR19","doi-asserted-by":"crossref","first-page":"778","DOI":"10.2337\/diab.43.6.778","volume":"43","author":"DB Kaufman","year":"1994","unstructured":"Kaufman DB, Gores PF, Field MJ et al (1994) Effect of 15-deoxyspergualin on immediate function and long-term survival of transplanted islets in murine recipients of a marginal islet mass. Diabetes 43:778\u2013783","journal-title":"Diabetes"},{"key":"563_CR20","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1097\/00007890-199404270-00012","volume":"57","author":"ES Xenos","year":"1994","unstructured":"Xenos ES, Stevens RB, Sutherland DE et al (1994) The role of nitric oxide in IL-1 beta-mediated dysfunction of rodent islets of Langerhans: implications for the function of intrahepatic islet grafts. Transplantation 57:1208\u20131212","journal-title":"Transplantation"},{"key":"563_CR21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0092-8674(91)90098-J","volume":"65","author":"TG Boulton","year":"1991","unstructured":"Boulton TG, Nye SH, Robbins DJ et al (1991) ERKs: a family of protein-serine\/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65:663\u2013675","journal-title":"Cell"},{"key":"563_CR22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/prep.1998.0947","volume":"14","author":"GA Keesler","year":"1998","unstructured":"Keesler GA, Bray J, Hunt J et al (1998) Purification and activation of recombinant p38 isoforms alpha, beta, gamma, and delta. Protein Expr Purif 14:221\u2013228","journal-title":"Protein Expr Purif"},{"key":"563_CR23","first-page":"1","volume":"64","author":"RJ Davis","year":"1999","unstructured":"Davis RJ (1999) Signal transduction by the c-Jun N-terminal kinase. Biochem Soc Symp 64:1\u201312","journal-title":"Biochem Soc Symp"},{"key":"563_CR24","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.2337\/diabetes.49.9.1468","volume":"49","author":"A Ammendrup","year":"2000","unstructured":"Ammendrup A, Maillard A, Nielsen K et al (2000) The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic \u03b2-cells. Diabetes 49:1468\u20131476","journal-title":"Diabetes"},{"key":"563_CR25","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/geno.2000.6129","volume":"64","author":"S Negri","year":"2000","unstructured":"Negri S, Oberson A, Steinmann M et al (2000) cDNA cloning and mapping of a novel islet-brain\/JNK interacting protein. Genomics 64:324\u2013330","journal-title":"Genomics"},{"key":"563_CR26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","volume":"420","author":"J Hirosumi","year":"2002","unstructured":"Hirosumi J, Tuncman G, Chang L et al (2002) A central role for JNK in obesity and insulin resistance. Nature 420:333\u2013336","journal-title":"Nature"},{"key":"563_CR27","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1074\/jbc.275.12.9047","volume":"275","author":"V Aguirre","year":"2000","unstructured":"Aguirre V, Uchida T, Yenush L, Davis R, White MF (2000) The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275:9047\u20139054","journal-title":"J Biol Chem"},{"key":"563_CR28","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nrd1132","volume":"2","author":"AM Manning","year":"2003","unstructured":"Manning AM, Davis R (2003) Targeting JNK for therapeutic benefit: from junk to gold? Nature Rev Drug Discov 2:554\u2013565","journal-title":"Nature Rev Drug Discov"},{"key":"563_CR29","doi-asserted-by":"crossref","first-page":"30010","DOI":"10.1074\/jbc.M202066200","volume":"277","author":"H Kaneto","year":"2002","unstructured":"Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC (2002) Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem 277:30010\u201330018","journal-title":"J Biol Chem"},{"key":"563_CR30","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.2337\/diabetes.52.12.2896","volume":"52","author":"D Kawamori","year":"2003","unstructured":"Kawamori D, Kajimoto Y, Kaneto H et al (2003) Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes 52:2896\u20132904","journal-title":"Diabetes"},{"key":"563_CR31","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/j.1600-6143.2005.00985.x","volume":"5","author":"H Noguchi","year":"2005","unstructured":"Noguchi H, Nakai Y, Matsumoto S et al (2005) Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function. Am J Transplant 5:1848\u20131855","journal-title":"Am J Transplant"},{"key":"563_CR32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1089\/10430340252769833","volume":"13","author":"H Noguchi","year":"2002","unstructured":"Noguchi H, Kobayashi N, Westerman KA et al (2002) Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization. Hum Gene Ther 13:321\u2013334","journal-title":"Hum Gene Ther"},{"key":"563_CR33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nm994","volume":"10","author":"H Noguchi","year":"2004","unstructured":"Noguchi H, Matsushita M, Okitsu T et al (2004) A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat Med 10:305\u2013309","journal-title":"Nat Med"},{"key":"563_CR34","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1172\/JCI116129","volume":"90","author":"JA Corbett","year":"1992","unstructured":"Corbett JA, Wang JL, Sweetland MA, Lancaster JR Jr, McDaniel ML (1992) Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. J Clin Invest 90:2384\u20132391","journal-title":"J Clin Invest"},{"key":"563_CR35","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2337\/diab.44.7.733","volume":"44","author":"H Kaneto","year":"1995","unstructured":"Kaneto H, Fujii J, Seo HG et al (1995) Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells. Diabetes 44:733\u2013738","journal-title":"Diabetes"},{"key":"563_CR36","doi-asserted-by":"crossref","first-page":"16466","DOI":"10.1074\/jbc.M908297199","volume":"275","author":"C Bonny","year":"2000","unstructured":"Bonny C, Oberson A, Steinmann M, Schorderet DF, Nicod P, Waeber G (2000) IB1 reduces cytokine-induced apoptosis of insulin-secreting cells. J Biol Chem 275:16466\u201316472","journal-title":"J Biol Chem"},{"key":"563_CR37","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nm1111","volume":"10","author":"H Kaneto","year":"2004","unstructured":"Kaneto H, Nakatani Y, Miyatsuka T et al (2004) Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat Med 10:1128\u20131132","journal-title":"Nat Med"},{"key":"563_CR38","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.2337\/diabetes.54.10.2859","volume":"54","author":"H Noguchi","year":"2005","unstructured":"Noguchi H, Bonner-Weir S, Wei FY, Matsushita M, Matsumoto S (2005) BETA2\/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes 54:2859\u20132866","journal-title":"Diabetes"},{"key":"563_CR39","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.2337\/diabetes.52.7.1732","volume":"52","author":"H Noguchi","year":"2003","unstructured":"Noguchi, H, Kaneto H, Weir GC, Bonner-Weir S (2003) PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes 52:1732\u20131737","journal-title":"Diabetes"},{"key":"563_CR40","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3727\/000000005783982648","volume":"14","author":"H Noguchi","year":"2005","unstructured":"Noguchi H, Matsumoto S, Okitsu T et al (2005) PDX-1 protein is internalized by lipid raft-dependent macropinocytosis. Cell Transplant 14:637\u2013645","journal-title":"Cell Transplant"},{"key":"563_CR41","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0092-8674(00)81843-7","volume":"88","author":"G Elliott","year":"1997","unstructured":"Elliott G, O\u2019Hare P (1997) Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88:223\u2013233","journal-title":"Cell"},{"key":"563_CR42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2337\/diabetes.50.1.77","volume":"50","author":"C Bonny","year":"2001","unstructured":"Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF (2001) Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50:77\u201382","journal-title":"Diabetes"},{"key":"563_CR43","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1126\/science.285.5433.1569","volume":"285","author":"SR Schwarze","year":"1999","unstructured":"Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285:1569\u20131572","journal-title":"Science"},{"key":"563_CR44","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.2337\/diabetes.50.8.1706","volume":"50","author":"J Embury","year":"2001","unstructured":"Embury J, Klein D, Pileggi A et al (2001) Proteins linked to a protein transduction domain efficiently transduce pancreatic islets. Diabetes 50:1706\u20131713","journal-title":"Diabetes"},{"key":"563_CR45","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0006-291X(03)00856-8","volume":"305","author":"MM Ribeiro","year":"2003","unstructured":"Ribeiro MM, Klein D, Pileggi A et al (2003) Heme oxygenase-1 fused to a TAT peptide transduces and protects pancreatic beta-cells. Biochem Biophys Res Commun 305:876\u2013881","journal-title":"Biochem Biophys Res Commun"},{"key":"563_CR46","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbrc.2004.08.116","volume":"323","author":"D Klein","year":"2004","unstructured":"Klein D, Ribeiro MM, Mendoza V et al (2004) Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets. Biochem Biophys Res Commun 323:473\u2013478","journal-title":"Biochem Biophys Res Commun"},{"key":"563_CR47","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1074\/jbc.M007540200","volume":"276","author":"S Futaki","year":"2001","unstructured":"Futaki S, Suzuki T, Ohashi W et al (2001) Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem 276:5836\u20135840","journal-title":"J Biol Chem"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-006-0563-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-006-0563-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-006-0563-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T07:45:59Z","timestamp":1558597559000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-006-0563-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,16]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,2,5]]}},"alternative-id":["563"],"URL":"https:\/\/doi.org\/10.1007\/s00125-006-0563-2","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,16]]}}}