{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:07:26Z","timestamp":1773904046703,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2007,10,6]],"date-time":"2007-10-06T00:00:00Z","timestamp":1191628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2007,11,5]]},"DOI":"10.1007\/s00125-007-0835-5","type":"journal-article","created":{"date-parts":[[2007,10,5]],"date-time":"2007-10-05T08:00:42Z","timestamp":1191571242000},"page":"2504-2515","source":"Crossref","is-referenced-by-count":83,"title":["Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells"],"prefix":"10.1007","volume":"50","author":[{"given":"V.","family":"Dror","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Walia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. B.","family":"Kalynyak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,10,6]]},"reference":[{"key":"835_CR1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","volume":"284","author":"S Artavanis-Tsakonas","year":"1999","unstructured":"Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284:770\u2013776","journal-title":"Science"},{"key":"835_CR2","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1101\/gad.12.12.1751","volume":"12","author":"I Greenwald","year":"1998","unstructured":"Greenwald I (1998) LIN-12\/Notch signaling: lessons from worms and flies. Genes Dev 12:1751\u20131762","journal-title":"Genes Dev"},{"key":"835_CR3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1097-4547(19981015)54:2<125::AID-JNR1>3.0.CO;2-G","volume":"54","author":"P Beatus","year":"1998","unstructured":"Beatus P, Lendahl U (1998) Notch and neurogenesis. J Neurosci Res 54:125\u2013136","journal-title":"J Neurosci Res"},{"key":"835_CR4","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/18979","volume":"398","author":"J Hardy","year":"1999","unstructured":"Hardy J, Israel A (1999) Alzheimer's disease. In search of gamma-secretase. Nature 398:466\u2013467","journal-title":"Nature"},{"key":"835_CR5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/23716","volume":"400","author":"A Apelqvist","year":"1999","unstructured":"Apelqvist A, Li H, Sommer L et al (1999) Notch signalling controls pancreatic cell differentiation. Nature 400:877\u2013881","journal-title":"Nature"},{"key":"835_CR6","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S0012-1606(03)00326-9","volume":"260","author":"J Hald","year":"2003","unstructured":"Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J (2003) Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol 260:426\u2013437","journal-title":"Dev Biol"},{"key":"835_CR7","doi-asserted-by":"crossref","first-page":"14920","DOI":"10.1073\/pnas.2436557100","volume":"100","author":"LC Murtaugh","year":"2003","unstructured":"Murtaugh LC, Stanger BZ, Kwan KM, Melton DA (2003) Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A 100:14920\u201314925","journal-title":"Proc Natl Acad Sci U S A"},{"key":"835_CR8","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1210\/en.2004-1576","volume":"146","author":"JF Habener","year":"2005","unstructured":"Habener JF, Kemp DM, Thomas MK (2005) Minireview: transcriptional regulation in pancreatic development. Endocrinology 146:1025\u20131034","journal-title":"Endocrinology"},{"key":"835_CR9","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1242\/dev.127.16.3533","volume":"127","author":"VM Schwitzgebel","year":"2000","unstructured":"Schwitzgebel VM, Scheel DW, Conners JR et al (2000) Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127:3533\u20133542","journal-title":"Development"},{"key":"835_CR10","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jcp.10467","volume":"199","author":"MS Jang","year":"2004","unstructured":"Jang MS, Miao H, Carlesso N et al (2004) Notch-1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathways. J Cell Physiol 199:418\u2013433","journal-title":"J Cell Physiol"},{"key":"835_CR11","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1128\/JVI.77.12.7106-7112.2003","volume":"77","author":"P Nair","year":"2003","unstructured":"Nair P, Somasundaram K, Krishna S (2003) Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB\/Akt-dependent pathway. J Virol 77:7106\u20137112","journal-title":"J Virol"},{"key":"835_CR12","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/sj.cdd.4401827","volume":"13","author":"J Jang","year":"2006","unstructured":"Jang J, Choi YI, Choi J et al (2006) Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter. Cell Death Differ 13:1495\u20131505","journal-title":"Cell Death Differ"},{"key":"835_CR13","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1053\/j.gastro.2004.12.008","volume":"128","author":"JN Jensen","year":"2005","unstructured":"Jensen JN, Cameron E, Garay MV, Starkey TW, Gianani R, Jensen J (2005) Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology 128:728\u2013741","journal-title":"Gastroenterology"},{"key":"835_CR14","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.2353\/ajpath.2006.050926","volume":"169","author":"I Rooman","year":"2006","unstructured":"Rooman I, De Medts N, Baeyens L et al (2006) Expression of the notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Am J Pathol 169:1206\u20131214","journal-title":"Am J Pathol"},{"key":"835_CR15","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.bbrc.2005.11.111","volume":"339","author":"MI Darville","year":"2006","unstructured":"Darville MI, Eizirik DL (2006) Notch signaling: a mediator of beta-cell de-differentiation in diabetes? Biochem Biophys Res Commun 339:1063\u20131068","journal-title":"Biochem Biophys Res Commun"},{"key":"835_CR16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/00007890-200209270-00023","volume":"74","author":"PR Salvalaggio","year":"2002","unstructured":"Salvalaggio PR, Deng S, Ariyan CE et al (2002) Islet filtration: a simple and rapid new purification procedure that avoids ficoll and improves islet mass and function. Transplantation 74:877\u2013879","journal-title":"Transplantation"},{"key":"835_CR17","doi-asserted-by":"crossref","first-page":"24794","DOI":"10.1074\/jbc.M401216200","volume":"279","author":"JD Johnson","year":"2004","unstructured":"Johnson JD, Han Z, Otani K et al (2004) RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J Biol Chem 279:24794\u201324802","journal-title":"J Biol Chem"},{"key":"835_CR18","doi-asserted-by":"crossref","first-page":"14566","DOI":"10.1073\/pnas.222099799","volume":"99","author":"JD Johnson","year":"2002","unstructured":"Johnson JD, Misler S (2002) Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells. Proc Natl Acad Sci U S A 99:14566\u201314571","journal-title":"Proc Natl Acad Sci U S A"},{"key":"835_CR19","doi-asserted-by":"crossref","first-page":"19575","DOI":"10.1073\/pnas.0604208103","volume":"103","author":"JD Johnson","year":"2006","unstructured":"Johnson JD, Bernal-Mizrachi E, Alejandro EU et al (2006) Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome. Proc Natl Acad Sci U S A 103:19575\u201319580","journal-title":"Proc Natl Acad Sci USA"},{"key":"835_CR20","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1074\/jbc.M411727200","volume":"280","author":"M Ohsugi","year":"2005","unstructured":"Ohsugi M, Cras-Meneur C, Zhou Y et al (2005) Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion. J Biol Chem 280:4992\u20135003","journal-title":"J Biol Chem"},{"key":"835_CR21","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/dvdy.20733","volume":"235","author":"C Carson","year":"2006","unstructured":"Carson C, Murdoch B, Roskams AJ (2006) Notch 2 and Notch 1\/3 segregate to neuronal and glial lineages of the developing olfactory epithelium. Dev Dyn 235:1678\u20131688","journal-title":"Dev Dyn"},{"key":"835_CR22","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1172\/JCI200316537","volume":"111","author":"JD Johnson","year":"2003","unstructured":"Johnson JD, Ahmed NT, Luciani DS et al (2003) Increased islet apoptosis in Pdx1+\/\u2212 mice. J Clin Invest 111:1147\u20131160","journal-title":"J Clin Invest"},{"key":"835_CR23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/(SICI)1097-4652(199912)181:3<393::AID-JCP3>3.0.CO;2-6","volume":"181","author":"L Miele","year":"1999","unstructured":"Miele L, Osborne B (1999) Arbiter of differentiation and death: Notch signaling meets apoptosis. J Cell Physiol 181:393\u2013409","journal-title":"J Cell Physiol"},{"key":"835_CR24","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/embo-reports\/kve180","volume":"2","author":"M Sastre","year":"2001","unstructured":"Sastre M, Steiner H, Fuchs K et al (2001) Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep 2:835\u2013841","journal-title":"EMBO Rep"},{"key":"835_CR25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1471-4159.2001.00012.x","volume":"76","author":"HF Dovey","year":"2001","unstructured":"Dovey HF, John V, Anderson JP et al (2001) Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem 76:173\u2013181","journal-title":"J Neurochem"},{"key":"835_CR26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1096\/fj.02-0394fje","volume":"17","author":"CA Micchelli","year":"2003","unstructured":"Micchelli CA, Esler WP, Kimberly WT et al (2003) Gamma-secretase\/presenilin inhibitors for Alzheimer\u2019s disease phenocopy Notch mutations in Drosophila. FASEB J 17:79\u201381","journal-title":"FASEB J"},{"key":"835_CR27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1535-6108(03)00140-5","volume":"3","author":"Y Miyamoto","year":"2003","unstructured":"Miyamoto Y, Maitra A, Ghosh B et al (2003) Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 3:565\u2013576","journal-title":"Cancer Cell"},{"key":"835_CR28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0925-4773(00)00317-8","volume":"94","author":"E Lammert","year":"2000","unstructured":"Lammert E, Brown J, Melton DA (2000) Notch gene expression during pancreatic organogenesis. Mech Dev 94:199\u2013203","journal-title":"Mech Dev"},{"key":"835_CR29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ydbio.2003.08.013","volume":"264","author":"GA Norgaard","year":"2003","unstructured":"Norgaard GA, Jensen JN, Jensen J (2003) FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol 264:323\u2013338","journal-title":"Dev Biol"},{"key":"835_CR30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0925-4773(95)00425-4","volume":"53","author":"I Ahmad","year":"1995","unstructured":"Ahmad I, Zaqouras P, Artavanis-Tsakonas S (1995) Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells. Mech Dev 53:73\u201385","journal-title":"Mech Dev"},{"key":"835_CR31","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/dev.129.10.2447","volume":"129","author":"G Gu","year":"2002","unstructured":"Gu G, Dubauskaite J, Melton DA (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447\u20132457","journal-title":"Development"},{"key":"835_CR32","doi-asserted-by":"crossref","first-page":"15116","DOI":"10.1073\/pnas.0507567102","volume":"102","author":"K Minami","year":"2005","unstructured":"Minami K, Okuno M, Miyawaki K et al (2005) Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci USA 102:15116\u201315121","journal-title":"Proc Natl Acad Sci USA"},{"key":"835_CR33","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/sj.cdd.4401883","volume":"13","author":"L Baeyens","year":"2006","unstructured":"Baeyens L, Bonne S, German MS, Ravassard P, Heimberg H, Bouwens L (2006) Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK\/STAT pathway. Cell Death Differ 13:1892\u20131899","journal-title":"Cell Death Differ"},{"key":"835_CR34","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2337\/diabetes.54.3.720","volume":"54","author":"J Dominguez-Bendala","year":"2005","unstructured":"Dominguez-Bendala J, Klein D, Ribeiro M et al (2005) TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro. Diabetes 54:720\u2013726","journal-title":"Diabetes"},{"key":"835_CR35","doi-asserted-by":"crossref","first-page":"20345","DOI":"10.1074\/jbc.M312483200","volume":"279","author":"S Dalle","year":"2004","unstructured":"Dalle S, Longuet C, Costes S et al (2004) Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1\/2 in MIN6 cell line and isolated islets of Langerhans. J Biol Chem 279:20345\u201320355","journal-title":"J Biol Chem"},{"key":"835_CR36","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.2337\/diabetes.50.10.2244","volume":"50","author":"LJ Elrick","year":"2001","unstructured":"Elrick LJ, Docherty K (2001) Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1. Diabetes 50:2244\u20132252","journal-title":"Diabetes"},{"key":"835_CR37","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1074\/jbc.M508510200","volume":"281","author":"D Kawamori","year":"2006","unstructured":"Kawamori D, Kaneto H, Nakatani Y et al (2006) The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J Biol Chem 281:1091\u20131098","journal-title":"J Biol Chem"},{"key":"835_CR38","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1016\/j.ejca.2005.06.025","volume":"41","author":"J Sjolund","year":"2005","unstructured":"Sjolund J, Manetopoulos C, Stockhausen MT, Axelson H (2005) The Notch pathway in cancer: differentiation gone awry. Eur J Cancer 41:2620\u20132629","journal-title":"Eur J Cancer"},{"key":"835_CR39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2337\/diabetes.51.1.66","volume":"51","author":"M Biarnes","year":"2002","unstructured":"Biarnes M, Montolio M, Nacher V, Raurell M, Soler J, Montanya E (2002) Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 51:66\u201372","journal-title":"Diabetes"},{"key":"835_CR40","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2337\/diab.45.9.1161","volume":"45","author":"AM Davalli","year":"1996","unstructured":"Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC (1996) Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes 45:1161\u20131167","journal-title":"Diabetes"},{"key":"835_CR41","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1096\/fj.01-0403fje","volume":"16","author":"W Moritz","year":"2002","unstructured":"Moritz W, Meier F, Stroka DM et al (2002) Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression. FASEB J 16:745\u2013747","journal-title":"FASEB J"},{"key":"835_CR42","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.transproceed.2004.04.036","volume":"36","author":"J Stagner","year":"2004","unstructured":"Stagner J, Mokshagundam S, Wyler K et al (2004) Beta-cell sparing in transplanted islets by vascular endothelial growth factor. Transplant Proc 36:1178\u20131180","journal-title":"Transplant Proc"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-007-0835-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-007-0835-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-007-0835-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T06:39:27Z","timestamp":1629873567000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-007-0835-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,6]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,11,5]]}},"alternative-id":["835"],"URL":"https:\/\/doi.org\/10.1007\/s00125-007-0835-5","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,6]]}}}