{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:26:54Z","timestamp":1791012414337,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1007\/s00125-008-1237-z","type":"journal-article","created":{"date-parts":[[2008,12,22]],"date-time":"2008-12-22T06:34:45Z","timestamp":1229927685000},"page":"494-503","source":"Crossref","is-referenced-by-count":43,"title":["Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient"],"prefix":"10.1007","volume":"52","author":[{"given":"J. H.","family":"Velthuis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. W.","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"van der Slik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Duinkerken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Engelse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. F.","family":"Schaapherder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ringers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"van Kooten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"de Koning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. O.","family":"Roep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,12,23]]},"reference":[{"key":"1237_CR1","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.3748\/wjg.v13.i47.6347","volume":"13","author":"RM Meloche","year":"2007","unstructured":"Meloche RM (2007) Transplantation for the treatment of type 1 diabetes. World J Gastroenterol 13:6347\u20136355","journal-title":"World J Gastroenterol"},{"key":"1237_CR2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/345632a0","volume":"345","author":"BO Roep","year":"1990","unstructured":"Roep BO, Arden SD, de Vries RR, Hutton JC (1990) T cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins. Nature 345:632\u2013634","journal-title":"Nature"},{"key":"1237_CR3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00125-003-1089-5","volume":"46","author":"BO Roep","year":"2003","unstructured":"Roep BO (2003) The role of T cells in the pathogenesis of Type 1 diabetes: from cause to cure. Diabetologia 46:305\u2013321","journal-title":"Diabetologia"},{"key":"1237_CR4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0140-6736(01)05415-0","volume":"358","author":"MA Atkinson","year":"2001","unstructured":"Atkinson MA, Eisenbarth GS (2001) Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358:221\u2013229","journal-title":"Lancet"},{"key":"1237_CR5","doi-asserted-by":"crossref","first-page":"e2435","DOI":"10.1371\/journal.pone.0002435","volume":"3","author":"VAL Huurman","year":"2008","unstructured":"Huurman VAL, Hilbrands R, Pinkse GG et al (2008) Cellular islet autoimmunity influences clinical outcome of islet cell transplantation. PLoS One 3:e2435","journal-title":"PLoS One"},{"key":"1237_CR6","doi-asserted-by":"crossref","first-page":"18425","DOI":"10.1073\/pnas.0508621102","volume":"102","author":"GG Pinkse","year":"2005","unstructured":"Pinkse GG, Tysma OH, Bergen CA et al (2005) Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A 102:18425\u201318430","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1237_CR7","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ni1178","volume":"6","author":"S Sakaguchi","year":"2005","unstructured":"Sakaguchi S (2005) Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6:345\u2013352","journal-title":"Nat Immunol"},{"key":"1237_CR8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.smim.2006.01.007","volume":"18","author":"M Battaglia","year":"2006","unstructured":"Battaglia M, Gregori S, Bacchetta R, Roncarolo MG (2006) Tr1 cells: from discovery to their clinical application. Semin Immunol 18:120\u2013127","journal-title":"Semin Immunol"},{"key":"1237_CR9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1568-9972(02)00065-4","volume":"1","author":"G Filaci","year":"2002","unstructured":"Filaci G, Suciu-Foca N (2002) CD8+ T suppressor cells are back to the game: are they players in autoimmunity? Autoimmun Rev 1:279\u2013283","journal-title":"Autoimmun Rev"},{"key":"1237_CR10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0198-8859(02)00742-5","volume":"64","author":"AI Colovai","year":"2003","unstructured":"Colovai AI, Mirza M, Vlad G et al (2003) Regulatory CD8+ CD28\u2212 T cells in heart transplant recipients. Hum Immunol 64:31\u201337","journal-title":"Hum Immunol"},{"key":"1237_CR11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.humimm.2004.05.017","volume":"66","author":"R Sindhi","year":"2005","unstructured":"Sindhi R, Manavalan JS, Magill A, Suciu-Foca N, Zeevi A (2005) Reduced immunosuppression in pediatric liver-intestine transplant recipients with CD8+ CD28\u2212 T-suppressor cells. Hum Immunol 66:252\u2013257","journal-title":"Hum Immunol"},{"key":"1237_CR12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2337\/diab.37.4.413","volume":"37","author":"C Ricordi","year":"1998","unstructured":"Ricordi C, Lacy PE, Finke EH, Olack BJ, Scharp DW (1998) Automated method for isolation of human pancreatic islets. Diabetes 37:413\u2013420","journal-title":"Diabetes"},{"key":"1237_CR13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2337\/diab.44.3.278","volume":"44","author":"BO Roep","year":"1995","unstructured":"Roep BO, Kallan AA, Duinkerken G et al (1995) T cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM. Diabetes 44:278\u2013283","journal-title":"Diabetes"},{"key":"1237_CR14","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1172\/JCI7936","volume":"104","author":"M Peakman","year":"1999","unstructured":"Peakman M, Stevens EJ, Lohmann T et al (1999) Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4. J Clin Invest 104:1449\u20131457","journal-title":"J Clin Invest"},{"key":"1237_CR15","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.immunol.22.012703.104702","volume":"22","author":"F Sallusto","year":"2004","unstructured":"Sallusto F, Geginat J, Lanzavecchia A (2004) Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 22:745\u2013763:745\u2013763","journal-title":"Annu Rev Immunol"},{"key":"1237_CR16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-6143.2005.01162.x","volume":"6","author":"S Kim-Schulze","year":"2006","unstructured":"Kim-Schulze S, Seki T, Vlad G et al (2006) Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells. Am J Transplant 6:76\u201382","journal-title":"Am J Transplant"},{"key":"1237_CR17","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/sj.bmt.1703730","volume":"30","author":"M Hirokawa","year":"2002","unstructured":"Hirokawa M, Matsutani T, Saitoh H et al (2002) Distinct TCRAV and TCRBV repertoire and CDR3 sequence of T lymphocytes clonally expanded in blood and GVHD lesions after human allogeneic bone marrow transplantation. Bone Marrow Transplant 30:915\u2013923","journal-title":"Bone Marrow Transplant"},{"key":"1237_CR18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","volume":"22","author":"MA Cooper","year":"2001","unstructured":"Cooper MA, Fehniger TA, Caligiuri MA (2001) The biology of human natural killer-cell subsets. Trends Immunol 22:633\u2013640","journal-title":"Trends Immunol"},{"key":"1237_CR19","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4049\/jimmunol.161.1.400","volume":"161","author":"M Frey","year":"1998","unstructured":"Frey M, Packianathan NB, Fehniger TA et al (1998) Differential expression and function of L-selectin on CD56bright and CD56dim natural killer cell subsets. J Immunol 161:400\u2013408","journal-title":"J Immunol"},{"key":"1237_CR20","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature03625","volume":"435","author":"SC Kent","year":"2005","unstructured":"Kent SC, Chen Y, Bregoli L et al (2005) Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 435:224\u2013228","journal-title":"Nature"},{"key":"1237_CR21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/ni760","volume":"3","author":"CC Chang","year":"2002","unstructured":"Chang CC, Ciubotariu R, Manavalan JS et al (2002) Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 3:237\u2013243","journal-title":"Nat Immunol"},{"key":"1237_CR22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0966-3274(03)00058-3","volume":"11","author":"JS Manavalan","year":"2003","unstructured":"Manavalan JS, Rossi PC, Vlad G et al (2003) High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol 11:245\u2013258","journal-title":"Transpl Immunol"},{"key":"1237_CR23","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/intimm\/10.6.775","volume":"6","author":"Z Liu","year":"1998","unstructured":"Liu Z, Tugulea S, Cortesini R, Suciu-Foca N (1998) Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+ CD28\u2212 T cells. Int Immunol 6:775\u2013783","journal-title":"Int Immunol"},{"key":"1237_CR24","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/intimm\/dxh107","volume":"16","author":"JS Manavalan","year":"2004","unstructured":"Manavalan JS, Kim-Schulze S, Scotto L et al (2004) Alloantigen specific CD8+ CD28\u2212 FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity. Int Immunol 16:1055\u20131068","journal-title":"Int Immunol"},{"key":"1237_CR25","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2337\/diabetes.52.3.717","volume":"52","author":"JE Greening","year":"2003","unstructured":"Greening JE, Tree TI, Kotowicz KT et al (2003) Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T cells. Diabetes 52:717\u2013725","journal-title":"Diabetes"},{"key":"1237_CR26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s001250051177","volume":"42","author":"LD Peterson","year":"1999","unstructured":"Peterson LD, van der Keur M, de Vries RR, Roep BO (1999) Autoreactive and immunoregulatory T cell subsets in insulin-dependent diabetes mellitus. Diabetologia 42:443\u2013449","journal-title":"Diabetologia"},{"key":"1237_CR27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jaut.2004.04.002","volume":"23","author":"RG Naik","year":"2004","unstructured":"Naik RG, Beckers C, Wentwoord R et al (2004) Precursor frequencies of T cells reactive to insulin in recent onset type 1 diabetes mellitus. J Autoimmun 23:55\u201361","journal-title":"J Autoimmun"},{"key":"1237_CR28","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.2337\/diabetes.53.7.1692","volume":"53","author":"TI Tree","year":"2004","unstructured":"Tree TI, Duinkerken G, Willemen S, de Vries RR, Roep BO (2004) HLA-DQ-regulated T cell responses to islet cell autoantigens insulin and GAD65. Diabetes 53:1692\u20131699","journal-title":"Diabetes"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-008-1237-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00125-008-1237-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00125-008-1237-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T23:13:54Z","timestamp":1684797234000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00125-008-1237-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,23]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["1237"],"URL":"https:\/\/doi.org\/10.1007\/s00125-008-1237-z","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,23]]}}}